Brain Responses To Visceral and Somatic Stimuli in Patients With Irritable Bowel Syndrome With and Without Fibromyalgia
Abstract
Objective Symptoms of irritable bowel syndrome (IBS) and fibromyalgia (FM) commonly coexist. We hypothesized that one of the mechanisms underlying this comorbidity is increased activation of brain regions concerned with the processing and modulation of visceral and somatic afferent information, in particular subregions of the anterior cingulate cortex (ACC). Methods Regional cerebral blood flow (rCBF) was assessed in age-matched female IBS (n = 10) and IBS + FM (n = 10) subjects using H(2)(15)O positron emission tomography during noxious visceral (rectal) and somatic pressure stimuli. Results GI symptom severity was significantly higher in the IBS patients compared with the IBS + FM patients (p Conclusion Chronic stimulus-specific enhancement of ACC responses to sensory stimuli in both syndromes may be associated with cognitive enhancement of either visceral (IBS) or somatic (IBS + FM) sensory input and may play a key pathophysiologic role in these chronic pain syndromes.
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FMS is considered a disorder of somatic hypersensitivity, while IBS is considered a disorder of visceral hypersensitivity.
“FMS is considered a disorder of somatic hypersensitivity, while IBS is considered a disorder of visceral hypersensitivity.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [31]
Female IBS patients with co-morbid FMS have increased sensitivity to somatic stimuli.
“Chang et al.31 reported that female IBS patients with co-morbid FMS have increased sensitivity to somatic stimuli, while those with IBS without FMS show a blunted response.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [31]
IBS patients without FMS show a blunted response to somatic stimuli.
“Chang et al.31 reported that female IBS patients with co-morbid FMS have increased sensitivity to somatic stimuli, while those with IBS without FMS show a blunted response.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [31]
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- Authors
- Chang, L., Berman, S., Mayer, E. A., Suyenobu, B., Derbyshire, S., Naliboff, B., Vogt, B., FitzGerald, L., & Mandelkern, M. A.
- Affiliations
- University of California, Los Angeles (US)
- University of Pittsburgh Medical Center (US)
- University of California, Irvine (US)
- Corresponding author
- Chang, Lin
- Venue
- American Journal of Gastroenterology
- Published
- 2003-06
- Volume
- 98
- Issue
- 6
- Pages
- 1354-1361
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2042213686
- Cited by
- 122
- References
- 9
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 2 · 2014: 8 · 2013: 5 · 2012: 3
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- irritable bowel syndrome, fibromyalgia, visceral pain, somatic pain, anterior cingulate cortex, regional cerebral blood flow, comorbid pain, rectal distension, pain unpleasantness, chronic pain syndromes
- MeSH terms
- Adult, Afferent Pathways, Brain, Cerebrovascular Circulation, Cognition, Colonic Diseases, Functional, Emotions, Evoked Potentials, Somatosensory, Female, Fibromyalgia, Gyrus Cinguli, Humans, Middle Aged, Pain, Pressure, Tomography, Emission-Computed, Comorbidity
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