Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease

Tight junctions and the molecular basis for regulation of paracellular permeability

Anderson, J. M., & Itallie, C. M. V. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.269.4.g467 · Cited by 844 · see citing works

Antibiotics prevent liver injury in rats following long-term exposure to ethanol

Adachi, Y., Moore, L. E., Bradford, B. U., Gao, W., & Thurman, R. G. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90027-6 · Cited by 692 · see citing works

Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease

Parlesak, A., Schäfer, C., Schütz, T., Bode, J. C., & Bode, C. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80242-1 · Cited by 647 · see citing works

Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay

Fukui, H., Brauner, B., Bode, J. C., & Bode, C. (1991) · Journal of Hepatology · doi:10.1016/0168-8278(91)90933-3 · Cited by 461 · see citing works

Lactobacillus Feeding Reduces Endotoxemia and Severity of Experimental Alcoholic Liver (Disease)

Nanji, A. A., Khettry, U., & Sadrzadeh, S. M. H. (1994) · Experimental Biology and Medicine · doi:10.3181/00379727-205-43703 · Cited by 436 · see citing works

Leaky Gut in Alcoholic Cirrhosis: A Possible Mechanism for Alcohol-Induced Liver Damage

Keshavarzian, A., HOLMES, E. W., Patel, M., Iber, F. L., Fields, J. Z., & Pethkar, S. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.00797.x · Cited by 381 · see citing works

Effect of alcohol consumption on the gut.

Bode, C., & Christian Bode, J. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00034-9 · Cited by 379 · see citing works

Exacerbation of Alcoholic Liver Injury by Enteral Endotoxin in Rats

Mathurin, P., Deng, Q.-G., Keshavarzian, A., Choudhary, S., HOLMES, E. W., & Tsukamoto, H. (2000) · Hepatology · doi:10.1053/jhep.2000.19621 · Cited by 297 · see citing works

Ethanol modulation of intestinal epithelial tight junction barrier

Ma, T. Y., Nguyen, D., Bui, V., Nguyen, H. B., & Hoa, N. T. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.4.g965 · Cited by 261 · see citing works

Plasma Endotoxin and Serum Cytokine Levels in Patients With Alcoholic Hepatitis: Relation to Severity of Liver Disturbance

Fujimoto, M., Uemura, M., Nakatani, Y., Tsujita, S., Hoppo, K., Tamagawa, T., Kitano, H., Kikukawa, M., Ann, T., Ishii, Y., et al. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb00012.x · Cited by 186 · see citing works

Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions

Atkinson, K. J., & Rao, R. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.6.g1280 · Cited by 171 · see citing works

Ethanol-Induced Barrier Dysfunction and Its Prevention by Growth Factors in Human Intestinal Monolayers: Evidence for Oxidative and Cytoskeletal Mechanisms

Banan, A., Choudhary, S., Zhang, Y., Fields, J. Z., & Keshavarzian, A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35212-7 · Cited by 165 · see citing works

The differing effects of acute and chronic alcohol on gastric and intestinal permeability.

Keshavarzian, A., Fields, J. Z., Vaeth, J., & HOLMES, E. W. (1994) · PubMed · Cited by 165 · see citing works

Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines

Nanji, A. A., Jokelainen, K., Fotouhinia, M., Rahemtulla, A., Thomas, P., Tipoe, G. L., Su, G. L., & Dannenberg, A. J. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.6.g1348 · Cited by 161 · see citing works

Bacteriocolonic Pathway for Ethanol Oxidation: Characteristics and Implications

Salaspuro, M. (1996) · Annals of Medicine · doi:10.3109/07853899609033120 · Cited by 158 · see citing works

Preventing Gut Leakiness by Oats Supplementation Ameliorates Alcohol-Induced Liver Damage in Rats

Keshavarzian, A., Choudhary, S., HOLMES, E. W., Yong, S., Banan, A., Jakate, S. M., & Fields, J. Z. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29249-1 · Cited by 157 · see citing works

Prevention of Alterations in Intestinal Permeability Is Involved in Zinc Inhibition of Acute Ethanol-Induced Liver Damage in Mice

Lambert, J. C., Zhou, Z., Wang, L., Song, Z., McClain, C. J., & Kang, Y. J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.047852 · Cited by 143 · see citing works

Gut-associated lymphoid T cell suppression enhances bacterial translocation in alcohol and burn injury

Choudhry, M. A., Fazal, N., Gotō, M., et al. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00235.2001 · Cited by 122 · see citing works

Acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer

Rao, R. K. (1998) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03972.x · Cited by 95 · see citing works

Endotoxin, Endotoxin-Neutralizing-Capacity, sCD14, sICAM-1, and Cytokines in Patients With Various Degrees of Alcoholic Liver Disease

URBASCHEK, R., McCuskey, R. S., Rudi, V., Becker, K.-P., Stickel, F., Urbaschek, B., & Seitz, H. K. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02207.x · Cited by 95 · see citing works

PRESENCE OF PLASMA ENDOTOXIN IS CORRELATED WITH TUMOUR NECROSIS FACTOR RECEPTOR LEVELS AND DISEASE ACTIVITY IN ALCOHOLIC CIRRHOSIS

Hanck, C., Rossol, S., BOCKER, U., TOKUS, M., & SINGER, M. V. (1998) · Alcohol and Alcoholism · doi:10.1093/alcalc/33.6.606 · Cited by 89 · see citing works

Effect of Acute Ethanol Administration on the Intestinal Absorption of Endotoxin in Rats

Tamai, H., Kato, S., Horie, Y., Ohki, E., Yokoyama, H., & Ishii, H. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04629.x · Cited by 88 · see citing works

Comparison of Cross‐Sectional and Daily Reports in Studying the Relationship Between Depression and Use of Alcohol in Response to Stress in College Students

Flynn, H. A. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04552.x · Cited by 83 · see citing works

CURRENT LITERATURE REVIEWED AND CRITIQUED

Schenker, S. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03746.x · Cited by 56 · see citing works

Gender Differences in Phagocytic Responses in the Blood and Liver, and the Generation of Cytokine‐Induced Neutrophil Chemoattractant in the Liver of Acutely Ethanol‐Intoxicated Rats

Spitzer, J. A., & Zhang, P. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb05271.x · Cited by 42 · see citing works

Kupffer cell function in chronic ethanol‐fed rats

Shiratori, Y., Teraoka, H., Matano, S., Matsumoto, K., Kamii, K., & Tanaka, M. (1989) · Liver International · doi:10.1111/j.1600-0676.1989.tb00423.x · Cited by 34 · see citing works

CURRENT LITERATURE REVIEWED AND CRITIQUED

Gallant, D. M. (1985) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1985.tb05753.x · Cited by 18 · see citing works

Effects of ethanol and prostaglandin on rat gastric mucosal tight junctions

Schmidt, K. L., Henagan, J. M., Smith, G. S., et al. (1987) · Journal of Surgical Research · doi:10.1016/0022-4804(87)90079-5 · Cited by 6 · see citing works

Gut microbiota in human metabolic health and disease

Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724 · see citing works

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

Zhu, L., Baker, S. S., Gill, C., Liu, W., Alkhouri, R., Baker, R. D., & Gill, S. R. (2013) · Hepatology · doi:10.1002/hep.26093 · Cited by 1,708 · see citing works

Gut microbial metabolites in obesity, NAFLD and T2DM

Canfora, E. E., Meex, R. C. R., Venema, K., & Blaak, E. E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0156-z · Cited by 1,493 · see citing works

The gut-liver axis and the intersection with the microbiome

Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0011-z · Cited by 1,480 · see citing works

Interactions Between the Intestinal Microbiome and Liver Diseases

Schnabl, B., & Brenner, D. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.020 · Cited by 971 · see citing works

A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.

Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776 · see citing works

The gut microbiome and liver cancer: mechanisms and clinical translation

Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634 · see citing works

Endotoxin Accumulation Prevents Carcinogen-Induced Apoptosis and Promotes Liver Tumorigenesis in Rodents

Yu, L.-X., Yan, H.-X., Liu, Q., Yang, W., Wu, H.-P., Dong, W., Tang, L., Lin, Y., He, Y.-Q., Zou, S.-S., et al. (2010) · Hepatology · doi:10.1002/hep.23845 · Cited by 349 · see citing works

Supplementation of Saturated Long-Chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice

Chen, P., Torralba, M., Tan, J., Embree, M., Zengler, K., Stärkel, P., van Pijkeren, J.-P., DePew, J., Loomba, R., Ho, S. B., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.09.014 · Cited by 322 · see citing works

Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium

Purohit, V., Bode, J. C., Bode, C., Brenner, D. A., Choudhry, M. A., Hamilton, F., Kang, Y. J., Keshavarzian, A., Rao, R., Sartor, R. B., et al. (2008) · Alcohol · doi:10.1016/j.alcohol.2008.03.131 · Cited by 325 · see citing works

Role of intestinal permeability and inflammation in the biological and behavioral control of alcohol-dependent subjects

Leclercq, S., Cani, P. D., Neyrinck, A. M., Stärkel, P., Jamar, F., Mikolajczak, M., Delzenne, N. M., & de Timary, P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.04.001 · Cited by 310 · see citing works

Changes in blood microbiota profiles associated with liver fibrosis in obese patients: A pilot analysis

Lelouvier, B., Servant, F., Païssé, S., Brunet, A., Benyahya, S., Serino, M., Valle, C., Ortiz, M. R., Puig, J., Courtney, M., et al. (2016) · Hepatology · doi:10.1002/hep.28829 · Cited by 242 · see citing works

The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction

Zhong, W., McClain, C. J., Cave, M., Kang, Y. J., & Zhou, Z. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00350.2009 · Cited by 214 · see citing works

Alcohol or gut microbiota: who is the guilty?

Meroni, M., Longo, M., & Dongiovanni, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184568 · Cited by 183 · see citing works

Gut-Liver Axis and Sensing Microbes

Szabo, G., Bala, S., Petrasek, J., & Gattu, A. (2010) · Digestive Diseases · doi:10.1159/000324281 · Cited by 179 · see citing works

Exposure-dependent effects of ethanol on the innate immune system

Goral, J., Karavitis, J., & Kovacs, E. J. (2008) · Alcohol · doi:10.1016/j.alcohol.2008.02.003 · Cited by 152 · see citing works

The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic Toll-like receptor expression in a mouse model of alcoholic liver disease

Kirpich, I. A., Feng, W., Wang, Y., Liu, Y., Barker, D. F., Barve, S. S., & McClain, C. J. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01673.x · Cited by 135 · see citing works

Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and<scp>l</scp>-glutamine

Basuroy, S., Sheth, P., Mansbach, C. M., & Rao, R. K. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00464.2004 · Cited by 134 · see citing works

Acetaldehyde disrupts tight junctions in Caco-2 cell monolayers by a protein phosphatase 2A-dependent mechanism

Dunagan, M., Chaudhry, K., Samak, G., & Rao, R. K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00526.2011 · Cited by 103 · see citing works

Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness

Forsyth, C. B., Voigt, R. M., & Keshavarzian, A. (2014) · Redox Biology · doi:10.1016/j.redox.2014.10.002 · Cited by 76 · see citing works

Chronic alcohol administration causes expression of calprotectin and RAGE altering the distribution of zinc ions in mouse testis

Giannessi, F., Scavuzzo, M. C., Giambelluca, M. A., Fornai, F., Morelli, G., & Ruffoli, R. (2015) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2014.949905 · Cited by 3 · see citing works

Regulation of Tight-Junction Permeability During Nutrient Absorption Across the Intestinal Epithelium

Ballard, S. T., Hunter, J. H., & Taylor, A. E. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.000343 · Cited by 193 · see citing works

Permeabilization of the Tight Junction: A Perspective for Tissue-Specific Drug Targeting

Amasheh, S., Rosenthal, R., Schulzke, J., et al. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0031-1304769

Angulin-2/ILDR1, a tricellular tight junction protein, does not affect water transport in the mouse large intestine

Hempstock, W., Sugioka, S., Ishizuka, N., Sugawara, T., Furuse, M., & Hayashi, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-67319-5 · Cited by 14 · see citing works

The effect of non-specific tight junction modulators on the transepithelial transport of poorly permeable drugs across airway epithelial cells

Ghadiri, M., Young, P. M., Jarolimek, W., et al. (2016) · Journal of drug targeting · doi:10.1080/1061186x.2016.1258703 · Cited by 9 · see citing works

Contribution of the tricellular tight junction to paracellular permeability in leaky and tight epithelia

Krug, S. M. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13379 · Cited by 40 · see citing works