A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence
Open accessAbstract
OBJECTIVE: Although bipolar disorder and substance use disorder frequently co-occur, there is little information on the effectiveness of behavioral treatment for this population. Integrated group therapy, which addresses the two disorders simultaneously, was compared with group drug counseling, which focuses on substance use. The authors hypothesized that patients receiving integrated group therapy would have fewer days of substance use and fewer weeks ill with bipolar disorder. METHOD: A randomized controlled trial compared 20 weeks of integrated group therapy or group drug counseling with 3 months of posttreatment follow-up. Sixty-two patients with bipolar disorder and current substance dependence, treated with mood stabilizers for >or=2 weeks, were randomly assigned to integrated group therapy (N=31) or group drug counseling (N=31). The primary outcome measure was the number of days of substance use. The primary mood outcome was the number of weeks ill with a mood episode. RESULTS: Intention-to-treat analysis revealed significantly fewer days of substance use for integrated group therapy patients during treatment and follow-up. Groups were similar in the number of weeks ill with bipolar disorder during treatment and follow-up, although integrated group therapy patients had more depressive and manic symptoms. CONCLUSIONS: Integrated group therapy, a new treatment developed specifically for patients with bipolar disorder and substance dependence, appears to be a promising approach to reduce substance use in this population.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Integrated care is associated with better outcomes.
“Integrated care is associated with better outcomes”
From The substance use disorder treatment gap among US college students: Findings from the 2021 National Survey on Drug Use and Health (2024) · cites this paper as Weiss et al., 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
A Rating Scale for Mania: Reliability, Validity and Sensitivity
Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.5.429 · Cited by 8,744 · see citing works
The Fifth Edition of the Addiction Severity Index.
Mclellan, A., Kushner, H., Metzger, D., Peters, R., Smith, I. E., Grissom, G. R., Pettinati, H., & Argeriou, M. (1992) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(92)90062-s · Cited by 4,279 · see citing works
Sobell, L. C., & Sobell, M. B. (1992) · Measuring Alcohol Consumption · doi:10.1007/978-1-4612-0357-5_3 · Cited by 4,110 · see citing works
Structured Clinical Interview for DSM-IV Axis I Disorders
Spitzer, R. L., First, M. B., & Gibbon, M. (1997) · Medical Entomology and Zoology · Cited by 3,582 · see citing works
Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., Pickering, R. P., & Kaplan, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.807 · Cited by 2,889 · see citing works
(1997) · Journal of Studies on Alcohol · doi:10.15288/jsa.1997.58.7 · Cited by 1,905 · cited 1× · see citing works
“Moreover, the two largest recent substance use disorder psychotherapy trials (13, 14) excluded patients with bipolar disorder.”
BackgroundKeller, M. B. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800180050009 · Cited by 1,643 · see citing works
Colom, F., Vieta, E., Martínez‐Arán, A., Reinares, M., Goikolea, J. M., Benabarre, A., Torrent, C., Comes, M., Corbella, B., Parramón, G., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.4.402 · Cited by 793 · see citing works
Implementing Dual Diagnosis Services for Clients With Severe Mental Illness
Drake, R. E., Essock, S. M., Shaner, A. L., Carey, K. B., Minkoff, K., Kola, L. A., Lynde, D., Osher, F. C., Clark, R. E., & Rickards, L. D. (2001) · Psychiatric Services · doi:10.1176/appi.ps.52.4.469 · Cited by 694 · see citing works
Miklowitz, D. J., George, E. L., Richards, J. A., Simoneau, T. L., & Suddath, R. L. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.904 · Cited by 641 · see citing works
Interpersonal and social rhythm therapy: managing the chaos of bipolar disorder
Frank, E., Swartz, H. A., & Kupfer, D. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00969-0 · Cited by 521 · cited 1× · see citing works
“Although recent bipolar disorder psychotherapy studies have generated promising results (9–12), these trials have not focused specifically on patients with co-occurring substance use disorders.”
BackgroundCrits-Christoph, P. F. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.6.493 · Cited by 497 · see citing works
Najavits, L. M., Weiss, R. D., Shaw, S. R., & Muenz, L. R. (1998) · Journal of Traumatic Stress · doi:10.1023/a:1024496427434 · Cited by 451 · see citing works
Self-citationKeller, M. B. (1986) · JAMA · doi:10.1001/jama.255.22.3138 · Cited by 318 · see citing works
Exposure therapy in the treatment of PTSD among cocaine-dependent individuals
Brady, K. T., Dansky, B. S., Back, S. E., Foa, E. B., & Carroll, K. M. (2001) · Journal of Substance Abuse Treatment · doi:10.1016/s0740-5472(01)00182-9 · Cited by 299 · see citing works
Suicide risk in bipolar patients: the role of co‐morbid substance use disorders
Dalton, E. J., Cate‐Carter, T. D., Mundo, E., Parikh, S. V., & Kennedy, J. L. (2003) · Bipolar Disorders · doi:10.1034/j.1399-5618.2003.00017.x · Cited by 275 · see citing works
Salloum, I. M., Cornelius, J. R., Daley, D. C., Kirisci, L., Himmelhoch, J. M., & Thase, M. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.1.37 · Cited by 271 · see citing works
Self-citationIntegrated Treatment for Dually Diagnosed Homeless Adults
Drake, R. E., Yovetich, N. A., Bebout, R. R., Harris, M., & McHugo, G. J. (1997) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199705000-00003 · Cited by 213 · see citing works
Randall, C. L., Thomas, S., & Thevos, A. K. (2001) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02201.x · Cited by 188 · see citing works
Compliance with maintenance treatment in bipolar disorder.
Keck, P. E., McElroy, S. L., Strakowski, S. M., Bourne, M. L., & West, S. A. (1997) · PubMed · Cited by 154 · see citing works
Substance Abuse in an Inpatient Psychiatric Sample
Brady, K. T., Casto, S., Lydiarcl, R. B., Malcolm, R. J., & Arana, G. W. (1991) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952999109001598 · Cited by 141 · see citing works
Group Therapy for Patients With Bipolar Disorder and Substance Dependence
Weiss, R. D., Griffin, M. L., Greenfield, S. F., Najavits, L. M., Wyner, D., Soto, J. A., & Hennen, J. A. (2000) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v61n0507 · Cited by 135 · see citing works
Self-citationBipolar rapid cycling: focus on depression as its hallmark.
Calabrese, J. R., Shelton, M. D., Bowden, C. L., RAPPORT, D. J., Suppes, T. M., Shirley, E. R., Kimmel, S. E., & Caban, S. (2001) · PubMed · Cited by 133 · see citing works
Validity of Substance Use Self-Reports in Dually Diagnosed Outpatients
Weiss, R. D., Najavits, L. M., Greenfield, S. F., Soto, J. A., Shaw, S. R., & Wyner, D. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.127 · Cited by 115 · see citing works
Self-citationIntegrating Services for Schizophrenia and Substance Abuse
Hellerstein, D. J., Rosenthal, R. N., & Miner, C. R. (2001) · Psychiatric Quarterly · doi:10.1023/a:1010385114289 · Cited by 96 · see citing works
Lamotrigine in Patients With Bipolar Disorder and Cocaine Dependence
Brown, E. S., Nejtek, V. A., Perantie, D. C., Orsulak, P. J., & Bobadilla, L. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0213 · Cited by 90 · see citing works
Single versus multiple drug focus in substance abuse clinical trials research.
Rounsaville, B., Petry, N., & Carroll, K. (2003) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(03)00033-4 · Cited by 81 · see citing works
Weiss, R. D., Kolodziej, M. E., Griffin, M. L., Najavits, L. M., Jacobson, L. M., & Greenfield, S. F. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00454-8 · Cited by 75 · see citing works
Self-citationThree-year outcomes of long-term patients with co-occurring bipolar and substance use disorders
Drake, R. E., Xie, H., McHugo, G. J., & Shumway, M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.020 · Cited by 66 · see citing works
Treating substance abuse in schizophrenia
Bennett, M. E., Bellack, A. S., & Gearon, J. S. (2001) · Journal of Substance Abuse Treatment · doi:10.1016/s0740-5472(00)00167-7 · Cited by 48 · see citing works
Weiss, R. D., Kolodziej, M. E., Najavits, L., Greenfield, S. F., & Fucito, L. M. (2000) · American Journal on Addictions · doi:10.1080/105504900750047364 · Cited by 17 · see citing works
Self-citationRounsaville, B. J., Weiss, R. D., & Carroll, K. M. (1999) · American Journal on Addictions · doi:10.1080/105504999305794 · Cited by 9 · see citing works
Self-citationLam, D. H., Watkins, E. R., Hayward, P., Bright, J., Wright, K., Kerr, N., Parr-Davis, G., & Sham, P. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.2.145 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Grant BF, Stinson FS, Dawson DA, Chou SP, Dufour MC, Comp- ton W, Pickering RP, Kaplan K: Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders. Arch Gen Psychiatry 2004; 61:807-816
- Brown ES, Nejtek VA, Perantie DC, Orsulak PJ, Bobadilla L: La- motrigine in patients with bipolar disorder and cocaine depen- dence. J Clin Psychiatry 2003; 64:197-201
- Keller MB, Lavori PW, Friedman B, Nielsen E, Endicott J, Mc- Donald-Scott P, Andreasen NC: The Longitudinal Interval Fol- low-up Evaluation. Arch Gen Psychiatry 1987; 44:540-548
- Drake RE, Essock SM, Shaner A, Carey KB, Minkoff K, Kola L, Lynde D, Osher FC, Clark RE, Rickards L: Implementing dual di- agnosis services for clients with severe mental illness. Psychiatr Serv 2001; 52:469-476
Cited by
Sorted by citations
Geddes, J. R., & Miklowitz, D. J. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60857-0 · Cited by 848 · see citing works
Drake, R. E., O'Neal, E. L., & Wallach, M. A. (2008) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2007.01.011 · Cited by 447 · see citing works
McHugh, R. K., Murray, H. W., & Barlow, D. H. (2009) · Behaviour Research and Therapy · doi:10.1016/j.brat.2009.07.005 · Cited by 320 · see citing works
Adjunctive Psychotherapy for Bipolar Disorder: State of the Evidence
Miklowitz, D. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08040488 · Cited by 311 · see citing works
Psychosocial interventions in bipolar disorder: What, for whom, and when
Reinares, M., Sánchez-Moreno, J., & Fountoulakis, K. N. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.12.017 · Cited by 184 · see citing works
SULLIVAN, M. A., & RUDNIK‐LEVIN, F. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05783.x · Cited by 172 · see citing works
Psychological interventions for adults with bipolar disorder: systematic review and meta-analysis
Oud, M., Mayo-Wilson, E., Braidwood, R., Schulte, P., Jones, S. H., Morriss, R., Kupka, R., Cuijpers, P., & Kendall, T. (2016) · British Journal of Psychiatry · doi:10.1192/bjp.bp.114.157123 · Cited by 144 · see citing works
Weiss, R. D., Griffin, M. L., Jaffee, W. B., Bender, R. E., Graff, F. S., Gallop, R. J., & Fitzmaurice, G. M. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.04.018 · Cited by 106 · see citing works
Psychosocial interventions for people with both severe mental illness and substance misuse
Hunt, G. E., Siegfried, N., Morley, K., Brooke-Sumner, C., & Cleary, M. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001088.pub4 · Cited by 105 · see citing works
Psychosocial treatment and interventions for bipolar disorder: a systematic review
Miziou, S., Tsitsipa, E., Moysidou, S., Karavelas, V., Dimelis, D., Polyzoidou, V., & Fountoulakis, K. N. (2015) · Annals of General Psychiatry · doi:10.1186/s12991-015-0057-z · Cited by 102 · see citing works
Benningfield, M. M., Arria, A. M., Kaltenbach, K., Heil, S. H., Stine, S. M., Coyle, M. G., Fischer, G., Jones, H. E., & Martin, P. R. (2010) · The American Journal on Addictions · doi:10.1111/j.1521-0391.2010.00064.x · Cited by 96 · see citing works
Kikkert, M., Goudriaan, A., de Waal, M., Peen, J., & Dekker, J. (2018) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2018.09.005 · Cited by 67 · see citing works
Integrating Treatment for Co-Occurring Mental Health Conditions
Yule, A. (2019) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v40.1.07 · Cited by 63 · see citing works
Psychotherapy for bipolar II disorder: The role of interpersonal and social rhythm therapy.
Swartz, H. A., Levenson, J. C., & Frank, E. (2012) · Professional Psychology: Research and Practice · doi:10.1037/a0027671 · Cited by 62 · see citing works
Thekiso, T. B., Murphy, P., Milnes, J., Lambe, K., Curtin, A., & Farren, C. K. (2015) · Behavior Therapy · doi:10.1016/j.beth.2015.05.005 · Cited by 55 · see citing works
A Randomized Controlled Trial of Cognitive Behavioral Group Therapy for Bipolar Disorder
Gomes, B. C., Abreu, L. N., Brietzke, E., Caetano, S. C., Kleinman, A., Nery, F. G., & Lafer, B. (2011) · Psychotherapy and Psychosomatics · doi:10.1159/000320738 · Cited by 52 · see citing works
Beaulieu, S., Saury, S., Sareen, J., Tremblay, J., Schütz, C. G., McIntyre, R. S., & Schaffer, A. (2012) · Annals of Clinical Psychiatry · doi:10.1177/104012371202400105 · Cited by 38 · see citing works
Psychosocial interventions for stimulant use disorder
Minozzi, S., Saulle, R., Amato, L., Traccis, F., & Agabio, R. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011866.pub3 · Cited by 32 · see citing works
Pasman, E., Blair, L., Solberg, M. A., McCabe, S. E., Schepis, T., & Resko, S. M. (2024) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2024.100279 · Cited by 24 · see citing works
Psychosocial Interventions in Patients with Dual Diagnosis
Subodh, B., Sharma, N., & Shah, R. (2018) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_18_18 · Cited by 22 · see citing works
Psychoeducation for Bipolar Mood Disorder
Fayyazi Bordbar, M. R., & Faridhosseini, F. (2012) · Clinical, Research and Treatment Approaches to Affective Disorders · doi:10.5772/31698 · Cited by 21 · see citing works
Sokol, R., Albanese, M., Chew, A., Early, J., Grossman, E., Roll, D., Sawin, G., Wu, D. J., & Schuman-Olivier, Z. (2019) · Addiction Science & Clinical Practice · doi:10.1186/s13722-019-0176-y · Cited by 14 · see citing works
- Authors
- Weiss, R. D., Griffin, M. L., Kolodziej, M. E., Greenfield, S. F., Najavits, L. M., Daley, D. C., Doreau, H. R., & Hennen, J. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Weiss, Roger D.
- Venue
- American Journal of Psychiatry
- Published
- 2007-01
- Volume
- 164
- Issue
- 1
- Pages
- 100-107
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2161512986
- Cited by
- 252
- References
- 34
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 11 · 2018: 12 · 2017: 17 · 2016: 14 · 2015: 18 · 2014: 17 · 2013: 14 · 2012: 19
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- Dr. Ralph and Marian Falk Medical Research Trust
- National Institutes of Health (5r01da009400-06)
- National Institute on Drug Abuse (DA00326, K02DA000326, DA09400, R01DA015968, DA 15968)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- bipolar disorder, substance dependence, comorbid substance use disorders, mood episodes, substance use reduction, behavior therapy, mood stabilizers
- MeSH terms
- Adult, Bipolar Disorder, Counseling, Female, Follow-Up Studies, Humans, Male, Psychotherapy, Group, Comorbidity, Cognitive Behavioral Therapy, Treatment Outcome, Diagnosis, Dual (Psychiatry), Substance-Related Disorders, Secondary Prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
