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Cited by 290

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Electrophysiologic and Anatomic Characterization of Sites Resistant to Electrical Isolation During Circumferential Pulmonary Vein Ablation for Atrial Fibrillation: A Prospective Study

KISTLER, PETER M., HO, SIEW YEN, RAJAPPAN, KIM, MORPER, MICHAEL, HARRIS, STUART, ABRAMS, DOMINIC, SPORTON, SIMON C., SCHILLING, RICHARD J.·2007·Journal of Cardiovascular Electrophysiology

Abstract

Background: Catheter ablation (CA) by wide encirclement of pulmonary veins (WEPV) restores sinus rhythm in up to 95%. Complex PV–left atrial (LA) connections make achieving electrical isolation (EI) challenging. We examined anatomical and technical features associated with resistance to EI during WEPV in a prospective study. Methods: One hundred one consecutive patients with symptomatic AF underwent first‐time CA guided by electroanatomic mapping and CT integration (Cartomerge™). Following double‐transseptal access, WEPV was performed. After completion of PV encirclement, the line was mapped and where no signal could be obtained, CA was performed inside the WE line at the site of earliest PV breakthrough on the circular mapping catheter. Sites of EI were tagged. Anatomic studies of corresponding regions of the venoatrial junction in 24 adult hearts were performed. Results: Sites resistant to EI were located at the inferior quadrant (P < 0.001) for the RSPV, superior quadrant (P < 0.001) for the RIPV, and the inferior and anterior quadrants (P < 0.001) for the LSPV. EI was significantly less frequent at the posterior quadrant (P < 0.001) for the LIPV. To achieve EI, CA was necessary inside the WE on the intervenous ridge on the right in 51% and on the left in 41%. The LPV/LAA ridge was investigated by anatomic studies that demonstrated considerable variation in the narrowest width (3–23.7 mm) and transmural thickness (1–5 mm). Conclusion: Sites of EI after WEPV have a preferential distribution determined by anatomic features. CA on the intervenous ridge is required in a significant proportion of patients to achieve EI. Atrial folds and ridges increase myocardial thickness creating technical and anatomic challenges for achieving transmural lesions.

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Metadata

Authors
KISTLER, P. M., HO, S. Y., RAJAPPAN, K., MORPER, M., HARRIS, S., ABRAMS, D., SPORTON, S. C., & SCHILLING, R. J.
Venue
Journal of Cardiovascular Electrophysiology
Publisher
Wiley
Published
2007-10-25
Volume
18
Issue
12
Pages
1282-1288
ISSN
  • 1045-3873 (ISSN-L)
  • 1540-8167
OpenAlex
W1988616809
Cited by
290
References
22
FWCI
15.34
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Electrophysiologic and Anatomic Characterization of Sites Resistant to Electrical Isolation During Circumferential Pulmonary Vein Ablation for Atrial Fibrillation: A Prospective Study. https://app.cochat.ai/papers/10.1111/j.1540-8167.2007.00981.x
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KISTLER, P. M., HO, S. Y., RAJAPPAN, K., MORPER, M., HARRIS, S., ABRAMS, D., SPORTON, S. C., & SCHILLING, R. J. (2007). Electrophysiologic and Anatomic Characterization of Sites Resistant to Electrical Isolation During Circumferential Pulmonary Vein Ablation for Atrial Fibrillation: A Prospective Study. Journal of Cardiovascular Electrophysiology. https://doi.org/10.1111/j.1540-8167.2007.00981.x

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