Cited by 116Hormonal and reproductive studiesMuscle metabolism and nutritionNutrition and Health in Aging

DHEA enhances effects of weight training on muscle mass and strength in elderly women and men

Villareal, Dennis T., Holloszy, John O.·2006·American Journal of Physiology-Endocrinology and Metabolism

Abstract

The plasma levels of dehydroepiandrosterone (DHEA) and its sulfated form (DHEAS) decline approximately 80% between the ages of 25 and 75 yr. Muscle mass and strength also decrease with aging. Published data on the effects of DHEA replacement on muscle mass and strength are conflicting. The goals of this study were to determine whether DHEA replacement increases muscle mass and strength and/or enhances the effects of heavy resistance exercise in elderly women and men. We conducted a randomized, double-blind, placebo-controlled study of the effects of 10 mo of DHEA replacement therapy with the addition of weightlifting exercise training during the last 4 mo of the study (DHEA + exercise group, n = 29; placebo + exercise group, n = 27). DHEA alone for 6 mo did not significantly increase strength or thigh muscle volume. However, DHEA therapy potentiated the effect of 4 mo of weightlifting training on muscle strength, evaluated by means of one-repetition maximum measurement and Cybex dynamometry, and on thigh muscle volume, measured by magnetic resonance imaging. Serum insulin-like growth factor concentration increased in response to DHEA replacement. This study provides evidence that DHEA replacement has the beneficial effect of enhancing the increases in muscle mass and strength induced by heavy resistance exercise in elderly individuals.

Integrity signals

Registry

Crossref · 10.1152/ajpendo.00100.2006

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

2 of the 45 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Villareal, D. T., & Holloszy, J. O.
Affiliations
Washington University in St. Louis (US)
Venue
American Journal of Physiology-Endocrinology and Metabolism
Published
2006-11
Volume
291
Issue
5
Pages
E1003-E1008
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
OpenAlex
W2149642946
Cited by
116
References
45
Citations by year
2026: 4 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 12 · 2020: 7 · 2019: 2 · 2018: 10 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 9 · 2012: 5
FWCI
4.30
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (P60AG013629, AG-13629, AG20076, R01AG020076)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK20579, DK56341, P30DK056341)
  • National Center for Research Resources (K23 RR16191, K23RR016191, RR.00036)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
dehydroepiandrosterone, DHEA replacement therapy, dehydroepiandrosterone sulfate, resistance training, weight training, muscle mass, muscle strength, aging, older adults, insulin-like growth factor, thigh muscle volume, sex differences
MeSH terms
Adjuvants, Immunologic, Aged, Aging, Dehydroepiandrosterone, Female, Humans, Insulin-Like Growth Factor I, Magnetic Resonance Imaging, Male, Muscle Contraction, Thigh, Exercise, Muscle, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review