Cited by 284Skin Protection and AgingDermatologic Treatments and Researchmelanin and skin pigmentation

Mechanisms and treatments of photoaging

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Poon, Flora, Kang, Sewon, Chien, Anna L.·2015·Photodermatology, Photoimmunology & Photomedicine

Abstract

Photoaging is frequently encountered in a dermatologic practice. This systematic literature review aims to explore the etiology of photoaging and address the evidence behind its current management. A comprehensive search of MEDLINE, EMBASE, UpToDate, and the Cochrane Library was conducted. Articles were limited to those relating to photoaging. There are two major approaches in the current management of photoaging. This includes strategies to prevent against ultraviolet damage (e.g. sunscreen) and medications that attempt to reverse existing skin damage (topical retinoids and 5-fluorouracil). There has been a large growth in the variety of treatment options in recent years. While it is important for such growth to continue, prevention via sensible photoprotection methods still remains the best current management option.

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Crossref · 10.1111/phpp.12145

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  • UV activates or inhibits various signal pathways in the dermis and epidermis, leading to a decrease in extracellular matrix content and causing uneven structure or skin collapse.

    “UV activates or inhibits various signal pathways in the dermis and epidermis, leading to a decrease in the content of the extracellular matrix (ECM) and causing uneven structure or even skin collapse [6].”

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Research works printed but not linked: 6

  1. Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998; 67: 753-791.
  2. Berneburg M, Plettenberg H, Krutmann J. Photoageing of human skin. Photoder- matol Photoimmunol Photomed 2000; 16: 239-244.
  3. Cordero A Jr. La vitamina a acida en la piel senile. Act Ter Derm 1983; 6: 49-54.
  4. Nusgens BV, Humbert P, Rougier A et al. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis. J Invest Dermatol 2001; 116: 853- 859.
  5. Hoppe U, Bergemann J, Diembeck W. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors 1999; 9: 371-378.
  6. Ghosh DK, Murthy UV. Antiageing ben- efits of a topical formulation containing coenzyme Q10: results of two clinical studies. Cosmet Dermatol 2002; 28: 231-6.

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Authors
Poon, F., Kang, S., & Chien, A. L.
Affiliations
  • The Royal Melbourne Hospital (AU)
  • Johns Hopkins University (US)
Corresponding author
Poon, Flora
Venue
Photodermatology, Photoimmunology & Photomedicine
Publisher
Wiley
Published
2014-11-25
Volume
31
Issue
2
Pages
65-74
ISSN
  • 0905-4383 (ISSN-L)
  • 1600-0781
OpenAlex
W1593918796
Cited by
284
References
83
Citations by year
2026: 15 · 2025: 37 · 2024: 41 · 2023: 45 · 2022: 37 · 2021: 29 · 2020: 21 · 2019: 22 · 2018: 11 · 2017: 9 · 2016: 12 · 2015: 3
FWCI
1.33
Type
journal article
Language
en
Open access
Locations
  • Photodermatology Photoimmunology & Photomedicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
photoaging, UV damage, photoprotection, sunscreen, topical retinoids, 5-fluorouracil
MeSH terms
Administration, Topical, Animals, Fluorouracil, Humans, Immunosuppressive Agents, Retinoids, Ultraviolet Rays, Skin Aging

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