Reversal of high-fat diet-induced hepatic steatosis by n-3 LCPUFA: Role of PPAR-α and SREBP-1c

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works

Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works

Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol

Morrison, W. R., & Smith, L. M. (1964) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40190-7 · Cited by 6,005 · see citing works

Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions

Brunt, E. M., Janney, C. G., Di Bisceglie, A. M., Neuschwander-Tetri, B. A., & Bacon, B. R. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01377.x · Cited by 3,907 · see citing works

Reactive oxygen species have a causal role in multiple forms of insulin resistance

Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works

[38] Oxidative damage to proteins: Spectrophotometric method for carbonyl assay

Reznick, A. Z., & Packer, L. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33041-7 · Cited by 2,455 · see citing works

Molecular mediators of hepatic steatosis and liver injury

Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772 · see citing works

Diet-Induced Type II Diabetes in C57BL/6J Mice

Surwit, R. S., Kuhn, C. M., Cochrane, C., McCubbin, J. A., & Feinglos, M. N. (1988) · Diabetes · doi:10.2337/diab.37.9.1163 · Cited by 1,211 · see citing works

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089 · see citing works

Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000 · see citing works

The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis

Wigg, A. J., Roberts-Thomson, I. C., Dymock, R. B., McCarthy, P. J., Grose, R. H., & Cummins, A. G. (2001) · Gut · doi:10.1136/gut.48.2.206 · Cited by 836 · see citing works

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

Gaggini, M., Morelli, M., Buzzigoli, E., DeFronzo, R. A., Bugianesi, E., & Gastaldelli, A. (2013) · Nutrients · doi:10.3390/nu5051544 · Cited by 824 · see citing works

Diagnosis and Management of the Metabolic Syndrome

Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169405 · Cited by 803 · see citing works

Mouse models in non‐alcoholic fatty liver disease and steatohepatitis research

Anstee, Q. M., & Goldin, R. D. (2006) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2006.00465.x · Cited by 714 · see citing works

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP‐1c

Ferré, P., & Foufelle, F. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01275.x · Cited by 704 · see citing works

Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease

ARAYA, J., RODRIGO, R., VIDELA, L. A., THIELEMANN, L., ORELLANA, M., PETTINELLI, P., & PONIACHIK, J. (2004) · Clinical Science · doi:10.1042/cs20030326 · Cited by 700 · see citing works

Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients

Crespo, J., Cayón, A., Fernández-Gil, P. L., Hernández‐Guerra, M., Mayorga, M., Domínguez‐Díez, A., Fernández-Escalante, J. C., & Pons‐Romero, F. (2001) · Hepatology · doi:10.1053/jhep.2001.29628 · Cited by 693 · see citing works

Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)

Musso, G., Gambino, R. J., & Cassader, M. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.08.001 · Cited by 678 · see citing works

Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Executive summary

Smith, S. C., Jr. (2019) · PubMed · doi:10.17615/x6gg-7674 · Cited by 548 · see citing works

Omega‐3 PUFA of marine origin limit diet‐induced obesity in mice by reducing cellularity of adipose tissue

Ruzickova, J., Rossmeisl, M., Prazak, T., Flachs, P., Sponarova, J., Vecka, M., TVRZICKÁ, E., Bryhn, M., & Kopecký, J. (2004) · Lipids · doi:10.1007/s11745-004-1345-9 · Cited by 327 · see citing works

Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

Singh, S., Vrishni, S., Singh, B. K., Rahman, I., & Kakkar, P. (2010) · Free Radical Research · doi:10.3109/10715762.2010.507670 · Cited by 294 · see citing works

Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease

Spadaro, L., Magliocco, O., Spampinato, D., Piro, S., Oliveri, C. E., Alagona, C., Papa, G. F. S., Rabuazzo, A. M., & Purrello, F. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2007.10.003 · Cited by 292 · see citing works

Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition

Cave, M. C., Deaciuc, I. V., Mendez, C. M., Song, Z., Joshi‐Barve, S., Barve, S. S., & McClain, C. J. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.12.006 · Cited by 290 · see citing works

Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis

Rensen, S. S., Slaats, Y., Nijhuis, J., Jans, A., Bieghs, V., Driessen, A., Malle, E., Greve, J. W., & Buurman, W. A. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080999 · Cited by 290 · see citing works

A role for phospholipid polyunsaturation in modulating membrane protein function

Litman, B. J., & Mitchell, D. C. (1996) · Lipids · doi:10.1007/bf02637075 · Cited by 287 · see citing works

Molecular mechanisms involved in NAFLD progression

Malaguarnera, M., Rosa, M. D., Nicoletti, F., & Malaguarnera, L. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0464-1 · Cited by 281 · see citing works

Novel n-3 Fatty Acid Oxidation Products Activate Nrf2 by Destabilizing the Association between Keap1 and Cullin3

Gao, L., Wang, J., Sekhar, K. R., Yin, H., Yared, N. F., Schneider, S. N., Sasi, S., Dalton, T. P., Anderson, M. E., Chan, J. Y., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607622200 · Cited by 278 · see citing works

Docosahexaenoic acid affects cell signaling by altering lipid rafts

Stillwell, W. H., Shaikh, S. R., Zerouga, M., Siddiqui, R. A., & Wassall, S. R. (2005) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2005046 · Cited by 266 · see citing works

PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver1–3

Abdelmegeed, M. A., Yoo, S.-H., Henderson, L. E., Gonzalez, F. J., Woodcroft, K. J., & Song, B. (2011) · Journal of Nutrition · doi:10.3945/jn.110.135210 · Cited by 250 · see citing works

Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion

Pettinelli, P., del Pozo, T., Julia Araya, A., Rodrigo, R., Araya, A. V., Smok, G., Csendes, A., Gutiérrez, L., Rojas, J., Owen Korn, B., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.015 · Cited by 228 · see citing works

Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S‐hydroxy‐DHA

González‐Périz, A., Planagumà, A., Gronert, K., Miquel, R., López‐Parra, M., Titos, E., Horrillo, R., Ferré, N., Deulofeu, R., Arroyo, V., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-6250fje · Cited by 226 · see citing works

n -3 Polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle

Taouis, M., Dagou, C., Ster, C., Durand, G., Pinault, M., & Delarue, J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00320.2001 · Cited by 181 · see citing works

Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease

Videla, L. A., Rodrigo, R., Julia Araya, A., & Poníachik, J. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.10.001 · Cited by 159 · see citing works

Long‐chain n‐3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease

de Roos, B., Mavrommatis, Y., & Brouwer, I. A. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00189.x · Cited by 151 · see citing works

Cytochrome P-450 Epoxygenase Metabolites of Docosahexaenoate Potently Dilate Coronary Arterioles by Activating Large-Conductance Calcium-Activated Potassium Channels

Ye, D., Zhang, D., Oltman, C. L., Dellsperger, K. C., Lee, H.-C., & VanRollins, M. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.303.2.768 · Cited by 146 · see citing works

Mechanism underlying oxidative stress-mediated lipotoxicity: Exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis

Aronis, A., Madar, Z., & Tirosh, O. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.01.015 · Cited by 119 · see citing works

The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease

Shapiro, H., Tehilla, M., Attal-Singer, J., Bruck, R., Luzzatti, R., & Singer, P. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.06.001 · Cited by 112 · see citing works

Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model

de Meijer, V. E., Le, H. D., Meisel, J. A., Sharif, M. R. A., Pan, A., Nosé, V., & Puder, M. (2010) · Metabolism · doi:10.1016/j.metabol.2009.11.006 · Cited by 107 · see citing works

Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease

Malaguarnera, L., Rosa, M. D., Zambito, A. M., dell’Ombra, N., Nicoletti, F., & Malaguarnera, M. (2006) · Gut · doi:10.1136/gut.2005.075697 · Cited by 104 · see citing works

N-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Significantly Reduces Liver Oxidative Stress in High Fat Induced Steatosis

Valenzuela, R., Espinosa, A., Gonzalez‐Mañán, D., D’Espessailles, A., Fernández, V., Videla, L. A., & Tapia, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046400 · Cited by 104 · see citing works

Identification of putative metabolites of docosahexaenoic acid as potent PPARγ agonists and antidiabetic agents

Yamamoto, K., Itoh, T., Abe, D., Shimizu, M., Kanda, T., Koyama, T., Nishikawa, M., Tamai, T., Ooizumi, H., & Yamada, S. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.11.053 · Cited by 87 · see citing works

New unsaturated long‐chain fatty acids in the phospholipids from the axinellida spongesTrikentrion loeve andPseudaxinella cf.Lunaecharta

Barnathan, G., Korpnrobst, J., Doumenq, P., & Mirallès, J. (1996) · Lipids · doi:10.1007/bf02522620 · Cited by 81 · see citing works

Fish oil and argan oil intake differently modulate insulin resistance and glucose intolerance in a rat model of dietary-induced obesity

Samane, S., Christon, R., Dombrowski, L., Turcotte, S., Charrouf, Z., Lavigne, C., Levy, E. H., Bachelard, H., Amarouch, H., Marette, A., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.02.013 · Cited by 79 · see citing works

Eicosapentaenoic acid at hypotriglyceridemic dose enhances the hepatic antioxidant defense in mice

Demoz, A., Willumsen, N., & Berge, R. K. (1992) · Lipids · doi:10.1007/bf02535573 · Cited by 78 · see citing works

Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity

Videla, L. A., & Pettinelli, P. (2012) · PPAR Research · doi:10.1155/2012/107434 · Cited by 78 · see citing works

Molecular mechanisms of steatosis in nonalcoholic fatty liver disease.

Pettinelli, P., Obregón, A. M., & Videla, L. A. (2011) · PubMed · doi:10.1590/s0212-16112011000300003 · Cited by 75 · see citing works

Regulation of Glucose Transport and Transporter 4 (GLUT-4) in Muscle and Adipocytes of Sucrose-Fed Rats: Effects of N-3 Poly- and Monounsaturated Fatty Acids

Peyron-Caso, É., Fluteau-Nadler, S., Kabir, M., Guerre-Millo, M., Quignard‐Boulangé, A., Slama, G., & Rizkalla, S. W. (2002) · Hormone and Metabolic Research · doi:10.1055/s-2002-33467 · Cited by 69 · see citing works

Natural compounds regulate energy metabolism by the modulating the activity of lipid‐sensing nuclear receptors

Goto, T., Kim, Y., Takahashi, N., & Kawada, T. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200522 · Cited by 58 · see citing works

Recent advances in liver preconditioning: Thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron

Fernández, V. (2012) · World Journal of Hepatology · doi:10.4254/wjh.v4.i4.119 · Cited by 33 · see citing works

Fatty acids regulation of inflammatory and metabolic genes

Masi, L. N., Rodrigues, A. C., & Curi, R. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32836236df · Cited by 26 · see citing works

Fish oil reverses the altered glucose transporter, phosphorylation, insulin receptor substrate-1 protein level and lipid contents in the skeletal muscle of sucrose-rich diet fed rats

D’Alessandro, M. E., Chicco, A. G., & Lombardo, Y. B. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.11.003 · Cited by 23 · see citing works

Treatment of nonalcoholic fatty liver disease in adults and children: a closer look at the arsenal

Nobili, V., & Sanyal, A. J. (2011) · Journal of Gastroenterology · doi:10.1007/s00535-011-0467-x · Cited by 9 · see citing works

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476 · see citing works

High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms

Lian, C.-Y., Zhai, Z., Li, Z., & Wang, L. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109199 · Cited by 304 · see citing works

Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability

Yan, C., Chen, J., & Chen, N. (2016) · Scientific Reports · doi:10.1038/srep22640 · Cited by 210 · see citing works

Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration

Ortíz, M., Soto-Alarcón, S. A., Orellana, P., Espinosa, A., Campos, C., López‐Arana, S., Rincón‐Cervera, M. Á., Illesca, P., Valenzuela, R., & Videla, L. A. (2020) · Digestive and Liver Disease · doi:10.1016/j.dld.2020.04.019 · Cited by 124 · see citing works

Beneficial effects of probiotic combination with omega-3 fatty acids in NAFLD: a randomized clinical study

Kobyliak, N. M., Abenavoli, L., Falalyeyeva, T. M., Mykhalchyshyn, G., Boccuto, L., Kononenko, L., Kyriienko, D., Komisarenko, I., & Dynnyk, O. (2018) · Minerva Medica · doi:10.23736/s0026-4806.18.05845-7 · Cited by 109 · see citing works

Alcoholic Liver Disease: Update on the Role of Dietary Fat

Kirpich, I., Miller, M. E., Cave, M. C., Joshi‐Barve, S., & McClain, C. J. (2016) · Biomolecules · doi:10.3390/biom6010001 · Cited by 104 · see citing works

Impact of the Co-Administration of N-3 Fatty Acids and Olive Oil Components in Preclinical Nonalcoholic Fatty Liver Disease Models: A Mechanistic View

Valenzuela, R., & Videla, L. A. (2020) · Nutrients · doi:10.3390/nu12020499 · Cited by 94 · see citing works

The Impact of Moderate-Intensity Continuous or High-Intensity Interval Training on Adipogenesis and Browning of Subcutaneous Adipose Tissue in Obese Male Rats

Khalafi, M., Mohebbi, H., Symonds, M. E., Karimi, P., Akbari, A. M., Tabari, E., Faridnia, M., & Moghaddami, K. (2020) · Nutrients · doi:10.3390/nu12040925 · Cited by 90 · see citing works

Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action

Videla, L. A., & Valenzuela, R. (2021) · BioFactors · doi:10.1002/biof.1797 · Cited by 91 · see citing works

High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration

Echeverría, F., Valenzuela, R., Bustamante, A., Álvarez, D., Ortíz, M., Espinosa, A., Illesca, P., Gonzalez‐Mañán, D., & Videla, L. A. (2019) · Food & Function · doi:10.1039/c9fo01373c · Cited by 86 · see citing works

Docosahexaenoic acid inhibits proteolytic processing of sterol regulatory element-binding protein-1c (SREBP-1c) via activation of AMP-activated kinase

Deng, X., Dong, Q., Bridges, D., Raghow, R., Park, E. A., & Elam, M. B. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.08.007 · Cited by 78 · see citing works

The Role of Nuclear Receptors in the Pathophysiology, Natural Course, and Drug Treatment of NAFLD in Humans

Ballestri, S., Nascimbeni, F., Romagnoli, D., Baldelli, E., & Lonardo, A. (2016) · Advances in Therapy · doi:10.1007/s12325-016-0306-9 · Cited by 77 · see citing works

High Fat Diet-Induced miR-122 Regulates Lipid Metabolism and Fat Deposition in Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) Liver

Qiang, J., Tao, Y. F., Bao, J. W., Chen, D. J., Li, H. X., He, J., & Xu, P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01422 · Cited by 76 · see citing works

Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update

Jiménez‐Sánchez, A., Martínez-Ortega, A. J., Remón-Ruiz, P., Piñar-Gutiérrez, A., Cunill, J. L. P., & García‐Luna, P. P. (2022) · Nutrients · doi:10.3390/nu14071440 · Cited by 76 · see citing works

Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease

Valenzuela, R., Ortíz, M., Hernández‐Rodas, M. C., Echeverría, F., & Videla, L. A. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190410121716 · Cited by 75 · see citing works

Substitution of linoleic acid with α-linolenic acid or long chain n-3 polyunsaturated fatty acid prevents Western diet induced nonalcoholic steatohepatitis

Jeyapal, S., Kona, S. R., Mullapudi, S. V., Putcha, U. K., Gurumurthy, P., & Ibrahim, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-29222-y · Cited by 65 · see citing works

Oleate activates SREBP-1 signaling activity in SCD1 -deficient hepatocytes

Lounis, M. A., Bergeron, K., Burhans, M. S., Ntambi, J. M., & Mounier, C. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00151.2017 · Cited by 64 · see citing works

Hypolipidemic Activity of Peony Seed Oil Rich in α-Linolenic, is Mediated Through Inhibition of Lipogenesis and Upregulation of Fatty Acid β-Oxidation

Su, J., Ma, C., Liu, C., Gao, C., Nie, R., & Wang, H. (2016) · Journal of Food Science · doi:10.1111/1750-3841.13252 · Cited by 62 · see citing works

Posicionamento sobre o Consumo de Gorduras e Saúde Cardiovascular – 2021

Izar, M. C. D. O., Lottenberg, A. M., Giraldez, V. Z. R., Santos, R. D., Machado, R. M., Bertolami, A., Assad, M. H. V., Saraiva, J. F. K., Faludi, A. Á., Moreira, A. S. B., et al. (2021) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20201340 · Cited by 65 · see citing works

The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α

Ren, T., Zhu, J., Zhu, L., & Cheng, M. (2017) · Nutrients · doi:10.3390/nu9030198 · Cited by 41 · see citing works

Low-linoleic acid diet and oestrogen enhance the conversion ofα-linolenic acid into DHA through modification of conversion enzymes and transcription factors

Kim, D., Choi, J.-E., & Park, Y. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518003252 · Cited by 41 · see citing works

Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS

Song, H.-M., Li, X., Liu, Y.-Y., Lu, W., Cui, Z., Zhou, L., Yao, D., & Zhang, H. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3593 · Cited by 39 · see citing works

Rosa Mosqueta Oil Prevents Oxidative Stress and Inflammation through the Upregulation of PPAR-α and NRF2 in C57BL/6J Mice Fed a High-Fat Diet

Gonzalez‐Mañán, D., D’Espessailles, A., Dossi, C. G., Martín, M. S., Mancilla, R. A., & Tapia, G. (2017) · Journal of Nutrition · doi:10.3945/jn.116.243261 · Cited by 37 · see citing works

Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice

Worsch, S., Heikenwalder, M., Hauner, H., & Bader, B. L. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0291-x · Cited by 34 · see citing works

Crosstalk mechanisms in hepatoprotection: Thyroid hormone-docosahexaenoic acid (DHA) and DHA-extra virgin olive oil combined protocols

Valenzuela, R., & Videla, L. A. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.013 · Cited by 32 · see citing works

Interrelationship between alcohol consumption, overnutrition, and pharmacotherapy for liver steatosis: Considerations and proposals

Valenzuela, R., Farías, C., Muñoz, Y., Zúñiga‐Hernández, J., & Videla, L. A. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112676 · Cited by 33 · see citing works

A regulatory insertion-deletion polymorphism in the FADS gene cluster influences PUFA and lipid profiles among Chinese adults: a population-based study

Li, P., Zhao, J., Kothapalli, K. S. D., Li, X., Li, H., Han, Y., Mi, S., Zhao, W., Li, Q., Zhang, H., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy063 · Cited by 29 · see citing works

Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates Diet‐Induced Accumulation of Lipid in the Liver of ApoE−/− Mice

Liu, L., Hu, Q., Wu, H., Wang, X., Gao, C., Chen, G., Yao, P., & Gong, Z. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6256802 · Cited by 29 · see citing works

Extracts and lignans of Schisandra chinensis fruit alter lipid and glucose metabolism in vivo and in vitro

Liu, H., Wu, C., Wang, S., Gao, S., Liu, J., Dong, Z., Zhang, B., Liu, M., Sun, X., & Guo, P. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.09.049 · Cited by 27 · see citing works

High Density Lipoprotein from Egg Yolk (EYHDL) Improves Dyslipidemia by Mediating Fatty Acids Metabolism in High Fat Diet-induced Obese Mice

Yu, Z., Mao, C., Fu, X., & Ma, M. (2018) · Food Science of Animal Resources · doi:10.5851/kosfa.2018.e38 · Cited by 27 · see citing works

Structural characterization of Poria cocos oligosaccharides and their effects on the hepatic metabolome in high-fat diet-fed mice

Zhu, L., Chen, G., Guo, Y., Zheng, J., Yang, H., Sun, X., Liu, Y., Hu, B., & Liu, H. (2022) · Food & Function · doi:10.1039/d2fo00638c · Cited by 24 · see citing works

Microalgal Oil fromSchizochytriumsp. Prevents HFD-Induced Abdominal Fat Accumulation in Mice

Yu, J., Ma, Y., Sun, J. L., Ran, L., Li, Y., Wang, N., Yu, T., Gao, W., Jia, W., Jiang, R., et al. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1302366 · Cited by 25 · see citing works

Omega-3 PUFA ameliorates hyperhomocysteinemia-induced hepatic steatosis in mice by inhibiting hepatic ceramide synthesis

Dong, Y.-Q., Zhang, X.-Z., Sun, L., Zhang, S., Liu, B., Liu, H., Wang, X., & Jiang, C. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.127 · Cited by 23 · see citing works

Preventive or Curative Administration of Taurine Regulates Lipid Metabolism in the Liver of Rats with Alcoholic Liver Disease

Tang, R., Yang, Q., Lin, S., Feng, Y., Yang, J., Lv, Q., Wu, G., & Hu, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-8023-5_11 · Cited by 21 · see citing works

Normocaloric Diet Restores Weight Gain and Insulin Sensitivity in Obese Mice

Lombardo, G. E., Arcidiacono, B., Rose, R. F. D., Lepore, S. M., Costa, N., Montalcini, T., Brunetti, A., Russo, D., Sarro, G. D., & Celano, M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00049 · Cited by 17 · see citing works

Effects of rosa mosqueta oil supplementation in lipogenic markers associated with prevention of liver steatosis

Dossi, C. G., Cadagan, C., Martín, M. S., Espinosa, A., Gonzalez‐Mañán, D., Silva, D., Mancilla, R. A., & Tapia, G. (2017) · Food & Function · doi:10.1039/c6fo01762b · Cited by 13 · see citing works

APOC3 rs2070667 Associates with Serum Triglyceride Profile and Hepatic Inflammation in Nonalcoholic Fatty Liver Disease

Xu, Q.-Y., Li, H., Cao, H., Pan, Q., & Fan, J. (2020) · BioMed Research International · doi:10.1155/2020/8869674 · Cited by 12 · see citing works

Dietary Rosa mosqueta (Rosa rubiginosa) oil prevents high diet-induced hepatic steatosis in mice

D’Espessailles, A., Dossi, C. G., Espinosa, A., Gonzalez‐Mañán, D., & Tapia, G. (2015) · Food & Function · doi:10.1039/c5fo00741k · Cited by 11 · see citing works

Relevant Aspects of Combined Protocols for Prevention of N(M)AFLD and Other Non‐Communicable Diseases

Videla, L. A., Valenzuela, R., Zúñiga‐Hernández, J., & del Campo, A. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400062 · Cited by 10 · see citing works

Effects of Fish Oil Supplementation on Reducing the Effects of Paternal Obesity and Preventing Fatty Liver in Offspring

Shrestha, A., Dellett, S. K., Yang, J., Sharma, U., & Ramalingam, L. (2023) · Nutrients · doi:10.3390/nu15245038 · Cited by 9 · see citing works

A combined docosahexaenoic acid–thyroid hormone protocol upregulates rat liver β-Klotho expression and downstream components of FGF21 signaling as a potential novel approach to metabolic stress conditions

Vargas, R., Riquelme, B., Fernández, J., & Videla, L. A. (2017) · Food & Function · doi:10.1039/c7fo00923b · Cited by 8 · see citing works

Supplementation with Docosahexaenoic Acid and Vitamin E Improves Hepatic Triglyceride Accumulation Induced by High‐Fat Diet in Mice

Yuan, G., Xu, M., Tan, M., Dong, J., & Chen, X. (2020) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.202000224 · Cited by 6 · see citing works

Taurine Enhances the Protective Actions of Fish Oil Against D-Galactosamine-Induced Metabolic Changes and Hepatic Lipid Accumulation and Injury in the Rat

Shen, Y., & Lau‐Cam, C. A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-8023-5_7 · Cited by 6 · see citing works

Chronic high-dosage fish oil exacerbates gut–liver axis injury in alcoholic steatohepatitis in mice: the roles of endotoxin and IL-4 in Kupffer cell polarization imbalance

Li, X.-J., Mu, Y., Qin, Q.-F., Zeng, Z., Li, Y.-S., Zhang, W. K., Tang, H., Tian, G.-H., & Shang, H. (2017) · Toxicology Research · doi:10.1039/c7tx00037e · Cited by 5 · see citing works

Stearidonic acid promotes insulin secretion via stimulation of G protein-coupled receptor 40 in MIN6 pancreatic β-cells

Gao, Y., Fan, C., Tan, X., Zhang, J., & Wang, J. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103450 · Cited by 5 · see citing works

n-3 LCPUFA in the reversal of hepatic steatosis: the role of ACOX and CAT-1

Tapia, G., Gonzalez‐Mañán, D., D’Espessailles, A., & Dossi, C. G. (2016) · Grasas y Aceites · doi:10.3989/gya.0886152 · Cited by 1 · see citing works

Acción de flavonoides sobre la conversión de ácidos grasos poliinsaturados de cadena larga a partir de ácidos grasos esenciales

Reyna, S., Valenzuela, R., & Villanueva, M. E. (2018) · Revista chilena de nutrición · doi:10.4067/s0717-75182018000300153 · Cited by 1 · see citing works

Fish Oil Supplements During Perinatal Life

Herrera, E., & Amusquivar, E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814466-4.00024-0

Bidirectional regulation of free fatty acid receptors and non-alcoholic fatty liver disease.

Lin, Y., Liu, Y., Liu, J., Wu, J., Wei, K.-H., Guo, J., & Su, Z.-Q. (2025) · Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110180

Effets préventifs des acides gras polyinsaturés en n-3 dans l’altération de la couche de mucus colique et du stress du réticulum endoplasmique induit par un régime obésogène.

Escoula, Q. (2020) · doi:10.70675/81797e03zd364z4b09zaa86z993af56f01bf

A comparative study of n-3 PUFA enrichment, antioxidative status, and underlying mechanism of Pekin ducks fed different dietary oil sources

Guo, Y., Zhao, Z., Zhuang, L., Wang, Q., Cao, J., Wu, Y., & Wen, Z. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107521

N-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Significantly Reduces Liver Oxidative Stress in High Fat Induced Steatosis

Valenzuela, R., Espinosa, A., Gonzalez‐Mañán, D., D’Espessailles, A., Fernández, V., Videla, L. A., & Tapia, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046400 · Cited by 104 · see citing works

N-3 long-chain polyunsaturated Fatty Acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis. PLoS One 2012

Valenzuela, R., Espinosa, R., Videla, L. A., & Tapia, G. (2016)

n-3 LCPUFA in the reversal of hepatic steatosis: the role of ACOX and CAT-1

Tapia, G., Gonzalez‐Mañán, D., D’Espessailles, A., & Dossi, C. G. (2016) · Grasas y Aceites · doi:10.3989/gya.0886152 · Cited by 1 · see citing works

N-3long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-α upregulation and NF-κB DNA binding abrogation

Tapia, G., Valenzuela, R., Espinosa, A., Pamela Romanque, U., Dossi, C. G., Gonzalez‐Mañán, D., Videla, L. A., & D’Espessailles, A. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300458 · Cited by 85 · see citing works

Hepatic n-3 Polyunsaturated Fatty Acid Depletion Promotes Steatosis and Insulin Resistance in Mice: Genomic Analysis of Cellular Targets

Pachikian, B. D., Essaghir, A., Demoulin, J., Neyrinck, A. M., Catry, É., Backer, F. C. D., Dejeans, N., Dewulf, E. M., Sohet, F. M., Portois, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023365 · Cited by 91 · see citing works