CoChat
Sign Up
Cited by 169Nonmelanoma Skin Cancer StudiesSkin Protection and AgingHead and Neck Cancer Studies

Effect of a Low-Fat Diet on the Incidence of Actinic Keratosis

Black, Homer S., Herd, J. Alan, Goldberg, Leonard H., Wolf, John E., Thornby, John I., Rosen, Theodore, Bruce, Suzanne, Tschen, Jaime A. +4 more·1994·New England Journal of Medicine
DOI 10.1056/nejm199405053301804
Open this paper in CoChat — free account

Abstract

Background Actinic keratoses are premalignant lesions and are a sensitive and important manifestation of sun-induced skin damage. Studies in animals have shown that dietary fat influences the incidence of sun-induced skin cancer, but the effect of diet on the incidence of actinic keratosis in humans is not known. Methods We randomly assigned 76 patients with nonmelanoma skin cancer either to continue their usual diet (control group) or to eat a diet with 20 percent of total caloric intake as fat (dietary-intervention group). For 24 months, the patients were examined for the presence of new actinic keratoses by physicians unaware of their assigned diets. Results At base line, the mean (+/- SD) percentage of caloric intake as fat was 40 +/- 4 percent in the control group and 39 +/- 3 percent in the dietary-intervention group. After 4 months of dietary therapy the percentage of calories as fat had decreased to 21 percent in the dietary-intervention group, and it remained below this level throughout the 24-month study period. The percentage of calories as fat in the control group did not fall below 36 percent at any time. The cumulative number of new actinic keratoses per patient from months 4 through 24 was 10 +/- 13 in the control group and 3 +/- 7 in the dietary-intervention group (P = 0.001). Conclusions In patients with a history of nonmelanoma skin cancer, a low-fat diet reduces the incidence of actinic keratosis.

Integrity signals

Registry

Crossref · 10.1056/nejm199405053301804

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Black, H. S., Herd, J. A., Goldberg, L. H., Wolf, J. E., Thornby, J. I., Rosen, T., Bruce, S., Tschen, J. A., Foreyt, J. P., Scott, L. W., Jaax, S., & Andrews, K.
Affiliations
Baylor College of Medicine (US)
ORCID
Herd, J. Alan
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1994-05-05
Volume
330
Issue
18
Pages
1272-1275
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199405053301804
OpenAlex
W2322868828
Cited by
169
References
20
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 8 · 2019: 2 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 10
FWCI
8.59
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ca044383-08)
  • National Cancer Institute (CA-44383)
Topics
  • Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Keywords
actinic keratosis, low-fat diet, dietary fat, non-melanoma skin cancer, premalignant skin lesions, dietary intervention, skin cancer prevention
MeSH terms
Basal Cell Carcinoma, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Dietary Fats, Female, Follow-Up Studies, Humans, Keratosis, Male, Middle Aged, Precancerous Conditions, Risk Factors, Skin Neoplasms, Sunlight, Incidence, Confidence Intervals, Logistic Models, Odds Ratio

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review