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Cited by 130Hepatitis C virus researchHelicobacter pylori-related gastroenterology studiesPlant Virus Research Studies

Sexual transmission of HCV between spouses.

Open access
Tahan, Veysel, Karaca, Cetin, Yildirim, Beytullah, Bozbas, Aysun, Ozaras, Resat, Demir, Kadir, Avsar, Erol, Mert, Ali +7 more·2005·The American Journal of Gastroenterology
DOI 10.1111/j.1572-0241.2005.40879.x
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Abstract

BACKGROUND AND AIMS: The sexual transmission of hepatitis C virus (HCV) is debated. By excluding other risk factors, the role of sexual intercourse in the transmission could be detected more accurately. We screened HCV prevalence and risk factors in the spouses of chronic hepatitis C (CHC) patients and followed the seroconversion rate of anti-HCV negative spouses. PATIENTS AND METHODS: Six hundred spouses of CHC patients were recruited. The spouses' HCV risk factors were questioned and the spouses were tested for anti-HCV. The 216 spouses who were anti-HCV negative were checked annually for anti-HCV. RESULTS: Anti-HCV was positive in 12 of 600 (2%) of the spouses. Of the 12 anti-HCV positive spouses, 11 were HCV-RNA positive. Of anti-HCV positive and negative spouse groups, mean age was 52.3 +/- 9.8 and 49.8 +/- 12.4 yr; duration of marriage was 1521 +/- 506.7 and 1532.4 +/- 670.2 wk (p > 0.05); and the number of total sexual intercourse was 434 +/- 295 and 307 +/- 333 (p= 0.055), respectively. In our prospective study, none of the spouses developed anti-HCV seroconversion in mean 35.7 +/- 6.3 months and 257.9 +/- 72.2 sexual intercourse. CONCLUSIONS: Anti-HCV was found positive in 2% of the spouses. None of the seronegative spouses developed seroconversion in the 3-yr follow-up period. This is the first study that stresses the importance of the total number of sexual intercourse in sexual transmission (p= 0.055). Our results of special monogamous group with very limited risk factors support the role of number of total sexual intercourse in HCV transmission. However, the seroprevalence rate of the spouses was still within the upper limit of our country population.

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  • Incident HCV has not been demonstrated to occur among heterosexual couples followed over time.

    “Because incident HCV has not been demonstrated to occur among heterosexual couples followed over time (1334,1371–1373), condom use might not be necessary in such circumstances.”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1372]

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Authors
Tahan, V., Karaca, C., Yildirim, B., Bozbas, A., Ozaras, R., Demir, K., Avsar, E., Mert, A., Besisik, F., Kaymakoglu, S., Senturk, H., Cakaloglu, Y., Kalayci, C., Okten, A., & Tozun, N.
Affiliations
Istanbul University-Cerrahpaşa (TR)
ORCID
Venue
The American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-04
Volume
100
Issue
4
Pages
821-824
ISSN
  • 0002-9270 (ISSN-L)
  • 1572-0241
DOI
10.1111/j.1572-0241.2005.40879.x
OpenAlex
W1989327505
Cited by
130
References
25
Citations by year
2025: 1 · 2021: 1 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 10 · 2015: 5 · 2014: 11 · 2013: 6 · 2012: 10
FWCI
7.06
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • Dspace Repository (Marmara Üniversitesi) (submittedVersion)
  • Dspace Repository (Marmara Üniversitesi) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Virus Research Studies
Keywords
hepatitis C virus, sexual transmission, spouses, chronic hepatitis C, seroconversion, HCV seroprevalence, monogamous couples, HCV RNA
MeSH terms
Adolescent, Adult, Aged, Coitus, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Retrospective Studies, Risk, RNA, Viral, Sexually Transmitted Diseases, Turkey, Seroepidemiologic Studies, Spouses, Hepatitis C Antibodies, Hepatitis C, Chronic

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