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The Cardiometabolic Syndrome and Sarcopenic Obesity in Older Persons
Abstract
The aging of the world's population is a major contributor to the growing prevalence of the cardiometabolic syndrome (CMS) because older persons are more affected by the constellation of cardiovascular risk factors that constitute the syndrome. The prevalence of CMS has been related to the increasing prevalence of obesity, which is growing progressively even among older age groups. Indeed, obesity and aging are 2 overlapping mounting public health problems. It is currently accepted that CMS predicts cardiovascular mortality and/or the development of type 2 diabetes mellitus, and this is also true in studies including older persons. CMS is further complicated by modifications in body composition and fat redistribution during aging; older adults are at higher risk for developing central obesity and sarcopenia or sarcopenic obesity, a condition characterized by an important reduction in lean body mass associated with obesity, linked to an increased production of inflammatory adipokines that may alter insulin sensitivity and muscle mass and strength. A better understanding of the pathophysiologic mechanisms of sarcopenic obesity may help to elucidate the complex relationship between CMS and mortality/morbidity in older adults.
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“On the other hand, the loss of muscle mass leads to less insulin-responsive target tissue, resulting in a severe condition of insulin resistance (12, 13).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [12]
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Metadata
- Authors
- Dominguez, L. J., & Barbagallo, M.
- Affiliations
- University of Palermo (IT)
- Corresponding author
- Dominguez, Ligia J.
- Venue
- Journal of the CardioMetabolic Syndrome
- Publisher
- Wiley
- Published
- 2007-06
- Volume
- 2
- Issue
- 3
- Pages
- 183-189
- ISSN
- 1559-4564 (ISSN-L)
- 1559-4572
- OpenAlex
- W2001276401
- Cited by
- 185
- References
- 61
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 8 · 2023: 16 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 23 · 2015: 23 · 2014: 15 · 2013: 12 · 2012: 10
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the CardioMetabolic Syndrome (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Keywords
- cardiometabolic syndrome, sarcopenic obesity, older adults, aging, obesity, sarcopenia, abdominal obesity, body composition, fat redistribution, adipokines, insulin sensitivity, type 2 diabetes, cardiovascular mortality, lean body mass
- MeSH terms
- Adipose Tissue, Aged, Aging, Body Composition, Cardiovascular Diseases, Humans, Insulin Resistance, Muscular Atrophy, Obesity, Inflammation Mediators, Metabolic Syndrome
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