Attenuation of Long-Term Rhodiola rosea Supplementation on Exhaustive Swimming-Evoked Oxidative Stress in the Rat

Huang, Shih-Chung

doi:10.4077/cjp.2009.amh029

Cited by 73Medicinal Plants and Bioactive CompoundsExercise and Physiological ResponsesAntioxidant Activity and Oxidative Stress

Attenuation of Long-Term Rhodiola rosea Supplementation on Exhaustive Swimming-Evoked Oxidative Stress in the Rat

Huang, Shih-Chung·2009·The Chinese Journal of Physiology

DOI 10.4077/cjp.2009.amh029

Open this paper in CoChat — free account

Abstract

Rhodiola rosea improves exercise endurance and fatigue. We hypothesized that ingredients in Rhodiola rosea may increase antioxidant capability against swimming induced oxidative stress. In this study, we have identified the Rhodiola rosea ingredients, p-tyrosol, salidroside, rosin, rosavin and rosarin by high performance liquid chromatography-mass spectrometer and evaluated their O2(-)*, H2O2, and HOCl scavenging activities by a chemiluminescence analyzer. We next explored the effect and mechanism of Rhodiola rosea on 90-min swimming-induced oxidative stress in male Wistar rats fed with three doses of Rhodiola rosea extracts in drinking water (5, 25, 125 mg/day/rat) for 4 weeks. Our results showed that the 4 major ingredients (salidroside, rosin, rosavin and rosarin) from Rhodiola rosea extracts scavenged O2(-)*, H2O2, and HOCl activity in a dose-dependent manner. The ninety-min swimming exercise increased the O2(-)* production in the order: liver > skeletal muscle > blood, indicating that liver is the most sensitive target organ. The level of plasma malonedialdehyde, a lipid peroxidation product, was also increased after exercise. Treatment of 4 weeks of Rhodiola rosea extracts significantly inhibited swimming exercise-enhanced O2(-)* production in the blood, liver and skeletal muscle and plasma malonedialdehyde concentration. The expression in Mn-superoxide dismutase Cu/Zn-superoxide dismutase, and catalase in livers were all enhanced after 4 weeks of Rhodiola rosea supplementation especially at the dose of 125 mg/day/rat. Treatment of Rhodiola rosea extracts for 4 weeks significantly increased swimming performance. In conclusion, treatment of Rhodiola rosea extracts for 4 weeks could reduce swimming-enhanced oxidative stress possibly via the reactive oxygen species scavenging capability and the enhancement of the antioxidant defense mechanisms.

Integrity signals

Registry

Crossref · 10.4077/cjp.2009.amh029

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Rhodiola is known to reduce physical and mental fatigue, improve cognitive function, and exert antidiabetic effects.
“Rhodiola is known to reduce physical and mental fatigue, improve cognitive function, and exert antidiabetic effects.”
From Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis and mechanical power in rats (2020) · cites this paper as [7]
Rhodiola was administered for its adaptogenic activity under strenuous physical effort, delaying fatigue and exerting metabolic effects such as promoting fatty acid utilization.
“In our experiments, Rhodiola was administered owing to its adaptogenic activity under strenuous physical effort, delaying fatigue and exerting metabolic effects such as promoting fatty acid utilization [7].”
From Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis and mechanical power in rats (2020) · cites this paper as [7]
Rhodiola is used to improve cognitive function and endurance performance, reduce mental fatigue and reactive oxygen species production, and exert antidiabetic effects.
“Rhodiola is used to improve cognitive function and endurance performance, reduce mental fatigue and reactive oxygen species (ROS) production, and exert antidiabetic effects [7].”
From Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis and mechanical power in rats (2020) · cites this paper as [7]
Rhodiola could improve the consumption of substrates, enhancing lipid oxidation and sparing glycogen.
“Thus, Rhodiola could improve the consumption of substrates, enhancing lipid oxidation and sparing glycogen [7].”
From Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis and mechanical power in rats (2020) · cites this paper as [7]

Free radicals and tissue damage produced by exercise
Davies, K. J. A., Quintanilha, A. T., Brooks, G. A., & Packer, L. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80124-1 · Cited by 1,739 · see citing works
[39] Assay for blood plasma or serum
Yagi, K. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05042-4 · Cited by 776 · see citing works
Systemic adaptation to oxidative challenge induced by regular exercise
Radak, Z., Chung, H. Y., & Goto, S. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.029 · Cited by 623 · see citing works
Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice
Kim, S. H., Hyun, S. H., & Choung, S. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.08.059 · Cited by 502 · see citing works
Decreasing xanthine oxidase‐mediated oxidative stress prevents useful cellular adaptations to exercise in rats
Gómez‐Cabrera, M. C., Borrás, C., Pallardó, F. V., Sastre, J., Ji, L. L., & Viña, J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080564 · Cited by 477 · see citing works
Aging and acute exercise enhance free radical generation in rat skeletal muscle
Bejma, J., & Ji, L. L. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.465 · Cited by 445 · see citing works
Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil
Polavarapu, R., Spitz, D. R., Sim, J. E., Follansbee, M. H., Oberley, L. W., Rahemtulla, A., & Nanji, A. A. (1998) · Hepatology · doi:10.1002/hep.510270518 · Cited by 301 · see citing works
Acute exercise activates nuclear factor (NF)‐ΚB signaling pathway in rat skeletal muscle
Ji, L. L., Gómez‐Cabrera, M. C., Steinhafel, N. W., & Viña, J. (2004) · The FASEB Journal · doi:10.1096/fj.04-1846com · Cited by 279 · see citing works
Rhodiola rosea in stress induced fatigue — A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty
Darbinyan, V., Kteyan, A., Panossian, A. G., Gabrielian, E. S., Wikman, G., & Wagner, H. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80055-0 · Cited by 276 · see citing works
Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells
Zhang, L., Yu, H., Sun, Y., Lin, X., Chen, B., Tan, C., Cao, G.-X., & Wang, Z. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.089 · Cited by 262 · see citing works
A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen
Спасов, А. А., Wikman, G., Мандриков, В. Б., Mironova, I. A., & Neumoin, V. V. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80078-1 · Cited by 232 · see citing works
De Novo Demonstration and Co-localization of Free-Radical Production and Apoptosis Formation in Rat Kidney Subjected to Ischemia/Reperfusion
Chiang‐Ting, C., Lee, P., Chen, C., Ma, M., Lai, M., & Hsu, S.-M. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v125973 · Cited by 220 · see citing works
A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work
Шевцов, В. А., Zholus, B. I., Shervarly, V. I., Vol'skij, V. B., Korovin, Y. P., Khristich, M. P., Roslyakova, N. A., & Wikman, G. (2003) · Phytomedicine · doi:10.1078/094471103321659780 · Cited by 201 · see citing works
Rhodiola rosea: A Phytomedicinal Overview
Brown, R. P., Gerbarg, P. L., & Ramazanov, Z. (2006) · Cited by 199 · see citing works
Age‐associated increases in oxidative stress and nuclear transcription factor κB activation are attenuated in rat liver by regular exercise
Radak, Z. O., Chung, H. Y., Naıto, H., Takahashi, R., Jung, K. J., Kim, H., & Goto, S. (2004) · The FASEB Journal · doi:10.1096/fj.03-0509fje · Cited by 173 · see citing works
Superoxide dismutase derivative reduces oxidative damage in skeletal muscle of rats during exhaustive exercise
Radak, Z. O., Asano, K., Inoue, M., et al. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.1.129 · Cited by 158 · see citing works
Acute Rhodiola Rosea Intake Can Improve Endurance Exercise Performance
De Bock, K., Eijnde, B. O., Ramaekers, M., & Hespel, P. (2004) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.14.3.298 · Cited by 149 · see citing works
Rhodiola rosea : A Versatile Adaptogen
Khanum, F., Bawa, A. S., & Singh, B. (2005) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2005.tb00073.x · Cited by 124 · see citing works
Effect of Extracts from Rhodiola Rosea and Rhodiola Crenulata (Crassulaceae) Roots on ATP Content in Mitochondria of Skeletal Muscles
Abidov, M. T., Crendal, F., Grachev, S. V., Сейфулла, Р. Д., & Ziegenfuss, T. N. (2003) · Bulletin of Experimental Biology and Medicine · doi:10.1023/b:bebm.0000020211.24779.15 · Cited by 119 · see citing works
Chronic green tea extract supplementation reduces hemodialysis-enhanced production of hydrogen peroxide and hypochlorous acid, atherosclerotic factors, and proinflammatory cytokines
Hsu, S., Wu, M., Yang, C.-C., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1539 · Cited by 117 · see citing works
Adenovirus-Mediated bcl-2 Gene Transfer Inhibits Renal Ischemia/Reperfusion Induced Tubular Oxidative Stress and Apoptosis
Chiang-Ting, C., Chang, T.-C., Ching-Yi, T., Shyue, S., & Ming-Kuen, L. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2005.00826.x · Cited by 114 · see citing works
Bioactive compounds fromRhodiola rosea (Crassulaceae)
Ming, D. S., Hillhouse, B. J., Guns, E. S. T., et al. (2005) · Phytotherapy Research · doi:10.1002/ptr.1597 · Cited by 112 · see citing works
Analysis of the Marker Compounds of Rhodiola rosea L. (Golden Root) by Reversed Phase High Performance Liquid Chromatography.
Ganzera, M., Akgül, Y., & Khan, I. A. (2001) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.49.465 · Cited by 103 · see citing works
Quantitative determination of salidroside and tyrosol from the underground part ofRhodiola rosea by high performance liquid chromatography
Linh, P. T., Kim, Y. H., Hong, S. P., et al. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02975446 · Cited by 92 · see citing works
Bioactive Constituents from Chinese Natural Medicines. XXVI. Chemical Structures and Hepatoprotective Effects of Constituents from Roots of Rhodiola sachalinensis
Nakamura, S., Li, X., Matsuda, H., et al. (2007) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.55.1505 · Cited by 79 · see citing works
[Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine].
Kučinskaitė, A., Briedis, V., & Savickas, A. (2004) · PubMed · Cited by 77 · see citing works
Lycopene supplementation attenuated xanthine oxidase and myeloperoxidase activities in skeletal muscle tissues of rats after exhaustive exercise
Liu, C.-C., Huang, C., Lin, W., Hsieh, C.-C., Huang, S., Lin, S.-J., & Yang, S. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051541 · Cited by 73 · see citing works
Self-citation
Rhodiola rosea as antioxidant in red blood cells: ultrastructural and hemolytic behaviour.
Battistelli, M., Sanctis, R. D., Bellis, R. D., Cucchiarini, L., Dachà, M., & Gobbi, P. (2005) · PubMed · doi:10.4081/951 · Cited by 73 · see citing works
In vitro protective effect of Rhodiola rosea extract against hypochlorous acid‐induced oxidative damage in human erythrocytes
Sanctis, R. D., Bellis, R. D., Scesa, C., Mancini, U., Cucchiarini, L., & Dachà, M. (2004) · BioFactors · doi:10.1002/biof.5520200304 · Cited by 72 · see citing works
Superoxide dismutase derivative prevents oxidative damage in liver and kidney of rats induced by exhausting exercise
k, Z. R., Asano, K., Inoue, M., Kizaki, T., Oh‐ishi, S., Suzuki, K., Taniguchi, N., & Ohno, H. (1996) · European Journal of Applied Physiology · doi:10.1007/bf00838637 · Cited by 69 · see citing works
Phytochemical and analytical studies of extracts from Rhodiola rosea and Rhodiola quadrifida
Wiedenfeld, H., Думаа, М., Malinowski, M., et al. (2007) · Die Pharmazie · doi:10.31083/ph.2007.4.6664 · Cited by 65 · see citing works
Sympathetic vesicovascular reflex induced by acute urinary retention evokes proinflammatory and proapoptotic injury in rat liver
Yu, H., Lin, B., Lee, H.-S., Shun, C., Yang, C.-C., Lai, T.-Y., Chien, C., & Hsu, S.-M. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00223.2004 · Cited by 63 · see citing works
Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients
Huang, K., Yang, C.-C., Hsu, S., Lee, K.-T., Liu, H.-W., Morisawa, S., Otsubo, K., & Chien, C. (2006) · Kidney International · doi:10.1038/sj.ki.5001576 · Cited by 56 · see citing works
Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice
Kim, S. H., Hyun, S. H., & Choung, S. (2006) · BioFactors · doi:10.1002/biof.5520260306 · Cited by 55 · see citing works
Liver ultrastructure during acute stress.
Salas, M., Tuchweber, B., & Kourounakis, P. (1980) · Pathology, Research and Practice · doi:10.1016/s0344-0338(80)80052-5 · Cited by 48 · see citing works
Determination of p -tyrosol and salidroside in three samples of Rhodiola crenulata and one of Rhodiola kirilowii by capillary zone electrophoresis
Cui, S., Hu, X., Chen, X., et al. (2003) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-003-2045-4 · Cited by 47 · see citing works
Endurance exercise training inhibits activity of plasma GOT and liver caspase-3 of rats exposed to stress by induction of heat shock protein 70
Mikami, T., Sumida, S., Ishibashi, Y., et al. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00795.2002 · Cited by 43 · see citing works
Lack of Effect of Rhodiola or Oxygenated Water Supplementation on Hypoxemia and Oxidative Stress☆
Wing, S. L., Askew, E. W., Luetkemeier, M. J., et al. (2003) · Wilderness and Environmental Medicine · doi:10.1580/1080-6032(2003)014[0009:loeoro]2.0.co;2 · Cited by 40 · see citing works
Effect of Exercise Duration on Characteristics of Mitochondrial Population from Rat Liver
Venditti, P., Masullo, P., & Meo, S. D. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1269 · Cited by 34 · see citing works
Haemolysis caused by alterations of α- and β-spectrin after 10 to 35 min of severe exercise
Beneke, R., Bihn, D., Hütler, M., et al. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0010-y · Cited by 26 · see citing works
[Study on effects of salidroside on lipid peroxidation on oxidative stress in rat hepatic stellate cells].
Zhang, Y., & Liu, Y. (2005) · PubMed · Cited by 24 · see citing works

Flagged first, then by citations

Sorted by citations

Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men
Jówko, E., Sadowski, J., Długołęcka, B., Gierczuk, D., Opaszowski, B., & Cieśliński, I. (2018) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2016.05.005 · Cited by 68 · see citing works
Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise‐Induced Muscle Damage through Enhancement of Mitochondrial Quality Control
Dun, Y., Liu, S., Zhang, W., Xie, M., & Qiu, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8024857 · Cited by 46 · see citing works
Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis and mechanical power in rats
Roumanille, R., Vernus, B., Brioche, T., Descossy, V., Van Ba, C. T., Campredon, S., Philippe, A. G., Delobel, P., Bertrand-Gaday, C., Chopard, A., et al. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00390-5 · Cited by 26 · see citing works

Authors: Huang, S.-C.
Affiliations: Kuang Tien General Hospital (TW)
Corresponding author: Huang, Shih-Chung
ORCID: Huang, Shih-Chung
Venue: The Chinese Journal of Physiology
Publisher: Medknow
Published: 2009-10-01
Volume: 52
Issue: 5
Pages: 316-324
ISSN: 0304-4920 (ISSN-L)
DOI: 10.4077/cjp.2009.amh029
OpenAlex: W2162840353
Cited by: 73
References: 41
Citations by year: 2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 9 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 5 · 2012: 3
FWCI: 1.07
Type: journal article
Language: en
Open access: closed
Locations: The Chinese Journal of Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: Rhodiola rosea, oxidative stress, swimming training, antioxidant activity, salidroside, rosin, rosavin, rosarin, p-tyrosol, superoxide radical scavenging, hydrogen peroxide scavenging, hypochlorous acid scavenging, lipid peroxidation, malondialdehyde, superoxide dismutase, catalase, exercise endurance, fatigue
MeSH terms: Animals, Catalase, Dose-Response Relationship, Drug, Fatigue, Liver, Male, Malondialdehyde, Oxygen, Plant Extracts, Superoxide Dismutase, Swimming, Rats, Wistar, Oxidative Stress, Muscle, Skeletal, Dietary Supplements, Models, Animal, Rhodiola, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Attenuation of Long-Term Rhodiola rosea Supplementation on Exhaustive Swimming-Evoked Oxidative Stress in the Rat

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks