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The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection
Abstract
Aging is accompanied by the development of low-grade systemic inflammation, termed 'inflammaging', characterized by raised serum C-reactive protein (CRP) and pro-inflammatory cytokines. Importantly, inflammaging is implicated in the pathogenesis of several of the major age-related diseases including cardiovascular disease, type 2 diabetes, and dementia and is associated with increased mortality. The incidence of infection with the persistent herpes virus cytomegalovirus (CMV) also increases with age. Cross-sectional studies have proposed CMV infection as a significant driver of inflammaging, but a definitive case for CMV as a causative agent in inflammaging has not yet been made. We studied longitudinally 249 subjects (153 men, 96 women) who participated in the Hertfordshire Ageing Study at baseline (1993/5, mean age 67·5 years) and at 10 year follow-up. At both times, anthropometric measurements were made and subjects provided blood samples for analysis of inflammatory status and CMV seropositivity. In the cohort as a whole, serum CRP (P < 0·02) and pro-inflammatory cytokines TNFα (P < 0·001) and IL-6 (P < 0·001) were increased between baseline and follow-up sampling whereas levels of the anti-inflammatory cytokine IL-10 were decreased (P < 0·001). These changes to cytokine status over time occurred equally in the 60% of subjects who were seropositive for CMV at baseline and follow-up, the 8% who were CMV negative at baseline but who became CMV positive by the 10 year follow-up, and also in the 32% who were CMV seronegative throughout. We conclude that CMV infection is not a primary causative factor in the age-related increase in systemic inflammation.
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“However, a longitudinal study of 249 research participants followed for 10 years has strongly suggested that HCMV infection is not a primary causative factor in the age-related increase in systemic inflammation (48).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [48]
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Cites
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488
Inflammation in Atherosclerosis: Transition From Theory to Practice
Libby, P., Okamoto, Y., Rocha, V. Z., & Folco, E. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0706 · Cited by 799
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
Self-citationDoes Exercise Reduce Inflammation? Physical Activity and C-Reactive Protein Among U.S. Adults
Ford, E. S. (2002) · Epidemiology · doi:10.1097/00001648-200209000-00012 · Cited by 575
The immunology of exceptional individuals: the lesson of centenarians
Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 535
Simanek, A. M., Dowd, J. B., Pawelec, G., Melzer, D. R., Dutta, A., & Aiello, A. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016103 · Cited by 398
Obesity and inflammation: the effects of weight loss
Forsythe, L. K., Wallace, J. M. W., & Livingstone, M. B. E. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138732 · Cited by 381 · cited 4×
“Various factors have been proposed to drive inflammaging including increased adiposity with age (Forsythe et al., 2008), and decreased production of sex steroids (Maggio et al.”
BackgroundInfluentialCytomegalovirus and human immunosenescence
Pawelec, G., Derhovanessian, E., Larbi, A., Strindhall, J., & Wikby, A. (2008) · Reviews in Medical Virology · doi:10.1002/rmv.598 · Cited by 339
Wikby, A., Nilsson, B.-O., Forsey, R. J., Thompson, J., Strindhall, J., Löfgren, S., Ernerudh, J., Pawelec, G., Ferguson, F. G., & Johansson, B. E. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.04.003 · Cited by 284
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Taylor, J. A., Greenhaff, P. L., Bartlett, D. B., Jackson, T., Duggal, N. A., & Lord, J. M. (2022) · Physiological Reviews · doi:10.1152/physrev.00037.2021 · Cited by 218
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Sauce, D., Dong, Y., Campillo-Gimenez, L., Casulli, S., Bayard, C., Autran, B., Boddaert, J., Appay, V., & Elbim, C. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw062 · Cited by 83
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Metadata
- Authors
- Bartlett, D. B., Firth, C. M., Phillips, A. C., Moss, P., Baylis, D., Syddall, H., Sayer, A. A., Cooper, C., & Lord, J. M.
- Affiliations
- University of Birmingham (GB)
- MRC Lifecourse Epidemiology Unit (GB)
- Corresponding author
- Lord, Janet M.
- ORCID
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2012-07-12
- Volume
- 11
- Issue
- 5
- Pages
- 912-915
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1527094386
- Cited by
- 278
- References
- 28
- Citations by year
- 2026: 6 · 2025: 38 · 2024: 39 · 2023: 12 · 2022: 9 · 2021: 18 · 2020: 19 · 2019: 21 · 2018: 15 · 2017: 16 · 2016: 13 · 2015: 19 · 2014: 27 · 2013: 21 · 2012: 1
- FWCI
- 16.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Institutional Research Archive (University of Birmingham) (acceptedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Stirling Online Research Repository (University of Stirling) (submittedVersion, public-domain)
- ePrints Soton (University of Southampton) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- National Institute for Health and Care Research (ACF-2007-26-005, NF-SI-0508-10082, DRF-2011-04-011)
- Medical Research Council (MR/K00414X/1)
- Biotechnology and Biological Sciences Research Council
- Economic and Social Research Council (ES/H043772/1)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- inflammaging, low-grade inflammation, cytomegalovirus infection, aging, C-reactive protein, inflammatory cytokines, TNF-α, interleukin-6, IL-10, CMV seropositivity, age-related diseases
- MeSH terms
- Age Factors, Aged, C-Reactive Protein, Cytomegalovirus Infections, Female, Humans, Inflammation, Longitudinal Studies, Male, Risk Factors, Protozoan Proteins, Interleukin-6, Cytokines, Interleukin-10
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