Rhodiola rosea : A Versatile Adaptogen
Open accessAbstract
Rhodiola rosea (rose root) belonging to the family Crassulaceae is a popular medicinal plant in Russia, Scandinavia, and many other countries. Extracts of the roots of this plant have been found to favorably affect a number of physiological functions including neurotransmitter levels, central nervous system activity, and cardiovascular function. It is being used to stimulate the nervous system, decrease depression, enhance work performance, eliminate fatigue, and prevent high-altitude sickness. Most of these effects have been ascribed to constituents such as salidroside (rhodioloside), rosavins, and p-tyrosol. It has also been found to be a strong antioxidant and anticarcinogen due to the presence of several phenolic compounds. Adaptogens are plant extracts that allow an organism to counteract adverse physical, chemical, and biological stressors by generating nonspecific resistance. Adaptogens are known to increase the availability of energy during the day, reduce stressed feelings, increase endurance, and increase mental alertness. This multipurpose medicinal plant (R. rosea), with adaptogenic properties that increase the body's nonspecific resistance and normalize functions, has been traditionally grown and used in Russia and Mongolia. Due to increasing consumer demands toward natural health products and the growing interests in the secondary metabolites of plants and their application in biotechnology and therapy, much focus has been put on the rose root and its medical properties. The rose root imparts normalizing influences on adverse physical, chemical, and biological disturbances but is otherwise innocuous. In India, the plant has been growing wild in the high altitudes of the Himalayas. The Defence Research and Development Organization in India has taken on the responsibilities of its conservation, as well as the development of multiple management practices and the development of health foods, supplements, and nutraceuticals in India.
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The main phenylethanol derivatives of Rhodiola rosea are salidroside, para-tyrosol, and phenylpropanoid-rosavin, and these are responsible for its adaptogenic and ergogenic effects.
“The main phenylethanol derivatives are salidroside (rhodioloside), para-tyrosol, and phenylpropanoid-rosavin. These are also responsible for the adaptogenic and ergogenic effects of Rhodiola rosea [8,73,75].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [75]
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Cites
Cortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653 · see citing works
Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J., & Bickford, P. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08114.1999 · Cited by 980 · see citing works
New Substances of Plant Origin Which Increase Nonspecific Resistance
Brekhman, I. I., & Dardymov, I. V. (1969) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.09.040169.002223 · Cited by 595 · cited 1× · see citing works
“Salidroside (rhodioloside), the additional salidroside-like glycoside compounds (rhodiolin, rosin, rosavin, rosarin, and rosiridin), and p-tyrosol have been believed to be the most critical plant constituents needed for therapeutic activity ( Brekhman and Dardymov 1969; Petkov and others 1986).”
BackgroundOlive oil phenolics are dose‐dependently absorbed in humans
Visioli, F., Galli, C., Bornet, F. R. J., Mattei, A., Patelli, R., Galli, G., & Caruso, D. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01216-3 · Cited by 375 · see citing works
Darbinyan, V., Kteyan, A., Panossian, A. G., Gabrielian, E. S., Wikman, G., & Wagner, H. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80055-0 · Cited by 276 · see citing works
Спасов, А. А., Wikman, G., Мандриков, В. Б., Mironova, I. A., & Neumoin, V. V. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80078-1 · Cited by 232 · see citing works
Plant adaptogens III. Earlier and more recent aspects and concepts on their mode of action
Panossian, A., Wikman, G., & Wagner, H. (1999) · Phytomedicine · doi:10.1016/s0944-7113(99)80023-3 · Cited by 211 · see citing works
Ohsugi, M., Fan, W., Hase, K., et al. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00245-1 · Cited by 149 · see citing works
Volatiles from rhizomes of Rhodiola rosea L.
Rohloff, J. (2002) · Phytochemistry · doi:10.1016/s0031-9422(02)00004-3 · Cited by 98 · see citing works
Antioxidative phenolic compounds from the roots ofRhodiola sachalinensis A. Bor
Lee, M. W., Lee, Y. A., Park, H. M., et al. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02976571 · Cited by 98 · see citing works
Linh, P. T., Kim, Y. H., Hong, S. P., et al. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02975446 · Cited by 92 · see citing works
Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory.
Petkov, V. D., Yonkov, D. I., Mosharrof, A. H., Kambourova, T., Alova, L. G., Vv, P., & Todorov, I. (1986) · PubMed · Cited by 92 · see citing works
Investigations on oxidative stress and therapeutical implications in dementia
Durany, N., Münch, G. W., Michel, T. M., & Riederer, P. F. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/pl00014177 · Cited by 88 · see citing works
Удинцев, С. Н., & Schakhov, V. P. (1991) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(91)90323-6 · Cited by 67 · see citing works
Boon-Niermeijer, E. K., van den Berg, A. J. J., Wikman, G., & Wiegant, F. A. C. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80060-4 · Cited by 51 · see citing works
Petkov, V. D., Stancheva, S. L., Tocuschieva, L., & Petkov, V. V. (1990) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(90)90598-g · Cited by 47 · see citing works
Mb, L., Petkov, V. D., Vl, M., et al. (1986) · PubMed · Cited by 38 · see citing works
[Plasma beta-endorphin and stress hormones in stress and adaptation].
Lishmanov, I. B., Trifonova, Z. V., Tsibin, A. N., Maslova, L. V., & Dement'eva, L. A. (1987) · PubMed · Cited by 29 · see citing works
[Antioxidant properties of a series of extracts from medicinal plants].
Bol'shakova, I. V., Lozovskaia, E. L., & Sapezhinskiĭ, I. I. (1997) · PubMed · Cited by 27 · see citing works
[Effect of Rhodiola rosea on the yield of mutation alterations and DNA repair in bone marrow cells].
Salikhova, R. A., Александрова, И. В., Vk, M., et al. (1998) · PubMed · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 7
- Gerasimova HD. 1970. Effect of Rhodiola rosea extract on ovarian functional ac- tivity. Proc of Scientific Conference on Endocrinology and Gynecology; Sverd- lovsk, Russia; 1970 Sept 15-6. Siberia, Russia: Siberian Branch of the Russian Academy of Sciences. p 46-8.
- Krasik ED, Morozova ES, Petrova KP, Ragulina GA, Shemetova LA, Shuvaev VP. 1970. Therapy of asthenic conditions: clinical perspectives of application of Rhodiola rosea extract (golden root). In: Proceedings modern problems in psycho- pharmacology. Kemerovo, Russia; 27-9 May 1070; Siberian Branch of Russian Academy of Sciences. p 298-330.
- Krylov GV. 1969. Herbs for Life. Novosibirsk, Russia: Academic Press. p 264.
- Kurkin VA, Zapesochnaya GG. 1985. Chemical composition and pharmacological characteristics of Rhodiola rosea [review]. J Med Plants (Moscow) 1985:1231- 445.
- Kurkin VA, Zapesochnaya GG. 1986. Chemical composition and pharmacological properties of Rhodiola rosea. Chem Pharm J (Moscow) 20(10):1231-44.
- Saratikov AS, Krasnov EA. 1987. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State Univ. Press.
- Stancheva SL, Mosharrof A. 1987. Effect of the extract of Rhodiola rosea L. on the content of the brain biogenic monoamines. Med Physiol Comp Rend Acad Bulg Sci 40(6):85-7.
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Panossian, A. G., Efferth, T., Shikov, A. N., Pozharitskaya, O. N., Kuchta, K., Mukherjee, P. K., Banerjee, S., Heinrich, M., Wu, W., Guo, D., et al. (2021) · Medicinal Research Reviews · doi:10.1002/med.21743 · Cited by 347 · see citing works
Plant Adaptogens—History and Future Perspectives
Todorova, V., Ivanov, K., Delattre, C., Nalbantova, V., Karcheva-Bahchevanska, D., & Ivanova, S. (2021) · Nutrients · doi:10.3390/nu13082861 · Cited by 121 · see citing works
Huang, S.-C. (2009) · The Chinese Journal of Physiology · doi:10.4077/cjp.2009.amh029 · Cited by 73 · see citing works
Spanakis, M., Bakaros, E., Papadopoulou, S.-N., Fournaraki, A., & Symvoulakis, E. K. (2025) · Pharmacoepidemiology · doi:10.3390/pharma4040022 · Cited by 6 · see citing works
- Authors
- Khanum, F., Bawa, A. S., & Singh, B.
- Affiliations
- Defence Food Research Laboratory (IN)
- ORCID
- Khanum, Farhath
- Venue
- Comprehensive Reviews in Food Science and Food Safety
- Publisher
- Wiley
- Published
- 2005-07
- Volume
- 4
- Issue
- 3
- Pages
- 55-62
- ISSN
- 1541-4337 (ISSN-L)
- OpenAlex
- W2071960728
- Cited by
- 124
- References
- 20
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 14 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 3
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Comprehensive Reviews in Food Science and Food Safety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- Rhodiola rosea, adaptogens, medicinal plants, salidroside, rosavin, p-tyrosol, antioxidant activity, anticarcinogenic activity, phenolic compounds, stress tolerance, fatigue, depression, altitude sickness, nutraceuticals, plant conservation, Himalaya
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