Mechanisms and treatments of photoaging
Open accessAbstract
Photoaging is frequently encountered in a dermatologic practice. This systematic literature review aims to explore the etiology of photoaging and address the evidence behind its current management. A comprehensive search of MEDLINE, EMBASE, UpToDate, and the Cochrane Library was conducted. Articles were limited to those relating to photoaging. There are two major approaches in the current management of photoaging. This includes strategies to prevent against ultraviolet damage (e.g. sunscreen) and medications that attempt to reverse existing skin damage (topical retinoids and 5-fluorouracil). There has been a large growth in the variety of treatment options in recent years. While it is important for such growth to continue, prevention via sensible photoprotection methods still remains the best current management option.
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UV activates or inhibits various signal pathways in the dermis and epidermis, leading to a decrease in extracellular matrix content and causing uneven structure or skin collapse.
“UV activates or inhibits various signal pathways in the dermis and epidermis, leading to a decrease in the content of the extracellular matrix (ECM) and causing uneven structure or even skin collapse [6].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [6]
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- Authors
- Poon, F., Kang, S., & Chien, A. L.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Johns Hopkins University (US)
- Corresponding author
- Poon, Flora
- Venue
- Photodermatology, Photoimmunology & Photomedicine
- Publisher
- Wiley
- Published
- 2014-11-25
- Volume
- 31
- Issue
- 2
- Pages
- 65-74
- ISSN
- 0905-4383 (ISSN-L)
- 1600-0781
- OpenAlex
- W1593918796
- Cited by
- 284
- References
- 83
- Citations by year
- 2026: 15 · 2025: 37 · 2024: 41 · 2023: 45 · 2022: 37 · 2021: 29 · 2020: 21 · 2019: 22 · 2018: 11 · 2017: 9 · 2016: 12 · 2015: 3
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Photodermatology Photoimmunology & Photomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- photoaging, UV damage, photoprotection, sunscreen, topical retinoids, 5-fluorouracil
- MeSH terms
- Administration, Topical, Animals, Fluorouracil, Humans, Immunosuppressive Agents, Retinoids, Ultraviolet Rays, Skin Aging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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