Chronic ethanol disrupts circadian photic entrainment and daily locomotor activity in the mouse
Open accessAbstract
BACKGROUND: Chronic ethanol abuse is associated with disrupted circadian rhythms and sleep. Ethanol administration impairs circadian clock phase-resetting, suggesting a mode for the disruptive effect of alcohol abuse on circadian timing. Here, we extend previous studies to explore the effects of chronic forced ethanol on photic phase-resetting, photic entrainment, and daily locomotor activity patterns in C57BL/6J mice. METHODS: First, microdialysis was used to characterize the circadian patterns of ethanol uptake in the suprachiasmatic (SCN) circadian clock and correlate this with systemic ethanol levels and episodic drinking of 10 or 15% ethanol. Second, the effects of chronic forced ethanol drinking and withdrawal on photic phase-delays of the circadian activity rhythm were assessed. Third, the effects of chronic ethanol drinking on entrainment to a weak photic zeitgeber (1 minute of 25 lux intensity light per day) were assessed. This method was used to minimize any masking actions of light that could mask ethanol effects on clock entrainment. RESULTS: Peak ethanol levels in the SCN and periphery occurred during the dark phase and coincided with the time when light normally induces phase-delays in mice. These delays were dose-dependently inhibited by chronic ethanol and its withdrawal. Chronic ethanol did not impede re-entrainment to a shifted light cycle but affected entrainment under the weak photic zeitgeber and disrupted the daily pattern of locomotor activity. CONCLUSIONS: These results confirm that chronic ethanol consumption and withdrawal markedly impair circadian clock photic phase-resetting. Ethanol also disturbs the temporal structure of nighttime locomotor activity and photic entrainment. Collectively, these results suggest a direct action of ethanol on the SCN clock.
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Animal studies provide strong evidence that both acute and chronic alcohol use disrupts circadian timing through direct effects on the central clock.
“These limited data are generally cohesive with animal studies, which have provided strong evidence that both acute and chronic alcohol use disrupts circadian timing through direct effects on the central clock (Brager, Ruby, Prosser, & Glass, 2010; Ruby, Brager, DePaul, Prosser, & Glass, 2009).”
From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Brager et al., 2010
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- Authors
- Brager, A. J., Ruby, C. L., Prosser, R. A., & Glass, J. D.
- Affiliations
- Kent State University (US)
- Corresponding author
- Glass, J. David
- Venue
- Alcoholism Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2010-06-23
- Volume
- 34
- Issue
- 7
- Pages
- 1266-1273
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- PMC
- PMC3201813
- OpenAlex
- W2104178312
- Cited by
- 70
- References
- 37
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 9 · 2014: 10 · 2013: 6 · 2012: 5
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (AA-015948, R21AA015948, R01AA017898)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- chronic ethanol exposure, alcohol withdrawal, circadian rhythm, light entrainment, suprachiasmatic nucleus, circadian clock, locomotor activity, alcohol abuse
- MeSH terms
- Alcohol Drinking, Ethanol, Animals, Circadian Rhythm, Male, Mice, Inbred C57BL, Motor Activity, Photic Stimulation, Suprachiasmatic Nucleus, Photoperiod, Mice
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