Reduction in the incidence of squamous cell carcinoma in solid organ transplant recipients treated with cyclic photodynamic therapy
Abstract
BACKGROUND AND OBJECTIVES: Squamous cell carcinomas (SCCs) produce significant morbidity in solid organ transplant recipients (SOTRs), particularly in patients who develop multiple tumors. Topical photodynamic therapy (PDT) has been shown to decrease the number of keratotic lesions in SOTRs, but the duration of the beneficial effect is limited. The aim of this study was to evaluate the potential benefit of cyclic PDT in the prevention of new SCCs in SOTRs. METHODS: Twelve high-risk SOTRs received cyclic PDT treatments at 4- to 8-week intervals for 2 years. The development of new SCCs (invasive and in situ) performed 12 and 24 months after the start of cyclic PDT were compared with the number of SCCs developed during the year before initiation of cyclic PDT. RESULTS: The median reduction in the 12- and 24-month post-treatment counts from the 1-month pretreatment counts was 79.0% (73.3-81.8%) and 95.0% (87.5-100.0%), respectively. Treatments were well tolerated. CONCLUSION: Cyclic PDT with 5-aminolevulinic acid may reduce the incidence of SCC in SOTRs. Additional studies with larger numbers of patients and optimized protocols are necessary to further explore the potential benefits of cyclic PDT in the prevention of skin cancer in this high-risk patient population.
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Willey et al. carried out cyclic ALA/PDT on twelve solid organ transplant recipients and found a 95% mean reduction in SCC lesion count at 24 months post-treatment, compared to 1 month pre-treatment.
“There was a 95% mean reduction in SCC lesion count at 24 months post-treatment, compared to 1 month pre-treatment [60].”
From Photodynamic Therapy for Non-Melanoma Skin Cancers (2016) · cites this paper as [60]
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Photodynamic Therapy for Non-Melanoma Skin Cancers
Cohen, D., & Lee, P. (2016) · Cancers · doi:10.3390/cancers8100090 · Cited by 128 · see citing works
Self-citationPhotodynamic Therapy and Non-Melanoma Skin Cancer
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Subhadarshani, S., Athar, M., & Elmets, C. A. (2020) · Current Dermatology Reports · doi:10.1007/s13671-020-00307-0 · Cited by 21 · see citing works
- Authors
- Willey, A., Mehta, S., & Lee, P. K.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Willey, Andrea
- Mehta, Sheetal
- Lee, Peter K.
- ORCID
- Lee, Peter K.
- Venue
- Dermatologic Surgery
- Published
- 2010-05
- Volume
- 36
- Issue
- 5
- Pages
- 652-658
- ISSN
- 1076-0512 (ISSN-L)
- OpenAlex
- W1979397247
- Cited by
- 124
- References
- 24
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 3 · 2016: 13 · 2015: 14 · 2014: 13 · 2013: 8 · 2012: 9
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dermatologic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- squamous cell carcinoma, solid organ transplant recipients, 5-aminolevulinic acid, skin cancer prevention, multiple primary neoplasms, keratotic lesions, Bowen's disease
- MeSH terms
- Adult, Aged, Aminolevulinic Acid, Carcinoma, Squamous Cell, Female, Follow-Up Studies, Humans, Male, Middle Aged, Minnesota, Photochemotherapy, Pilot Projects, Primary Prevention, Prospective Studies, Skin Neoplasms, Incidence, Organ Transplantation, Treatment Outcome, Photosensitizing Agents, Risk Assessment
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