Cited by 185Nutrition and Health in AgingDiabetes, Cardiovascular Risks, and LipoproteinsHIV-related health complications and treatments

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The Cardiometabolic Syndrome and Sarcopenic Obesity in Older Persons

Dominguez, Ligia J., Barbagallo, Mario·2007·Journal of the CardioMetabolic Syndrome

DOI 10.1111/j.1559-4564.2007.06673.x

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Abstract

The aging of the world's population is a major contributor to the growing prevalence of the cardiometabolic syndrome (CMS) because older persons are more affected by the constellation of cardiovascular risk factors that constitute the syndrome. The prevalence of CMS has been related to the increasing prevalence of obesity, which is growing progressively even among older age groups. Indeed, obesity and aging are 2 overlapping mounting public health problems. It is currently accepted that CMS predicts cardiovascular mortality and/or the development of type 2 diabetes mellitus, and this is also true in studies including older persons. CMS is further complicated by modifications in body composition and fat redistribution during aging; older adults are at higher risk for developing central obesity and sarcopenia or sarcopenic obesity, a condition characterized by an important reduction in lean body mass associated with obesity, linked to an increased production of inflammatory adipokines that may alter insulin sensitivity and muscle mass and strength. A better understanding of the pathophysiologic mechanisms of sarcopenic obesity may help to elucidate the complex relationship between CMS and mortality/morbidity in older adults.

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Authors: Dominguez, L. J., & Barbagallo, M.
Affiliations: University of Palermo (IT)
Corresponding author: Dominguez, Ligia J.
ORCID: Dominguez, Ligia J.
Barbagallo, Mario
Venue: Journal of the CardioMetabolic Syndrome
Publisher: Wiley
Published: 2007-06
Volume: 2
Issue: 3
Pages: 183-189
ISSN: 1559-4564 (ISSN-L)
1559-4572
DOI: 10.1111/j.1559-4564.2007.06673.x
OpenAlex: W2001276401
Cited by: 185
References: 61
Citations by year: 2026: 1 · 2025: 7 · 2024: 8 · 2023: 16 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 23 · 2015: 23 · 2014: 15 · 2013: 12 · 2012: 10
FWCI: 0.54
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 95 d)
Locations: Journal of the CardioMetabolic Syndrome (publishedVersion)
PubMed (publishedVersion)
Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Keywords: cardiometabolic syndrome, sarcopenic obesity, older adults, aging, obesity, sarcopenia, abdominal obesity, body composition, fat redistribution, adipokines, insulin sensitivity, type 2 diabetes, cardiovascular mortality, lean body mass
MeSH terms: Adipose Tissue, Aged, Aging, Body Composition, Cardiovascular Diseases, Humans, Insulin Resistance, Muscular Atrophy, Obesity, Inflammation Mediators, Metabolic Syndrome

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The Cardiometabolic Syndrome and Sarcopenic Obesity in Older Persons

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