Cited by 457Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

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The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats

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Clarke, P.B.S., Kumar, R.·1983·British Journal of Pharmacology

DOI 10.1111/j.1476-5381.1983.tb09398.xPMC PMC2044704

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Abstract

1--Rats were tested for locomotor activity in photocell cages, for 80 min starting immediately after subcutaneous injection of (-)-nicotine bitartrate or 0.9% w/v NaCl solution (saline). In non-tolerant subjects, nicotine (0.1 to 0.4 mg/kg base) depressed activity and induced ataxia in the first 20 min, but increased activity later in the session; these actions were dose-dependent. 2--Tolerance was studied by comparing rats given nicotine (0.4 mg/kg s.c.) every day with control rats given saline instead. Each week, every subject was tested once with nicotine (0.4 mg/kg) and once with saline. With daily or even weekly injections of nicotine, the initial depressant action of the drug was replaced by a dose-dependent stimulant action which occurred throughout the session. In these tolerant animals, little ataxia was seen except when a larger dose of 0.8 mg/kg was given. Tolerance to the depressant action of nicotine persisted for at least 3 weeks. 3--In non-tolerant subjects, mecamylamine (0.5, 1.0 mg/kg s.c.) prevented the initial depressant action of nicotine (0.4 mg/kg). In tolerant rats, the locomotor stimulant action of nicotine (0.4 mg/kg) was prevented by mecamylamine (0.1, 0.32, 1.0 mg/kg s.c.) in a dose-related way; the quaternary ganglion blocker, hexamethonium (0.2, 1.0, 5.0 mg/kg s.c.) had little or no such effect. Neither mecamylamine nor hexamethonium altered activity when given alone. 4--It is suggested that a few treatments with nicotine can unmask a stimulant action of the drug, probably of central origin, which possibly reflects a stimulation of nicotine receptors.

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Authors: Clarke, P. B. S., & Kumar, R.
ORCID: Clarke, P.B.S.
Kumar, R.
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 1983-02
Volume: 78
Issue: 2
Pages: 329-337
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1111/j.1476-5381.1983.tb09398.x
PMC: PMC2044704
OpenAlex: W2054668681
Cited by: 457
References: 30
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 1 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 11 · 2014: 8 · 2013: 7 · 2012: 12
FWCI: 4.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 10761 d)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship@McGill (McGill) (submittedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotine, locomotor activity, nicotine tolerance, mecamylamine, hexamethonium, nicotinic acetylcholine receptors, dose-dependent effects
MeSH terms: Animals, Dose-Response Relationship, Drug, Drug Tolerance, Hexamethonium Compounds, Humans, Male, Mecamylamine, Motor Activity, Nicotine, Substance Withdrawal Syndrome, Hexamethonium, Rats

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The effects of nicotine on locomotor activity in non‐tolerant and tolerant rats

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