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Cited by 287Tryptophan and brain disordersStress Responses and CortisolTreatment of Major Depression

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Association of Interleukin‐6 and Other Biologic Variables with Depression in Older People Living in the Community

Dentino, Andrew N., Pieper, Carl F., Rao, K. Murali K., Currie, Mark S., Harris, Tamara, Blazer, Dan G., Cohen, Harvey Jay·1999·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.1999.tb01894.x
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Abstract

OBJECTIVES: The prevalence of depression increases with age, as does the prevalence of higher levels of the cytokine interleukin‐6 (IL‐6). This analysis was performed to determine the association between increased levels of this cytokine and depression in a population‐based sample. DESIGN: Cross‐sectional cohort study. SETTING: Rural and urban counties in North Carolina. PARTICIPANTS: Community‐dwelling older people. MEASUREMENTS: The association between IL‐6 and other biologic variables with self‐report depression was examined in 1686 persons aged 70 years and older in the third in‐person survey wave (1991) of the Duke Established Population for Epidemiologic Studies of the Elderly (EPESE). Bivariate associations were established by the Spearman correlation, adjusted for age. A stepwise linear logistic regression model was used to derive a final model to assess multivariable effects on CES‐D scores. RESULTS: Depression was correlated with IL‐6 ( P = .011), D‐Dimer ( P = .017), alpha‐l‐globulin ( P = .023), alphas‐2‐globulin ( P = .002), and beta globulin ( P = .012). After controlling for age, race, and gender, IL‐6 levels remained the only biologic variable significantly associated with depression ( P = .035). CONCLUSION: These data suggest that the inflammatory marker, IL‐6, is associated with depression in older people in this cross‐sectional study. These results are compatible with the hypothesis of cytokine (IL‐6) stimulation in geriatric depression as part of an overall immunoendocrine dysregulation.

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Citations

Cites

Research works printed but not linked: 9

  1. Blazer DG, 1981, Depression in Late Life
  2. Grunfeld C, 1990, Tumor necrosis factor: Immunologic, antitumor, metabolic and cardiovascular activities (rev), Adv Intern Med, 35, 45
  3. Cornoni‐Huntley J, 1990, Established Populations for Epidemiologic Studies of the Elderly, Vol. II: Resource Data Book
  4. Williams TF, 1990, Established Populations for Epidemiologic Studies of the Elderly, Vol. II: Resource Data Book
  5. Cornoni‐Huntley J, 1990, Established Populations for Epidemiologic Studies of the Elderly, Vol. II: Resource Data Book
  6. Cornoni‐Huntley J, 1990, Established Populations for Epidemiologic Studies of the Elderly, Vol. II: Resource Data Book
  7. SAS Institute, 1990, SAS/STAT User's Guide
  8. Dentino AN, 1996, A positive feedback model of immune‐endocrine dysregulation in major depression: Cytokines, the HPA axis and aging, Proc Am Assoc Geriatr Psychiatry, 43
  9. 1994, Diagnostic and Statistical Manual, 193

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Metadata

Authors
Dentino, A. N., Pieper, C. F., Rao, K. M. K., Currie, M. S., Harris, T., Blazer, D. G., & Cohen, H. J.
Affiliations
  • Duke University (US)
  • National Institutes of Health (US)
Corresponding author
Cohen, Harvey Jay
ORCID
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
1999-01
Volume
47
Issue
1
Pages
6-11
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.1999.tb01894.x
OpenAlex
W2010664010
Cited by
287
References
36
Citations by year
2026: 2 · 2025: 5 · 2024: 2 · 2022: 7 · 2021: 3 · 2020: 9 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 16 · 2012: 14
FWCI
4.17
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5960 d)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (5P60-AG11268, N01‐AG12102, P60AG011268)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
interleukin-6, depression, older adults, community-dwelling older adults, cytokines, inflammation, D-dimer, serum globulin, geriatric depression
MeSH terms
Aged, Alpha-Globulins, Analysis of Variance, Beta-Globulins, Cross-Sectional Studies, Depression, Female, Fibrin Fibrinogen Degradation Products, Follow-Up Studies, Health Surveys, Humans, Male, North Carolina, Biomarkers, Interleukin-6, Prevalence, Linear Models, Age Distribution, Statistics, Nonparametric

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