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Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease

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de Roos, Baukje, Mavrommatis, Yiannis, Brouwer, Ingeborg A·2009·British Journal of Pharmacology

DOI 10.1111/j.1476-5381.2009.00189.xPMC PMC2757681

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Abstract

Evidence from observational studies, prospective cohort studies and randomized clinical intervention studies indicate that moderate doses of long‐chain n‐3 polyunsaturated fatty acids (LC n‐3 PUFA) significantly decrease risk of fatal coronary heart disease (CHD). Higher doses and longer duration of intervention may also protect from non‐fatal CHD events. The exact mechanisms through which LC n‐3 PUFA has an effect on CHD are not well established but may include a decrease in fasting and postprandial triacylglycerol levels, a decrease in arrhythmias, modulation of platelet aggregation and decreased synthesis of pro‐inflammatory agents. The mechanistic relation between LC n‐3 PUFA and inflammation has attracted great interest, and in vitro studies have revealed that these fatty acids decrease endothelial activation, affect eicosanoid metabolism (including epoxygenation pathways) and induce inflammatory resolution. However, the effects of LC n‐3 PUFA on established biomarkers of inflammation and endothelial activation in vivo are not strong. Consequently we need new and more sensitive and systemic biomarkers to reveal the effects of LC n‐3 PUFA on localized inflammatory processes.

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BackgroundInfluential
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Authors: de Roos, B., Mavrommatis, Y., & Brouwer, I. A.
Affiliations: University of Aberdeen (GB)
Vrije Universiteit Amsterdam (NL)
ORCID: Mavrommatis, Yiannis
Brouwer, Ingeborg A
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2009-08-28
Volume: 158
Issue: 2
Pages: 413-428
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1111/j.1476-5381.2009.00189.x
PMC: PMC2757681
OpenAlex: W2148516429
Cited by: 151
References: 209
Citations by year: 2026: 2 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 11 · 2020: 4 · 2019: 12 · 2018: 11 · 2017: 5 · 2016: 12 · 2015: 10 · 2014: 17 · 2013: 10 · 2012: 18
FWCI: 1.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: British Journal of Pharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
VU Research Portal (publishedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Scottish Government
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Keywords: n-3 long-chain polyunsaturated fatty acids, omega-3 fatty acids, coronary artery disease, inflammation, inflammation resolution, endothelial activation, eicosanoid metabolism, triglycerides, cardiac arrhythmias, platelet aggregation, biomarkers of inflammation, cardiovascular risk
MeSH terms: Animals, Clinical Trials as Topic, Coronary Disease, Dose-Response Relationship, Drug, Humans, Inflammation, Biomarkers, Fatty Acids, Omega-3

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Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease

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