The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic Toll-like receptor expression in a mouse model of alcoholic liver disease
Open accessAbstract
BACKGROUND: Interactions between the gut, immune system, and the liver, as well as the type of fat in the diet, are critical components of alcoholic liver disease (ALD). The goal of the present study was to determine the effects of saturated fat (SF) and unsaturated fat (USF) on ethanol (EtOH)-induced gut-liver interactions in a mouse model of ALD. METHODS: C57BL/6N mice were fed Lieber-DeCarli liquid diets containing EtOH and enriched in USF (corn oil) or SF (medium chain triglycerides:beef tallow). Control mice were pair-fed on an isocaloric basis. Liver injury and steatosis, blood endotoxin levels, intestinal permeability, and tight junction (TJ) integrity, as well as hepatic Toll-like receptor (TLR) gene expression, were evaluated. RESULTS: After 8 weeks of EtOH feeding, liver injury and steatosis were observed in USF + EtOH group compared with control and SF + EtOH. Significantly increased intestinal permeability in conjunction with elevated blood endotoxin levels were observed in the ileal segments of the mice fed USF + EtOH. USF diet alone resulted in down-regulation of intestinal TJ protein mRNA expression compared with SF. Importantly, alcohol further suppressed TJ proteins in USF + EtOH, but did not affect intestinal TJ in SF + EtOH group. The type of fat in the diet alone did not affect hepatic TLR expression. Compared with control animals, hepatic TLR (TLR 1, 2, 3, 4, 7, 8, 9) mRNA expression was significantly (p < 0.05) increased in USF + EtOH, but not in SF + EtOH group. Notably, TLR5 was the only up-regulated TLR in both SF + EtOH and USF + EtOH groups. CONCLUSIONS: Dietary fat is an important cofactor in alcohol-associated liver injury. We demonstrate that USF (corn oil/linoleic acid) by itself results in dysregulation of intestinal TJ integrity leading to increased gut permeability, and alcohol further exacerbates these alterations. We postulate that elevated blood endotoxin levels in response to USF and alcohol in conjunction with up-regulation of hepatic TLRs combine to cause hepatic injury in ALD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“binge alcohol exposure [232], [233], [234], [235], [236], [237], [238], [239] and nonalcoholic substances including fructose [240], [241], [242] are known to promote gut leakiness, contributing to more severe inflammatory liver disease.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Zarember, K. A., & Godowski, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.554 · Cited by 1,251
Ma, T., Iwamoto, G. K., Hoa, N., Akotia, V., Pedram, A., Boivin, M., & Said, H. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00173.2003 · Cited by 811
Chylomicrons promote intestinal absorption of lipopolysaccharides
Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662
Parlesak, A., Schäfer, C., Schütz, T., Bode, J. C., & Bode, C. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80242-1 · Cited by 647
Signalling pathways in alcohol-induced liver inflammation
Mandrekar, P., & Szabó, G. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.007 · Cited by 500
Fukui, H., Brauner, B., Bode, J. C., & Bode, C. (1991) · Journal of Hepatology · doi:10.1016/0168-8278(91)90933-3 · Cited by 461
Hritz, I., Mandrekar, P., Velayudham, A., Catalano, D., Dolganiuc, A., Kodys, K., Kurt‐Jones, E., & Szabo, G. (2008) · Hepatology · doi:10.1002/hep.22470 · Cited by 415
Ye, D., Ma, I., & Ma, T. (2006) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00318.2005 · Cited by 395
Rao, R. K., Seth, A., & Sheth, P. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00006.2004 · Cited by 340
Research works printed but not linked: 1
- Rozen S, 2000, Bioinformatics Methods and Protocols: Methods in Molecular Biology, 365
Cited by
Sorted by citations
Mouse model of chronic and binge ethanol feeding (the NIAAA model)
Bertola, A., Mathews, S., Ki, S. H., Wang, H., & Gao, B. (2013) · Nature Protocols · doi:10.1038/nprot.2013.032 · Cited by 1,239
High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review
Malesza, I. J., Malesza, M., Walkowiak, J., Mussin, N. M., Walkowiak, D., Aringazina, R. A., Bartkowiak-Wieczorek, J., & Mądry, E. (2021) · Cells · doi:10.3390/cells10113164 · Cited by 847
Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review
Rohr, M., Narasimhulu, C. A., Rudeski-Rohr, T., & Parthasarathy, S. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz061 · Cited by 794
Alcohol and Gut-Derived Inflammation
Bishehsari, F. (2017) · Alcohol research · doi:10.35946/arcr.v38.2.02 · Cited by 380
Gut–liver axis, nutrition, and non-alcoholic fatty liver disease
Kirpich, I. A., Marsano, L. S., & McClain, C. J. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.06.023 · Cited by 327
Self-citationChen, P., Torralba, M., Tan, J., Embree, M., Zengler, K., Stärkel, P., van Pijkeren, J.-P., DePew, J., Loomba, R., Ho, S. B., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.09.014 · Cited by 322
Alcoholic Liver Disease: The Gut Microbiome and Liver Cross Talk
Hartmann, P., Seebauer, C. T., & Schnabl, B. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12704 · Cited by 285
Wang, Y., Liu, Y., Sidhu, A., Ma, Z., McClain, C. J., & Feng, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00024.2012 · Cited by 238
Self-citationToxicant-associated Steatohepatitis
Wahlang, B., Beier, J. I., Clair, H. B., Bellis-Jones, H. J., Falkner, K. C., McClain, C. J., & Cave, M. C. (2012) · Toxicologic Pathology · doi:10.1177/0192623312468517 · Cited by 216
Self-citationYu, J., Marsh, S., Hu, J., Feng, W., & Wu, C. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/2862173 · Cited by 199
Self-citationWang, Y., Liu, Y., Kirpich, I., Ma, Z., Wang, C., Zhang, M., Suttles, J., McClain, C. J., & Feng, W. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.02.001 · Cited by 171
Self-citationNonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet
Mokhtari, Z., Gibson, D. L., & Hekmatdoost, A. (2017) · Advances in Nutrition · doi:10.3945/an.116.013151 · Cited by 170
Microbiota, NASH, HCC and the potential role of probiotics
Brandi, G., Lorenzo, S. D., Candela, M., Pantaleo, M. A., Bellentani, S., Tovoli, F., Saccoccio, G., & Biasco, G. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx007 · Cited by 141
Song, B.-J., Akbar, M., Abdelmegeed, M. A., Byun, K., Lee, B., Yoon, S. K., & Hardwick, J. P. (2014) · Redox Biology · doi:10.1016/j.redox.2014.10.004 · Cited by 123
Non-alcoholic fatty liver disease: An update with special focus on the role of gut microbiota
Doulberis, M., Kotronis, G., Gialamprinou, D., Kountouras, J., & Katsinelos, P. (2017) · Metabolism · doi:10.1016/j.metabol.2017.03.013 · Cited by 117
Targeting the gut barrier for the treatment of alcoholic liver disease
Zhou, Z., & Zhong, W. (2017) · Liver Research · doi:10.1016/j.livres.2017.12.004 · Cited by 116
Dietary lipids from body to brain
Custers, Emma, E. M., Kiliaan, & Amanda, J. K. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101144 · Cited by 119
Tributyrin Supplementation Protects Mice from Acute Ethanol-Induced Gut Injury
Cresci, G., Bush, K., & Nagy, L. E. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12428 · Cited by 113
Chen, W.-Y., Wang, M., Zhang, J., Barve, S. S., McClain, C. J., & Joshi‐Barve, S. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.08.015 · Cited by 109
Self-citationMir, H., Meena, A. S., Chaudhry, K. K., Shukla, P. K., Gangwar, R., Manda, B., Padala, M. K., Shen, L., Turner, J. R., Dietrich, P., et al. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.12.013 · Cited by 109
Zhao, H., Zhao, C., Dong, Y., Zhang, M., Wang, Y., Li, F., Li, X., McClain, C. J., Yang, S., & Feng, W. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.03.002 · Cited by 104
Self-citationAlcoholic Liver Disease: Update on the Role of Dietary Fat
Kirpich, I., Miller, M. E., Cave, M. C., Joshi‐Barve, S., & McClain, C. J. (2016) · Biomolecules · doi:10.3390/biom6010001 · Cited by 104
Self-citationKirpich, I., Petrosino, J. F., Ajami, N. J., Feng, W., Wang, Y., Liu, Y., Beier, J. I., Barve, S. S., Yin, X., Wei, X., et al. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.11.017 · Cited by 96
Self-citationJoshi‐Barve, S., Kirpich, I., Cave, M. C., Marsano, L. S., & McClain, C. J. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.05.006 · Cited by 93
Self-citationShi, X., Wei, X., Yin, X., Wang, Y., Zhang, M., Zhao, C., Zhao, H., McClain, C. J., Feng, W., & Zhang, X. (2015) · Journal of Proteome Research · doi:10.1021/pr501121c · Cited by 88
Self-citationMolecular and Cellular Mediators of the Gut-Liver Axis in the Progression of Liver Diseases
Bruneau, A., Hundertmark, J., Guillot, A., & Tacke, F. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.725390 · Cited by 93
A role for the peripheral immune system in the development of alcohol use disorders?
de Timary, P., Stärkel, P., Delzenne, N. M., & Leclercq, S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.013 · Cited by 82
Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma
Purohit, V., Rapaka, R. S., Kwon, O. S., & Song, B. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.10.009 · Cited by 76
Warner, D. R., Liu, H., Miller, M. E., Ramsden, C. E., Gao, B., Feldstein, A. E., Schuster, S., McClain, C. J., & Kirpich, I. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.06.008 · Cited by 76
Self-citationDevelopment, Prevention, and Treatment of Alcohol-Induced Organ Injury: The Role of Nutrition
Barve, S. S. (2017) · Alcohol research · doi:10.35946/arcr.v38.2.11 · Cited by 76
Self-citationSato, H., Zhang, L. S., Martinez, K., Chang, E. B., Yang, Q., Wang, F., Howles, P. N., Hokari, R., Miura, S., & Tso, P. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.009 · Cited by 75
Kirpich, I., McClain, C. J., Vatsalya, V., Schwandt, M. L., Phillips, M. J., Falkner, K. C., Zhang, L., Harwell, C., George, D. T., & Umhau, J. C. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13346 · Cited by 74
Self-citationKirpich, I., Feng, W., Wang, Y., Liu, Y., Beier, J. I., Arteel, G. E., Falkner, K. C., Barve, S. S., & McClain, C. J. (2013) · Alcohol · doi:10.1016/j.alcohol.2013.01.005 · Cited by 73
Self-citationAlcoholic and non-alcoholic steatohepatitis
Neuman, M. G., French, S. W., French, B. A., Seitz, H. K., Cohen, L. B., Mueller, S., Osna, N. A., Kharbanda, K. K., Seth, D., Bautista, A. P., et al. (2014) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2014.09.005 · Cited by 73
Self-citationWang, J., Wang, Z., Li, B., Yu, Q., Yuan, T., Tan, X., Wang, Z., Liu, Z., & Liu, X. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0277-9 · Cited by 69
Warner, D. R., Warner, J. B., Hardesty, J., Song, Y., King, T. N., Kang, J. X., Chen, C., Xie, S., Yuan, F., Prodhan, M. A. I., et al. (2019) · Journal of Lipid Research · doi:10.1194/jlr.ra119000200 · Cited by 65
Self-citationShi, X., Wei, X., Koo, I., Schmidt, R. H., Yin, X., Kim, S. H., Vaughn, A., McClain, C. J., Arteel, G. E., Zhang, X., et al. (2013) · Journal of Proteome Research · doi:10.1021/pr400719u · Cited by 66
Self-citationALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice
Chaudhry, K. K., Samak, G., Shukla, P. K., Mir, H., Gangwar, R., Manda, B., Isse, T., Kawamoto, T., Salaspuro, M. P., Kaihovaara, P., et al. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12777 · Cited by 60
Shi, Y., Liu, Y., Wang, S., Huang, J., Luo, Z., Jiang, M., Lu, Y., Lin, Q., Liu, H., Cheng, N., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121720 · Cited by 58
Self-citationProbiotics in the Treatment of the Liver Diseases
Kirpich, I., & McClain, C. J. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720004 · Cited by 58
Self-citationIsraelsen, M. E., Kim, M. G., Suvitaival, T., Madsen, B. S., Hansen, C. D., Torp, N., Trôst, K., Thiele, M. S., Hansen, T. F., Legido‐Quigley, C., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100325 · Cited by 57
Chen, W.-Y., Zhang, J., Ghare, S. S., Barve, S. S., McClain, C. J., & Joshi‐Barve, S. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.05.010 · Cited by 57
Self-citationInsulin resistance in clinical and experimental alcoholic liver disease
Carr, R. M., & Correnti, J. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12787 · Cited by 57
Loss of Gut Barrier Integrity In Lupus
Ma, L., & Morel, L. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.919792 · Cited by 55
Shukla, P. K., Meena, A. S., Manda, B., Gomes-Solecki, M. J. C., Dietrich, P., Dragatsis, I., & Rao, R. (2018) · The FASEB Journal · doi:10.1096/fj.201800351r · Cited by 54
Zhong, W. H., Li, Q., Xie, G., Sun, X., Tan, X., Sun, X., Jia, W. P., & Zhou, Z. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00226.2013 · Cited by 52
Enos, R. T., Velázquez, K. T., McClellan, J. L., Cranford, T. L., Nagarkatti, M., Nagarkatti, P. S., Davis, J. M., & Murphy, E. A. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00345.2015 · Cited by 49
Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation
Avila, D. V., Myers, S. A., Zhang, J., Kharebava, G., McClain, C. J., Kim, H., Whittemore, S. R., Gobejishvili, L., & Barve, S. S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.011 · Cited by 48
Self-citationThe Link between Gut Dysbiosis Caused by a High-Fat Diet and Hearing Loss
Kociszewska, D., Chan, J., Thorne, P. R., & Vlajkovic, S. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413177 · Cited by 51
Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage
Neuman, M. G., French, S. W., Zakhari, S., Malnick, S. D. H., Seitz, H. K., Cohen, L. B., Salaspuro, M. P., Voinea‐Griffin, A., Barasch, A., Kirpich, I., et al. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.01.003 · Cited by 44
Self-citationSerum and Fecal Oxylipins in Patients with Alcohol-Related Liver Disease
Gao, B., Lang, S., Duan, Y., Wang, Y., Shawcross, D. L., Louvet, A., Mathurin, P., Ho, S. B., Stärkel, P., & Schnabl, B. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05638-y · Cited by 43
Self-citationLuo, P., Wang, F., Wong, N.-K., Lv, Y., Li, X., Li, M., Tipoe, G. L., So, K., Xu, A., Chen, S., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.09.002 · Cited by 42
Jung, J. H., Kim, S. E., Suk, K. T., & Kim, D. J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.913842 · Cited by 42
Jia, N., Lin, X., Ma, S., Ge, S., Mu, S., Yang, C., Shi, S., Gao, L., Xu, J., Bo, T., et al. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0323-6 · Cited by 38
Murine Models of Acute Alcoholic Hepatitis and Their Relevance to Human Disease
Wilkin, R. J. W., Lalor, P. F., Parker, R., & Newsome, P. N. (2016) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.12.003 · Cited by 36
Diet‐induced obesity causes metabolic impairment independent of alterations in gut barrier integrity
Kleß, C., Müller, V. M., Schüppel, V. L., Lichtenegger, M., Rychlik, M., Daniel, H., Klingenspor, M., & Haller, D. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400840 · Cited by 36
Outside the liver box: The gut microbiota as pivotal modulator of liver diseases
Wahlstrom, A. M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.004 · Cited by 35
Zeng, Y., Zhang, H., Tsao, R., & Mine, Y. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00118 · Cited by 34
A perspective of intestinal immune-microbiome interactions in alcohol-associated Liver Disease
Bruellman, R. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.53589 · Cited by 35
Zhang, L., Wang, X., Chen, S., Wang, S., Tu, Z., Zhang, G., Zhu, H., Li, X., Xiong, J., & Liu, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113697 · Cited by 33
Self-citationWarner, D. R., Liu, H., Dastidar, S. G., Warner, J. B., Prodhan, M. A. I., Yin, X., Zhang, X., Feldstein, A. E., Gao, B., Prough, R. A., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204119 · Cited by 30
Self-citationKitagawa, R., Kon, K., Uchiyama, A., Arai, K., Yamashina, S., Kuwahara‐Arai, K., Kirikae, T., Ueno, T., & Ikejima, K. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00372.2018 · Cited by 29
Dietary fatty acids and bioactive fatty acid metabolites in alcoholic liver disease
Zirnheld, K. H., Warner, D. R., Warner, J. B., Hardesty, J., McClain, C. J., & Kirpich, I. (2019) · Liver Research · doi:10.1016/j.livres.2019.10.001 · Cited by 29
Self-citationOsna, N. A., Carter, W. G., Ganesan, M., Kirpich, I., McClain, C. J., Petersen, D. R., Shearn, C. T., Tomasi, M. L., & Kharbanda, K. K. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i27.6192 · Cited by 28
Self-citationWarner, J. B., Zirnheld, K. H., Hu, H., Floyd, A., Kong, M., McClain, C. J., & Kirpich, I. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14944 · Cited by 27
Self-citationBartsch, M., Hahn, A., & Berkemeyer, S. (2023) · Metabolites · doi:10.3390/metabo13121182 · Cited by 28
Liu, H., Beier, J. I., Arteel, G. E., Ramsden, C. E., Feldstein, A. E., McClain, C. J., & Kirpich, I. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.09.007 · Cited by 26
Self-citationMeyer, S. K., Probert, P. M. E., Lakey, A. F., Axon, A., Leitch, A. C., Williams, F. M., Jowsey, P. A., Blain, P. G., Kass, G. E. N., & Wright, M. C. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.03.024 · Cited by 26
Role of IRAK-M in Alcohol Induced Liver Injury
Wang, Y., Hu, Y., Chen, C., Yüksel, M., Colle, I. O., Flavell, R. A., Ma, Y., Yan, H., & Li, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057085 · Cited by 21
Self-citationLyu, Y., Zhong, L., Liu, Y., Lu, J. N., LaPointe, G., Lü, F., & Lu, Z. (2017) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.5521 · Cited by 20
Self-citationJackson, M. I., & Jewell, D. E. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229868 · Cited by 20
Menta, P. L. D. R., Andrade, M. E. R., de Castro, L. F., Trindade, L. M., Dias, M. T. S., Miyamoto, J. É., dos Santos, R. M., Cassali, G. D., Leal, R. F., Ribeiro, A. P. B., et al. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110897 · Cited by 16
Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress
Kharbanda, K. K., Ronis, M. J. J., Shearn, C. T., Petersen, D. R., Zakhari, S., Warner, D. R., Feldstein, A. E., McClain, C. J., & Kirpich, I. (2018) · Biomolecules · doi:10.3390/biom8020016 · Cited by 16
Self-citationWarner, J. B., Hardesty, J., Song, Y., Sun, R., Deng, Z., Xu, R., Yin, X., Zhang, X., McClain, C. J., Warner, D. R., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.711590 · Cited by 14
Self-citationMacronutrients as Regulators of Intestinal Epithelial Permeability: Where Do We Stand?
Martínez‐Augustin, O., Tena‐Garitaonaindia, M., Ceacero‐Heras, D., Jiménez‐Ortas, Á., Enguix-Huete, J. J., Álvarez‐Mercado, A. I., Ruiz‐Henares, G., Aranda, C. J., Gámez‐Belmonte, R., & de Medina, F. S. (2025) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70178 · Cited by 19
Balakrishnan, J., Kannan, S., Arivazhagan, G., Ramachandran, N., & Sundarasamy, V. G. (2025) · Medicine in Microecology · doi:10.1016/j.medmic.2025.100154 · Cited by 15
Mao, X., Paerhati, G., Wu, Y., & Cheng, L. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1499142 · Cited by 14
Natarajan, G., Perriotte‐Olson, C., Casey, C. A., Donohue, T. M., Talmon, G. A., Harris, E. N., Kabanov, A. V., & Saraswathi, V. (2019) · Alcohol · doi:10.1016/j.alcohol.2018.12.005 · Cited by 14
Fu, A., Li, J., Ding, Q., Guo, R., Pi, A., Yang, W., Chen, Y., Dou, X., Song, Z., & Li, S. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c00852 · Cited by 13
Effect of ethanol exposure on innate immune response in sepsis
Roychowdhury, S., Pant, B. D., Cross, E., Scheraga, R. G., & Vachharajani, V. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad156 · Cited by 15
Ketogenic Diet Protects from Experimental Colitis in a Mouse Model Regardless of Dietary Fat Source
Toivio, L., Lindén, J., Lehto, M. J., Salmenkari, H., & Korpela, R. (2024) · Nutrients · doi:10.3390/nu16091348 · Cited by 12
Zhang, Y., Xun, L., Qiao, R., Jin, S., Zhang, B., Luo, M., Wan, P., Zuo, Z., Song, Z., & Qi, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1478374 · Cited by 13
Ray, S., Huang, E., West, G. A., Mrdjen, M., McMullen, M. R., de la Motte, C., & Nagy, L. E. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.11.008 · Cited by 12
Depressionen und Lebererkrankungen: Die Rolle von Mikrobiom und Inflammation
Kahl, K. G., Krüger, T. H. C., Eckermann, G., & Wedemeyer, H. H. (2018) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-0043-123068 · Cited by 13
Niu, H., Yang, Y., Zhou, Y., Ma, X., Ding, Z., Xu, M., Wu, L., Li, X., Xing, M., Zhang, Q., et al. (2025) · Metabolites · doi:10.3390/metabo15080557 · Cited by 11
Singh, T., Kwatra, M., Kushwah, P., Pant, R., Bezbaruah, B. K., & Jangra, A. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110039 · Cited by 10
Fenretinide Improves Intestinal Barrier Function and Mitigates Alcohol Liver Disease
Tang, X., Melis, M., Mai, K., Gudas, L. J., & Trasino, S. E. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.630557 · Cited by 9
Shi, H., Prough, R. A., McClain, C. J., & Song, M. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109189 · Cited by 9
Self-citationTan, T. C. H., Crawford, D. H. G., Jaskowski, L., Murphy, T. L., Santrampurwala, N., Crane, D., Clouston, A. D., Subramaniam, V., Anderson, G. J., & Fletcher, L. (2013) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12155 · Cited by 7
Koltes, D. A., Lester, H., Frost, M., Aldridge, D. J., Christensen, K. D., & Scanes, C. G. (2017) · BMC Research Notes · doi:10.1186/s13104-017-2781-8 · Cited by 9
Si, W., Zhao, Y., Wu, Y., Jiang, J., Zheng, H., Yang, Y., & Zheng, T. (2025) · Nutrients · doi:10.3390/nu17233688 · Cited by 9
Toivio, L., Launonen, H., Lindén, J., Lehto, M. J., Vapaatalo, H., Salmenkari, H., & Korpela, R. (2023) · Nutrients · doi:10.3390/nu16010018 · Cited by 8
Marchix, J., Alain, C., Gall‐David, S. L., Acuña-Amador, L., Druart, C., Delzenne, N. M., Barloy-Hubler, F., Legrand, P., & Boudry, G. (2020) · Nutrients · doi:10.3390/nu12113451 · Cited by 7
Vatsalya, V., Royer, A. J., Jha, S. K., Parthasarathy, R., Tiwari, H., Feng, W., Ramchandani, V. A., Kirpich, I., & McClain, C. J. (2023) · Advances in clinical chemistry · doi:10.1016/bs.acc.2023.02.001 · Cited by 7
Self-citationHardesty, J., Warner, J. B., Song, Y., Rouchka, E. C., McClain, C. J., Warner, D. R., & Kirpich, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041582 · Cited by 7
Self-citationWatson, W. H., Ritzenthaler, J. D., Torres-González, E., Arteel, G. E., & Roman, J. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14893 · Cited by 6
Matheson, P. J., Fernandez-Botrán, R., Smith, J. W., Matheson, S. A., Downard, C. D., McClain, C. J., & Garrison, R. N. (2015) · JAMA Surgery · doi:10.1001/jamasurg.2015.4050 · Cited by 6
Self-citationPrenatal alcohol exposure alters the cerebral cortex proteome in weanling rats
Canales, L., Gambrell, C., Chen, J., & Neal, R. E. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.04.003 · Cited by 5
Chang, H.-Y., Chen, J., Chen, Y.-H., Xiao, Q., Chen, Y., & Yang, S. (2022) · Bioengineering · doi:10.3390/bioengineering9100526 · Cited by 5
Durairaj, V., Shakya, G., Pajaniradje, S., & Rajagopalan, R. (2014) · The Journal of Membrane Biology · doi:10.1007/s00232-014-9661-0 · Cited by 5
Metadata
- Authors
- Kirpich, I. A., Feng, W., Wang, Y., Liu, Y., Barker, D. F., Barve, S. S., & McClain, C. J.
- Affiliations
- University of Louisville (US)
- Corresponding author
- McClain, Craig J.
- ORCID
- Venue
- Alcoholism Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2011-12-07
- Volume
- 36
- Issue
- 5
- Pages
- 835-846
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- PMC
- PMC3319492
- OpenAlex
- W2098539191
- Cited by
- 135
- References
- 51
- Citations by year
- 2025: 11 · 2024: 6 · 2023: 7 · 2022: 12 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 18 · 2016: 11 · 2015: 11 · 2014: 10 · 2013: 11 · 2012: 4
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Forest Service
- U.S. Public Health Service (R01 AAO14371)
- National Institute on Alcohol Abuse and Alcoholism (R01AA018016, R37AA010762, U01AA021901, R01AA010496, R21AA020849, P30AA019360, R01AA010762, R01AA015970, R01AA014371, P01AA017103, R01AA018869, R01 AA0015970, RC2AA019385)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071765)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- alcoholic liver disease, dietary fat, saturated fat, unsaturated fat, medium-chain triglycerides, corn oil, ethanol, intestinal tight junctions, intestinal permeability, endotoxin, TLR5, liver injury, hepatic steatosis, gut-liver axis
- MeSH terms
- Ethanol, Animals, Body Composition, Body Weight, Dietary Fats, Unsaturated, Disease Models, Animal, Eating, Endotoxins, Liver, Liver Diseases, Alcoholic, Macrophages, Male, Mice, Inbred C57BL, Permeability, Up-Regulation, Oxidative Stress, Tight Junctions, Gastrointestinal Tract, Toll-Like Receptors, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review