Involvement of Arginine Vasopressin and V1b Receptor in Alcohol Drinking in Sardinian Alcohol-Preferring Rats: VASOPRESSIN AND V1b IN ALCOHOL DRINKING
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BACKGROUND: Recent animal studies have shown that the level of stress-responsive arginine vasopressin (AVP) gene expression in the amygdala is increased during early withdrawal from long-term heroin or cocaine administration. The selective AVP V1b receptor antagonist SSR149415 (capable of exerting antidepressant-like and anxiolytic effects in animal models) also blocked stress-induced reinstatement of drug-seeking behavior. This study was undertaken to investigate the effects of alcohol and to determine whether (i) there are genetically determined differences in basal AVP mRNA levels in the medial/central amygdala (Me/CeA) and medial hypothalamus (MH) between selectively bred Sardinian alcohol-preferring (sP) and alcohol-nonpreferring (sNP) rats; (ii) the AVP mRNA levels are altered by long-term alcohol drinking in sP rats; and (iii) the V1b receptor antagonist SSR149415 alters alcohol drinking in sP rats. METHODS: In Experiment 1, AVP mRNA levels were measured in the Me/CeA and MH of alcohol-naïve sP and sNP rats, and sP rats exposed to the standard, homecage 2-bottle "alcohol versus water" choice regimen 24 h/d for 17 days. In Experiment 2, SSR149415 (0, 3, 10, or 30 mg/kg; intraperitoneal) was acutely administered 30 minutes before lights off to alcohol-experienced sP rats. Alcohol, water, and food intake were monitored 6 and 24 hours later. RESULTS: We found higher basal AVP mRNA levels in both Me/CeA and MH of alcohol-naïve sP than sNP rats; alcohol consumption decreased AVP mRNA levels in both brain regions of sP rats, suggesting genetically determined differences between the 2 rat lines and in the effects of alcohol drinking in sP rats. Acute treatment with SSR149415 significantly reduced alcohol intake of sP rats. CONCLUSION: The stress-responsive AVP/V1b receptor system is 1 component of the neural circuitry underlying high alcohol drinking in sP rats.
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- Authors
- Zhou, Y., Colombo, G., Carai, M. A. M., Ho, A., Gessa, G. L., & Kreek, M. J.
- Affiliations
- National Research Council (IT)
- Corresponding author
- Zhou, Yan
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2011-05-16
- Volume
- 35
- Issue
- 10
- Pages
- 1876-1883
- ISSN
- 0145-6008 (ISSN-L)
- PMC
- PMC3182300
- OpenAlex
- W1522686917
- Cited by
- 57
- References
- 40
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (DA P60 05130, P60DA005130)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, alcohol consumption, Sardinian alcohol-preferring rats, alcohol-nonpreferring rats, amygdala, medial hypothalamus, genetic predisposition to alcoholism, alcohol consumption reduction
- MeSH terms
- Alcohol Drinking, Ethanol, Amygdala, Animals, Antidepressive Agents, Arginine Vasopressin, Central Nervous System Depressants, Disease Models, Animal, Hypothalamus, Indoles, Italy, Male, Pyrrolidines, Rats, Inbred Strains, RNA, Messenger, Time Factors, Anti-Anxiety Agents, Receptors, Vasopressin, Rats, Antidiuretic Hormone Receptor Antagonists
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