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Cited by 80Nonmelanoma Skin Cancer StudiesSkin Protection and AgingCancer and Skin Lesions

The actinic keratosis: A perspective and update

SCHWARTZ, ROBERT A.·1997·Dermatologic Surgery
DOI 10.1111/j.1524-4725.1997.tb00438.x
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Abstract

BACKGROUND: Actinic keratosis (AK) is a common sun-induced precancerous neoplasm confined to the epidermis. It is the initial manifestation of a continuum of clinical and histologic abnormalities that progresses to invasive squamous cell carcinoma (SCC), a disorder that accounts for thousands of preventable deaths in America each year. OBJECTIVE: The purpose of this work is to describe the actinic keratosis. METHODS: This effort was performed by a literature review and analysis. RESULTS: Like SCCs, the vast majority of AKs are asymptomatic. Although some actinic keratoses may become clinically inapparent, possibly either due to immune rejection or simply having their external surface unknowingly scraped off, an untreated AK represents a potentially curable fatal cancer. CONCLUSIONS: Each AK should be treated before it progresses to invasive squamous cell carcinoma. Destructive modalities such as cryosurgery using liquid nitrogen and electrodesiccation and curettage are the mainstays of therapy. Each case must be individualized. LEARNING OBJECTIVES: After studying this article, participant should be able to: 1. Understand the concept of an actinic keratosis. 2. Learn how to recognize its clinical manifestations. 3. Be aware of the danger it poses as an easily curable papulonodule that may become a fatal cancer.

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Crossref · 10.1111/j.1524-4725.1997.tb00438.x

Cites

260 of 260 references verified0 citation errors · 0 not checkable

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  • Actinic keratoses (AKs) are lesions on a spectrum of clinical and histologic abnormalities that can ultimately progress to squamous cell carcinoma (SCC).

    “Actinic keratoses (AKs) are lesions considered to be on a spectrum of clinical and histologic abnormalities that can ultimately progress to squamous cell carcinoma (SCC) [2].”

    From Photodynamic Therapy for Non-Melanoma Skin Cancers (2016) · cites this paper as [2]

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Authors
SCHWARTZ, R. A.
Affiliations
Rutgers New Jersey Medical School (US)
Corresponding author
SCHWARTZ, ROBERT A.
ORCID
SCHWARTZ, ROBERT A.
Venue
Dermatologic Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1997-11
Volume
23
Issue
11
Pages
1009-1019
ISSN
1076-0512 (ISSN-L)
DOI
10.1111/j.1524-4725.1997.tb00438.x
OpenAlex
W2073581208
Cited by
80
References
260
Citations by year
2026: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 10
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Locations
  • Dermatologic Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
Keywords
actinic keratosis, squamous cell carcinoma, precancerous skin lesions, sun damage, epidermal lesions, cryosurgery, actinic keratosis treatment, clinical features
MeSH terms
Carcinoma, Squamous Cell, Humans, Keratosis, Neoplasms, Radiation-Induced, Precancerous Conditions, Skin Neoplasms, Sunlight, Incidence, Prevalence

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