The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly
Abstract
BACKGROUND: IL-6 is a multifunctional cytokine that has been shown to increase with age. METHODS: Plasma IL-6 was measured by ELISA in 1,727 community-dwelling elderly subjects whose blood was drawn during the third in-person survey of the Duke Established Populations for Epidemiologic Studies of the Elderly (EPESE). Demographics, functional status (disability), and disease states were determined. Correlations of these factors with IL-6 were analyzed with Spearman's Rho while differences between groups were assessed by Wilcoxon test. RESULTS: IL-6 levels were higher with age (p = .0001) even in this older population (> 70 years). There was a positive correlation between IL-6 and functional disability for each of the functional status measures (p = .0001), as well as a correlation between self-rated health and IL-6. Significantly higher median levels of IL-6 were found in subjects reporting prevalent cancer, heart attack, and high blood pressure, but not diabetes or arthritis. The association between age and functional status with high IL-6 remained when all other variables were controlled, in multivariable analysis. CONCLUSIONS: This association between increased plasma IL-6 levels and functional status suggests that dysregulation of IL-6 may be related to the functional disability seen with aging, and that IL-6 may be useful as a component of an overall marker of health.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
High levels of age-associated pro-inflammatory markers are detected in most older individuals even without risk factors and clinically active diseases.
“High levels of age-associated pro-inflammatory markers are detected in the majority of older individuals, even in the absence of risk factors and clinically active diseases3,5–7.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [5]
Cites
Van Snick, J. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001345 · Cited by 1,890 · see citing works
Interleukin-6 family of cytokines and gp130.
Kishimoto, T., Akira, S., Narazaki, M., & Taga, T. (1995) · Blood · doi:10.1182/blood.v86.4.1243.bloodjournal8641243 · Cited by 1,362 · see citing works
Daynes, R. A., Araneo, B. A., Ershler, W. B., Maloney, C., Li, G. Z., & Ryu, S. Y. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5219 · Cited by 1,264 · see citing works
The Association of Age and Depression Among the Elderly: An Epidemiologic Exploration
Blazer, D. G., Burchett, B. M., Service, C., & George, L. K. (1991) · Journal of Gerontology · doi:10.1093/geronj/46.6.m210 · Cited by 688 · see citing works
Increased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665 · see citing works
Fillenbaum, G. G. (1985) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1985.tb01779.x · Cited by 511 · see citing works
Interleukin‐6: A Cytokine for Gerontolgists
Ershler, W. B. (1993) · Journal of The American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb02054.x · Cited by 480 · see citing works
Established Populations for Epidemiologic Studies of the Elderly: Resource Data Book
Kaplan, G. A. (1987) · Journal of Gerontology · doi:10.1093/geronj/42.6.688a · Cited by 421 · see citing works
Increase of plasma IL-6 concentration with age in healthy subjects
Wei, J., Xu, H., Davies, J. L., & Hemmings, G. P. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90112-3 · Cited by 402 · see citing works
The Predictive Validity of Self-Report and Performance-based Measures of Function and Health
Reuben, D. B., Siu, A. L., & Kimpau, S. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.4.m106 · Cited by 363 · see citing works
(1993) · PubMed · Cited by 330 · see citing works
Interleukin-6 and selected plasma proteins in healthy persons of different ages
Häger, K., Machein, U., Krieger, S., Platt, D., Seefried, G., & Bauer, J. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90066-3 · Cited by 172 · see citing works
Hirano, T. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000420758 · Cited by 148 · see citing works
Manicourt, D.-H., Triki, R., Fukuda, K., Devogelaer, J., de Deuxchaisnes, C. N., & Thonar, E. J. ‐. A. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360409 · Cited by 133 · see citing works
Merrill, J. E., & Jonakaitr, G. M. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.8.7768352 · Cited by 123 · see citing works
Lu, Z., Brailly, H., Wijdenes, J., Bataille, R., Rossi, J., & Klein, B. (1995) · Blood · doi:10.1182/blood.v86.8.3123.3123 · Cited by 119 · see citing works
Circulating levels of cytokines that modulate bone resorption: Effects of age and menopause in women
McKane, W. R., Khosla, S., Peterson, J. M., Egan, K. S., & Riggs, B. L. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090821 · Cited by 105 · see citing works
Circulating cytokine levels in osteoporotic and normal women
Khosla, S., Peterson, J. M., Egan, K. S., Jones, J. D., & Riggs, B. L. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.3.8077350 · Cited by 99 · see citing works
Investigations of the lymphokine system in elderly individuals
Sindermann, J. R., Kruse, A., Frercks, H.-J., Schütz, R., & Kirchner, H. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90066-z · Cited by 98 · see citing works
Rao, K. M. K., Pieper, C. F., Currie, M. S., & Cohen, H. J. (1994) · American Journal of Clinical Pathology · doi:10.1093/ajcp/102.6.802 · Cited by 98 · see citing works
Self-citationElevated Plasma Levels of Interleukin‐6 in Postmenopausal Women Do Not Correlate with Bone Density
Kania, D. M., Binkley, N., Checovich, M. M., Havighurst, T. C., Schilling, M. L., & Ershler, W. B. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb07328.x · Cited by 97 · see citing works
The Role of Interleukin-6 in Certain Age-Related Diseases
Ershler, W. B., Sun, W., & Binkley, N. (1994) · Drugs & Aging · doi:10.2165/00002512-199405050-00005 · Cited by 82 · see citing works
Hypothesis: Cytokines may be activated to cause depressive illness and chronic fatigue syndrome
Ur, E., White, P. D., & Grossman, A. B. (1992) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02195983 · Cited by 68 · see citing works
Influence of age and caloric restriction on macrophage IL-6 and TNF production.
Rb, E., Svoboda, K., & Rl, W. (1991) · PubMed · Cited by 62 · see citing works
Edgington, T. S., Curtiss, L. K., & Plow, E. F. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.1.471 · Cited by 57 · see citing works
Inhibiting IL-6 in Human Multiple Myeloma
Klein, B., Lu, Z., Gaillard, J., Harousseau, J., & Bataille, R. (1992) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-77633-5_29 · Cited by 37 · see citing works
Increased production of TGF-beta and Il-6 by aged spleen cells
Zhou, D., Chrest, F. J., Adler, W., Munster, A. M., & Winchurch, R. A. (1993) · Immunology Letters · doi:10.1016/0165-2478(93)90061-6 · Cited by 36 · see citing works
Currie, M. S., Rao, K. M. K., Blazer, D. G., & Cohen, H. J. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb06534.x · Cited by 33 · see citing works
Self-citationInhibiting the effects of cytokines in human diseases.
Wp, A. (1995) · PubMed · Cited by 28 · see citing works
Interleukin-1 beta and interleukin-6 release by peripheral blood monocytes in head and neck cancer
Gallo, O., Gori, A. M., Attanasio, M., Martini, F., Giusti, B., Boddi, M., Gallina, E., Fini, O., & Abbate, R. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.371 · Cited by 26 · see citing works
Serum concentrations of cytokines in patients with Hodgkin's disease
Blay, J., Farcet, J., Lavaud, A., Radoux, D., & Chouaı̈b, S. (1994) · European Journal of Cancer · doi:10.1016/0959-8049(94)90249-6 · Cited by 22 · see citing works
Cytokine interactions in the central nervous system.
Hofman, F. M., & Dr, H. (1991) · PubMed · Cited by 18 · see citing works
Modulation of lymphocyte subsets due to psychological stress in patients with rheumatoid arthritis.
Palm, S., Hinrichsen, H. M., Barth, J., Halabi, A., Ferstl, R., Tolk, J., Kirsten, R., & Kirch, W. (1992) · PubMed · Cited by 9 · see citing works
Lu, Z., Brailly, H., Wijdenes, J., et al. (1995) · Blood · doi:10.1182/blood.v86.8.3123.bloodjournal8683123 · Cited by 8 · see citing works
Cytokines: the fourth homeostatic system.
Borecky, L. (1993) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388 · see citing works
Senolytics improve physical function and increase lifespan in old age
Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works
Self-citationVisser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294 · see citing works
Self-citationAge-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282 · see citing works
Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology.
Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135217 · Cited by 1,176 · see citing works
The Pathophysiologic Roles of Interleukin-6 in Human Disease
Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146 · see citing works
Proinflammatory Cytokines, Aging, and Age-Related Diseases
Michaud, M., Balardy, L., Moulis, G., Gaudin, C., Peyrot, C., Vellas, B., Cesari, M., & Nourhashemi, F. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.009 · Cited by 1,094 · see citing works
Inflammatory markers and loss of muscle mass (sarcopenia) and strength
Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., & Visser, M. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.049 · Cited by 1,047 · see citing works
Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515386112 · Cited by 915 · see citing works
Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study
Cesari, M., Penninx, B. W. J. H., Pahor, M., Lauretani, F., Corsi, A. M., Williams, G. R., Guralnik, J. M., & Ferrucci, L. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m242 · Cited by 901 · see citing works
Inflammatory markers in population studies of aging
Singh, T., & Newman, A. B. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.11.002 · Cited by 866 · see citing works
Serum IL‐6 Level and the Development of Disability in Older Persons
Ferrucci, L., Harris, T. B., Guralnik, J. M., Tracy, R. P., Corti, M., Cohen, H. J., Penninx, B., Pahor, M., Wallace, R., & Havlik, R. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01583.x · Cited by 809 · see citing works
Self-citationAssociations of Subclinical Cardiovascular Disease With Frailty
Newman, A. B., Gottdiener, J. S., McBurnie, M. A., Hirsch, C. H., Kop, W. J., Tracy, R. P., Walston, J. D., & Fried, L. P. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.3.m158 · Cited by 803 · see citing works
Immune activation and inflammation in HIV‐1 infection: causes and consequences
Appay, V., & Sauce, D. (2007) · The Journal of Pathology · doi:10.1002/path.2276 · Cited by 742 · see citing works
Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway
Maggio, M. G., Guralnik, J. M., Longo, D. L., & Ferrucci, L. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.6.575 · Cited by 687 · see citing works
Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., Harris, T. B., Kritchevsky, S. B., Newman, A. B., Colbert, L. H., Pahor, M., Rubin, S. M., Tylavsky, F. A., et al. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp097 · Cited by 683 · see citing works
Self-citationPolymyalgia Rheumatica and Giant Cell Arteritis
Ettlinger, R. E., Hunder, G. G., & Ward, L. E. (1978) · Annual Review of Medicine · doi:10.1146/annurev.me.29.020178.000311 · Cited by 687 · see citing works
The Role of Inflammation in Age-Related Sarcopenia
Dalle, S., Rossmeislova, L., & Koppo, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01045 · Cited by 668 · see citing works
Psychoneuroimmunology: psychological influences on immune function and health
Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.3.537 · Cited by 686 · see citing works
Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637 · see citing works
Self-citationCachexia: pathophysiology and clinical relevance1,2
Morley, J. E., Thomas, D. R., & Wilson, M.-M. G. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.735 · Cited by 786 · see citing works
Age-related inflammatory cytokines and disease
Brüünsgaard, H., & Pedersen, B. K. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00056-5 · Cited by 608 · see citing works
Depression and immune function
Kiecolt-Glaser, J. K., & Glaser, R. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00309-4 · Cited by 571 · see citing works
Aging and proinflammatory cytokines
Bruunsgaard, H., Pedersen, M., & Pedersen, B. K. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200105000-00001 · Cited by 690 · see citing works
Thomas, D. R. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.03.008 · Cited by 521 · see citing works
The quest for genetic determinants of human longevity: challenges and insights
Christensen, K., Johnson, T. E., & Vaupel, J. W. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1871 · Cited by 489 · see citing works
Sarcopenia, Cachexia and Aging: Diagnosis, Mechanisms and Therapeutic Options - A Mini-Review
Ali, S., & Garcia, J. M. (2014) · Gerontology · doi:10.1159/000356760 · Cited by 462 · see citing works
Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans
GREIWE, J. S., CHENG, B., RUBIN, D. C., YARASHESKI, K. E., & SEMENKOVICH, C. F. (2001) · The FASEB Journal · doi:10.1096/fj.00-0274com · Cited by 454 · see citing works
Taaffe, D. R., Harris, T. B., Ferrucci, L., Rowe, J., & Seeman, T. E. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.12.m709 · Cited by 438 · see citing works
Self-citationInflammation and frailty in older women
Leng, S. X., Xue, Q., Tian, J., Walston, J. D., & Fried, L. P. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01186.x · Cited by 425 · see citing works
A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies
Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425 · see citing works
Cesari, M., Kritchevsky, S. B., Baumgartner, R., Atkinson, H. H., Penninx, B. W. J. H., Lenchik, L., Palla, S. L., Ambrosius, W. T., Tracy, R. P., & Pahor, M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.2.428 · Cited by 422 · see citing works
. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty.
Desquilbet, L., Jacobson, L. P., Fried, L. P., Phair, J. P., Jamieson, B. D., Holloway, M., Margolick, J. B., & Study, F. T. M. A. C. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.11.1279 · Cited by 420 · see citing works
Models, Definitions, and Criteria of Frailty
Hogan, D. B. (2006) · Elsevier eBooks · doi:10.1016/b978-012369391-4/50051-5 · Cited by 410 · see citing works
Ageing, tumour necrosis factor-alpha (TNF- α ) and atherosclerosis
Brüünsgaard, H., Skinhøj, P., Pedersen, B. K., Schroll, M., & Pedersen, B. K. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01281.x · Cited by 402 · see citing works
Leng, S., Chaves, P., Koenig, K., & Walston, J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50315.x · Cited by 387 · see citing works
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 368 · see citing works
Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment
Kovtonyuk, L. V., Fritsch, K., Feng, X., Manz, M. G., & Takizawa, H. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00502 · Cited by 371 · see citing works
Psychoneuroimmunology and Psychosomatic Medicine: Back to the Future
Kiecolt‐Glaser, J. K., McGuire, L. M., Robles, T. F., & Glaser, R. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200201000-00004 · Cited by 359 · see citing works
Molecular mechanisms of aging-associated inflammation.
Sarkar, D., & Fisher, P. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.04.009 · Cited by 379 · see citing works
Satellite cells in human skeletal muscle plasticity
Snijders, T., Nederveen, J. P., McKay, B. R., Joanisse, S., Verdijk, L. B., van Loon, L. J. C., & Parise, G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00283 · Cited by 359 · see citing works
Pawelec, G. (1998) · Frontiers in bioscience · doi:10.2741/a266 · Cited by 357 · see citing works
Onder, G., Penninx, B. W., Balkrishnan, R., Fried, L. P., Chaves, P. H., Williamson, J., Carter, C., Bari, M. D., Guralnik, J. M., & Pahor, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08024-8 · Cited by 339 · see citing works
Elevated levels of tumor necrosis factor alpha and mortality in centenarians
Bruunsgaard, H., Andersen-Ranberg, K., Hjelmborg, J. V. B., Pedersen, B. K., & Jeune, B. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00329-2 · Cited by 325 · see citing works
Cohen, H. J., Harris, T., & Pieper, C. F. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01484-5 · Cited by 327 · see citing works
Self-citationInflammatory Markers and Incident Mobility Limitation in the Elderly
Penninx, B. W. J. H., Kritchevsky, S. B., Newman, A. B., Nicklas, B. J., Simonsick, E. M., Rubin, S., Nevitt, M., Visser, M., Harris, T., & Pahor, M. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52308.x · Cited by 326 · see citing works
Self-citationHaack, M., Hinze‐Selch, D., Fenzel, T., Kraus, T., Kühn, M., Schuld, A., & Pollmächer, T. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00021-7 · Cited by 329 · see citing works
Association of circulating TNF-α and IL-6 with ageing and parkinsonism
Dobbs, R. J., Charlett, A., Purkiss, A. G., Dobbs, S. M., Weller, C., & Peterson, D. W. (1999) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1999.tb00721.x · Cited by 324 · see citing works
Endocrine and inflammatory markers as predictors of frailty
Puts, M. T. E., Visser, M., Twisk, J. W. R., Deeg, D. J. H., & Lips, P. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02355.x · Cited by 316 · see citing works
Brinkley, T. E., Leng, X., Miller, M. E., Kitzman, D. W., Pahor, M., Berry, M. J., Marsh, A. P., Kritchevsky, S. B., & Nicklas, B. J. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln038 · Cited by 311 · see citing works
Life stress, mood disturbance, and elevated interleukin-6 in healthy older women
Lutgendorf, S. K., Garand, L., Buckwalter, K. C., Reimer, T. T., Hong, S.-Y., & Lubaroff, D. M. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.9.m434 · Cited by 305 · see citing works
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
Barbieri, M., Ferrucci, L., Ragno, E., Corsi, A., Bandinelli, S., Bonafè, M., Olivieri, F., Giovagnetti, S., Franceschi, C., Guralnik, J. M., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00319.2002 · Cited by 303 · see citing works
Reuben, D. B., Cheh, A. I., Harris, T. B., Ferrucci, L., Rowe, J. W., Tracy, R. P., & Seeman, T. E. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50157.x · Cited by 296 · see citing works
Self-citationPredicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
BRUUNSGAARD, H., LADELUND, S., PEDERSEN, A. N., SCHROLL, M., JØRGENSEN, T., & PEDERSEN, B. K. (2003) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.2003.02137.x · Cited by 300 · see citing works
Increasing Burden of Cardiovascular Disease
Hennekens, C. H. (1998) · Circulation · doi:10.1161/01.cir.97.11.1095 · Cited by 290 · see citing works
Cappola, A. R., Xue, Q.-L., Ferrucci, L., Guralnik, J. M., Volpato, S., & Fried, L. P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021694 · Cited by 286 · see citing works
Chaves, P. H. M., Ashar, B. H., Guralnik, J. M., & Fried, L. P. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50313.x · Cited by 285 · see citing works
Dentino, A. N., Pieper, C. F., Rao, K. M. K., Currie, M. S., Harris, T., Blazer, D. G., & Cohen, H. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01894.x · Cited by 287 · see citing works
Self-citationExercise Training and Plasma C-reactive Protein and Interleukin-6 in the Elderly
Nicklas, B., Hsu, F.-C., Brinkley, T. J., Church, T., Goodpaster, B., Kritchevsky, S. B., & Pahor, M. (2008) · Journal of The American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01994.x · Cited by 345 · see citing works
Head Injury in Early Adulthood and the Lifetime Risk of Depression
Holsinger, T., Steffens, D. C., Phillips, C., Helms, M. J., Havlik, R. J., Breitner, J. C. S., Guralnik, J. M., & Plassman, B. L. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.1.17 · Cited by 267 · see citing works
Editorial: Something About Frailty
Morley, J. E., Perry, H. M., & Miller, D. K. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.11.m698 · Cited by 262 · see citing works
Chin, S. O., Rhee, S. Y., Chon, S., Hwang, Y.-C., Jeong, I.-K., Oh, S., Ahn, K. J., Chung, H. Y., Woo, J.-T., Kim, S.-W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060119 · Cited by 252 · see citing works
Koenig, H. G., Cohen, H. J., George, L. K., Hays, J. C., Larson, D. B., & Blazer, D. G. (1997) · The International Journal of Psychiatry in Medicine · doi:10.2190/40nf-q9y2-0gg7-4wh6 · Cited by 251 · see citing works
Self-citationPayette, H., Roubenoff, R., Jacques, P. F., Dinarello, C. A., Wilson, P. W. F., Abad, L. W., & Harris, T. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51407.x · Cited by 245 · see citing works
Self-citationPlasma cytokine profiles in elderly humans
Forsey, R. J., Thompson, J. M., Ernerudh, J., HURST, T. L., Strindhall, J., Johansson, B. E. A., Nilsson, B.-O., & Wikby, A. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00025-3 · Cited by 249 · see citing works
Peterson, C. A., & Heffernan, M. E. (2008) · Journal of Inflammation · doi:10.1186/1476-9255-5-10 · Cited by 250 · see citing works
Structural and Functional Changes and Possible Molecular Mechanisms in Aged Skin
Lee, H. J., Hong, Y., & Kim, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212489 · Cited by 269 · see citing works
C-Reactive Protein, Cardiovascular Risk Factors, and Mortality in a Prospective Study in the Elderly
Strandberg, T. E., & Tilvis, R. S. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.4.1057 · Cited by 246 · see citing works
Connective tissue and fibroblast senescence in skin aging
Wlaschek, M., Maity, P., Makrantonaki, E., & Scharffetter-Kochanek, K. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.010 · Cited by 245 · see citing works
Legrand, D., Vaes, B., Matheï, C., Adriaensen, W. J., Pottelbergh, G. V., & Degryse, J. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12840 · Cited by 239 · see citing works
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women
Richards, J. B., Valdes, A. M., Gardner, J. P., Paximadas, D., Kimura, M., Nessa, A., Lu, X., Surdulescu, G. L., Swaminathan, R., Spector, T. D., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1420 · Cited by 237 · see citing works
Plasma cytokines profile in older subjects with late onset Alzheimer’s disease or vascular dementia
Zuliani, G., Ranzini, M., Guerra, G., Rossi, L., Munari, M. R., Zurlo, A., Volpato, S., Atti, A. R., Blè, A., & Fellin, R. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.02.008 · Cited by 234 · see citing works
Inflammation and the pathophysiology of work-related musculoskeletal disorders
Barbe, M. F., & Barr, A. E. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.001 · Cited by 227 · see citing works
Reuben, D. B., Judd‐Hamilton, L., Harris, T. B., & Seeman, T. E. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51380.x · Cited by 224 · see citing works
MacIntosh, C. G., Morley, J. E., & Chapman, I. M. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00405-6 · Cited by 224 · see citing works
Inflammatory markers and cardiovascular health in older adults
Kritchevsky, S. B., Cesari, M., & Pahor, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.12.026 · Cited by 222 · see citing works
Geriatric cachexia: the role of cytokines
Yeh, S., & Schuster, M. W. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.70.2.183 · Cited by 220 · see citing works
Psychosocial factors and interleukin-6 among women with advanced ovarian cancer
Costanzo, E. S., Lutgendorf, S. K., Sood, A. K., Anderson, B., Sorosky, J., & Lubaroff, D. M. (2005) · Cancer · doi:10.1002/cncr.21147 · Cited by 217 · see citing works
Poorer self-rated health is associated with elevated inflammatory markers among older adults
Christian, L. M., Glaser, R., Porter, K. M., Malarkey, W. B., Beversdorf, D. Q., & Kiecolt‐Glaser, J. K. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.04.003 · Cited by 214 · see citing works
Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis
Miyoshi, N., Oubrahim, H., Chock, P. B., & Stadtman, E. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510346103 · Cited by 207 · see citing works
Jylhä, M. K., Guralnik, J. M., Balfour, J. H., & Fried, L. P. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.10.m609 · Cited by 202 · see citing works
Raiten, D. J., Ashour, F. A. S., Ross, A. C., Meydani, S. N., Dawson, H. D., Stephensen, C. B., Brabin, B. J., Suchdev, P. S., & van Ommen, B. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.194571 · Cited by 234 · see citing works
Influence of Physical Activity on Serum IL-6 and IL-10 Levels in Healthy Older Men
Jankord, R., & Jemioło, B. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000128186.09416.18 · Cited by 196 · see citing works
Cytokine-Related Aging Process
Morley, J. E., & Baumgartner, R. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.9.m924 · Cited by 189 · see citing works
Boyle, P. A., Buchman, A. S., & Bennett, D. A. (2010) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181d6c259 · Cited by 185 · see citing works
Marcos-Pérez, D., Sánchez-Flores, M., Proietti, S., Bonassi, S., Costa, S., Teixeira, J. P., Fernandez-Tajes, J. J., Pásaro, E., Laffón, B., & Valdiglesias, V. (2020) · GeroScience · doi:10.1007/s11357-020-00247-4 · Cited by 188 · see citing works
Boxer, R. S., Dauser, D., Walsh, S. J., Hager, W. D., & Kenny, R. A. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01601.x · Cited by 186 · see citing works
Acanfora, D., Gheorghiade, M., Trojano, L., Furgi, G., Pasini, E., Picone, C., Papa, A., Iannuzzi, G. L., Bonow, R. O., & Rengo, F. (2001) · American Heart Journal · doi:10.1067/mhj.2001.115792 · Cited by 186 · see citing works
Religious Participation, Interleukin-6, and Mortality in Older Adults.
Lutgendorf, S. K., Russell, D., Ullrich, P., Harris, T. B., & Wallace, R. (2004) · Health Psychology · doi:10.1037/0278-6133.23.5.465 · Cited by 184 · see citing works
Self-citationPlasma Cytokine Levels in a Population-Based Study: Relation to Age and Ethnicity
Stowe, R. P., Peek, M. K., Cutchin, M. P., & Goodwin, J. S. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp198 · Cited by 182 · see citing works
Baggio, G., Donazzan, S., Monti, D., Mari, D., Martini, S., Gabelli, C., Vestra, M. D., Previato, L., Guido, M., Pigozzo, S., et al. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.6.433 · Cited by 180 · see citing works
Cognitive dysfunction with aging and the role of inflammation
Simen, A. A., Bordner, K. A., Martin, M. P., Moy, L. A., & Barry, L. C. (2011) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311399145 · Cited by 174 · see citing works
Impact of Multimorbidity on Disability and Quality of Life in the Spanish Older Population
Garín, N., Olaya, B., Moneta, M. V., Miret, M., Lobo, A., Ayuso‐Mateos, J. L., & Haro, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111498 · Cited by 175 · see citing works
Measures of lower body function and risk of mortality over 7 years of follow-up
Ostir, G. V., Kuo, Y.-F., Berges, I. M., Markides, K. S., & Ottenbacher, K. J. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm121 · Cited by 165 · see citing works
Fitness, Inflammation, and the Metabolic Syndrome in Men With Paraplegia
Manns, P. J., McCubbin, J. A., & Williams, D. P. (2005) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2004.11.020 · Cited by 165 · see citing works
Ferrucci, L., Penninx, B. W. J. H., Leveille, S. G., Corti, M., Pahor, M., Wallace, R. B., Harris, T. B., Havlik, R. J., & Guralnik, J. M. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04787.x · Cited by 163 · see citing works
Self-citationImpact of aging on innate immunity
Pawelec, G., Solana, R., Remarque, E. J., & Mariani, E. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.64.6.703 · Cited by 163 · see citing works
- Authors
- Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M. K., & Currie, M. S.
- Affiliations
- Duke University (US)
- National Institutes of Health (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-07-01
- Volume
- 52A
- Issue
- 4
- Pages
- M201-M208
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2149814390
- Cited by
- 476
- References
- 35
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 18 · 2023: 14 · 2022: 13 · 2021: 20 · 2020: 23 · 2019: 15 · 2018: 14 · 2017: 13 · 2016: 12 · 2015: 18 · 2014: 15 · 2013: 25 · 2012: 18
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01ag012102-011)
- National Institute on Aging (5P60-AG11268, N01‐AG12102, P60AG011268)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- interleukin-6, plasma cytokines, functional disability, community-dwelling older adults, aging, self-rated health, cancer, myocardial infarction, hypertension, health indicators
- MeSH terms
- Aged, Aging, Community Medicine, Enzyme-Linked Immunosorbent Assay, Female, Persons with Disabilities, Disabled Persons, Health Status, Humans, Male, Self-Assessment, Interleukin-6, Multivariate Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
