Effects of Dehydroepiandrosterone and Atamestane Supplementation on Frailty in Elderly Men
Open accessAbstract
Background: It has been suggested that the age-related decline of androgens in men plays a distinct role in the development of several aspects of frailty. Therefore, hormone replacement might improve the course of frailty by increasing lean body mass and muscle strength, decreasing fat mass, and improving the subjective quality of life. Objective: The objective of the study was to assess whether hormone replacement with dehydroepiandrosterone (DHEA) and/or atamestane might improve the course of frailty. Design: This was a double-blind, randomized, controlled trial. Setting: The study was conducted in the general community. Participants: Participants included 100 nonhospitalized, nondiseased, independently living men, aged 70 yr and over with low scores on strength tests. Seventeen participants did not complete the trial. Intervention: Subjects were randomly assigned to one of four intervention arms: atamestane (100 mg/d) and placebo, DHEA (50 mg/d) and placebo, a combination of atamestane (100 mg/d) and DHEA (50 mg/d), or two placebo tablets for 36 wk. Main Outcome Measures: Physical frailty was measured by means of a specific test battery, including isometric grip strength, leg extensor power, and physical performance. Results: The randomization was successful, and 83 (83%) men completed the intervention. There were no differences between the treatment arms and placebo group in any of the outcome measurements after intervention. Conclusions: The results of this double-blind, randomized trial do not support the hypothesis that hormone replacement with DHEA and/or atamestane might improve the course of frailty.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
When testicular testosterone and estradiol synthesis are suppressed and testosterone is administered exogenously in combination with letrozole, the estradiol/testosterone ratio is suppressed by 81%.
“When testicular testosterone and estradiol synthesis are suppressed and testosterone is administered exogenously in combination with letrozole, however, the estradiol/testosterone ratio is suppressed by 81% [30], which is only marginally different from the suppression of this ratio in intact men after treatment with letrozole.”
From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [30]
In experimental settings, selective withdrawal of estradiol in men was associated with an increase in markers of bone resorption.
“In experimental settings, selective withdrawal of estradiol in men was associated with an increase in markers of bone resorption [30,81].”
From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [30]
Smaller RCTs have similarly reported that despite robust increases in testosterone, AIs had no effect on a large array of psychological and somatic measures in men with age- or obesity-associated reductions in testosterone.
“Smaller RCTs have similarly reported that despite robust increases in testosterone, AIs had no effect on a large array of psychological and somatic measures in men with age-or obesity-associated reductions in testosterone.[116][117][118]”
From Hypogonadism and male obesity: Focus on unresolved questions (2018) · cites this paper as [117]
Cites
Lamberts, S. W. J., van den Beld, A. W., & van der Lely, A.-J. (1997) · Science · doi:10.1126/science.278.5337.419 · Cited by 980 · see citing works
Self-citationA program to prevent functional decline in physically frail, elderly persons who live at home
Gill, T. M., Baker, D. I., Gottschalk, M., Peduzzi, P. N., Allore, H., & Byers, A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020423 · Cited by 871 · see citing works
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales, A. J., Nolan, J. J., Nelson, J. C., & Yen, S. S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7515387 · Cited by 841 · see citing works
van den Beld, A. W., de Jong, F. H., Grobbee, D. E., Pols, H. A. P., & Lamberts, S. W. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6825 · Cited by 620 · see citing works
Self-citationBaulieu, E.-E., Thomas, G., Legrain, S., Lahlou, N., Roger, M., Debuire, B., Faucounau, V., Girard, L., Hervy, M.-P., Latour, F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4279 · Cited by 577 · see citing works
Effect of Testosterone Treatment on Bone Mineral Density in Men Over 65 Years of Age
Snyder, P. J. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.1966 · Cited by 460 · see citing works
Kenny, A. M., Prestwood, K. M., Gruman, C. A., Marcello, K. M., & Raisz, L. G. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.5.m266 · Cited by 456 · see citing works
Testosterone supplementation improves spatial and verbal memory in healthy older men
Cherrier, M. M., Asthana, S., Plymate, S. R., Baker, L. D., Matsumoto, A. M., Peskind, E. R., Raskind, M. A., Brodkin, K. I., Bremner, W., Petrova, A., et al. (2001) · Neurology · doi:10.1212/wnl.57.1.80 · Cited by 450 · see citing works
Morales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00507.x · Cited by 418 · see citing works
Sex Steroids Modify Working Memory
Janowsky, J. S., Chavez, B., & ORWOLL, E. S. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900562228 · Cited by 360 · see citing works
Endogenous Sex Hormones and Progression of Carotid Atherosclerosis in Elderly Men
Muller, M., van den Beld, A. W., Bots, M. L., Grobbee, D. E., Lamberts, S. W. J., & van der Schouw, Y. T. (2004) · Circulation · doi:10.1161/01.cir.0000125854.51637.06 · Cited by 318 · see citing works
Self-citationWolf, O. T., Neumann, O., Hellhammer, D. H., Geiben, A. C., Strasburger, C. J., Dressendörfer, R. A., Pirke, K., & Kirschbaum, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4056 · Cited by 235 · see citing works
Wolf, O. T. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.7.2363 · Cited by 164 · see citing works
Arlt, W., Callies, F., Koehler, I., van Vlijmen, J. C., Faßnacht, M., Strasburger, C. J., Seibel, M. J., Huebler, D., Ernst, M. E., Oettel, M., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7974 · Cited by 139 · see citing works
Diagnosis of hypogonadism in the aging male
Vermeulen, A., & Kaufman, J. (2002) · The Aging Male · doi:10.1080/tam.5.3.170.176 · Cited by 116 · see citing works
O’Donnell, A. B., Travison, T. G., Harris, S. S., Tenover, J. L., & McKinlay, J. B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1227 · Cited by 94 · see citing works
Experience With Testosterone Replacement in the Elderly
Tenover, J. L. (2000) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(19)30648-2 · Cited by 69 · see citing works
Effects of an oral androgen on muscle and metabolism in older, community-dwelling men
Schroeder, E. T., Singh, A. B., Bhasin, S., Storer, T. W., Azen, C. G., Davidson, T., Martinez, C., Sinha‐Hikim, I., Jaque, S. V., Terk, M. R., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00363.2002 · Cited by 67 · see citing works
Dehydroepiandrosterone Supplementation and Bone Turnover in Middle-Aged to Elderly Men
Kahn, A., & Halloran, B. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8396 · Cited by 44 · see citing works
Sex hormones and male health: effects on components of the frailty syndrome.
Muller, M., Grobbee, D., Thijssen, J., van den Beld, A. W., & van der Schouw, Y. (2003) · Trends in endocrinology and metabolism · doi:10.1016/s1043-2760(03)00083-3 · Cited by 43 · see citing works
Self-citationGingell, J. C., Knönagel, H., Kurth, K. H., & Tunn, U. W. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)67061-7 · Cited by 43 · see citing works
Gingell, J. C., Knönagel, H., Kurth, K. H., et al. (1995) · The Journal of Urology · doi:10.1097/00005392-199508000-00020 · Cited by 19 · see citing works
Flagged first, then by citations
1 of the 23 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Apóstolo, J., Cooke, R. W. I., Campos, E. B., Santana, S., Marcucci, M., Cano, A., Vollenbroek-Hutten, M. M. R., Germini, F., D’Avanzo, B., Gwyther, H., et al. (2018) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2017-003382 · Cited by 621 · see citing works
The physical frailty syndrome as a transition from homeostatic symphony to cacophony
Fried, L. P., Cohen, A. A., Xue, Q., Walston, J. D., Bandeen‐Roche, K., & Varadhan, R. (2021) · Nature Aging · doi:10.1038/s43587-020-00017-z · Cited by 591 · see citing works
Delaying and reversing frailty: a systematic review of primary care interventions
Travers, J., Romero‐Ortuño, R., Bailey, J., & Cooney, M. T. (2018) · British Journal of General Practice · doi:10.3399/bjgp18x700241 · Cited by 403 · see citing works
Differences in handgrip strength protocols to identify sarcopenia and frailty - a systematic review
Sousa‐Santos, A. R., & do Amaral, T. F. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0625-y · Cited by 273 · see citing works
Current and emerging biomarkers of frailty in the elderly
Saedi, A. A., Feehan, J., Phu, S., & Duque, G. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s168687 · Cited by 179 · see citing works
Hypogonadism and male obesity: Focus on unresolved questions
Grossmann, M. (2018) · Clinical Endocrinology · doi:10.1111/cen.13723 · Cited by 164 · see citing works
Aromatase inhibitors in men: effects and therapeutic options
de Ronde, W., & de Jong, F. H. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-93 · Cited by 155 · see citing works
Therapeutic Interventions for Frail Elderly Patients: Part I. Published Randomized Trials
Bibas, L., Levi, M., Bendayan, M., Mullie, L., Forman, D. E., & Afilalo, J. (2014) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2014.07.004 · Cited by 150 · see citing works
Strandberg, T. E., Pitkälä, K. H., & Tilvis, R. S. (2011) · European Geriatric Medicine · doi:10.1016/j.eurger.2011.08.003 · Cited by 129 · see citing works
Kenny, A. M., Boxer, R. S., Kleppinger, A., Brindisi, J., Feinn, R., & Burleson, J. A. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03019.x · Cited by 125 · see citing works
Macdonald, S. H.-F., Travers, J., Shé, É. N., Bailey, J., Romero‐Ortuño, R., Keyes, M., O’Shea, D., & Cooney, M. T. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228821 · Cited by 104 · see citing works
Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly people
Evans, J. G., Malouf, R. S., Huppert, F. A., & van Niekerk, J. K. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006221 · Cited by 99 · see citing works
Liu, D., Si, H., Reynolds, K. A., Wei, Z. C., Jia, Z., & Dillon, J. S. (2007) · Endocrinology · doi:10.1210/en.2006-1378 · Cited by 98 · see citing works
Sex hormones and sarcopenia in older persons
Maggio, M. G., Lauretani, F., & Ceda, G. P. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835b6044 · Cited by 91 · see citing works
The association between dehydroepiandosterone and frailty in older men and women
Voznesensky, M., Walsh, S., Dauser, D., Brindisi, J., & Kenny, A. M. (2009) · Age and Ageing · doi:10.1093/ageing/afp015 · Cited by 88 · see citing works
Sex Steroid Hormone Levels and Body Composition in Men
Gates, M. A., Mekary, R. A., Chiu, G. R., Ding, E. L., Wittert, G., & de Araújo, A. B. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2582 · Cited by 84 · see citing works
A High Serum Cortisol/DHEA-S Ratio Is a Risk Factor for Sarcopenia in Elderly Diabetic Patients
Yanagita, I., Fujihara, Y., Kitajima, Y., Tajima, M., Honda, M., Kawajiri, T., Eda, T., Yonemura, K., Yamaguchi, N., Asakawa, H., et al. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2018-00271 · Cited by 67 · see citing works
Burnett‐Bowie, S. M., Roupenian, K. C., Dere, M. E., Lee, H., & Leder, B. Z. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03327.x · Cited by 73 · see citing works
Might DHEA be Considered a Beneficial Replacement Therapy in the Elderly?
Genazzani, A. D., Lanzoni, C., & Genazzani, A. R. (2007) · Drugs & Aging · doi:10.2165/00002512-200724030-00001 · Cited by 69 · see citing works
Baker, W. L., Karan, S., & Kenny, A. M. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03410.x · Cited by 67 · see citing works
Gwyther, H., Campos, E. B., Apóstolo, J., Marcucci, M., Cano, A., & Holland, C. (2018) · Health Psychology Review · doi:10.1080/17437199.2018.1488601 · Cited by 56 · see citing works
Golpanian, S., DiFede, D. L., Pujol, M. V., Lowery, M. H., Levis-Dusseau, S., Goldstein, B. J., Schulman, I. H., Longsomboon, B., Wolf, A., Khan, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7727 · Cited by 49 · see citing works
Loves, S., de Jong, J., van Sorge, A., Telting, D., Tack, C. J., Hermus, A., Westerterp, K., & de Boer, H. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0190 · Cited by 45 · see citing works
Maggio, M. G., Lauretani, F., Vita, F., Basaria, S. S., Lippi, G., Buttò, V., Luci, M., Cattabiani, C., Ceresini, G., Verzicco, I., et al. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660062 · Cited by 44 · see citing works
Interventions targeting geriatric frailty: A systemic review
Lee, P.-H., Lee, Y., & Chan, D. (2012) · Journal of Clinical Gerontology and Geriatrics · doi:10.1016/j.jcgg.2012.04.001 · Cited by 43 · see citing works
Serum estradiol is associated with lean mass in elderly Swedish men
Vandenput, L., Mellström, D., Karlsson, M. K., ORWOLL, E. S., Labrie, F., Ljunggren, Ö., & Ohlsson, C. (2010) · European Journal of Endocrinology · doi:10.1530/eje-09-0696 · Cited by 38 · see citing works
Metabolic syndrome and sexual dysfunction
Chughtai, B. I., Lee, R. K., Te, A. E., & Kaplan, S. A. (2011) · Current Opinion in Urology · doi:10.1097/mou.0b013e32834b8681 · Cited by 37 · see citing works
Pharmaceutical Interventions for Frailty and Sarcopenia
Laosa, O., Alonso, C., Castro, M., & Rodríguez‐Mañas, L. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660705 · Cited by 29 · see citing works
Morley, J. E. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.07.008 · Cited by 29 · see citing works
Aging and Fountain-of-Youth Hormones
Stewart, P. M. (2006) · New England Journal of Medicine · doi:10.1056/nejme068189 · Cited by 29 · see citing works
Clinical Use of Aromatase Inhibitors in Adult Males
Tan, R., Guay, A. T., & Hellstrom, W. J. G. (2014) · Sexual Medicine Reviews · doi:10.1002/smrj.23 · Cited by 28 · see citing works
Therapeutic uses of aromatase inhibitors in men
de Ronde, W. (2007) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e328121aad2 · Cited by 26 · see citing works
Obesity, Body Composition, and Sex Hormones: Implications for Cardiovascular Risk
Singh, P., Covassin, N., Marlatt, K. L., Gadde, K. M., & Heymsfield, S. B. (2021) · Comprehensive physiology · doi:10.1002/cphy.c210014 · Cited by 43 · see citing works
Gonadal steroids and bone metabolism in men
Leder, B. Z. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32814db87b · Cited by 23 · see citing works
Obesity, Body Composition, and Sex Hormones: Implications for Cardiovascular Risk
Singh, P., Covassin, N., Marlatt, K. L., Gadde, K. M., & Heymsfield, S. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00200.x · Cited by 16 · see citing works
Frailty: A Core Geriatric Concept
Kim, K. (2010) · Journal of the Korean Geriatrics Society · doi:10.4235/jkgs.2010.14.1.1 · Cited by 16 · see citing works
Therapies for adrenal insufficiency
Oki, K., & Yamane, K. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.9.1283 · Cited by 17 · see citing works
Ohlsson, C., Nethander, M., Karlsson, M. K., Rosengren, B. E., Ribom, E. L., Mellström, D., & Vandenput, L. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3418 · Cited by 14 · see citing works
Fougère, B., Morley, J. E., Little, M. O., Barreto, P. D. S., Cesari, M., & Vellas, B. J. (2017) · The journal of nutrition health & aging · doi:10.1007/s12603-017-0987-z · Cited by 14 · see citing works
RetractedSabnis, G. J., Macedo, L. F., Goloubeva, O. G., Schayowitz, A., Zhu, Y., & Brodie, A. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.04.005 · Cited by 11 · see citing works
Lamberts, S. W. J., & van den Beld, A. W. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00027-7 · Cited by 10 · see citing works
Self-citationAndrogen therapy in non-gonadal disease
Handelsman, D. J. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139003353.018 · Cited by 9 · see citing works
Approaches to therapy and prevention of frailty in the light of contemporary medicine
Bujnowska–Fedak, M. M., Waligóra, J., D’Avanzo, B., Holland, C., & Kurpas, D. (2017) · Family Medicine & Primary Care Review · doi:10.5114/fmpcr.2017.69293 · Cited by 7 · see citing works
Testosterone and male rejuvenation
Helo, S., Thomas, P., & Tadros, N. N. (2019) · Panminerva Medica · doi:10.23736/s0031-0808.18.03513-9 · Cited by 5 · see citing works
Hernández‐Arteaga, E., González, M. H., Bonilla‐Jaime, H., Guevara, M. Á., & Ågmo, A. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146937 · Cited by 6 · see citing works
Lamberts, S. W. J. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00027-4 · Cited by 4 · see citing works
Self-citationZENGİN, M. N., Şahin, Y., & Çiftçi, O. (2023) · Journal of Reconstructive Urology · doi:10.5336/urology.2022-92478 · Cited by 3 · see citing works
González, M. H., Arteaga, E. H., Guevara, M. Á., Jaime, H. B., & Silva, M. A. (2020) · Salud Mental · doi:10.17711/sm.0185-3325.2020.003 · Cited by 3 · see citing works
Rabe, T., Hj, A., Albring, C., Bachmann, A., Bitzer, J., Blume‐Peytavi, U., Egarter, C., Hinney, B., Kentenich, H., König, K. G., et al. (2016) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 3 · see citing works
DHEA as a Putative Replacement Therapy in the Elderly
WATSON, R. R. (2011) · CRC Press eBooks · doi:10.1201/b11019-7 · Cited by 2 · see citing works
Nabipour, I., Ebeling, P. R., & Seibel, M. J. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.11.45 · Cited by 2 · see citing works
Interventions pour restaurer la masse musculaire du sujet âgé
Bonnefoy, M. (2008) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2008.04.002
Antiaging Medicine: What Should We Tell Our Patients?
Perls, T. T. (2010) · Aging Health · doi:10.2217/ahe.10.11
Androgens and the Skeleton – Humans
Leder, B. Z. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374602-3.00026-2
DHEA as a Putative Replacement Therapy in the Elderly
Genazzani, A. D., & Lanzoni, C. (2011) · CRC Press eBooks · doi:10.1201/b11019-4
Frailty and anabolic hormones in ageing men
O’Connell, M. D. L. (2011) · Research Explorer (The University of Manchester)
CHANGES IN FUNCTIONAL CAPACITY IN POSTMENOPAUSAL WOMEN ADHERING TO A MEDITERRANEAN DIET
Ardolino, E., Ramos, A. G., Hutchins-Wiese, H., Kerstetter, J. E., Bihuniak, J. D., Kleppinger, A., & Kenny, R. A. (2017) · Journal of Aging Research and Lifestyle · doi:10.14283/jarcp.2017.9
(2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f315ef
IGeL kritisch betrachtet: DHEA in der „Anti-Aging-Medizin”
Garrido, M. V., Erler, A., Beyer, M., & Otterbach, I. (2009) · Zeitschrift für Allgemeinmedizin · doi:10.1007/bf03652657
Male Hypogonadism and Fertility
Khalafalla, K. M., de Souza, R. P., Ohlander, S. J., & NIEDERBERGER, C. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-31501-5_11
Männlicher Hypogonadismus und Fruchtbarkeit
Khalafalla, K. M., de Souza, R. P., Ohlander, S. J., & NIEDERBERGER, C. S. (2024) · Springer eBooks · doi:10.1007/978-3-031-65245-5_11
Bandura, A., Ďurina, P., Cambal, E., & Kečkéš, Š. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.107121
- Authors
- Muller, M., van den Beld, A. W., van der Schouw, Y. T., Grobbee, D. E., & Lamberts, S. W. J.
- Affiliations
- University Medical Center Utrecht (NL)
- Department of Internal Medicine (A.W.v.d.B., S.W.J.L.), Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
- Julius Center for Health Sciences and Primary Care (M.M., Y.T.v.d.S., D.E.G.) 3508 GA Utrecht, The Netherlands
- Erasmus MC (NL)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-10-01
- Volume
- 91
- Issue
- 10
- Pages
- 3988-3991
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1977616846
- Cited by
- 62
- References
- 23
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 3 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- dehydroepiandrosterone, hormone replacement therapy, frailty, older men, androgen deficiency, grip strength, leg extensor power, physical performance, muscle strength, lean body mass
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Androstenedione, Dehydroepiandrosterone, Double-Blind Method, Humans, Male, Testosterone, Bone Density, Frail Elderly, Hormone Replacement Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
