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Cited by 80Frailty in Older AdultsElectrolyte and hormonal disordersAging, Health, and Disability

Plasma Hypertonicity: Another Marker of Frailty?

Stookey, Jodi D., Purser, Jama L., Pieper, Carl F., Cohen, Harvey J.·2004·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.2004.52361.x
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Abstract

Objectives To determine whether plasma hypertonicity might be a marker of early frailty, this study tested the associations between plasma hypertonicity, incident disability, and mortality in nondisabled older adults. Design Longitudinal, observational study. Setting Community-based. Participants Older adults (> or =70), who reported no disability and gave blood in the 1992 Duke Established Populations for Epidemiologic Studies of the Elderly survey (n=705), were re-interviewed in 1996 for functional status (n=561) and followed for all deaths up to January 1, 2000. Measurements Plasma tonicity was estimated from plasma glucose, sodium, and potassium measures and used to classify subjects as normo- (285-294 mOsm/L) or hypertonic (> or =300 mOsm/L). Disability was defined as any impairment on the Rosow-Breslau, activity of daily living (ADL), and instrumental activity of daily living (IADL) scales. The relative risk (RR) of any new disability and relative hazard of death associated with hypertonicity were estimated using logistic regression models and Cox proportional hazards models, respectively. All models were controlled for age, sex, race, weight status, current smoking, activity level, plasma blood urea nitrogen and creatinine, cognitive impairment, depression, and chronic disease status. To determine whether observed effects were attributable to plasma glucose alone, all models were repeated on a subsample of nondiabetic, normoglycemic subjects. Results Plasma hypertonici…

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  • Older adults with raised serum osmolality (>300 mOsm/kg or equivalent) have an increased risk of mortality.

    “High-quality cohort studies which have adjusted for key confounding factors have consistently found that older adults with raised serum osmolality (>300 mOsm/kg or equivalent) have an increased risk of mortality (216-218)”

    From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [217]

  • Raised serum osmolality (>300 mOsm/kg or equivalent) is associated with a doubling in risk of 4-year disability in older adults.

    “and one showed an associated doubling in risk of 4-year disability (217).”

    From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [217]

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Authors
Stookey, J. D., Purser, J. L., Pieper, C. F., & Cohen, H. J.
Affiliations
Duke University (US)
Corresponding author
Stookey, Jodi D.
ORCID
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2004-07-19
Volume
52
Issue
8
Pages
1313-1320
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.2004.52361.x
OpenAlex
W1549989427
Cited by
80
References
38
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 8 · 2016: 2 · 2015: 7 · 2014: 6 · 2013: 5 · 2012: 3
FWCI
1.36
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01ag012102-011)
  • National Institute on Aging (AG 00029, R01AG012765, AG-11268, N01‐AG12102, P60AG011268)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
plasma tonicity, frailty, older adults, disability, mortality, plasma glucose, sodium, potassium, instrumental activities of daily living, activities of daily living, functional status, blood urea nitrogen, creatinine, chronic disease, cognitive impairment, depression, chronic kidney disease, chronic liver disease, chronic heart disease
MeSH terms
Activities of Daily Living, Aged, Aged, 80 and over, Blood Glucose, Female, Follow-Up Studies, Persons with Disabilities, Humans, Longitudinal Studies, Male, Potassium, Sodium, Frail Elderly

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