Cited by 114Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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NOX1, 2, 4, 5: counting out oxidative stress

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Wingler, K, Hermans, JJR, Schiffers, P, Moens, AL, Paul, M, Schmidt, HHHW·2011·British Journal of Pharmacology

DOI 10.1111/j.1476-5381.2011.01249.xPMC PMC3195911

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Abstract

For decades, oxidative stress has been discussed as a key mechanism of endothelial dysfunction and cardiovascular disease. However, attempts to validate and exploit this hypothesis clinically by supplementing antioxidants have failed. Nevertheless, this does not disprove the oxidative stress hypothesis. As a certain degree of reactive oxygen species (ROS) formation appears to be physiological and beneficial. To reduce oxidative stress therapeutically, two alternative approaches are being developed. One is the repair of key signalling components that are compromised by oxidative stress. These include uncoupled endothelial nitric oxide (NO) synthase and oxidized/heme‐free NO receptor soluble guanylate cyclase. A second approach is to identify and effectively inhibit the relevant source(s) of ROS in a given disease condition. A highly likely target in this context is the family of NADPH oxidases. Animal models, including NOX knockout mice and new pharmacological inhibitors of NADPH oxidases have opened up a new era of oxidative stress research and have paved the way for new cardiovascular therapies. LINKED ARTICLES This article is part of a themed issue on Vascular Endothelium in Health and Disease. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2011.164.issue‐3

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The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the American Heart Association Nutrition Committee
Lichtenstein, A. H., Appel, L. J., Brands, M., Carnethon, M., Daniels, S., Franch, H. A., Franklin, B., Kris-Etherton, P., Harris, W. S., Howard, B., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176158 · Cited by 2,705
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,651
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400
Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Primary Prevention of Coronary Heart Disease in Women through Diet and Lifestyle
Stampfer, M. J., Hu, F. B., Manson, J. E., Rimm, E. B., & Willett, W. C. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007063430103 · Cited by 1,794
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652
Antioxidants prevent health-promoting effects of physical exercise in humans
Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903485106 · Cited by 1,582
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
Niethammer, P., Grabher, C., Look, A. T., & Mitchison, T. J. (2009) · Nature · doi:10.1038/nature08119 · Cited by 1,541
Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease.
Treasure, C. B., Klein, J., Weintraub, W. S., Talley, J., Stillabower, M., Kosinski, A. S., Zhang, J., Boccuzzi, S., Cedarholm, J. C., & Alexander, R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502233320801 · Cited by 1,335
Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
Rubanyi, G. M., & Vanhoutte, P. M. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.5.h822 · Cited by 1,193
Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction: Its Role in Hypercholesterolemia
Böger, R. H., Bode-Böger, S. M., Szuba, A., Tsao, P. S., Chan, J. R., Tangphao, O., Blaschke, T. F., & Cooke, J. P. (1998) · Circulation · doi:10.1161/01.cir.98.18.1842 · Cited by 1,181
Tadalafil Therapy for Pulmonary Arterial Hypertension
Galiè, N., Brundage, B. H., Ghofrani, H. A., Oudiz, R. J., Simonneau, G., Safdar, Z., Shapiro, S., White, R. J., Chan, M., Beardsworth, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.839274 · Cited by 1,096
Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials
Vivekananthan, D. P., Penn, M. S., Sapp, S. K., Hsu, A., & Topol, E. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13637-9 · Cited by 1,083
Beneficial Effects of Cholesterol-Lowering Therapy on the Coronary Endothelium in Patients with Coronary Artery Disease
&NA; (1996) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-199605000-00005 · Cited by 1,071
Lipid peroxidation: Physiological levels and dual biological effects
Niki, E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.032 · Cited by 1,032
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Z., Irie, H. Y., Gao, S., Puigserver, P., & Brugge, J. S. (2009) · Nature · doi:10.1038/nature08268 · Cited by 1,031
Vascular NAD(P)H oxidases: specific features, expression, and regulation
Lassegue, B. P., & Clempus, R. E. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00758.2002 · Cited by 1,026
Simvastatin, an HMG–Coenzyme A Reductase Inhibitor, Improves Endothelial Function Within 1 Month
O’Driscoll, G., Green, D., & Taylor, R. R. (1997) · Circulation · doi:10.1161/01.cir.95.5.1126 · Cited by 947
Erectile Dysfunction and Subsequent Cardiovascular Disease
Thompson, I. M. (2005) · JAMA · doi:10.1001/jama.294.23.2996 · Cited by 877
Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5
Cheng, G., Cao, Z., Xu, X., Meir, E. G. V., & Lambeth, J. D. (2001) · Gene · doi:10.1016/s0378-1119(01)00449-8 · Cited by 820
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart
Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D., & Sadoshima, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002178107 · Cited by 772
Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene
Riemersma, R. A., Wood, D. A., Oliver, M. F., Elton, R. A., Macintyre, C. C. A., & GEY, K. F. (1991) · The Lancet · doi:10.1016/0140-6736(91)93327-6 · Cited by 771
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
Evgenov, O. V., Pacher, P., Schmidt, P. M., Haskó, G., Schmidt, H. H. H. W., & Stasch, J. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2038 · Cited by 758
Self-citation
Therapeutic Targeting of Mitochondrial Superoxide in Hypertension
Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 745
Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant
Heumüller, S., Wind, S., Barbosa-Sicard, E., Schmidt, H. H. H. W., Busse, R., Schröder, K., & Brandes, R. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.100214 · Cited by 735
Self-citation
Oxidative Stress and Cardiovascular Injury
Griendling, K. K., & FitzGerald, G. A. (2003) · Circulation · doi:10.1161/01.cir.0000093661.90582.c4 · Cited by 727
Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction
Doughan, A. K., Harrison, D. G., & Dikalov, S. I. (2008) · Circulation Research · doi:10.1161/circresaha.107.162800 · Cited by 710
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
Cai, H., Griendling, K. K., & Harrison, D. G. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00233-5 · Cited by 687
Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice
Zang, M., Xu, S., Maitland, K. A., Zuccollo, A., Hou, X., Jiang, B., Wierzbicki, M., Verbeuren, T. J., & Cohen, R. A. (2006) · Diabetes · doi:10.2337/db05-1188 · Cited by 672
NADPH Oxidases in Cardiovascular Health and Disease
Cave, A. C., Brewer, A. C., Narayanapanicker, A., Ray, R., Grieve, D. J., Walker, S., & Shah, A. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.691 · Cited by 630
A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes
Bánfi, B., Molnár, G., Maturana, A., Steger, K., Hegedûs, B., Demaurex, N., & Krause, K.-H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103034200 · Cited by 622
Novel Competitive Inhibitor of NAD(P)H Oxidase Assembly Attenuates Vascular O2−and Systolic Blood Pressure in Mice
Rey, F. E., Cifuentes-Pagano, E., Kiarash, A., Quinn, M. T., & Pagano, P. J. (2001) · Circulation Research · doi:10.1161/hh1701.096037 · Cited by 613
A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall
Görlach, A., Brandes, R. P., Nguyen, K., Amidi, M., Dehghani, F., & Busse, R. (2000) · Circulation Research · doi:10.1161/01.res.87.1.26 · Cited by 598 · cited 2×
“Nevertheless, it can be said with some certainty that NOX2 is not only present in leukocytes, but also in endothelial cells (Gorlach et al., 2000; Bedard and Krause, 2007), fibroblasts (Chamseddine and Miller, 2003) and cardiac myocytes (Nabeebaccus et al.”
NADPH Oxidases: Functions and Pathologies in the Vasculature
Lassègue, B., & Griendling, K. K. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.181610 · Cited by 592
Cellular Antioxidant Effects of Atorvastatin In Vitro and In Vivo
Waßmann, S., Laufs, U., Müller, K., Konkol, C., Ahlbory, K., Bäumer, A. T., Linz, W., Böhm, M., & Nickenig, G. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0202.104081 · Cited by 590
Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries: Regulation by Angiotensin II
Touyz, R. M., Chen, X., Tabet, F., Yao, G., He, G., Quinn, M. T., Pagano, P. J., & Schiffrin, E. L. (2002) · Circulation Research · doi:10.1161/01.res.0000020404.01971.2f · Cited by 590
Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase
O’Donnell, V. B., Tew, D. G., Jones, O. T. G., & ENGLAND, P. J. (1993) · Biochemical Journal · doi:10.1042/bj2900041 · Cited by 588
Free radicals in cerebral ischemia.
Flamm, E. S., Demopoulos, H. B., Seligman, M. L., Poser, R. G., & Ransohoff, J. (1978) · Stroke · doi:10.1161/01.str.9.5.445 · Cited by 577
Healthy Living Is the Best Revenge
Ford, E. S., Bergmann, M. M., Kröger, J., Schienkiewitz, A., Weikert, C., & Boeing, H. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.237 · Cited by 577
Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence
Zhao, H., Joseph, J., Fales, H. M., Sokoloski, E. A., Levine, R. L., Vasquez-Vivar, J., & Kalyanaraman, B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501719102 · Cited by 576
Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study
Khaw, K., Bingham, S. A., Welch, A. A., Luben, R., Wareham, N. J., Oakes, S., & Day, N. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04128-3 · Cited by 576
Measurement of Reactive Oxygen Species in Cardiovascular Studies
Dikalov, S., Griendling, K. K., & Harrison, D. G. (2007) · Hypertension · doi:10.1161/01.hyp.0000258594.87211.6b · Cited by 532
Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant
Bowry, V. W., Ingold, K. U., & Stocker, R. (1992) · Biochemical Journal · doi:10.1042/bj2880341 · Cited by 511
Primary Prevention of Stroke by Healthy Lifestyle
Chiuve, S. E., Rexrode, K. M., Spiegelman, D. L., Logroscino, G., Manson, J. E., & Rimm, E. B. (2008) · Circulation · doi:10.1161/circulationaha.108.781062 · Cited by 508
Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes
Ago, T., Kuroda, J., Pain, J., Fu, C., Li, H., & Sadoshima, J. (2010) · Circulation Research · doi:10.1161/circresaha.109.213116 · Cited by 506
Subcellular localization of Nox4 and regulation in diabetes
Block, K. L., Gorin, Y. C., & Abboud, H. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906805106 · Cited by 484
Nox1 Is Involved in Angiotensin II–Mediated Hypertension: A Study in Nox1-Deficient Mice
Matsuno, K., Yamada, H., Iwata, K., Jin, D., Katsuyama, M., Matsuki, M., Takai, S., Yamanishi, K., Miyazaki, M., Matsubara, H., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.573709 · Cited by 470
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
Stasch, J., Schmidt, P. M., Nedvetsky, P. I., Nedvetskaya, T. Y., Kumar, A. H. S., Meurer, S., Deile, M., Taye, A., Knorr, A., Lapp, H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28371 · Cited by 461
Self-citation
The Antioxidants and Pro-Antioxidants Network: An Overview
Vertuani, S., Angusti, A., & Manfredini, S. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384655 · Cited by 449
Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration
Kleinschnitz, C., Grund, H., Wingler, K., Armitage, M. E., Jones, E., Mittal, M., Barit, D., Schwarz, T., Geis, C., Kraft, P., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000479 · Cited by 447
Self-citation
Methods for detection and measurement of hydrogen peroxide inside and outside of cells
Rhee, S. G., Chang, T.-S., Jeong, W., & Kang, D. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0082-3 · Cited by 446
Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice
Dikalova, A., Clempus, R., Lassègue, B., Cheng, G., McCoy, J., Dikalov, S., Martin, A. S., Lyle, A., Weber, D. S., Weiss, D., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.538934 · Cited by 438
Self-citation
Human αB-Crystallin Mutation Causes Oxido-Reductive Stress and Protein Aggregation Cardiomyopathy in Mice
Rajasekaran, N. S., Connell, P., Christians, E. S., Yan, L.-J., Taylor, R. P., Orosz, A., Zhang, X. Q., Stevenson, T. J., Peshock, R. M., Leopold, J. A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.06.044 · Cited by 437
Lipid peroxidation cannot be used as a universal criterion of oxidative stress
Dotan, Y. (2003) · Progress in Lipid Research · doi:10.1016/j.plipres.2003.10.001 · Cited by 434
Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
Schulz, E., Jansen, T., Wenzel, P., Daiber, A., & Münzel, T. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1989 · Cited by 430
Reactive oxygen species as mediators of angiotensin II signaling
Griendling, K. K., & Ushio‐Fukai, M. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00136-1 · Cited by 417
Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking
Lykkesfeldt, J. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.028 · Cited by 416
Critical role of nox4-based nadph oxidase in glucose-induced oxidative stress in the kidney: Implications in type 2 diabetic nephropathy
Sedeek, M., Callera, G., Montezano, A., Gutsol, A., Heitz, F., Szyndralewiez, C., Page, P., Kennedy, C. R. J., Burns, K. D., Touyz, R. M., et al. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00028.2010 · Cited by 396
Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Induces Monocyte Adhesion by Stimulating Reactive Oxygen Species Production From a Nox1-Based NADPH Oxidase
Sorescu, G. P., Song, H. W., Tressel, S. L., Hwang, J., Dikalov, S., Smith, D. A., Boyd, N. L., Platt, M. O., Lassegue, B. P., Griendling, K. K., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000145728.22878.45 · Cited by 383
Lifestyle Risk Factors and New-Onset Diabetes Mellitus in Older Adults: The Cardiovascular Health Study
Mozaffarian, D., Kamineni, A., Carnethon, M., Djoussé, L., Mukamal, K. J., & Siscovick, D. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.21 · Cited by 358
Endothelial Function in Hypertension
McIntyre, M., Bohr, D. F., & Dominiczak, A. F. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.539 · Cited by 355
Reactive oxygen species in hypertension*1An update
Lassegue, B. P. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.02.004 · Cited by 351
Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase
Walder, C. E., Green, S. P., Darbonne, W. C., Mathias, J., Rae, J., Dinauer, M. C., Curnutte, J. T., & Thomas, G. R. (1997) · Stroke · doi:10.1161/01.str.28.11.2252 · Cited by 349
Decreased blood pressure in NOX1‐deficient mice
Gavazzi, G., Banfi, B., Deffert, C., Fiette, L., Schappi, M., Herrmann, F., & Krause, K.-H. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.049 · Cited by 321
Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people
Gale, C., Martyn, C., Winter, P., & Cooper, C. (1995) · British medical journal · doi:10.1136/bmj.310.6994.1563 · Cited by 316
Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion
Chen, H., Song, Y. S., & Chan, P. H. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.47 · Cited by 291
Detection of Superoxide in Vascular Tissue
Münzel, T. F., Afanasʹev, I. B., Kleschyov, A. L., & Harrison, D. G. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000034022.11764.ec · Cited by 281
Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease
Guzik, T. J., Chen, W., Gongora, M. C., Guzik, B., Lob, H. E., Mangalat, D., Hoch, N., Dikalov, S., Rudzinski, P., Kapelak, B., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.063 · Cited by 281
Effect of the HMG-CoA Reductase Inhibitors on Blood Pressure in Patients With Essential Hypertension and Primary Hypercholesterolemia
Glorioso, N., Troffa, C., Filigheddu, F., Dettori, F., Soro, A., Parpaglia, P. P., Collatina, S., & Pahor, M. (1999) · Hypertension · doi:10.1161/01.hyp.34.6.1281 · Cited by 278
NADPH oxidases in cardiovascular disease
Brandes, R. P., Weißmann, N., & Schröder, K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.030 · Cited by 273
Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo
Wingler, K., Wünsch, S., Kreutz, R. H., Rothermund, L., Paul, M., & Schmidt, H. H. H. W. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00727-4 · Cited by 273
Self-citation
The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease
Stephens, J. W., Khanolkar, M., & Bain, S. C. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.06.006 · Cited by 262
Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay
Fink, B., Laude, K. M., McCann, L. A., Doughan, A. K., Harrison, D. G., & Dikalov, S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00028.2004 · Cited by 259
Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation☆
TENFREYHAUS, H., HUNTGEBURTH, M., WINGLER, K., SCHNITKER, J., BAUMER, A., VANTLER, M., BEKHITE, M., WARTENBERG, M., SAUER, H., & ROSENKRANZ, S. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.022 · Cited by 259
Self-citation
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Tsunekawa, T., Hayashi, T., Kano, H., Sumi, D., Matsui‐Hirai, H., Thakur, N. K., Egashira, K., & Iguchi, A. (2001) · Circulation · doi:10.1161/hc2901.094094 · Cited by 256
NOX5 variants are functionally active in endothelial cells
BelAiba, R. S., Djordjevic, T., Petry, A., Diemer, K., Bonello, S., Banfi, B., Hess, J., Pogrebniak, A., Bickel, C., & Görlach, A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.10.054 · Cited by 255
Vitamin C deficiency and risk of myocardial infarction: prospective population study of men from eastern Finland
Nyyssonen, K., Parviainen, M. T., Salonen, R., Tuomilehto, J. O., & Salonen, J. T. (1997) · BMJ · doi:10.1136/bmj.314.7081.634 · Cited by 254
gp91phox-Containing NADPH Oxidase Mediates Endothelial Dysfunction in Renovascular Hypertension
Jung, O., Schreiber, J. G., Geiger, H., Pedrazzini, T., Busse, R., & Brandes, R. P. (2004) · Circulation · doi:10.1161/01.cir.0000124223.00113.a4 · Cited by 254
Evidence for the Pathophysiological Role of Endogenous Methylarginines in Regulation of Endothelial NO Production and Vascular Function
Cardounel, A. J., Cui, H., Samouilov, A., Johnson, W., Kearns, P. N., Tsai, A.-L., Berka, V., & Zweier, J. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603606200 · Cited by 249
NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition
Selemidis, S., Sobey, C. G., Wingler, K., Schmidt, H. H. H. W., & Drummond, G. R. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.08.005 · Cited by 249
Self-citation
Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets
Jaquet, V., Scapozza, L., Clark, R. A., Krause, K. H., & Lambeth, J. D. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2585 · Cited by 245
Comparative pharmacology of chemically distinct nadph oxidase inhibitors
Wind, S., Beuerlein, K., Eucker, T., Müller, H., Scheurer, P., Armitage, M., Ho, H., Schmidt, H., & Wingler, K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00920.x · Cited by 241
Self-citation
NADPH oxidase 4 is an oncoprotein localized to mitochondria
Graham, K., Kulawiec, M., Owens, K. M., Li, X., Desouki, M. M., Chandra, D., & Singh, K. K. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.3.12207 · Cited by 240
Asymmetric dimethylarginine (ADMA): A novel risk marker in cardiovascular medicine and beyond
Böger, R. H. (2006) · Annals of Medicine · doi:10.1080/07853890500472151 · Cited by 238
Novel NAD(P)H oxidases in the cardiovascular system: Table 1
Griendling, K. K. (2004) · Heart · doi:10.1136/hrt.2003.029397 · Cited by 215
Carotenoids, vitamins C and E, and mortality in an elderly population.
Sahyoun, N. R., Jacques, P. F., & Russell, R. M. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008957 · Cited by 212
NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries
Miller, A. A., Drummond, G. R., Schmidt, H. H. H. W., & Sobey, C. G. (2005) · Circulation Research · doi:10.1161/01.res.0000189301.10217.87 · Cited by 211 · cited 5×
“Likewise, vitamin E supplements can no longer be considered safe for the general population (Dotan et al., 2009; Miller et al., 2005b; Miller and Guallar, 2009).”
InfluentialSelf-citation
Novel Mechanism of Activation of NADPH Oxidase 5
Jagnandan, D., Church, J. E., Banfi, B., Stuehr, D. J., Marrero, M. B., & Fulton, D. J. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608966200 · Cited by 210
Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific
Aldieri, E., Riganti, C., Polimeni, M., Gazzano, E., Lussiana, C., Campia, I., & Ghigo, D. (2008) · Current Drug Metabolism · doi:10.2174/138920008786049285 · Cited by 201
Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I).
Majander, A. S., Finel, M., & Wikström, M. K. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31926-9 · Cited by 200
BiP/Kar2p serves as a molecular chaperone during carboxypeptidase Y folding in yeast.
Simons, J. F., Ferro‐Novick, S., Rose, M. D., & Helenius, A. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.1.41 · Cited by 199
Inhibition of NADPH Oxidase Activation by 4-(2-Aminoethyl)-benzenesulfonyl Fluoride and Related Compounds
Diatchuk, V., Lotan, O., Koshkin, V., Wikstroem, P., & Pick, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13292 · Cited by 195
Contractions to oxygen-derived free radicals are augmented in aorta of the spontaneously hypertensive rat.
Auch–Schwelk, W., Katušić, Z. S., & Vanhoutte, P. M. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.859 · Cited by 194
A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells
Gianni, D., Taulet, N., Zhang, H., DerMardirossian, C., Kister, J., Martinez, L., Roush, W. R., Brown, S. J., Bokoch, G. M., & Rosen, H. (2010) · ACS Chemical Biology · doi:10.1021/cb100219n · Cited by 192
Using Isoprostanes as Biomarkers of Oxidative Stress: Some Rarely Considered Issues
Halliwell, B. B., & Lee, J. C. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2934 · Cited by 191
Discovery of Riociguat (BAY 63‐2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension
Mittendorf, J., Weigand, S., Alonso‐Alija, C., Bischoff, E., Feurer, A., Gerisch, M., Kern, A., Knorr, A., Lang, D. H., Muenter, K., et al. (2009) · ChemMedChem · doi:10.1002/cmdc.200900014 · Cited by 189
Vitamin C status and mortality in US adults
Loria, C. M., Klag, M. J., Caulfield, L. E., & Whelton, P. K. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.1.139 · Cited by 188
Rates of interactions of superoxide with vitamin E, vitamin C and related compounds as measured by chemiluminescence
Gotoh, N., & Niki, E. (1992) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(92)90054-x · Cited by 188
Kinetics of Cytochrome C2+ Oxidation by Peroxynitrite: Implications for Superoxide Measurements in Nitric Oxide-Producing Biological-Systems
Thomson, L., Trujillo, M., Telleri, R., & Radi, R. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1321 · Cited by 186
PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox.
Shi, J. N., Ross, C. R., Leto, T. L., & Blecha, F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.6014 · Cited by 185
Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012
Daiber, A., August, M., Baldus, S. E., Wendt, M., Oelze, M. W., Sydow, K., Kleschyov, A. L., & Münzel, T. F. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.012 · Cited by 184
Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition
Wind, S., Beuerlein, K., Armitage, M. E., Taye, A., Kumar, A. H. S., Janowitz, D., Neff, C., Shah, A. M., Wingler, K., & Schmidt, H. H. H. W. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.149187 · Cited by 181
Self-citation
Measurement of total antioxidant capacity
Young, I. S. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.5.339 · Cited by 180
Upregulation of nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via enos uncoupling
Dikalova, A. E., Góngora, M. C., Harrison, D. G., Lambeth, J. D., Dikalov, S., & Griendling, K. K. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00242.2010 · Cited by 179
Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells
Vejražka, M., MICEK, R., & Štípek, S. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2004.12.008 · Cited by 173
Effects of the soluble guanylyl cyclase activator, YC‐1, on vascular tone, cyclic GMP levels and phosphodiesterase activity
Galle, J., Zabel, U., Hübner, U., Hatzelmann, A., Wagner, B., Wanner, C., & Schmidt, H. H. H. W. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702495 · Cited by 173
Self-citation
Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells
Jay, D. B., Papaharalambus, C. A., Seidel-Rogol, B., Dikalova, A. E., Lassègue, B., & Griendling, K. K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.024 · Cited by 166
Withdrawal of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Elicits Oxidative Stress and Induces Endothelial Dysfunction in Mice
Vecchione, C., & Brandes, R. P. (2002) · Circulation Research · doi:10.1161/01.res.0000028004.76218.b8 · Cited by 160
A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1α
Li, S. H., Shin, D. H., Chun, Y.-S., Lee, M. K., Kim, M.-S., & Park, J.-W. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0074 · Cited by 160
Reactive Oxygen Species, NADPH Oxidases, and Hypertension
Datla, S. R., & Griendling, K. K. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.142422 · Cited by 152
Turning Back the Clock: Adopting a Healthy Lifestyle in Middle Age
King, D. E., Mainous, A. G., & Geesey, M. E. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.09.020 · Cited by 151
HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements
Zielonka, J., Hardy, M., & Kalyanaraman, B. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.10.031 · Cited by 151
Phosphodiesterase inhibitors for the treatment of pulmonary hypertension
Wilkins, M. R., Wharton, J., Grimminger, F., & Ghofrani, H. A. (2008) · European Respiratory Journal · doi:10.1183/09031936.00124007 · Cited by 151
Thioredoxins are required for protection against a reductive stress in the yeast Saccharomyces cerevisiae
Trotter, E. W., & Grant, C. M. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03216.x · Cited by 146
NADPH Oxidase Inhibitors: New Antihypertensive Agents?
Williams, H. C., & Griendling, K. K. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318063e820 · Cited by 146
Vascular Hypertrophy in Angiotensin II–Induced Hypertension Is Mediated by Vascular Smooth Muscle Cell–Derived H 2 O 2
Zhang, Y., Griendling, K. K., Dikalova, A., Owens, G. K., & Taylor, W. R. (2005) · Hypertension · doi:10.1161/01.hyp.0000182660.74266.6d · Cited by 141
Cytokine Biomarkers, Endothelial Inflammation, and Atherosclerosis in the Metabolic Syndrome: Emerging Concepts
Rizvi, A. A. (2009) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181a4158c · Cited by 138
NADPH oxidases and cardiac remodelling
Nabeebaccus, A., Zhang, M., & Shah, A. M. (2011) · Heart Failure Reviews · doi:10.1007/s10741-010-9186-2 · Cited by 138
Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells
Stielow, C., Catar, R. A., Müller, G. M., Wingler, K., Scheurer, P., Schmidt, H. H. H. W., & Morawietz, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.114 · Cited by 127
Self-citation
Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39.
Gudmundsson, G. H., Magnússon, K. P., Chowdhary, B. P., Johansson, M., Andersson, L., & Boman, H. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.7085 · Cited by 125
Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2‐deficient mice
Jackman, K. A., Miller, A. A., Silva, T. M. D., Crack, P. J., Drummond, G. R., & Sobey, C. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00073.x · Cited by 120
Systemic Regulation of Vascular NAD(P)H Oxidase Activity and Nox Isoform Expression in Human Arteries and Veins
Guzik, T. J., Sadowski, J., Kapelak, B., Jopek, A., Rudziński, P., Pillai, R. G., Korbut, R., & Channon, K. M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000139011.94634.9d · Cited by 120
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice
Bhandarkar, S. S., Jaconi, M. E., Fried, L. E., Bonner, M. Y., Lefkove, B., Govindarajan, B., Perry, B. N., Parhar, R., MacKelfresh, J. B., Sohn, A. M., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci33877 · Cited by 117
S17834, a New Inhibitor of Cell Adhesion and Atherosclerosis That Targets NADPH Oxidase
Cayatte, A. J., Rupin, A., Oliver-Krasinski, J. M., Maitland, K. A., Sansilvestri, P., Boussard, M.-F., Wierzbicki, M., Verbeuren, T. J., & Cohen, R. A. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1001.096723 · Cited by 116
Hydrogen peroxide as an endothelium-derived hyperpolarizing factor
Shimokawa, H. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0790-8 · Cited by 115
Involvement of Reductive Stress in the Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Heat Shock Protein 27
Zhang, X., Min, X., Li, C., Benjamin, I. J., Qian, B., Zhang, X., Ding, Z., Gao, X., Yao, Y., Ma, Y., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.147066 · Cited by 114
Tetrahydrobiopterin Inhibits Monomerization and Is Consumed during Catalysis in Neuronal NO Synthase
Reif, A., Fröhlich, L. G., Kotsonis, P., Frey, A., Bömmel, H. M., Schmidt, H. H. H. W., Wink, D. A., & Pfleiderer, W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24921 · Cited by 113
Self-citation
?Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2
Dhamrait, S. S. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.01.007 · Cited by 110
Nitric Oxide–Independent Vasodilator Rescues Heme-Oxidized Soluble Guanylate Cyclase From Proteasomal Degradation
Meurer, S., Pioch, S., Pabst, T., Opitz, N., Schmidt, P. M., Beckhaus, T., Wagner, K., Matt, S., Gegenbauer, K., Geschka, S., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.198234 · Cited by 107
Self-citation
Paradoxical Activation of Endothelial Nitric Oxide Synthase by NADPH Oxidase
Zhang, Q., Malik, P., Pandey, D., Gupta, S. A., Jagnandan, D., de Chantemèle, E. J. B., Bánfi, B., Marrero, M. B., Rudic, R. D., Stepp, D. W., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.168278 · Cited by 106
Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis
Melichar, V. O., Behr‐Roussel, D., Zabel, U., UTTENTHAL, L. O., Rodrigo, J., Rupin, A., Verbeuren, T. J., Kumar, A. H. S., & Schmidt, H. H. H. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405509101 · Cited by 102
Self-citation
Dietary intake, plasma levels of antioxidant vitamins, and oxidative stress in relation to coronary artery disease in elderly subjects
Singh, R. B., Ghosh, S., Niaz, M. A., Singh, R., Beegum, R., Chibo, H., Shoumin, Z., & Postiglione, A. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80348-8 · Cited by 101
Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition
Chen, W., Pendyala, S., Natarajan, V., Garcia, J. G. N., & Jacobson, J. R. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00428.2007 · Cited by 100
Reduced NAD(P)H Oxidase in Low Renin Hypertension
Zhou, M.-S., Schulman, I. H., Pagano, P. J., Jaimes, E. A., & Raij, L. R. (2005) · Hypertension · doi:10.1161/01.hyp.0000197182.65554.c7 · Cited by 99
Platelet-derived growth factor BB stimulates vasculogenesis of embryonic stem cell-derived endothelial cells by calcium-mediated generation of reactive oxygen species
Lange, S., Heger, J., Euler, G., Wartenberg, M., Piper, H. M., & Sauer, H. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn258 · Cited by 97
NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin
Tirone, F., & Cox, J. A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.02.047 · Cited by 96
The SOD Mimetic Tempol Ameliorates Glomerular Injury and Reduces Mitogen-Activated Protein Kinase Activity in Dahl Salt-Sensitive Rats
Nishiyama, A., Yoshizumi, M., Hitomi, H., Kagami, S., Kondo, S., Miyatake, A., Fukunaga, M., Tamaki, T., Kiyomoto, H., Kohno, M., et al. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000108523.02100.e0 · Cited by 95
NADPH Oxidases Regulate CD44 and Hyaluronic Acid Expression in Thrombin-treated Vascular Smooth Muscle Cells and in Atherosclerosis
Vendrov, A. E., Madamanchi, N. R., Niu, X.-L., Molnar, K., Runge, M., Szyndralewiez, C., Page, P., & Runge, M. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.143917 · Cited by 93
NADPH oxidase Nox1 contributes to ischemic injury in experimental stroke in mice
Kahles, T., Kohnen, A., Heumueller, S., Rappert, A., Bechmann, I., Liebner, S., Wittko, I. M., Neumann-Haefelin, T., Steinmetz, H., Schroeder, K., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.023 · Cited by 91
Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition
Schluter, T., Steinbach, A. C., Steffen, A., Rettig, R., & Grisk, O. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn185 · Cited by 90
The NADPH oxidase inhibitor apocynin (acetovanillone) induces oxidative stress
Riganti, C., Costamagna, C., Bosìa, A., & Ghigo, D. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.07.011 · Cited by 88
cGMP: Generators, Effectors and Therapeutic Implications
Schmidt, H. H. H. W., Hofmann, F. B., & Stasch, J. (2008) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-68964-5 · Cited by 83
Self-citation
Angiotensin II and NADPH Oxidase Increase ADMA in Vascular Smooth Muscle Cells
Luo, Z., Teerlink, T., Griendling, K. K., Aslam, S., Welch, W. J., & Wilcox, C. S. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.152959 · Cited by 83
Phenothiazine: The Parent Molecule
Mitchell, S. C. (2006) · Current Drug Targets · doi:10.2174/138945006778226552 · Cited by 82
l-Arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease
Settergren, M., Böhm, F., Malmström, R. E., Channon, K. M., & Pernow, J. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.08.034 · Cited by 80
How We Learned to Say NO
Vanhoutte, P. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.190215 · Cited by 76
gp91phox Contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells
Chamseddine, A. H., & Miller, F. J. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00459.2003 · Cited by 75
Hydrogen peroxide is an endothelium‐dependent contracting factor in rat renal artery
Gao, Y., & Lee, R. M. K. W. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706423 · Cited by 74
Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin‐1‐induced stroke in conscious rats
McCann, S., Dusting, G. J., & Roulston, C. L. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21700 · Cited by 72
Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen
Didion, S. P., Ryan, M. J., Baumbach, G. L., Sigmund, C. D., & Faraci, F. M. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00079.2002 · Cited by 68
Biomarkers of Inflammation and Oxidative Stress in Atherosclerosis
Uno, K., & Nicholls, S. J. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.57 · Cited by 65
The ‘A’s and ‘O’s of NADPH oxidase regulation: A commentary on “Subcellular localization and function of alternatively spliced Noxo1 isoforms”
Opitz, N., Drummond, G. R., Selemidis, S., Meurer, S., & Schmidt, H. H. H. W. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.003 · Cited by 64
Self-citation
Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation‐induced degradation
Hoffmann, L., Schmidt, P., Keim, Y., Schaefer, S., Schmidt, H. H. H. W., & Stasch, J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00263.x · Cited by 64
Self-citation
Pro-oxidant activity of apocynin radical
Castor, L. R. G., Locatelli, K. A., & Ximenes, V. F. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.010 · Cited by 63
Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide
Kotsonis, P., Fröhlich, L. G., SHUTENKO, Z., Horejsi, R., Pfleiderer, W., & Schmidt, H. H. H. W. (2000) · Biochemical Journal · doi:10.1042/bj3460767 · Cited by 62
Self-citation
Decision Analysis Supports the Paradigm That Indiscriminate Supplementation of Vitamin E Does More Harm than Good
Dotan, Y., Pinchuk, I., Lichtenberg, D. A., & Leshno, M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.178699 · Cited by 60
Protective Effects of BAY 41-2272 (sGC Stimulator) on Hypertension, Heart, and Cardiomyocyte Hypertrophy Induced by Chronic L-NAME Treatment in Rats
Zanfolin, M., Faro, R., de Araújo, E. G., Guaraldo, A. M. A., Antunes, E., & Nucci, G. D. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000210071.54828.9b · Cited by 56
Small-Molecule Inhibitors of NADPH Oxidase 4
Borbély, G., Szabadkai, I., Horváth, Z., Markó, P., Varga, Z. V., Breza, N., Baska, F., Vántus, T., Huszár, M., Geiszt, M., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm1004368 · Cited by 53
Reactive oxygen species are involved in regulating α1-adrenoceptor-activated vascular smooth muscle contraction
Tsai, M.-H., & Jiang, M. J. (2010) · Journal of Biomedical Science · doi:10.1186/1423-0127-17-67 · Cited by 51
Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress
Zhou, Z., Pyriochou, A., Kotanidou, A. N., Dalkas, G. A., van Eickels, M., Spyroulias, G. A., Roussos, C., & Papapetropoulos, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.51.2008 · Cited by 50
The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca2+pump
Tazzeo, T., Worek, F., & Janssen, L. J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00394.x · Cited by 42
Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: Effect of valsartan
Wang, P., Tang, F., Li, R., Zhang, H., Chen, S., Liu, P., & Huang, H. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.016 · Cited by 40
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10.1042/0264-6021:3460767 · DOI

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Authors: Wingler, K., Hermans, J., Schiffers, P., Moens, A., Paul, M., & Schmidt, H.
Affiliations: Maastricht University (NL)
Maastricht University Medical Centre (NL)
ORCID: Schiffers, P
Paul, M
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2011-09-08
Volume: 164
Issue: 3
Pages: 866-883
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1111/j.1476-5381.2011.01249.x
PMC: PMC3195911
OpenAlex: W1512037315
Cited by: 113
References: 176
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 12 · 2013: 15 · 2012: 15
FWCI: 1.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: British Journal of Pharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Funders: ZonMw
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Servier
Medical Research Council
National Health and Medical Research Council
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: oxidative stress, NADPH oxidase, NOX1, NOX2, NOX4, NADPH oxidase 5, reactive oxygen species, endothelial dysfunction, cardiovascular disease, antioxidant supplementation, soluble guanylate cyclase, NADPH oxidase inhibitors
MeSH terms: Animals, Cardiovascular Agents, Cardiovascular Diseases, Humans, Oxidative Stress, NADPH Oxidases

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NOX1, 2, 4, 5: counting out oxidative stress

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