The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Association of Interleukin‐6 and Other Biologic Variables with Depression in Older People Living in the Community
Abstract
OBJECTIVES: The prevalence of depression increases with age, as does the prevalence of higher levels of the cytokine interleukin‐6 (IL‐6). This analysis was performed to determine the association between increased levels of this cytokine and depression in a population‐based sample. DESIGN: Cross‐sectional cohort study. SETTING: Rural and urban counties in North Carolina. PARTICIPANTS: Community‐dwelling older people. MEASUREMENTS: The association between IL‐6 and other biologic variables with self‐report depression was examined in 1686 persons aged 70 years and older in the third in‐person survey wave (1991) of the Duke Established Population for Epidemiologic Studies of the Elderly (EPESE). Bivariate associations were established by the Spearman correlation, adjusted for age. A stepwise linear logistic regression model was used to derive a final model to assess multivariable effects on CES‐D scores. RESULTS: Depression was correlated with IL‐6 ( P = .011), D‐Dimer ( P = .017), alpha‐l‐globulin ( P = .023), alphas‐2‐globulin ( P = .002), and beta globulin ( P = .012). After controlling for age, race, and gender, IL‐6 levels remained the only biologic variable significantly associated with depression ( P = .035). CONCLUSION: These data suggest that the inflammatory marker, IL‐6, is associated with depression in older people in this cross‐sectional study. These results are compatible with the hypothesis of cytokine (IL‐6) stimulation in geriatric depression as part of an overall immunoendocrine dysregulation.
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“Production of IL-6 and other proinflammatory cytokines can be directly stimulated by depression and other negative emotions and stressful experiences (16-20).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [16]
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A Meta-Analysis of Cytokines in Major Depression
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Metadata
- Authors
- Dentino, A. N., Pieper, C. F., Rao, K. M. K., Currie, M. S., Harris, T., Blazer, D. G., & Cohen, H. J.
- Affiliations
- Duke University (US)
- National Institutes of Health (US)
- Corresponding author
- Cohen, Harvey Jay
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 1999-01
- Volume
- 47
- Issue
- 1
- Pages
- 6-11
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2010664010
- Cited by
- 287
- References
- 36
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2022: 7 · 2021: 3 · 2020: 9 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 12 · 2013: 16 · 2012: 14
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (5P60-AG11268, N01‐AG12102, P60AG011268)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- interleukin-6, depression, older adults, community-dwelling older adults, cytokines, inflammation, D-dimer, serum globulin, geriatric depression
- MeSH terms
- Aged, Alpha-Globulins, Analysis of Variance, Beta-Globulins, Cross-Sectional Studies, Depression, Female, Fibrin Fibrinogen Degradation Products, Follow-Up Studies, Health Surveys, Humans, Male, North Carolina, Biomarkers, Interleukin-6, Prevalence, Linear Models, Age Distribution, Statistics, Nonparametric
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