Cited by 47Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

Substance use disorders: Psychoneuroimmunological mechanisms and new targets for therapy

Open access
Loftis, Jennifer M., Huckans, Marilyn·2013·Pharmacology & Therapeutics

Abstract

An estimated 76.4 million people worldwide meet criteria for alcohol use disorders, and 15.3 million meet criteria for drug use disorders. Given the high rates of addiction and the associated health, economic, and social costs, it is essential to develop a thorough understanding of the impact of substance abuse on mental and physical health outcomes and to identify new treatment approaches for substance use disorders (SUDs). Psychoneuroimmunology is a rapidly expanding, multidisciplinary area of research that may be of particular importance to addiction medicine, as its focus is on the dynamic and complex interactions among behavioral factors, the central nervous system, and the endocrine and immune systems (Ader, 2001). This review, therefore, focuses on: 1) the psychoneuroimmunologic effects of SUDs by substance type and use pattern, and 2) the current and future treatment strategies, including barriers that can impede successful recovery outcomes. Evidence-based psychosocial and pharmacotherapeutic treatments are reviewed. Psychological factors and central nervous system correlates that impact treatment adherence and response are discussed. Several novel therapeutic approaches that are currently under investigation are introduced; translational data from animal and human studies is presented, highlighting immunotherapy as a promising new direction for addiction medicine.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.pharmthera.2013.04.011

Cites

163 of 163 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • During substance abuse, microglia-mediated neuroinflammation can exert direct neural toxicity and potentially exacerbate addiction via modulation of synapse plasticity.

    “Particularly, during substance abuse, microglia-mediated neuroinflammation can exert direct neural toxicity and potentially exacerbate addiction via modulation of synapse plasticity.13, 14”

    From Tubular human brain organoids to model microglia-mediated neuroinflammation (2021) · cites this paper as [14]

    Section 2.2 (Stimulants; page unavailable) links activated microglia during stimulant exposure to neuroinflammation, neurodegeneration and neuronal damage. Section 2.3 (Opiates; page unavailable) links microglial signaling to morphine-induced reward. Neither passage identifies modulation of synaptic plasticity as the mechanism by which inflammation might exacerbate addiction. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 164 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Johnson BA Rosenthal N Capece JA Wiegand F Mao L Beyers K 2007b Topiramate for treating alcohol dependence: a randomized controlled trial JAMA 298 1641 1651 17925516

Cited by

Sorted by citations

Authors
Loftis, J. M., & Huckans, M.
Affiliations
Oregon Health & Science University (US)
Corresponding author
Loftis, Jennifer M.
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2013-08
Volume
139
Issue
2
Pages
289-300
ISSN
0163-7258 (ISSN-L)
OpenAlex
W1980954468
Cited by
47
References
164
Citations by year
2026: 3 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 6
FWCI
0.36
Type
journal article
Language
en
Open access
Locations
  • Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (DA018165, P50DA018165)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
substance use disorders, psychoneuroimmunology, alcoholism, drug use disorders, addiction treatment, pharmacotherapy, psychosocial interventions, medication adherence, immunotherapy, immune system, central nervous system, endocrine system, novel therapeutic targets
MeSH terms
Animals, Humans, Immunotherapy, Substance-Related Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review