Cited by 661Dementia and Cognitive Impairment ResearchPhysical Activity and HealthGeriatric Care and Nursing Homes

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Exercise program for nursing home residents with Alzheimer’s disease: a 1-year randomized, controlled trial

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Rolland, Yves, Pillard, Fabien, Klapouszczak, Adrian, Reynish, Emma, Thomas, David, Andrieu, Sandrine, Rivière, Daniel, Vellas, Bruno·2007·Journal of the American Geriatrics Society

DOI 10.1111/j.1532-5415.2007.01035.x

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Abstract

OBJECTIVES: To investigate the effectiveness of an exercise program in improving ability to perform activities of daily living (ADLs), physical performance, and nutritional status and decreasing behavioral disturbance and depression in patients with Alzheimer's disease (AD). DESIGN: Randomized, controlled trial. SETTING: Five nursing homes. PARTICIPANTS: One hundred thirty‐four ambulatory patients with mild to severe AD. INTERVENTION: Collective exercise program (1 hour, twice weekly of walk, strength, balance, and flexibility training) or routine medical care for 12 months. MEASUREMENTS: ADLs were assessed using the Katz Index of ADLs. Physical performance was evaluated using 6‐meter walking speed, the get‐up‐and‐go test, and the one‐leg‐balance test. Behavioral disturbance, depression, and nutritional status were evaluated using the Neuropsychiatric Inventory, the Montgomery and Asberg Depression Rating Scale, and the Mini‐Nutritional Assessment. For each outcome measure, the mean change from baseline to 12 months was calculated using intention‐to‐treat analysis. RESULTS: ADL mean change from baseline score for exercise program patients showed a slower decline than in patients receiving routine medical care (12‐month mean treatment differences: ADL=0.39, P =.02). A significant difference between the groups in favor of the exercise program was observed for 6‐meter walking speed at 12 months. No effect was observed for behavioral disturbance, depression, or nutritional assessment scores. In the intervention group, adherence to the program sessions in exploratory analysis predicted change in ability to perform ADLs. No adverse effects of exercise occurred. CONCLUSION: A simple exercise program, 1 hour twice a week, led to significantly slower decline in ADL score in patients with AD living in a nursing home than routine medical care.

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Authors: Rolland, Y., Pillard, F., Klapouszczak, A., Reynish, E., Thomas, D., Andrieu, S., Rivière, D., & Vellas, B.
Affiliations: Inserm (FR)
ORCID: Rolland, Yves
Pillard, Fabien
Reynish, Emma
Andrieu, Sandrine
Rivière, Daniel
Vellas, Bruno
Venue: Journal of the American Geriatrics Society
Publisher: Wiley
Published: 2007-01-08
Volume: 55
Issue: 2
Pages: 158-165
ISSN: 0002-8614 (ISSN-L)
1532-5415
DOI: 10.1111/j.1532-5415.2007.01035.x
OpenAlex: W1991189029
Cited by: 661
References: 41
Citations by year: 2026: 4 · 2025: 17 · 2024: 21 · 2023: 20 · 2022: 33 · 2021: 33 · 2020: 33 · 2019: 36 · 2018: 47 · 2017: 38 · 2016: 35 · 2015: 42 · 2014: 40 · 2013: 53 · 2012: 44
FWCI: 21.94
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of the American Geriatrics Society (publishedVersion)
PubMed (publishedVersion)
Funders: Université de Toulouse
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Geriatrics and Gerontology › Geriatric Care and Nursing Homes
Keywords: Alzheimer's disease, exercise program, nursing home residents, activities of daily living, physical performance, walking speed, balance, resistance training, flexibility training, behavioral problems, depression, nutritional status, functional decline, program adherence
MeSH terms: Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Mental Disorders, Depression, Exercise Therapy, Female, Homes for the Aged, Humans, Male, Middle Aged, Nursing Homes, Nutritional Status, Walking, Outcome Assessment, Health Care

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Exercise program for nursing home residents with Alzheimer’s disease: a 1-year randomized, controlled trial

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