The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
MRI‐Based Hippocampal Volume Measurements in Epilepsy
Abstract
Summary: In the study of brain morphometry, it is accepted that a relationship exists between brain structure and function, both normal and abnormal. One descriptor of morphometric structure is volume. Abnormalities in hippocampal morphology, including unilateral or bilateral volume loss, are known to occur in epilepsy, Alzheimer's disease, and in certain amnestic syndromes. Precise quantitation should improve understanding of the role of any biologic system in normal function and in disease. The objectives of magnetic resonance (MR)‐based hippocampal volume measurements are precise quantitation, identification of a normal range, and identification of the association between biologic variables and aberrations in this volumetric parameter. Volumetric measures introduce a level of precision in the estimation of hippocampal size that is not available simply by visually inspecting a set of MR images, thus enabling statistically based hypothesis testing. To produce accurate hippocampal volume measurements with magnetic resonance imaging (MRI), attention must be directed to the two major components of the operation as a whole, MR image acquisition and image processing.
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“Of the three MTL structures measured, the anatomic boundaries presented by MRI are more precise, and less normal anatomic variability exits, for the hippocampus than for the amygdala or PHG ([29](#R29)).”
From Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease (1997) · cites this paper as [29]
In the citing paper
“One caveat however is that the absolute numeric output of any image based volume measurement technique is methodology-dependent([29](#R29)).”
From Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease (1997) · cites this paper as [29]
Citations
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Self-citationAnatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging
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Self-citationMRI of Amygdala and Hippocampus in Temporal Lobe Epilepsy
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Temporal Lobe Volume Measurement from MR Images
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Self-citation
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Sorted by citations
Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y. C., Waring, S. C., O'Brien, P. C., Tangalos, E. G., Smith, G. E., Ivnik, R. J., & Kokmen, E. (1997) · Neurology · doi:10.1212/wnl.49.3.786 · Cited by 1,128
Self-citationRates of hippocampal atrophy correlate with change in clinical status in aging and AD
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Self-citationComparison of different MRI brain atrophy rate measures with clinical disease progression in AD
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Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease
Jack, C. R., Petersen, R. C., Xu, Y., O'Brien, P. C., Smith, G. E., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1998) · Neurology · doi:10.1212/wnl.51.4.993 · Cited by 666
Self-citation
Metadata
- Authors
- Jack, C. R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Jack, Clifford R.
- ORCID
- Jack, Clifford R.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 1994-12
- Volume
- 35
- Issue
- s6
- Pages
- S21-9
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W2104517703
- Cited by
- 224
- References
- 31
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 8 · 2013: 5 · 2012: 6
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS28374)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Keywords
- hippocampal volume, epilepsy, hippocampal atrophy, brain morphometry, volumetric MRI, reference values, image acquisition, image processing, hippocampal morphology
- MeSH terms
- Atrophy, Epilepsy, Epilepsy, Temporal Lobe, Hippocampus, Humans, Image Interpretation, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Reference Values, Temporal Lobe, Reproducibility of Results
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