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Cited by 278Cytomegalovirus and herpesvirus researchGenetics, Aging, and Longevity in Model OrganismsViral-associated cancers and disorders

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection

Bartlett, David B., Firth, Charlotte M., Phillips, Anna C., Moss, Paul, Baylis, Daniel, Syddall, Holly, Sayer, Avan A., Cooper, Cyrus, Lord, Janet M.·2012·Aging Cell
DOI 10.1111/j.1474-9726.2012.00849.x
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Abstract

Aging is accompanied by the development of low-grade systemic inflammation, termed 'inflammaging', characterized by raised serum C-reactive protein (CRP) and pro-inflammatory cytokines. Importantly, inflammaging is implicated in the pathogenesis of several of the major age-related diseases including cardiovascular disease, type 2 diabetes, and dementia and is associated with increased mortality. The incidence of infection with the persistent herpes virus cytomegalovirus (CMV) also increases with age. Cross-sectional studies have proposed CMV infection as a significant driver of inflammaging, but a definitive case for CMV as a causative agent in inflammaging has not yet been made. We studied longitudinally 249 subjects (153 men, 96 women) who participated in the Hertfordshire Ageing Study at baseline (1993/5, mean age 67·5 years) and at 10 year follow-up. At both times, anthropometric measurements were made and subjects provided blood samples for analysis of inflammatory status and CMV seropositivity. In the cohort as a whole, serum CRP (P < 0·02) and pro-inflammatory cytokines TNFα (P < 0·001) and IL-6 (P < 0·001) were increased between baseline and follow-up sampling whereas levels of the anti-inflammatory cytokine IL-10 were decreased (P < 0·001). These changes to cytokine status over time occurred equally in the 60% of subjects who were seropositive for CMV at baseline and follow-up, the 8% who were CMV negative at baseline but who became CMV positive by the 10 year follow-up, and also in the 32% who were CMV seronegative throughout. We conclude that CMV infection is not a primary causative factor in the age-related increase in systemic inflammation.

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Crossref · 10.1111/j.1474-9726.2012.00849.x

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Metadata

Authors
Bartlett, D. B., Firth, C. M., Phillips, A. C., Moss, P., Baylis, D., Syddall, H., Sayer, A. A., Cooper, C., & Lord, J. M.
Affiliations
  • University of Birmingham (GB)
  • MRC Lifecourse Epidemiology Unit (GB)
Corresponding author
Lord, Janet M.
ORCID
Venue
Aging Cell
Publisher
Wiley
Published
2012-07-12
Volume
11
Issue
5
Pages
912-915
ISSN
  • 1474-9718 (ISSN-L)
  • 1474-9726
DOI
10.1111/j.1474-9726.2012.00849.x
OpenAlex
W1527094386
Cited by
278
References
28
Citations by year
2026: 6 · 2025: 38 · 2024: 39 · 2023: 12 · 2022: 9 · 2021: 18 · 2020: 19 · 2019: 21 · 2018: 15 · 2017: 16 · 2016: 13 · 2015: 19 · 2014: 27 · 2013: 21 · 2012: 1
FWCI
16.28
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Aging Cell (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Institutional Research Archive (University of Birmingham) (acceptedVersion)
  • Open Research (University of Surrey) (submittedVersion)
  • Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
  • National Institute for Health and Care Research (ACF-2007-26-005, NF-SI-0508-10082, DRF-2011-04-011)
  • Medical Research Council (MR/K00414X/1)
  • Biotechnology and Biological Sciences Research Council
  • Economic and Social Research Council (ES/H043772/1)
Topics
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords
inflammaging, low-grade inflammation, cytomegalovirus infection, aging, C-reactive protein, inflammatory cytokines, TNF-α, interleukin-6, IL-10, CMV seropositivity, age-related diseases
MeSH terms
Age Factors, Aged, C-Reactive Protein, Cytomegalovirus Infections, Female, Humans, Inflammation, Longitudinal Studies, Male, Risk Factors, Protozoan Proteins, Interleukin-6, Cytokines, Interleukin-10

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