Retracted: Effects of Whey Peptides on Cardiovascular Disease Risk Factors
Open accessAbstract
Previous studies have shown that peptides derived from milk proteins can improve blood pressure. Therefore, the authors tested the blood pressure-lowering effects of a hydrolyzed whey protein supplement rich in bioactive peptides. In a 6-week controlled study, 30 prehypertensive or stage 1 hypertensive subjects (blood pressure >or=120/80 mm Hg and <or=155/95 mm Hg) were randomized to receive 20 g/d of either a hydrolyzed whey protein (active treatment) or an unmodified whey protein (control treatment). Blood pressure, blood lipids, safety measures, side effects, and diet were evaluated throughout the trial. After completion of treatment, a 4-week follow-up was conducted. There was a mean reduction of 8.0+/-3.2 mm Hg in systolic blood pressure (P<.05) and of 5.5+/-2.1 mm Hg in diastolic blood pressure (P<.05) in the treatment group compared with the control group. Low-density lipoprotein cholesterol and high-sensitivity C-reactive protein were significantly improved by treatment. Whey-derived peptides might be a viable treatment option for prehypertensive and/or stage 1 hypertensive populations.
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In healthy adults, supplementation with EPA and DHA at 2.0 or 6.6 g/d for 12 weeks did not affect CRP.
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- Authors
- Pins, J. J., & Keenan, J. M.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Pins, Joel J.
- Venue
- The Journal of Clinical Hypertension
- Publisher
- Wiley
- Published
- 2006-11
- Volume
- 8
- Issue
- 11
- Pages
- 775-782
- ISSN
- 1524-6175 (ISSN-L)
- 1751-7176
- PMC
- PMC8109393
- OpenAlex
- W1986733864
- Cited by
- 71
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2020: 1 · 2019: 7 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 8 · 2012: 9
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2008-08-01)
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Hypertension (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Minnesota
- Olympus
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- whey peptides, whey protein hydrolysate, bioactive peptides, blood pressure reduction, hypertension, prehypertension, cardiovascular risk factors, LDL cholesterol, C-reactive protein, serum lipids
- MeSH terms
- Whey Proteins, Blood Pressure, Cardiovascular Diseases, Double-Blind Method, Female, Follow-Up Studies, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Milk Proteins, Pilot Projects, Surveys and Questionnaires, Triglycerides, Treatment Outcome
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