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Exercise program for nursing home residents with Alzheimer’s disease: a 1-year randomized, controlled trial
Open accessAbstract
OBJECTIVES: To investigate the effectiveness of an exercise program in improving ability to perform activities of daily living (ADLs), physical performance, and nutritional status and decreasing behavioral disturbance and depression in patients with Alzheimer's disease (AD). DESIGN: Randomized, controlled trial. SETTING: Five nursing homes. PARTICIPANTS: One hundred thirty‐four ambulatory patients with mild to severe AD. INTERVENTION: Collective exercise program (1 hour, twice weekly of walk, strength, balance, and flexibility training) or routine medical care for 12 months. MEASUREMENTS: ADLs were assessed using the Katz Index of ADLs. Physical performance was evaluated using 6‐meter walking speed, the get‐up‐and‐go test, and the one‐leg‐balance test. Behavioral disturbance, depression, and nutritional status were evaluated using the Neuropsychiatric Inventory, the Montgomery and Asberg Depression Rating Scale, and the Mini‐Nutritional Assessment. For each outcome measure, the mean change from baseline to 12 months was calculated using intention‐to‐treat analysis. RESULTS: ADL mean change from baseline score for exercise program patients showed a slower decline than in patients receiving routine medical care (12‐month mean treatment differences: ADL=0.39, P =.02). A significant difference between the groups in favor of the exercise program was observed for 6‐meter walking speed at 12 months. No effect was observed for behavioral disturbance, depression, or nutritional assessment scores. In the intervention group, adherence to the program sessions in exploratory analysis predicted change in ability to perform ADLs. No adverse effects of exercise occurred. CONCLUSION: A simple exercise program, 1 hour twice a week, led to significantly slower decline in ADL score in patients with AD living in a nursing home than routine medical care.
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“A high-quality French trial involved twice-weekly, one-hour exercise sessions over a year and demonstrated a slower decline in Activities of Daily Living (ADL) in the intervention group compared to the control group [492].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [492]
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Boongird, C., Anothaisintawee, T., Tearneukit, W., Wongpipathpong, W., Suthutvoravut, U., Thongpan, M., Pongsettakul, N., Attia, J., McKay, G. J., Rattanasiri, S., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251378354 · Cited by 2
Carollo, L., Lawson, E. A., Stanley, T. L., Wang, J., Bhattacharya, R., Bishop, D. J., Carmichael, O. T., Esser, K. A., Febbraio, M. A., Fielding, R. A., et al. (2026) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2026.101262 · Cited by 3
Metadata
- Authors
- Rolland, Y., Pillard, F., Klapouszczak, A., Reynish, E., Thomas, D., Andrieu, S., Rivière, D., & Vellas, B.
- Affiliations
- Inserm (FR)
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2007-01-08
- Volume
- 55
- Issue
- 2
- Pages
- 158-165
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1991189029
- Cited by
- 661
- References
- 41
- Citations by year
- 2026: 4 · 2025: 17 · 2024: 21 · 2023: 20 · 2022: 33 · 2021: 33 · 2020: 33 · 2019: 36 · 2018: 47 · 2017: 38 · 2016: 35 · 2015: 42 · 2014: 40 · 2013: 53 · 2012: 44
- FWCI
- 21.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Université de Toulouse
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Geriatric Care and Nursing Homes
- Keywords
- Alzheimer's disease, exercise program, nursing home residents, activities of daily living, physical performance, walking speed, balance, resistance training, flexibility training, behavioral problems, depression, nutritional status, functional decline, program adherence
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Mental Disorders, Depression, Exercise Therapy, Female, Homes for the Aged, Humans, Male, Middle Aged, Nursing Homes, Nutritional Status, Walking, Outcome Assessment, Health Care
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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