DHEA enhances effects of weight training on muscle mass and strength in elderly women and men
Abstract
The plasma levels of dehydroepiandrosterone (DHEA) and its sulfated form (DHEAS) decline approximately 80% between the ages of 25 and 75 yr. Muscle mass and strength also decrease with aging. Published data on the effects of DHEA replacement on muscle mass and strength are conflicting. The goals of this study were to determine whether DHEA replacement increases muscle mass and strength and/or enhances the effects of heavy resistance exercise in elderly women and men. We conducted a randomized, double-blind, placebo-controlled study of the effects of 10 mo of DHEA replacement therapy with the addition of weightlifting exercise training during the last 4 mo of the study (DHEA + exercise group, n = 29; placebo + exercise group, n = 27). DHEA alone for 6 mo did not significantly increase strength or thigh muscle volume. However, DHEA therapy potentiated the effect of 4 mo of weightlifting training on muscle strength, evaluated by means of one-repetition maximum measurement and Cybex dynamometry, and on thigh muscle volume, measured by magnetic resonance imaging. Serum insulin-like growth factor concentration increased in response to DHEA replacement. This study provides evidence that DHEA replacement has the beneficial effect of enhancing the increases in muscle mass and strength induced by heavy resistance exercise in elderly individuals.
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DHEA is not changed by exercise training in elderly subjects.
“However, like the response of T to exercise training, DHEA is not altered following exercise training in elderly subjects.”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [228]
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- Authors
- Villareal, D. T., & Holloszy, J. O.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Villareal, Dennis T.
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2006-11
- Volume
- 291
- Issue
- 5
- Pages
- E1003-E1008
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2149642946
- Cited by
- 116
- References
- 45
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 12 · 2020: 7 · 2019: 2 · 2018: 10 · 2017: 4 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 9 · 2012: 5
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P60AG013629, AG-13629, AG20076, R01AG020076)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK20579, DK56341, P30DK056341)
- National Center for Research Resources (K23 RR16191, K23RR016191, RR.00036)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- dehydroepiandrosterone, DHEA replacement therapy, dehydroepiandrosterone sulfate, resistance training, weight training, muscle mass, muscle strength, aging, older adults, insulin-like growth factor, thigh muscle volume, sex differences
- MeSH terms
- Adjuvants, Immunologic, Aged, Aging, Dehydroepiandrosterone, Female, Humans, Insulin-Like Growth Factor I, Magnetic Resonance Imaging, Male, Muscle Contraction, Thigh, Exercise, Muscle, Skeletal
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