Cited by 278Cytomegalovirus and herpesvirus researchGenetics, Aging, and Longevity in Model OrganismsViral-associated cancers and disorders

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection

Bartlett, David B., Firth, Charlotte M., Phillips, Anna C., Moss, Paul, Baylis, Daniel, Syddall, Holly, Sayer, Avan A., Cooper, Cyrus, Lord, Janet M.·2012·Aging Cell

DOI 10.1111/j.1474-9726.2012.00849.x

Open this paper in CoChat — free account

Abstract

Aging is accompanied by the development of low-grade systemic inflammation, termed 'inflammaging', characterized by raised serum C-reactive protein (CRP) and pro-inflammatory cytokines. Importantly, inflammaging is implicated in the pathogenesis of several of the major age-related diseases including cardiovascular disease, type 2 diabetes, and dementia and is associated with increased mortality. The incidence of infection with the persistent herpes virus cytomegalovirus (CMV) also increases with age. Cross-sectional studies have proposed CMV infection as a significant driver of inflammaging, but a definitive case for CMV as a causative agent in inflammaging has not yet been made. We studied longitudinally 249 subjects (153 men, 96 women) who participated in the Hertfordshire Ageing Study at baseline (1993/5, mean age 67·5 years) and at 10 year follow-up. At both times, anthropometric measurements were made and subjects provided blood samples for analysis of inflammatory status and CMV seropositivity. In the cohort as a whole, serum CRP (P < 0·02) and pro-inflammatory cytokines TNFα (P < 0·001) and IL-6 (P < 0·001) were increased between baseline and follow-up sampling whereas levels of the anti-inflammatory cytokine IL-10 were decreased (P < 0·001). These changes to cytokine status over time occurred equally in the 60% of subjects who were seropositive for CMV at baseline and follow-up, the 8% who were CMV negative at baseline but who became CMV positive by the 10 year follow-up, and also in the 32% who were CMV seronegative throughout. We conclude that CMV infection is not a primary causative factor in the age-related increase in systemic inflammation.

Integrity signals

Registry

Crossref · 10.1111/j.1474-9726.2012.00849.x

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488
Inflammation in Atherosclerosis: Transition From Theory to Practice
Libby, P., Okamoto, Y., Rocha, V. Z., & Folco, E. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0706 · Cited by 799
Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
Self-citation
Does Exercise Reduce Inflammation? Physical Activity and C-Reactive Protein Among U.S. Adults
Ford, E. S. (2002) · Epidemiology · doi:10.1097/00001648-200209000-00012 · Cited by 575
The immunology of exceptional individuals: the lesson of centenarians
Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 535
Seropositivity to Cytomegalovirus, Inflammation, All-Cause and Cardiovascular Disease-Related Mortality in the United States
Simanek, A. M., Dowd, J. B., Pawelec, G., Melzer, D. R., Dutta, A., & Aiello, A. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016103 · Cited by 398
Obesity and inflammation: the effects of weight loss
Forsythe, L. K., Wallace, J. M. W., & Livingstone, M. B. E. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138732 · Cited by 381 · cited 4×
“Various factors have been proposed to drive inflammaging including increased adiposity with age (Forsythe et al., 2008), and decreased production of sex steroids (Maggio et al.”
BackgroundInfluential
Cytomegalovirus and human immunosenescence
Pawelec, G., Derhovanessian, E., Larbi, A., Strindhall, J., & Wikby, A. (2008) · Reviews in Medical Virology · doi:10.1002/rmv.598 · Cited by 339
The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning
Wikby, A., Nilsson, B.-O., Forsey, R. J., Thompson, J., Strindhall, J., Löfgren, S., Ernerudh, J., Pawelec, G., Ferguson, F. G., & Johansson, B. E. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.04.003 · Cited by 284

Show all 28 references

Sorted by citations

Items 101–200 of 278

T-cell immunity against cytomegalovirus in HIV infection and aging: relationships with inflammation, immune activation, and frailty
Tavenier, J., Margolick, J. B., & Leng, S. X. (2019) · Medical Microbiology and Immunology · doi:10.1007/s00430-019-00591-z · Cited by 25
Differences in the association between persistent pathogens and mood disorders among young- to middle-aged women and men in the U.S.
Simanek, A. M., Parry, A., & Dowd, J. B. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.09.017 · Cited by 25
Decreased Proportion of Cytomegalovirus Specific CD8 T-Cells but No Signs of General Immunosenescence in Alzheimer’s Disease
Westman, G., Lidehäll, A. K., Magnusson, P. U., Ingelsson, M., Kilander, L., Lannfelt, L., Korsgren, O., & Eriksson, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077921 · Cited by 24
The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation
Ziegler, A. K., Jensen, S. M., Schjerling, P., Mackey, A. L., Andersen, J. L., & Kjær, M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.03.007 · Cited by 23
Immunity and the Endocrine System
Stelzer, I. A., & Arck, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.19001-0 · Cited by 23
UVB induces epidermal 11β‐hydroxysteroid dehydrogenase type 1 activity in vivo
Tiganescu, A., Hupe, M., Jiang, Y. J., Celli, A., Uchida, Y., Mauro, T. M., Bikle, D. D., Elias, P. M., & Holleran, W. M. (2015) · Experimental Dermatology · doi:10.1111/exd.12682 · Cited by 22
Serum levels of IL-6 are associated with cognitive impairment in the salus in apulia population-based study
Griseta, C., Battista, P., Castellana, F., Colonna, I., Sciarra, S., Zupo, R., Bortone, I., Lampignano, L., Tirelli, S., Berardino, G., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13972 · Cited by 21
Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: A transcriptomic analysis
Kuparinen, T., Marttila, S., Jylhävä, J., Tserel, L., Peterson, P., Jylhä, M. K., Hervonen, A., & Hurme, M. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2012.12.010 · Cited by 21
The role of attenuated redox and heat shock protein responses in the age-related decline in skeletal muscle mass and function
McArdle, A., & Jackson, M. J. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160088 · Cited by 19
Maintenance of muscle strength following a one-year resistance training program in older adults
Gylling, A. T., Bloch‐Ibenfeldt, M., Eriksen, C. S., Ziegler, A. K., Wimmelmann, C. L., Baekgaard, M., Boraxbekk, C., Siebner, H. R., Mortensen, E. L., & Kjær, M. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111049 · Cited by 20
Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients
Mainali, S., & Darsie, M. E. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.648662 · Cited by 21
Testosterone treatment of aged male mice improves some but not all aspects of age-associated increases in influenza severity
Steeg, L. G. V., Attreed, S. E., Zirkin, B. R., & Klein, S. L. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.103988 · Cited by 20
Does Lifelong Exercise Counteract Low-Grade Inflammation Associated with Aging? A Systematic Review and Meta-Analysis
Pérez-Castillo, Í. M., Rueda, R., Bouzamondo, H., Aparicio-Pascual, D., Valiño-Marques, A., Chicharro, J. L., & Segura-Ortiz, F. (2025) · Sports Medicine · doi:10.1007/s40279-024-02152-8 · Cited by 19
HIV patients, healthy aging and transplant recipients can reveal the hidden footprints of CMV
Waters, S., Brook, E., Lee, S., Estiasari, R., Ariyanto, I. A., & Price, P. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.11.001 · Cited by 19
Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Oxi-Immune Markers, Clinical Parameters and Modifiable Risk Factors
Gomes, A., Laffón, B., Valdiglesias, V., Gostner, J. M., Felder, T. K., Costa, C., Madureira, J., Fuchs, D., Teixeira, J. P., & Costa, S. (2021) · Antioxidants · doi:10.3390/antiox10121975 · Cited by 19
When GETomics meets aging and exercise in COPD
Pellegrino, D., Casas-Recasens, S., Faner, R., Palange, P., & Agustí, A. G. N. (2023) · Respiratory Medicine · doi:10.1016/j.rmed.2023.107294 · Cited by 19
A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population
Lee, S., Brook, E., Affandi, J. S., Howson, P., Tanudjaja, S. A., Dhaliwal, S. S., Irish, A. B., & Price, P. (2019) · Clinical & Translational Immunology · doi:10.1002/cti2.1043 · Cited by 17
Feeding en route : Prey availability and traits influence prey selection by an avian predator on migration
Bourbour, R. P., Aylward, C. M., Meehan, T. D., Martinico, B. L., Badger, M. E., Goodbla, A. M., Fish, A. M., Ely, T. E., Briggs, C. W., & Hull, E. M. (2024) · Journal of Animal Ecology · doi:10.1111/1365-2656.14122 · Cited by 16
Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions
Shafqat, A., Masters, M. C., Tripathi, U., Tchkonia, T., Kirkland, J. L., & Hashmi, S. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102400 · Cited by 15
Circulating Muramyl Dipeptide Is Negatively Associated with Interleukin-10 in the Frail Elderly
Verschoor, C. P., Naidoo, A., Wallace, J. G., Johnstone, J., Loeb, M. B., Bramson, J. L., & Bowdish, D. M. E. (2014) · Inflammation · doi:10.1007/s10753-014-0030-z · Cited by 14
RNA‐Based Therapies for Neurodegenerative Diseases Targeting Pathogenic Proteins
Rabbani, S. A., El‐Tanani, M., Sharma, S., El‐Tanani, Y., Kumar, R., Saini, M., Yadav, M., Khan, M. A., & Parvez, S. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70110 · Cited by 15
Cytomegalovirus and herpes simplex type 1 infections and immunological profile of community-dwelling older adults
Noronha, B. P., Mambrini, J. V. D. M., Torres, K., Martins‐Filho, O. A., Teixeira‐Carvalho, A., Lima‐Costa, M. F., & Peixoto, S. V. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111337 · Cited by 15
Cytomegalovirus serostatus, inflammation, and antibody response to influenza vaccination in older adults: The moderating effect of beta blockade
Reed, R. G., Greenberg, R. N., & Segerstrom, S. C. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.025 · Cited by 13
Advanced age influences the dynamic changes in circulating C-reactive protein following injury
Pinato, D. J., Bains, J., Irkulla, S., Pomroy, J., Ujam, B., Gaze, D. C., & Mendall, M. A. (2013) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2012-201374 · Cited by 13
Testing the information centre hypothesis in a multilevel society
Papageorgiou, D., Cherono, W., Gall, G. E. C., Nyaguthii, B., & Farine, D. R. (2024) · Journal of Animal Ecology · doi:10.1111/1365-2656.14131 · Cited by 12
Pathogenic load and frailty in older adults: Singapore longitudinal ageing study
Ng, T. P., Lu, Y., Tan, C. T. Y., Gao, Q., Gwee, X., Fülöp, T., & Larbi, A. (2020) · Aging · doi:10.18632/aging.104076 · Cited by 12
The role of gender and labour status in immunosenescence of 65+ Polish population
Dudkowska, M., Janiszewska, D., Karpa, A., Broczek, K., Dabrowski, M., & Sikora, E. (2017) · Biogerontology · doi:10.1007/s10522-017-9702-z · Cited by 11
“Considering studies performed by Bartlett and others we can argue against CMV infection as cause of these differences (Bartlett et al. 2012).”
Result
Revisiting niche divergence hypothesis in sexually dimorphic birds: Is diet overlap correlated with sexual size dimorphism?
Bravo, C., Bautista-Sopelana, L. M., & Alonso, J. C. (2024) · Journal of Animal Ecology · doi:10.1111/1365-2656.14058 · Cited by 11
Senescent adipocytes and type 2 diabetes – current knowledge and perspective concepts
Kruczkowska, W., Gałęziewska, J., Kciuk, M., Gielecińska, A., Płuciennik, E., Pasieka, Z. W., Zhao, L.-Y., Yu, Y.-J., Kołat, D., & Kałuzińska‐Kołat, Ż. (2024) · BioMolecular Concepts · doi:10.1515/bmc-2022-0046 · Cited by 12
Unravelling the complexities of biotic homogenization and heterogenization in the British avifauna
Wayman, J. P., Sadler, J. P., Martin, T. E., Graham, L., White, H. J., Tobias, J. A., & Matthews, T. J. (2024) · Journal of Animal Ecology · doi:10.1111/1365-2656.14145 · Cited by 11
Immune-endocrine biomarkers associated with mental health: A 9-year longitudinal investigation from the Hertfordshire Ageing Study
Hou, R. H., Westbury, L. D., Fuggle, N. R., Cooper, C. C., & Dennison, E. M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.12.022 · Cited by 11
Self-citation
Limited Impact of Human Cytomegalovirus Infection in African Infants on Vaccine-Specific Responses Following Diphtheria-Tetanus-Pertussis and Measles Vaccination
Cox, M., Adetifa, J. U., Noho‐Konteh, F., Njie-Jobe, J., Sanyang, L. C., Drammeh, A., Plebanski, M., Whittle, H. C., Rowland‐Jones, S., Robertson, I. K., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01083 · Cited by 12
Better immunity in later life: a position paper
Faragher, R., Frasca, D., Remarque, E. J., & Pawelec, G. (2014) · AGE · doi:10.1007/s11357-014-9619-2 · Cited by 11
Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespanPreprint
Reiné, J., Carniel, B. F., Solórzano, C., Mitsi, E., Pojar, S., Nikolaou, E., German, E. L., Hyder-Wright, A. D., Hill, H. C., Hales, C., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/576744 · Cited by 10
A circumpolar study unveils a positive non‐linear effect of temperature on arctic arthropod availability that may reduce the risk of warming‐induced trophic mismatch for breeding shorebirds
Chagnon‐Lafortune, A., Duchesne, É., Legagneux, P., McKinnon, L., Reneerkens, J. W. H., Casajus, N., Abraham, K. F., Bolduc, É., Brown, G. S., Brown, S. C., et al. (2024) · Global Change Biology · doi:10.1111/gcb.17356 · Cited by 10
Potential relationship between cytomegalovirus and immunosenescence: Evidence from observational studies
Gadoth, A., Ourfalian, K., Basnet, S., Kunzweiler, C. P., Bohn, R. L., Fülöp, T., & Diaz-Decaro, J. D. (2024) · Reviews in Medical Virology · doi:10.1002/rmv.2560 · Cited by 10
Effects of human depopulation and warming climate on bird populations in Japan
Katayama, N., Fujita, T., Ueta, M., Morelli, F., & Amano, T. (2023) · Conservation Biology · doi:10.1111/cobi.14175 · Cited by 11
Therapeutic Strategies for Idiopathic Pulmonary Fibrosis – Thriving Present and Promising Tomorrow
Gupta, N., Paryani, M., Patel, S. S., Bariya, A. H., Srivastava, A., Pathak, Y. V., & Butani, S. (2024) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.2408 · Cited by 11
Community‐science reveals delayed fall migration of waterfowl and spatiotemporal effects of a changing climate
Frei, B., Cox, A. R., Morales, A. C., & Roy, C. (2024) · Journal of Animal Ecology · doi:10.1111/1365-2656.14055 · Cited by 9
Cell‐Surface LAMP1 is a Senescence Marker in Aging and Idiopathic Pulmonary Fibrosis
Meca-Laguna, G., Qiu, M., Hou, Y., Barkovskaya, A., Shankar, A., Dixit, B., Rae, M. J., Boominathan, A., & Sharma, A. (2025) · Aging Cell · doi:10.1111/acel.70141 · Cited by 10
Genomic landscapes of divergence among island bird populations: Evidence of parallel adaptation but at different loci?
Martin, C. A., Sheppard, E. C., Ali, H. A. A., Illera, J. C., Suh, A., Spurgin, L. G., & Richardson, D. S. (2024) · Molecular Ecology · doi:10.1111/mec.17365 · Cited by 10
Adipose stromal cell and sarpogrelate orchestrate the recovery of inflammation‐induced angiogenesis in aged hindlimb ischemic mice
Fan, W., Li, C., Qin, X., Wang, S., Da, H., Cheng, K., Zhou, R., Tong, C., Li, X., Bu, Q., et al. (2012) · Aging Cell · doi:10.1111/acel.12014 · Cited by 9
Supporting healthy ageing: Training multi-disciplinary healthcare students
Shneerson, C., Bartlett, D. B., Lord, J. M., & Gale, N. K. (2014) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2013.12.021 · Cited by 9
Self-citation
Tissue‐Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched‐Chain Amino Acids
Calubag, M. F., Ademi, I., Grunow, I., Breuer, L., Babygirija, R., Lialios, P., Le, S. M., Minton, D. M., Sonsalla, M. M., Illiano, J., et al. (2025) · Aging Cell · doi:10.1111/acel.70176 · Cited by 9
Association of inflammatory biomarkers with physical and cognitive frailty in a Spanish population of older adults
Lema‐Arranz, C., Hemadeh, A., Fernández‐Bertólez, N., Cibeira, N., López‐López, R., Costa, S., Millán-Calentí, J. C., Lorenzo‐López, L., Valdiglesias, V., & Laffón, B. (2025) · GeroScience · doi:10.1007/s11357-025-01931-z · Cited by 8
Investigating the dual functions of butylated hydroxytoluene, vitamin E and vitamin C as antioxidants and anti‐glycation agents in vitro: Implications for skin health
Markiewicz, E., Ruth, N., Mammone, T., & Idowu, O. C. (2025) · International Journal of Cosmetic Science · doi:10.1111/ics.13079 · Cited by 9
New distribution record of the Forest Owlet Heteroglaux blewitti Hume, 1873, (Aves: Strigiformes: Strigidae) in Purna Wildlife Sanctuary, Gujarat, India
Patel, J. R., Patel, S. B., Rathor, S. C., Patel, J. A., Patel, P. B., & Vasava, A. G. (2015) · Journal of Threatened Taxa · doi:10.11609/jott.o4237.7940-4 · Cited by 8
Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19
Freidin, M. B., Cheetham, N. J., Duncan, E. L., Steves, C. J., Doores, K. J., Malim, M. H., Rossi, N., Lord, J. M., Franks, P. W., Borsini, A., et al. (2023) · Inflammation Research · doi:10.1007/s00011-023-01722-2 · Cited by 8
Self-citation
Increased Basal and Alum-Induced Interleukin-6 Levels in Geriatric Patients Are Associated with Cardiovascular Morbidity
Compté, N., Boudjeltia, K. Z., Vanhaeverbeek, M., Breucker, S. D., Pepersack, T., Joel, T., Trelcat, A., & Goriely, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081911 · Cited by 8
Traversing the land‐sea interface: A climate change risk assessment of terrestrially breeding marine predators
Sojitra, M., Corney, S. P., Hemer, M., Hamilton, S., McInnes, J. C., Thalmann, S., & Lea, M. (2024) · Global Change Biology · doi:10.1111/gcb.17452 · Cited by 7
Review: Are moles senescent?
Bennett, D. C. (2024) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.13163 · Cited by 7
Prospects for Neotropical Forest Birds and Their Habitats Under Contrasting Emissions Scenarios
Brawn, J. D., Luther, D., Qu, M., Farinelli, S. M., Cooper, W. J., & Fu, R. (2024) · Global Change Biology · doi:10.1111/gcb.17544 · Cited by 7
Subtle stressors—Strong responses. Consistent negative effects of avian blood parasites on phenotypic and demographic traits across songbirds
Grabow, M., Mang, S., Blaum, N., Tiedemann, R., Radchuk, V., & Kramer‐Schadt, S. (2025) · Journal of Animal Ecology · doi:10.1111/1365-2656.70106 · Cited by 7
Investigating population-level immunosenescence: From bench to bedside
Cunha, L. L., Valsecchi, V. A. D. S., & Ward, L. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.949928 · Cited by 7
Linking activation of synaptic NMDA receptors‐induced CREB signaling to brief exposure of cortical neurons to oligomeric amyloid‐beta peptide
Ferreira, I. L., Marinho, D., de Rosa, V., Castanheira, B., Fang, Z., Caldeira, G. L., Mota, S. I., & Rego, A. C. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16222 · Cited by 6
Age-related exacerbation of lung damage after trauma is associated with increased expression of inflammasome components
Zhou, Y., Meng, F., Köhler, K., Bülow, J. M., Wagner, A., Neunaber, C., Bundkirchen, K., & Relja, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1253637 · Cited by 6
How interacting anthropogenic pressures alter the plasticity of breeding time in two common songbirds
Cuchot, P., Bonnet, T., Dehorter, O., Henry, P., & Teplitsky, C. (2024) · Journal of Animal Ecology · doi:10.1111/1365-2656.14113 · Cited by 8
Picky eaters: Selective microbial diet of avian ectosymbionts
Matthews, A. E., Trevelline, B. K., Wijeratne, A., & Boves, T. J. (2024) · Journal of Animal Ecology · doi:10.1111/1365-2656.14215 · Cited by 6
T‐ CLASS : An Online Tool for the Identification and Classification of Aging and Senescence Using Transcriptome Data
Lee, S. J., Lee, G., Kim, S. S., Bae, Y., Ham, S., Sohn, J., Han, S. K., & Lee, S. (2025) · Aging Cell · doi:10.1111/acel.70193 · Cited by 6
Postbiotic Parabacteroides Distasonis Supplementation Enhances Intestinal and Skeletal Muscle Function in Aged Mice
Morgado-Cáceres, P., Huerta, H., Bergman, C., Figueroa, R., Farías, P., Quiroz, G., Woehlbier, U., Mella, K., Díaz-Rivera, O., Linsambarth, S., et al. (2025) · Aging and Disease · doi:10.14336/ad.2025.0188 · Cited by 5
Reduced Accumulation Rate and Morphological Changes of Newly Generated Myelinating Oligodendrocytes in the Corpus Callosum of Aged Mice
Looprasertkul, S., Yamazaki, R., Osanai, Y., & Ohno, N. (2025) · Glia · doi:10.1002/glia.70070 · Cited by 5
Identification of diagnostic biomarkers used in the diagnosis of cardiovascular diseases and diabetes mellitus: A systematic review of quantitative studies
Wilson, M., Hamid, A. A., Abbas, I. I., Birkett, J. W., Khan, I., Harper, M., Al‐Jumeily, D., & Assi, S. A. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15593 · Cited by 7
Individual quality overwrites carry‐over effects across the annual cycle of a long‐distance migrant
Léandri‐Breton, D., Elliott, K. H., Tarroux, A., Moe, B., Jouanneau, W., Amélineau, F., Angelier, F., Blévin, P., Bråthen, V. S., Fauchald, P., et al. (2024) · Journal of Animal Ecology · doi:10.1111/1365-2656.14125 · Cited by 5
Optimizing orthobiologic therapies with exercise, diet, and supplements
Montagnino, J., Kaufman, M. W., Shetty, M., Centeno, C. J., & Fredericson, M. (2025) · PM&R · doi:10.1002/pmrj.13320 · Cited by 4
Factors associated with reaching maintenance therapy in patients with advanced biliary tract cancer treated with durvalumab: Real‐world results from a multicenter and multinational study
Rimini, M., Fornaro, L., Prinzi, F. L., Rizzato, M. D., Saborowski, A. L., Antonuzzo, L., Rossari, F., Satake, T., Peeters, F., Vivaldi, C., et al. (2025) · International Journal of Cancer · doi:10.1002/ijc.35481 · Cited by 4
A comprehensive review on p38MAPK signaling as a potent radioprotector in testis
Yang, J., Ou, X., Zeng, H., & Shao, L. (2024) · Andrology · doi:10.1111/andr.13760 · Cited by 5
A specialist predator in a food web with cyclic alternative prey: The gyrfalcon‐ptarmigan case revisited
Kleiven, E. F., Johansen, K., Ims, R. A., Soininen, E. M., Oksanen, L., Oksanen, T., Jacobsen, K., & Østlyngen, A. (2025) · Journal of Animal Ecology · doi:10.1111/1365-2656.70056 · Cited by 4
Anticytomegalovirus antibody titres are not associated with caregiving burden in younger caregivers
Vitlić, A., Phillips, A. C., Gallagher, S. M., Oliver, C., Lord, J. M., & Moss, P. A. H. (2014) · British Journal of Health Psychology · doi:10.1111/bjhp.12092 · Cited by 4
Self-citation
Immunosenescence, Oxidative Stress, and Cancers
Fülöp, T., Pawelec, G., Dupuis, G., Kotb, R. R., Friguet, B., Witkowski, J. M., & Larbi, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-30845-2_23 · Cited by 4
Cationic ribosomal proteins can inhibit pro‐inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products
Watanabe, M., Toyomura, T., Wake, H., Nishinaka, T., Hatipoğlu, Ö. F., Takahashi, H. K., Nishibori, M., & Mori, S. (2023) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2538 · Cited by 4
Sarcopenia: Nutrition and Related Diseases
Du, Y., & 노재경 (2017) · Culinary Science & Hospitality Research · doi:10.20878/cshr.2017.23.1.008 · Cited by 4
An exercise immune fitness test to unravel mechanisms of Post-Acute Sequelae of COVID-19
Deng, M. C.-H. K. (2023) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2023.2214364 · Cited by 4
Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST ‐44
Kaiser, C. S., Lubisch, M., Schröder, E., Ressmann, L., Nicolaus, M., Leusder, D., Moyzio, S., Peuß, R., Miranda‐Vizuete, A., & Liebau, E. (2025) · FEBS Journal · doi:10.1111/febs.70088 · Cited by 3
Patient‐Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson‐Gilford Progeria Syndrome
Jeon, S., Park, C., Hong, J., Kim, J., Lee, Y. J., Hur, J. K., & Lee, J. Y. (2025) · Aging Cell · doi:10.1111/acel.70143 · Cited by 3
Clinical Inflammasome Biomarkers: Progress and Prospects
Coombs, J. R., Burgener, S. S., & Schroder, K. (2026) · Journal of Molecular Biology · doi:10.1016/j.jmb.2026.169941 · Cited by 3
Natural Killer Cells in Alzheimer's Disease: From Foe to Friend
Kostić, M. S., Živković, N., Cvetanović, A., Bašić, J., & Stojanović, I. R. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70096 · Cited by 3
tRNA ‐Derived Fragments in Age‐Related Diseases: A Systematic Review
Bakowska‐Zywicka, K., Rzepczak, A., Plawgo, K., Sobańska, D., & Tyczewska, A. (2025) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.70013 · Cited by 3
Muscle Growth, Repair and Preservation
Erskine, R. M., & Degens, H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396454-0.00025-4 · Cited by 3
Effects of Aging on Human Toll-Like Receptor Function
Shaw, A. C. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_98 · Cited by 2
Spatial learning and memory of young and aging rats following injection with human Wharton’s jelly‐mesenchymal stem cells
Juliandi, B., Mubarok, W., Anggraini, D. P., Boediono, A., Subangkit, M., Bachtiar, I., Murti, H., Yaprianto, K., & Setiawan, B. (2021) · Indonesian Journal of Biotechnology · doi:10.22146/ijbiotech.64734 · Cited by 3
Aging Immunity and the Impact of Physical Exercise
Bigley, A. B., Baker, F. L., Spielmann, G., & Simpson, R. J. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_165 · Cited by 3
Sarcopenia and rheumatic diseases: is there any connection?
Dzhus, M., Kulyk, M., Karasevska, T. A., Mostbauer, H. V., Ivashkivsky, O. I., Potomka, R., & Novytska, H. L. (2022) · PAIN JOINTS SPINE · doi:10.22141/pjs.12.4.2022.349 · Cited by 3
Is African non‐annual killifish Fundulopanchax gardneri (Teleostei; Cyprinodontiformes; Nothobranchiidae) true non‐annual?
Borisov, V., Shkil, F. N., Селезнев, Д. Г., & Smirnov, S. (2023) · Developmental Dynamics · doi:10.1002/dvdy.668 · Cited by 3
A Transition From Interindividual Uniformity to Diversity in Appearance and Transcriptional Features at Midlife in Caenorhabditis elegans
Uno, M., Nono, M., Takahashi, C., Kishimoto, S., Okabe, E., Yamamoto, T., & Nishida, E. (2025) · Genes to Cells · doi:10.1111/gtc.13187 · Cited by 3
Stress Response to Surgery in the Elderly
Hashmi, N. K., & Podgoreanu, M. V. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316676325.013 · Cited by 3
Aging Immunity and the Impact of Physical Exercise
Spielmann, G., Bigley, A. B., LaVoy, E. C. P., & Simpson, R. J. (2013) · Springer eBooks · doi:10.1007/978-3-642-39495-9_26 · Cited by 4
Lifestyle Interventions to Improve Immunesenescence
Bartlett, D. B., & Huffman, K. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-43365-3_10 · Cited by 3
Self-citation
Immunity and Ageing
Caruso, C., Accardi, G., Aiello, A., & Candore, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00029-6 · Cited by 3
Comprehensive Postnatal Anatomical, Histological and Geometric Morphometric Analysis of Thymus Development in Dromedary Camels (Camelus dromedarius)
Fares, M. A., Khenenou, T., & Eddine, R. D. (2024) · Anatomia Histologia Embryologia · doi:10.1111/ahe.13109 · Cited by 2
Catalyzing early ovarian cancer detection: Platelet RNA-based precision screening
Ahn, E., Kim, S. I., Park, S., Kim, S. Y., Lee, H., Kim, Y., Park, S., Lee, S., Hwang, D. W., Kim, H., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112280 · Cited by 3
Efficacy of Glucocorticoids in the Treatment of Retinal Detachment With Choroidal Detachment: Analysis by Proteomics
Li, P., Han, M., Zhang, R., Chen, F., Li, Y., Yuan, J., Ma, N., Li, L., & Wu, J. (2025) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.70008 · Cited by 2
Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age
Brodeau, C., Joly, C., Chekroun, A., Nakhle, J., Blase, V., Espagnolle, N., Dray, C., Yart, A., Planat‐Benard, V., Tertrais, M., et al. (2025) · Aging Cell · doi:10.1111/acel.70153 · Cited by 5
Gene Flow Accompanies Divergence in Beringian Birds
Brown, C. C. O., Glenn, T. C., & Winker, K. S. (2025) · Molecular Ecology · doi:10.1111/mec.70056 · Cited by 2
Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment
Chesnokova, V., Zonis, S., Ainsworth, R. I., Apaydın, T., Valencia, C. W., Greiner, E. C., Barrett, R. J., Kettenbach, A. N., & Melmed, S. K. (2025) · Aging Cell · doi:10.1111/acel.70187 · Cited by 2
Immune cells and inflammatory proteins are differentially associated with subsequent DNA methylation biological aging measures in the Framingham Heart Study Offspring Cohort
Rotti, L., Murabito, J. M., Chen, J., Cao, Y., Ragab, A. A. Y., Liu, C., Wang, M., Doyle, M. F., & Lunetta, K. L. (2025) · GeroScience · doi:10.1007/s11357-025-01883-4 · Cited by 2
Femoral fracture leads to moderate pulmonary organ damage in aged mice and induces immune alterations
Bülow, J. M., Rinderknecht, H., Wagner, A., Haffner‐Luntzer, M., Bundkirchen, K., Neunaber, C., Relja, B., & Becker, N. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1763857 · Cited by 2
Immune Responses to Persistent or Recurrent Antigens: Implications for Immunological Memory and Immunotherapy
(2021) · Frontiers research topics · doi:10.3389/978-2-88966-718-5 · Cited by 3
The Immune and Inflammatory Response to Major Traumatic Injury
Hazeldine, J., & Foster, M. (2022) · Springer eBooks · doi:10.1007/978-3-031-10355-1_13 · Cited by 2
Positive effect of peptide‐calcium chelates from Grifola frondosa on a mouse model of senile osteoporosis
Xiong, Y. C., Li, J., Peng, P., Liu, B., & Zhao, L. (2024) · Journal of Food Science · doi:10.1111/1750-3841.17073 · Cited by 2
Among‐species variation in six decades of changing migration timings explained through ecology, life‐history and local migratory abundance
Dale, V. R., Bolton, M., Dornelas, M., Magurran, A. E., Dennis, R., Broad, R., Riddiford, N. J., Harvey, P. V., Riddington, R., Shaw, D. N., et al. (2024) · Global Change Biology · doi:10.1111/gcb.17400 · Cited by 2

Authors: Bartlett, D. B., Firth, C. M., Phillips, A. C., Moss, P., Baylis, D., Syddall, H., Sayer, A. A., Cooper, C., & Lord, J. M.
Affiliations: University of Birmingham (GB)
MRC Lifecourse Epidemiology Unit (GB)
Corresponding author: Lord, Janet M.
ORCID: Bartlett, David B.
Phillips, Anna C.
Moss, Paul
Syddall, Holly
Sayer, Avan A.
Cooper, Cyrus
Lord, Janet M.
Venue: Aging Cell
Publisher: Wiley
Published: 2012-07-12
Volume: 11
Issue: 5
Pages: 912-915
ISSN: 1474-9718 (ISSN-L)
1474-9726
DOI: 10.1111/j.1474-9726.2012.00849.x
OpenAlex: W1527094386
Cited by: 278
References: 28
Citations by year: 2026: 6 · 2025: 38 · 2024: 39 · 2023: 12 · 2022: 9 · 2021: 18 · 2020: 19 · 2019: 21 · 2018: 15 · 2017: 16 · 2016: 13 · 2015: 19 · 2014: 27 · 2013: 21 · 2012: 1
FWCI: 16.28
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Aging Cell (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Institutional Research Archive (University of Birmingham) (acceptedVersion)
Open Research (University of Surrey) (submittedVersion)
Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
ePrints Soton (University of Southampton) (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: National Institute for Health and Care Research (ACF-2007-26-005, NF-SI-0508-10082, DRF-2011-04-011)
Medical Research Council (MR/K00414X/1)
Biotechnology and Biological Sciences Research Council
Economic and Social Research Council (ES/H043772/1)
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords: inflammaging, low-grade inflammation, cytomegalovirus infection, aging, C-reactive protein, inflammatory cytokines, TNF-α, interleukin-6, IL-10, CMV seropositivity, age-related diseases
MeSH terms: Age Factors, Aged, C-Reactive Protein, Cytomegalovirus Infections, Female, Humans, Inflammation, Longitudinal Studies, Male, Risk Factors, Protozoan Proteins, Interleukin-6, Cytokines, Interleukin-10

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks