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Cited by 147Skin Protection and AgingTea Polyphenols and EffectsPhytochemicals and Antioxidant Activities

Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin

Chiu, Annie E., Chan, Joanna L., Kern, Dale G., Kohler, Sabine, Rehmus, Wingfield E., Kimball, Alexa B.·2005·Dermatologic Surgery
DOI 10.1111/j.1524-4725.2005.31731
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Abstract

BACKGROUND: Green tea extracts have gained popularity as ingredients in topical skin care preparations to treat aging skin. Green tea polyphenolic compounds have significant antioxidant and anti-inflammatory activities, and studies suggest that these extracts help mediate ultraviolet radiation damage. OBJECTIVE: To evaluate the effects of a combination regimen of topical and oral green tea supplementation on the clinical and histologic characteristics of photoaging. METHODS: Forty women with moderate photoaging were randomized to either a combination regimen of 10% green tea cream and 300 mg twice-daily green tea oral supplementation or a placebo regimen for 8 weeks. RESULTS: No significant differences in clinical grading were found between the green tea-treated and placebo groups, other than higher subjective scores of irritation in the green tea-treated group. Histologic grading of skin biopsies did show significant improvement in the elastic tissue content of treated specimens (p<.05). CONCLUSION: Participants treated with a combination regimen of topical and oral green tea showed histologic improvement in elastic tissue content. Green tea polyphenols have been postulated to protect human skin from the cutaneous signs of photoaging, but clinically significant changes could not be detected. Longer supplementation may be required for clinically observable improvements.

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Crossref · 10.1111/j.1524-4725.2005.31731

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  • In a double-blind placebo trial in 40 women, a 10-percent green tea cream applied together with 300 mg twice-daily green tea oral supplementation showed significant improvements in elastic tissue content, but no significant clinical changes.

    “Histological examination showed significant improvements in elastic tissue content, but no significant changes were demonstrated clinically.”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [214]

  • Green tea polyphenols exhibit anti-inflammatory and antioxidant properties and the ability to scavenge free radicals.

    “GTPs also exhibit anti-inflammatory and antioxidant properties and the ability to scavenge free radicals [214].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [214]

  • A clinically perceptible improvement might require a longer period of green tea polyphenol administration.

    “The authors concluded that a clinically perceptible improvement might require a longer period of GTP administration.”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [214]

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Authors
Chiu, A. E., Chan, J. L., Kern, D. G., Kohler, S., Rehmus, W. E., & Kimball, A. B.
Affiliations
  • Emory University (US)
  • Stanford University (US)
  • Nu Skin (United States) (US)
  • Harvard University (US)
ORCID
Venue
Dermatologic Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-07
Volume
31
Issue
s1
Pages
855-860
ISSN
1076-0512 (ISSN-L)
DOI
10.1111/j.1524-4725.2005.31731
OpenAlex
W1981710223
Cited by
147
References
24
Citations by year
2026: 4 · 2025: 7 · 2024: 13 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 7
FWCI
7.22
Type
journal article
Language
en
Open access
closed
Locations
  • Dermatologic Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
green tea extract, photoaging, green tea polyphenols, oral supplementation, elastic tissue, skin histology, UV damage, topical irritation, skin aging
MeSH terms
Administration, Oral, Administration, Topical, Dermatologic Agents, Double-Blind Method, Emollients, Female, Humans, Phototherapy, Pilot Projects, Plant Extracts, Skin Aging, Treatment Outcome, Dietary Supplements, Camellia sinensis

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