Cited by 82Alcohol Consumption and Health EffectsImmune Response and InflammationLiver physiology and pathology

The unfolding web of innate immune dysregulation in alcoholic liver injury

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Szabo, G., Mandrekar, P., Petrasek, J., Catalano, D.·2011·Alcoholism: Clinical and Experimental Research

Abstract

Inflammatory cell and cytokine cascade activation is present in humans with alcoholic liver disease as well as in animal models of alcohol-induced liver damage. Gut-derived lipopolysaccharide (LPS), a ligand of the Toll-like receptor 4 (TLR4), plays a central role in triggering and maintaining activation of Kupffer cells in alcoholic hepatitis. In this mini-review, we describe molecular mechanisms that lead to increased inflammatory cell activation by alcohol and LPS and discuss the mechanism for activation in alcohol-exposed macrophages. In alcohol-induced liver disease we discuss the role of MyD88-independent but IRF3-mediated TLR4 signaling in alcohol-related liver inflammation and liver damage.

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Crossref · 10.1111/j.1530-0277.2010.01398.x

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  • Alcoholic liver disease involves inflammation, in part through an alcohol-induced increase in gut permeability to endotoxins such as lipopolysaccharide that activate innate immune cells in the liver.

    “Alcoholic liver disease involves inflammation, in part through an alcohol-induced increase in the permeability of the gut to endotoxins, such as lipopolysaccharide, that activate innate immune cells in the liver (Szabo et al., 2011).”

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Authors
Szabo, G., Mandrekar, P., Petrasek, J., & Catalano, D.
Affiliations
University of Massachusetts Chan Medical School (US)
Venue
Alcoholism: Clinical and Experimental Research
Publisher
Wiley
Published
2011-02-01
Volume
35
Issue
5
Pages
782-786
ISSN
0145-6008 (ISSN-L)
OpenAlex
W1563860173
Cited by
82
References
39
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 6 · 2013: 14 · 2012: 7
FWCI
1.09
Type
journal article
Language
en
Open access
Locations
  • Alcoholism Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (R01AA017729, R21AA017545, AA017729, #AA011576, R01AA011576, R01AA017986)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
alcoholic liver disease, alcoholic hepatitis, innate immunity, lipopolysaccharide, TLR4, Kupffer cells, macrophages, MyD88-independent signaling, IRF3 signaling, cytokine cascade, gut-liver axis, liver inflammation
MeSH terms
Alcoholism, Animals, Humans, Immunity, Innate, Liver, Liver Diseases, Alcoholic, Gastrointestinal Tract, Toll-Like Receptor 4

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