Cited by 387Alcohol Consumption and Health EffectsImmune Response and InflammationImmunotoxicology and immune responses

A Recent Perspective on Alcohol, Immunity, and Host Defense

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Szabo, Gyongyi, Mandrekar, Pranoti·2009·Alcoholism: Clinical and Experimental Research

Abstract

Background: Multiple line of clinical and experimental evidence demonstrates that both acute, moderate, and chronic, excessive alcohol use result in various abnormalities in the functions of the immune system. Methods: Medline and Pubmed databases were used to identify published reports with particular interest in the period of 2000–2008 in the subject of alcohol use, infection, inflammation, innate, and adaptive immunity. Results: This review article summarizes recent findings relevant to acute or chronic alcohol use‐induced immunomodulation and its consequences on host defense against microbial pathogens and tissue injury. Studies with in vivo and in vitro alcohol administration are both discussed. The effects of alcohol on lung infections, trauma and burn injury, liver, pancreas, and cardiovascular diseases are evaluated with respect to the role of immune cells. Specific changes in innate immune response and abnormalities in adaptive immunity caused by alcohol intake are detailed. Conclusion: Altered inflammatory cell and adaptive immune responses after alcohol consumption result in increased incidence and poor outcome of infections and other organ‐specific immune‐mediated effects.

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Crossref · 10.1111/j.1530-0277.2008.00842.x

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  1. Szabo G Marshal C 2008 Hepatitis C and Alcohol Up-TO-Date in press

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Authors
Szabo, G., & Mandrekar, P.
Affiliations
University of Massachusetts Chan Medical School (US)
Venue
Alcoholism: Clinical and Experimental Research
Publisher
Wiley
Published
2009-01-22
Volume
33
Issue
2
Pages
220-232
ISSN
  • 0145-6008 (ISSN-L)
  • 1530-0277
OpenAlex
W2132641230
Cited by
387
References
170
Citations by year
2026: 8 · 2025: 18 · 2024: 11 · 2023: 13 · 2022: 18 · 2021: 19 · 2020: 21 · 2019: 13 · 2018: 20 · 2017: 23 · 2016: 19 · 2015: 43 · 2014: 23 · 2013: 23 · 2012: 37
FWCI
3.05
Type
journal article
Language
en
Open access
Locations
  • Alcoholism Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders
National Institute on Alcohol Abuse and Alcoholism (R01AA017729, R21AA017545, R01AA017986)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
alcohol, immunomodulation, host defense, innate immunity, adaptive immunity, inflammation, infection susceptibility, pulmonary infection, burns, trauma (physical injury), liver disease, pancreas, cardiovascular disease, tissue damage, immune-mediated diseases
MeSH terms
Alcohol Drinking, Ethanol, Animals, Central Nervous System Depressants, Humans, Immune System, Infections, Inflammation

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