Co‐occurring Psychiatric Symptoms Are Associated with Increased Psychological, Social, and Medical Impairment in Opioid Dependent Pregnant Women

Benningfield, Margaret M.; Arria, Amelia M.; Kaltenbach, Karol; Heil, Sarah H.; Stine, Susan M.; Coyle, Mara G.; Fischer, Gabriele; Jones, Hendrée E.; Martin, Peter R.

doi:10.1111/j.1521-0391.2010.00064.x

Cited by 96Opioid Use Disorder TreatmentMaternal Mental Health During Pregnancy and PostpartumPrenatal Substance Exposure Effects

Co‐occurring Psychiatric Symptoms Are Associated with Increased Psychological, Social, and Medical Impairment in Opioid Dependent Pregnant Women

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Benningfield, Margaret M., Arria, Amelia M., Kaltenbach, Karol, Heil, Sarah H., Stine, Susan M., Coyle, Mara G., Fischer, Gabriele, Jones, Hendrée E. +1 more·2010·The American Journal on Addictions

DOI 10.1111/j.1521-0391.2010.00064.xPMC PMC2924760

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Abstract

The interaction of psychiatric symptoms with drug dependence during pregnancy is not well understood. This study examines the relationship of psychiatric symptoms to severity of drug use and drug‐related problems among participants in a clinical trial of pharmacologic treatment of opioid dependence during pregnancy (N = 174). A total of 64.6% reported additional psychiatric symptoms (48.6% mood symptoms, 40.0% anxiety symptoms, and 12.6% suicidal thinking). Women who endorsed co‐occurring psychiatric symptoms showed more severe impairment on the Addiction Severity Index. Further investigation is warranted to understand the effect of psychiatric symptoms on long‐term maternal and neonatal outcomes. (Am J Addict 2010;00:1–6)

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Women with opioid use disorder have high rates of co-occurring mental health conditions, with depression and anxiety conditions ranging as high as 65-75%.
“Women with OUD have high rates of co-occurring mental health conditions, with depression and anxiety conditions ranging as high as 65–75% [7–9].”
From Mindful moms: acceptability and impact of co-designed and digitally delivered video meditations for pregnant and parenting women with opioid use disorder (2025) · cites this paper as [7]
The Background reports a previous estimate as high as 75% for mood or anxiety disorders in opioid-dependent pregnant women. The Results report that 64.6% of this study’s pregnant participants screened positive for one or more psychiatric diagnoses, but that figure is not a rate of diagnosed depression or anxiety. The claim extends these figures to women with OUD generally and treats screening results as conditions. (LLM, conf=0.86)
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Untitled work
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370 · see citing works
Untitled work
(1998) · PubMed · Cited by 10,216 · see citing works
The Structured Clinical Interview for DSM-III-R (SCID): I: History, Rationale, and Description
Spitzer, R. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080032005 · Cited by 4,336 · see citing works
Comorbidity of Mental Disorders With Alcohol and Other Drug Abuse: Results From the Epidemiologic Catchment Area (ECA) Study
Regier, D. A. (1990) · JAMA · doi:10.1001/jama.1990.03450190043026 · Cited by 3,962 · see citing works
Prevalence and Co-occurrence of Substance Use Disorders and IndependentMood and Anxiety Disorders: Results From the National Epidemiologic Survey on Alcohol and RelatedConditions
Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., Pickering, R. P., & Kaplan, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.807 · Cited by 2,889 · see citing works
Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study.
Regier, D. A., Farmer, M. E., Rae, D. S., et al. (1990) · PubMed · Cited by 1,913 · see citing works
Prevalence of Depression During Pregnancy: Systematic Review
Bennett, H. A., Einarson, A., Taddio, A., Koren, G., & Einarson, T. R. (2004) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000116689.75396.5f · Cited by 1,725 · see citing works
Relapse of Major Depression During Pregnancy in Women Who Maintain or Discontinue Antidepressant Treatment
Cohen, L. S. (2006) · JAMA · doi:10.1001/jama.295.5.499 · Cited by 1,031 · see citing works
Dialectical behavior therapy versus comprehensive validation therapy plus 12-step for the treatment of opioid dependent women meeting criteria for borderline personality disorder
Linehan, M. M., Dimeff, L. A., Reynolds, S. K., Comtois, K. A., Welch, S. S., Heagerty, P., & Kivlahan, D. R. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(02)00011-x · Cited by 741 · see citing works
Co-occurrence of 12-Month Alcohol and Drug Use Disorders and PersonalityDisorders in the United States: Results From the National Epidemiologic Survey on Alcohol and RelatedConditions
Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Ruan, W. J., & Pickering, R. P. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.4.361 · Cited by 644 · see citing works
Risk of Recurrence in Women With Bipolar Disorder During Pregnancy: Prospective Study of Mood Stabilizer Discontinuation
Viguera, A. C., Whitfield, T., Baldessarini, R. J., Newport, D. J., Stowe, Z., Reminick, A., Zurick, A., & Cohen, L. S. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06101639 · Cited by 599 · see citing works
A Controlled Trial of Buprenorphine Treatment for Opioid Dependence
Johnson, R. E. (1992) · JAMA · doi:10.1001/jama.1992.03480200058024 · Cited by 567 · see citing works
Trauma, PTSD, and Substance Use Disorders: Findings From the Australian National Survey of Mental Health and Well-Being
Mills, K. L., Teesson, M., Ross, J. E., & Peters, L. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.4.652 · Cited by 522 · see citing works
Borderline personality disorder and substance use disorders A review and integration
Trull, T. (2000) · Clinical Psychology Review · doi:10.1016/s0272-7358(99)00028-8 · Cited by 520 · see citing works
Trauma, PTSD, and Substance Use Disorders: Findings From the Australian National Survey of Mental Health and Well-Being
Mills, K. L. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.4.652 · Cited by 387 · see citing works
A Controlled Trial Comparing Buprenorphine and Methadone Maintenance in Opioid Dependence
Ling, W. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830050035005 · Cited by 366 · see citing works
Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome
Jones, H. E., Johnson, R. E., Jasinski, D. R., O’Grady, K. E., Chisholm, C. A., Choo, R. E., Crocetti, M. T., Dudas, R. A., Harrow, C., Huestis, M. A., et al. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.11.013 · Cited by 294 · see citing works
Self-citation
A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence
Weiss, R. D., Griffin, M. L., Kolodziej, M. E., Greenfield, S. F., Najavits, L. M., Daley, D. C., Doreau, H. R., & Hennen, J. A. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.1.100 · Cited by 252 · see citing works
Effects of Antenatal Depression and Antidepressant Treatment on Gestational Age at Birth and Risk of Preterm Birth
Suri, R., Altshuler, L. L., Hellemann, G., Burt, V. K., Aquino, A., & Mintz, J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06071172 · Cited by 246 · see citing works
Methadone versus buprenorphine in pregnant addicts: a double‐blind, double‐dummy comparison study
Fischer, G., Ortner, R., Rohrmeister, K., Jagsch, R., Baewert, A., Langer, M., & Aschauer, H. N. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01321.x · Cited by 235 · see citing works
Self-citation
A controlled trial of buprenorphine treatment for opioid dependence
Johnson, R. E. (1992) · JAMA · doi:10.1001/jama.267.20.2750 · Cited by 199 · see citing works
Treatment of opioid-dependent pregnant women: Clinical and research issues
Jones, H. E., Martin, P. R., Heil, S. H., Kaltenbach, K., Selby, P., Coyle, M. G., Stine, S. M., O'Grady, K. E., Arria, A. M., & Fischer, G. (2008) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2007.10.007 · Cited by 191 · see citing works
Self-citation
Buprenorphine and methadone treatment of opiate dependence during pregnancy: Comparison of fetal growth and neonatal outcomes in two consecutive case series
Kakko, J., Heilig, M. A., & Sarman, I. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.01.025 · Cited by 185 · see citing works
Borderline Personality Disorder, Mother–Infant Interaction and Parenting Perceptions: Preliminary Findings
Newman, L. K., Stevenson, C. S., Bergman, L. R., & Boyce, P. M. (2007) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670701392833 · Cited by 179 · see citing works
The Safety of Newer Antidepressants in Pregnancy and Breastfeeding
Gentile, S. (2005) · Drug Safety · doi:10.2165/00002018-200528020-00005 · Cited by 178 · see citing works
Prevalence of psychiatric and substance use disorders in opioid abusers in a community syringe exchange program
KIDORF, M. S., Disney, E. R., King, V. L., Neufeld, K. J., Beilenson, P. L., & Brooner, R. K. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2003.11.014 · Cited by 178 · see citing works
Race/ethnic differences in the prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions
Smith, S. M. R., Stinson, F. S., Dawson, D. A., Goldstein, R. B., Huang, B., & Grant, B. F. (2006) · Psychological Medicine · doi:10.1017/s0033291706007690 · Cited by 155 · see citing works
Contributions of the mother–infant relationship to dissociative, borderline, and conduct symptoms in young adulthood
Lyons‐Ruth, K. (2008) · Infant Mental Health Journal · doi:10.1002/imhj.20173 · Cited by 152 · see citing works
Reliability and Validity of the Kessler 10 and Patient Health Questionnaire among Injecting Drug Users
Hides, L. M., Lubman, D. I., Devlin, H., Cotton, S., Aitken, C. K., Gibbie, T., & Hellard, M. E. (2007) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670601109949 · Cited by 141 · see citing works
Borderline Personality Disorder and Substance Abuse: Consequences of Comorbidity
Links, P. S., Heslegrave, R. J., Mitton, M. J. E., van Reekum, R., & Patrick, J. (1995) · The Canadian Journal of Psychiatry · doi:10.1177/070674379504000105 · Cited by 106 · see citing works
Mood disorders affect drug treatment success of drug-dependent pregnant women
Fitzsimons, H., Tuten, M., Vaidya, V. M., & Jones, H. E. (2006) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2006.06.015 · Cited by 97 · see citing works
Self-citation
Psychiatric comorbidity and gender difference among treatment‐seeking heroin abusers in Taiwan
Chiang, S.-C., Chan, H., Chang, Y., Sun, H., Chen, W. J., & Chen, C. (2007) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01618.x · Cited by 63 · see citing works
Psychopharmacologic Management of Opioid‐Dependent Women during Pregnancy
Martin, P., Arria, A. M., Fischer, G., Kaltenbach, K. A., Heil, S. H., Stine, S. M., Coyle, M. G., Selby, P. L., & Jones, H. E. (2009) · American Journal on Addictions · doi:10.1080/10550490902772975 · Cited by 59 · see citing works
Self-citation
The Impact of Mood Disorders on the Delivery and Neonatal Outcomes of Methadone-Maintained Pregnant Patients
Tuten, M., Fitzsimons, H., Chisolm, M. S., Jones, H. E., Heil, S. H., & O’Grady, K. E. (2009) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990903108231 · Cited by 33 · see citing works
Self-citation
Illicit Drug Use Among Women with Children in the United States: 2002–2003
Simmons, L. A., Havens, J. R., Whiting, J. B., Holz, J. L., & Bada, H. S. (2009) · Annals of Epidemiology · doi:10.1016/j.annepidem.2008.12.007 · Cited by 31 · see citing works
Methadone Use During Pregnancy
Jarvis, M. A. E., & Schnoll, S. H. (1995) · PsycEXTRA Dataset · doi:10.1037/e495802006-006 · Cited by 21 · see citing works

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Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes
Benningfield, M. M., Dietrich, M. S., Jones, H. E., Kaltenbach, K., Heil, S. H., Stine, S. M., Coyle, M. G., Arria, A. M., O'Grady, K. E., Fischer, G., et al. (2012) · Addiction · doi:10.1111/j.1360-0443.2012.04041.x · Cited by 60 · see citing works
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Racial/ethnic differences in mental health treatment among a national sample of pregnant women with mental health and/or substance use disorders in the United States
Salameh, T. N., Hall, L. A., Crawford, T. N., Staten, R. R., & Hall, M. T. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2019.03.015 · Cited by 49 · see citing works
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Shen, Y., Lo-Ciganic, W.-H., Segal, R., & Goodin, A. J. (2021) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/0167482x.2020.1727882 · Cited by 38 · see citing works
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Authors: Benningfield, M. M., Arria, A. M., Kaltenbach, K., Heil, S. H., Stine, S. M., Coyle, M. G., Fischer, G., Jones, H. E., & Martin, P. R.
Affiliations: Vanderbilt University (US)
Treatment Research Institute (US)
Thomas Jefferson University (US)
University of Vermont (US)
Wayne State University (US)
Brown University (US)
Medical University of Vienna (AT)
Johns Hopkins University (US)
ORCID: Benningfield, Margaret M.
Arria, Amelia M.
Heil, Sarah H.
Stine, Susan M.
Coyle, Mara G.
Fischer, Gabriele
Jones, Hendrée E.
Martin, Peter R.
Venue: The American Journal on Addictions
Publisher: Wiley
Published: 2010-07-26
Volume: 19
Issue: 5
Pages: 416-421
ISSN: 1055-0496 (ISSN-L)
1521-0391
DOI: 10.1111/j.1521-0391.2010.00064.x
PMC: PMC2924760
OpenAlex: W1787431326
Cited by: 96
References: 37
Citations by year: 2026: 6 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 7 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 4 · 2012: 8
FWCI: 3.80
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: American Journal on Addictions (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA015778, R01DA 017513, R01DA015764, T32DA021123, R01DA015713, R01DA015832, R01DA015741, R01DA015738, R01DA018410, R01DA018417)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: opioid use disorder, pregnancy, psychiatric comorbidity, mood symptoms, anxiety symptoms, suicidal ideation, Addiction Severity Index, drug-related problems, neonatal outcomes
MeSH terms: Adolescent, Adult, Mental Disorders, Cross-Sectional Studies, Female, Humans, Opioid-Related Disorders, Pregnancy, Pregnancy Complications, Severity of Illness Index, Prevalence, Randomized Controlled Trials as Topic, Diagnosis, Dual (Psychiatry)

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Co‐occurring Psychiatric Symptoms Are Associated with Increased Psychological, Social, and Medical Impairment in Opioid Dependent Pregnant Women

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