Cited by 980Phytochemicals and Antioxidant ActivitiesAntioxidants, Aging, Portulaca oleraceaGenetics, Aging, and Longevity in Model Organisms

Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation

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Joseph, James A., Shukitt-Hale, Barbara, Denisova, Natalia A., Bielinski, Donna, Martin, Antonio, McEwen, John J., Bickford, Paula C.·1999·The Journal of Neuroscience

Abstract

Ample research indicates that age-related neuronal-behavioral decrements are the result of oxidative stress that may be ameliorated by antioxidants. Our previous study had shown that rats given dietary supplements of fruit and vegetable extracts with high antioxidant activity for 8 months beginning at 6 months of age retarded age-related declines in neuronal and cognitive function. The present study showed that such supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters including: oxotremorine enhancement of K(+)-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal Ca(45) buffering in striatal synaptosomes, motor behavioral performance on the rod walking and accelerod tasks, and Morris water maze performance. These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, phytochemicals present in antioxidant-rich foods may be beneficial in reversing the course of neuronal and behavioral aging.

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Crossref · 10.1523/jneurosci.19-18-08114.1999

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  • Treatment with Spirulina-enriched diets reduces malondialdehyde (MDA) levels in aged rats.

    “It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [47]

  • Treatment with Spirulina-enriched diets ameliorates both spatial and motor learning in aged rats.

    “It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [47]

  • Treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels in aged rats.

    “It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [47]

  • Treatment with Spirulina-enriched diets reduces pro-inflammatory cytokines in aged rats.

    “It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [47]

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Research works printed but not linked: 1

  1. Ingram DK, Jucker M, Spangler E (1994) Behavioral manifestations of aging. In: Pathobiology of the aging rat, Vol 2 (Mohr U, Cungworth DL, Capen CC, eds), pp 149 -170. Washington: IL SI.

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Authors
Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J., & Bickford, P. C.
Affiliations
  • Tufts University (US)
  • Veterans Health Administration (US)
Venue
The Journal of Neuroscience
Published
1999-09-15
Volume
19
Issue
18
Pages
8114-8121
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2170836456
Cited by
980
References
81
Citations by year
2026: 7 · 2025: 9 · 2024: 15 · 2023: 18 · 2022: 22 · 2021: 22 · 2020: 29 · 2019: 32 · 2018: 25 · 2017: 40 · 2016: 48 · 2015: 46 · 2014: 41 · 2013: 45 · 2012: 65
FWCI
16.81
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Department of Agriculture
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
dietary supplementation, blueberry, spinach, strawberry, fruit and vegetable extracts, oxidative stress, antioxidants, neuronal aging, cognitive aging, motor behavior, dopamine release, striatum, GTPase activity, calcium buffering, Morris water maze, phytochemicals, neuroprotection
MeSH terms
Aging, Animals, Calcium, Cognition, Corpus Striatum, Dopamine, Fruit, Glutathione, Motor Activity, Neurons, Plant Extracts, Potassium, Psychomotor Performance, Rats, Inbred F344, Synaptosomes, Signal Transduction, Spinacia oleracea, Maze Learning, Dietary Supplements, Rats, In Vitro Techniques

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