Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation
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Ample research indicates that age-related neuronal-behavioral decrements are the result of oxidative stress that may be ameliorated by antioxidants. Our previous study had shown that rats given dietary supplements of fruit and vegetable extracts with high antioxidant activity for 8 months beginning at 6 months of age retarded age-related declines in neuronal and cognitive function. The present study showed that such supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters including: oxotremorine enhancement of K(+)-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal Ca(45) buffering in striatal synaptosomes, motor behavioral performance on the rod walking and accelerod tasks, and Morris water maze performance. These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, phytochemicals present in antioxidant-rich foods may be beneficial in reversing the course of neuronal and behavioral aging.
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Treatment with Spirulina-enriched diets reduces malondialdehyde (MDA) levels in aged rats.
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [47]
Treatment with Spirulina-enriched diets ameliorates both spatial and motor learning in aged rats.
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [47]
Treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels in aged rats.
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [47]
Treatment with Spirulina-enriched diets reduces pro-inflammatory cytokines in aged rats.
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [47]
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Nutrition, Brain Aging, and Neurodegeneration: Table 1.
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The beneficial effects of fruit polyphenols on brain aging
Lau, F. C., Shukitt-Hale, B., & Joseph, J. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.007 · Cited by 217 · see citing works
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Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice
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Regulation of NF-Κb Activity in Astrocytes: Effects of Flavonoids at Dietary-Relevant Concentrations
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- Authors
- Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J., & Bickford, P. C.
- Affiliations
- Tufts University (US)
- Veterans Health Administration (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-09-15
- Volume
- 19
- Issue
- 18
- Pages
- 8114-8121
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6782471
- OpenAlex
- W2170836456
- Cited by
- 980
- References
- 81
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 15 · 2023: 18 · 2022: 22 · 2021: 22 · 2020: 29 · 2019: 32 · 2018: 25 · 2017: 40 · 2016: 48 · 2015: 46 · 2014: 41 · 2013: 45 · 2012: 65
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- dietary supplementation, blueberry, spinach, strawberry, fruit and vegetable extracts, oxidative stress, antioxidants, neuronal aging, cognitive aging, motor behavior, dopamine release, striatum, GTPase activity, calcium buffering, Morris water maze, phytochemicals, neuroprotection
- MeSH terms
- Aging, Animals, Calcium, Cognition, Corpus Striatum, Dopamine, Fruit, Glutathione, Motor Activity, Neurons, Plant Extracts, Potassium, Psychomotor Performance, Rats, Inbred F344, Synaptosomes, Signal Transduction, Spinacia oleracea, Maze Learning, Dietary Supplements, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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