Genetics of Irritable Bowel Syndrome

Saito, Yuri A.; Talley, Nicholas J.

doi:10.1111/j.1572-0241.2008.02048.x

Cited by 69Gastrointestinal motility and disordersGut microbiota and healthInfant Health and Development

Genetics of Irritable Bowel Syndrome

Open access

Saito, Yuri A., Talley, Nicholas J.·2008·The American Journal of Gastroenterology

DOI 10.1111/j.1572-0241.2008.02048.xPMC PMC3935287

Open this paper in CoChat — free account

Abstract

Irritable bowel syndrome (IBS) is one of the most common diagnoses made by gastroenterologists and primary care providers alike, and yet the underlying mechanism remains poorly understood. Family and twin studies suggest that IBS may have a genetic basis. Several candidate gene association studies have been performed, but thus far, they have failed to clearly identify an "IBS gene." Epidemiological studies are needed to facilitate phenotype definition and identify relevant environment risk factors that will need to factor in gene and environment interactions in all future genetic studies. As genetic research in IBS is relatively nascent, much opportunity, as well as many challenges, exists in identifying the genes responsible for IBS.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1572-0241.2008.02048.x

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Genetics, epigenetic changes, infection and early adverse life events may predispose an individual to developing IBS.
“Genetics, and epigenetic changes, infection and early adverse life events may predispose an individual to developing IBS, [25][26][27][28]”
From British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021) · cites this paper as [26]
The Abstract says family and twin studies suggest a genetic basis for IBS. The section “What in the Current State of Knowledge Is Lacking?” identifies infection and abuse as possible shared risk factors needing further study, but does not establish them as predisposing factors. No passage in our copy supports the claim about epigenetic changes. (LLM, conf=0.85)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works
A comprehensive review of genetic association studies
Hirschhorn, J. N., Lohmueller, K., Byrne, E., & Hirschhorn, K. (2002) · Genetics in Medicine · doi:10.1097/00125817-200203000-00002 · Cited by 1,674 · see citing works
Non-colonic features of irritable bowel syndrome.
Whorwell, P. J., McCallum, M., Creed, F. H., & Roberts, C. T. (1986) · Gut · doi:10.1136/gut.27.1.37 · Cited by 473 · see citing works
Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology
Levy, R. L., Jones, K. R., Whitehead, W. E., Feld, S. I., Talley, N. J., & Corey, L. A. (2001) · Gastroenterology · doi:10.1053/gast.2001.27995 · Cited by 458 · see citing works
Self-citation
Maintenance of Serotonin in the Intestinal Mucosa and Ganglia of Mice that Lack the High-Affinity Serotonin Transporter: Abnormal Intestinal Motility and the Expression of Cation Transporters
Chen, J. C., Li, Z., Pan, H., Murphy, D. L., Tamir, H., Koepsell, H., & Gershon, M. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06348.2001 · Cited by 397 · see citing works
Evidence of a Genetic Contribution to Functional Bowel Disorder
Morris‐Yates, A. D., Talley, N. J., Boyce, P. M., Nandurkar, S., & Andrews, G. (1998) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(98)00321-9 · Cited by 285 · see citing works
Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome
Camilleri, M., Atanasova, E. A., Carlson, P. J., Ahmad, U. S., Kim, H. J., Viramontes, B. E., McKinzie, S., & Urrutia, R. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.34780 · Cited by 285 · see citing works
Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?: Table 1
Gonsalkorale, W. M., Perrey, C., Pravica, V, Whorwell, P. J., & Hutchinson, I. V. (2003) · Gut · doi:10.1136/gut.52.1.91 · Cited by 273 · see citing works
Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women
Yeo, A., Boyd, P., Lumsden, S., Saunders, T., Handley, A., Stubbins, M., Knaggs, A., Asquith, S., Taylor, I., Bahari, B., et al. (2004) · Gut · doi:10.1136/gut.2003.035451 · Cited by 260 · see citing works
Evidence of a Genetic Contribution to Functional Bowel Disorder
Morris‐Yates, A. D., Talley, N. J., Boyce, P. M., Nandurkar, S., & Andrews, G. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.440_j.x · Cited by 225 · see citing works
Self-citation
Intergenerational Transmission of Gastrointestinal Illness Behavior
Levy, R. L., Whitehead, W. E., Korff, M. R. V., & Feld, A. D. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00825-4 · Cited by 219 · see citing works
Role of Tumor Necrosis Factor-alpha and Interleukin-10 Gene Polymorphisms in Irritable Bowel Syndrome
van der Veek, P. P. J., van den Berg, M., de Kroon, Y. E., Verspaget, H. W., & Masclee, A. A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00257.x · Cited by 217 · see citing works
Irritable bowel syndrome in twins: genes and environment
Bengtson, M.-B., Ronning, T., Vatn, M. H., & Harris, J. R. (2006) · Gut · doi:10.1136/gut.2006.097287 · Cited by 204 · see citing works
Intergenerational Transmission of Gastrointestinal Illness Behavior
Levy, R. L., Whitehead, W. E., Korff, M. R. V., et al. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01766.x · Cited by 178 · see citing works
Association of distinct α2 adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders
Kim, H. J., Camilleri, M., Carlson, P., Cremonini, F., Ferber, I., Stephens, D., Mckinzie, S., Zinsmeister, A., & Urrutia, R. (2004) · Gut · doi:10.1136/gut.2003.030882 · Cited by 168 · see citing works
Patients and Nonconsulters with Irritable Bowel Syndrome Reporting a Parental History of Bowel Problems Have More Impaired Psychological Distress
Kanazawa, M., Endo, Y., Whitehead, W. E., Kano, M., Hongo, M., & Fukudo, S. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000034570.52305.10 · Cited by 154 · see citing works
Serotonin Transporter Gene Polymorphism in Irritable Bowel Syndrome
Pata, C., Erdal, E. M., Derici, E., Yazar, A., Kanık, A., & Ulu, O. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05841.x · Cited by 146 · see citing works
Influence of genetics on irritable bowel syndrome, gastro‐oesophageal reflux and dyspepsia: a twin study
LEMBO, A., ZAMAN, M., Jones, M., & Talley, N. J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03326.x · Cited by 144 · see citing works
Self-citation
Genetic Influences in Irritable Bowel Syndrome: A Twin Study
Mohammed, I., Cherkas, L. F., Riley, S. A., Spector, T. D., & Trudgill, N. J. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41700.x · Cited by 118 · see citing works
Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation
Camilleri, M., Carlson, P., McKinzie, S., Grudell, A., Busciglio, I. A., Burton, D. D., Baxter, K. L., Ryks, M. D., & Zinsmeister, A. R. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00371.2007 · Cited by 95 · see citing works
Meta‐analysis: a functional polymorphism in the gene encoding for activity of the serotonin transporter protein is not associated with the irritable bowel syndrome
van Kerkhoven, L. A. S., Laheij, R. J. F., & Jansen, J. B. �. �. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03453.x · Cited by 93 · see citing works
Irritable bowel syndrome aggregates strongly in families: a family‐based case‐control study
Saito, Y. A., Zimmerman, J. M., Harmsen, W. S., de Andrade, M., Locke, G. R., Petersen, G. M., & Talley, N. J. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.01077.x · Cited by 81 · see citing works
Self-citation
The Association of Serotonin Transporter Genetic Polymorphisms and Irritable Bowel Syndrome and Its Influence on Tegaserod Treatment in Chinese Patients
Li, Y., Nie, Y., Xie, J., Tang, W., Liang, P., Sha, W., Yang, H., & Zhou, Y. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9679-y · Cited by 80 · see citing works
A genetic association study of 5‐HTT LPR and GNβ3 C825T polymorphisms with irritable bowel syndrome
Saito, Y. A., Locke, G. R., Zimmerman, J. M., Holtmann, G., Slusser, J. P., de Andrade, M., Petersen, G. M., & Talley, N. J. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00905.x · Cited by 61 · see citing works
Self-citation
Is There an Association Between GNβ3–C825T Genotype and Lower Functional Gastrointestinal Disorders?
Andresen, V., Camilleri, M., Kim, H. J., Stephens, D. A., Carlson, P. J., Talley, N. J., Saito, Y. A., Urrutia, R. A., & Zinsmeister, A. R. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.017 · Cited by 59 · see citing works
Self-citation
[Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome].
Lee, D. Y., Park, H., Kim, W. H., Lee, S. I., Seo, Y. J., & Choi, Y. (2004) · PubMed · Cited by 57 · see citing works
Association of the ???1438 G/A and 102 T/C Polymorphism of the 5-Ht2A Receptor Gene with Irritable Bowel Syndrome 5-Ht2A Gene Polymorphism in Irritable Bowel Syndrome
Pata, C., Erdal, M. E., Yazc, K., Ankaralı, H. Ç., zkaya, M., & Ulu, O. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200408000-00005 · Cited by 49 · see citing works
Association of the 1438G/A and 102T/C Polymorphism of the 5-HT2A Receptor Gene With Irritable Bowel Syndrome 5-HT2A Gene Polymorphism in Irritable Bowel Syndrome
Saito, Y. A., Cremonini, F., & Talley, N. J. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000177239.90005.b5 · Cited by 47 · see citing works
Self-citation
Family history of irritable bowel syndrome is the major determinant of persistent abdominal complaints in young adults with a history of pediatric recurrent abdominal pain
Pace, F. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i24.3874 · Cited by 42 · see citing works
Serotonin Transporter Gene Polymorphism in Healthy Adults and Patients with Irritable Bowel Syndrome
Xie, J., Li, Y., Nie, Y., Liang, P., & Zhang, L. (2005) · Academic Journal of Guangzhou Medical College · Cited by 29 · see citing works

Flagged first, then by citations

Sorted by citations

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
Vasant, D. H., Paine, P. A., Black, C. J., Houghton, L. A., Everitt, H. A., Corsetti, M., Agrawal, A., Aziz, I., Farmer, A. D., Eugenicos, M. P., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-324598 · Cited by 547 · see citing works
Pathophysiology of Fibromyalgia
Bradley, L. A. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.09.008 · Cited by 366 · see citing works
Genetic Risk Factors for Post-Infectious Irritable Bowel Syndrome Following a Waterborne Outbreak of Gastroenteritis
Villani, A., Lemire, M., Thabane, M., Belisle, A., Geneau, G., Garg, A. X., Clark, W. F., Moayyedi, P., Collins, S. M., Franchimont, D., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.049 · Cited by 244 · see citing works
S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM)
Layer, P., Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S., Claßen, M., Enck, P., Frieling, T., Haag, S., Holtmann, G., et al. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0029-1245976 · Cited by 231 · see citing works
The Impact of Rotating Shift Work on the Prevalence of Irritable Bowel Syndrome in Nurses
Nojkov, B., Rubenstein, J. H., Chey, W. D., & Hoogerwerf, W. A. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.48 · Cited by 226 · see citing works
Review article: associations between immune activation, intestinal permeability and the irritable bowel syndrome
Matricon, J., Méleine, M., Gelot, A., Piche, T., Dapoigny, M. C., Muller, E., & Ardid, D. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12080 · Cited by 216 · see citing works
Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?
O’Malley, D., Quigley, E. M. M., Dinan, T. G., & Cryan, J. F. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.04.009 · Cited by 139 · see citing works
Irritable bowel syndrome: Novel views on the epidemiology and potential risk factors
Rey, E., & Talley, N. J. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.005 · Cited by 115 · see citing works
Self-citation
Pain as a channelopathy
Raouf, R., Quick, K., & Wood, J. N. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43158 · Cited by 112 · see citing works
Irritable Bowel Syndrome and Migraine: Bystanders or Partners?
Chang, F.-Y., & Lu, C. (2013) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2013.19.3.301 · Cited by 91 · see citing works
Impact of Shiftwork on Irritable Bowel Syndrome and Functional Dyspepsia
Kim, H. I., Jung, S.-A., Choi, J. Y., Kim, S., Jung, H., Shim, K., & Yoo, K. (2013) · Journal of Korean Medical Science · doi:10.3346/jkms.2013.28.3.431 · Cited by 88 · see citing works
Pharmacological Approach for Managing Pain in Irritable Bowel Syndrome: A Review Article
Chen, L., Ilham, S., & Feng, B. (2017) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.42747 · Cited by 73 · see citing works
Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome
Barkhordari, E., Rezaei, N., Ansaripour, B., Larki, P., Alighardashi, M., Ahmadi-Ashtiani, H. R., Mahmoudi, M., Keramati, M.-R., Habibollahi, P., Bashashati, M., et al. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9342-4 · Cited by 78 · see citing works
Visceral pain hypersensitivity in functional gastrointestinal disorders
Farmer, A. D., & Aziz, Q. (2009) · British Medical Bulletin · doi:10.1093/bmb/ldp026 · Cited by 74 · see citing works
Disorders of Gut–Brain Interaction and the Rome V Process
Drossman, D. A., Chang, L., & Tack, J. F. (2026) · Gastroenterology · doi:10.1053/j.gastro.2026.02.014 · Cited by 69 · see citing works
Gut pain & visceral hypersensitivity
Farmer, A. D., & Aziz, Q. (2013) · British Journal of Pain · doi:10.1177/2049463713479229 · Cited by 60 · see citing works
Alpha 2 Delta (α2δ) Ligands, Gabapentin and Pregabalin: What is the Evidence for Potential Use of These Ligands in Irritable Bowel Syndrome
Gale, J. D., & Houghton, L. A. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00028 · Cited by 58 · see citing works
Genetic variants inCDC42andNXPH1as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome
Wouters, M. M., Lambrechts, D., Knapp, M., Cleynen, I., Whorwell, P. J., Agréus, L., Dlugosz, A., Schmidt, P. T., Halfvarson, J., Simrén, M., et al. (2013) · Gut · doi:10.1136/gutjnl-2013-304570 · Cited by 55 · see citing works
Novel associations with dyspepsia: a community‐based study of familial aggregation, sleep dysfunction and somatization
Gathaiya, N. W., Locke, G. R., Camilleri, M., Schleck, C. D., Zinsmeister, A. R., & Talley, N. J. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01320.x · Cited by 51 · see citing works
Self-citation
Irritable Bowel Syndrome: Modern Concepts and Management Options
Sayuk, G. S., & Gyawali, C. P. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.01.036 · Cited by 50 · see citing works
The GC-MS metabolomics signature in patients with fibromyalgia syndrome directs to dysbiosis as an aspect contributing factor of FMS pathophysiology
Malatji, B. G., Mason, S., Mienie, L. J., Wevers, R. A., Meyer, H., van Reenen, M., & Reinecke, C. J. (2019) · Metabolomics · doi:10.1007/s11306-019-1513-6 · Cited by 48 · see citing works
Susceptibility to stress induced visceral hypersensitivity in maternally separated rats is transferred across generations
van den Wijngaard, R. M., Stanisor, O. I., van Diest, S. A., Welting, O., Wouters, M. M., Cailotto, C., de Jonge, W. J., & Boeckxstaens, G. E. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12202 · Cited by 47 · see citing works
Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: Differential effects of acute psychological and physical stressors
O’Malley, D., Dinan, T. G., & Cryan, J. F. (2010) · Peptides · doi:10.1016/j.peptides.2010.01.004 · Cited by 47 · see citing works
Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat
O’Malley, D., Julio‐Pieper, M., Gibney, S. M., Gosselin, R., Dinan, T. G., & Cryan, J. F. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01412.x · Cited by 45 · see citing works
The Global Perspective on Irritable Bowel Syndrome: A Rome Foundation–World Gastroenterology Organisation Symposium
Sperber, A. D., Drossman, D. A., & Quigley, E. M. M. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.106 · Cited by 42 · see citing works
Prognostic Factors for Persistence of Chronic Abdominal Pain in Children
Gieteling, M. J., Bierma‐Zeinstra, S. M., van Leeuwen, Y., Passchier, J., & Berger, M. Y. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181e82a28 · Cited by 39 · see citing works
Biomarkers in IBS: when will they replace symptoms for diagnosis and management?: Table 1
Barbara, G., & Stanghellini, V. (2009) · Gut · doi:10.1136/gut.2008.169672 · Cited by 37 · see citing works
Assessment of high-sensitivity CRP as a marker of micro-inflammation in irritable bowel syndrome: Hs-CRP in irritable bowel syndrome
Hod, K., Dickman, R., Sperber, A., Melamed, S., Dekel, R., Ron, Y., Halpern, Z., Berliner, S., & Maharshak, N. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01788.x · Cited by 36 · see citing works
Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats
Tjong, Y.-W., Ip, S., Lao, L., Wu, J. C. Y., Fong, H. H. S., Sung, J. J. �., Berman, B., & Che, C. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01697.x · Cited by 34 · see citing works
Prevalence of irritable bowel syndrome (IBS) in first-degree relatives of patients with inflammatory bowel disease (IBD)
Aguas, M., Garrigues, V., Bastida, G., Nos, P., Ortiz, V., Fernández, A., & Ponce, J. D. C. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.01.008 · Cited by 29 · see citing works
Endocrine regulation of gut function – a role for glucagon‐like peptide‐1 in the pathophysiology of irritable bowel syndrome
O’Malley, D. (2018) · Experimental Physiology · doi:10.1113/ep087443 · Cited by 25 · see citing works
Lessons Learnt from Post-Infectious IBS
Sarna, S. K. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00049 · Cited by 23 · see citing works
Systematic review and meta-analysis of Chinese herbal formula Tongxie Yaofang for diarrhea-predominant irritable bowel syndrome: Evidence for clinical practice and future trials
Liang, S.-B., Cao, H., Kong, L., Wei, J., Robinson, N., Yang, S.-H., Zhu, S., Li, Y.-Q., Fei, Y., Han, M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.904657 · Cited by 22 · see citing works
Focus on irritable bowel syndrome.
Scalera, A., & Loguercio, C. (2012) · PubMed · Cited by 19 · see citing works
Cytokine gene polymorphisms in irritable bowel syndrome in Indian population--a pilot case control study.
Santhosh, S., Dutta, A. K., Samuel, P., Joseph, A. J., Kumar, J. A., & Kurian, G. P. (2010) · PubMed · Cited by 18 · see citing works
Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders
Sanger, G. J., Chang, L., Bountra, C., & Houghton, L. A. (2010) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x10369922 · Cited by 17 · see citing works
Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains
O’Malley, D., Julio‐Pieper, M., O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.076109 · Cited by 17 · see citing works
S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) 1 AWMF-Registriernummer: 021/016 Irritable Bowel Syndrome: German Consensus Guidelines on Definition, Pathophysiology and Management. German Society of Digestive and Metabolic Diseases (DGVS) and German Society of Neurogastroenterology …
Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S. C., Enck, P., Frieling, T., Haag, S., Holtmann, G., Karaus, M., Keller, J., et al. (2011) · Cited by 17 · see citing works
Association Between Irritable Bowel Syndrome and Restless Legs Syndrome: A Comparative Study With Control Group
Borji, R., Fereshtehnejad, S., Vakili, S. T. T., Daryani, N. E., & Ajdarkosh, H. (2012) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2012.18.4.426 · Cited by 15 · see citing works
Prospects of Psychosomatic Medicine
Komaki, G., Moriguchi, Y., Ando, T., Yoshiuchi, K., & Nakao, M. (2009) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-3-1 · Cited by 15 · see citing works
Prevalence and associated factors of chronic constipation among Japanese university students
Vu, N. T. H., Quach, D. T., Miyauchi, S., Luu, M. N., Yoshida, M., Nguyen, D. T. N., Yoshino, A., Miyaka, Y., Okamoto, Y., Oka, S., et al. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1258020 · Cited by 14 · see citing works
Acknowledgements
Almansa, C., Agrawal, A. K., & Houghton, L. A. (2012) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.12.9 · Cited by 14 · see citing works
Irritable Bowel Syndrome in Middle-Aged and Elderly Palestinians: Its Prevalence and Effect of Location of Residence
Qumseya, B. J., Tayem, Y. I., Almansa, C., Dasa, O., Hamadneh, M. K., Al-sharif, A. F., Hmidat, A. M., Abu–Limon, I. M., Nahhal, K. W., Alassas, K., et al. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.27 · Cited by 12 · see citing works
Abdominal Pain in Children
Zeiter, D. K. (2017) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2017.01.012 · Cited by 12 · see citing works
Chinese herbal formula Tongxie Yaofang granules for diarrhoea-predominant irritable bowel syndrome: a randomised, double-blind, placebo-controlled, phase II trial
Liang, S.-B., Cheng, H.-J., Zhang, Q., Han, M., Li, Y.-F., Cao, H., Yu, Z.-Y., Kong, L., Cai, Y.-M., An, L.-B., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-088410 · Cited by 9 · see citing works
New insight in the pathogenesis of functional gastrointestinal disorders: association between genetics and colonic transit
Wouters, M. M. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01774.x · Cited by 9 · see citing works
Association Between Irritable Bowel Syndrome and Shift Work: Prevalence and Associated Factors Among Nurses
Akere, A., & Akande, K. O. (2014) · Journal of Gastroenterology and Hepatology Research · doi:10.17554/j.issn.2224-3992.2014.03.474 · Cited by 9 · see citing works
Chinese herbal formula Tongxie Yaofang for diarrhea-predominant irritable bowel syndrome: study protocol for a randomized, multiple-blind, placebo-controlled trial
Liang, S.-B., Han, M., Cheng, H.-J., Zhang, Q., Zhang, N., Jia, B.-Y., Robinson, N., & Liu, J. (2022) · Trials · doi:10.1186/s13063-022-06142-x · Cited by 9 · see citing works
Green Light from the FDA for New Drug Development in Irritable Bowel Syndrome and Functional Dyspepsia
Talley, N. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.295 · Cited by 9 · see citing works
Self-citation
Influence of Family History on Children With Irritable Bowel Syndrome
Fu, Y., Thomas, R., & Cares, K. (2021) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000003059 · Cited by 7 · see citing works
Editorial: A Closer Look at Mucosal Inflammation in Irritable Bowel Syndrome: Sex- and Gender-Related Disparities—Quantity, Quality, or Both?
Alonso, C., & Santos, J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.105 · Cited by 7 · see citing works
Epigenetic Regulation of Gastrointestinal Epithelial Barrier and Developmental Origins of Health and Disease
Lallès, J. P., Michel, C., Theodorou, V., & Segain, J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801383-0.00017-7 · Cited by 6 · see citing works
Do MicroRNAs Modulate Visceral Pain?
Tao, Z.-Y., Yang, X. W., Li, J., Traub, R. J., & Cao, D. (2018) · BioMed Research International · doi:10.1155/2018/5406973 · Cited by 6 · see citing works
Tachykinin NK2 antagonist for treatments of various disease states
Jung, H. J., & Priefer, R. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102865 · Cited by 6 · see citing works
Fifth European Paediatric Motility Meeting
Benninga, M. A., Peeters, B., Hennekam, R. C. M., Smout, A. J. P. M., Wenzl, T. G., van der Pol, R. J., Smits, M., van Wijk, M. P., Hassall, E. G., Thomson, M. A., et al. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31823cadc6 · Cited by 5 · see citing works
Trastornos funcionales digestivos post-infecciosos: del episodio agudo a la molestia crónica
Mearin, F., & Balboa, A. (2011) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2011.03.016 · Cited by 3 · see citing works
Identifying and testing candidate genetic polymorphisms in irritable bowel syndrome: association with TNFSF15 and tumor necrosis factor-α
Sachdev, A. H., & Pimentel, M. (2013) · Europe PMC (PubMed Central) · Cited by 3 · see citing works
Irritable Bowel Syndrome
Talley, N. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6189-2.00118-9 · Cited by 3 · see citing works
Self-citation
Parents and Childhood Functional Abdominal Pain
van Tilburg, M. A. L. (2018) · Psihologijske teme · doi:10.31820/pt.27.1.7 · Cited by 3 · see citing works
Pathogenesis of Irritable Bowel Syndrome Are Genes a SERT-ainty?
Talley, N. J. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181b76700 · Cited by 2 · see citing works
Self-citation
Irritable Bowel Syndrome (IBS): A Review
Saleh, K. K., Hamarashid, B. R., Dalkılıç, S., Dalkılıç, L. K., & Kırbağ, S. (2020) · Advances in BioScience (Not affiliated with any institute repository.) · Cited by 1 · see citing works
Exploring the synergistic pharmacological mechanism of Huoxiang Drink against irritable bowel syndrome by integrated data mining and network pharmacology
Wang, R.-H., Lin, Y.-K., Xie, H., Li, H., Li, M., & He, D. (2023) · Medicine · doi:10.1097/md.0000000000035220 · Cited by 1 · see citing works
Étude de l'implication du Nerve Growth Factor et des Acid-Sensing Ion Channels dans l'hypersensibilité colique induite par le butyrate chez le rat
Matricon, J. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)
Psychological Co-morbidities of Irritable Bowel Syndrome
Keefer, L., Kiebles, J. L., & Taft, T. (2011) · Springer eBooks · doi:10.1007/978-1-4419-0029-6_10
Targeting cyclic GMP signaling for the treatment of gastrointestinal diseases
Sharman, S. K. (2017)
Gastroenterology & Hepatology Research
(2017) · Gastroenterology & Hepatology Research · doi:10.24966/ghr-2566
Stress, Social Problem Solving, and Irritable Bowel Syndrome: A Cross-Lagged Panel Design Investigation of Interactive Influences
Roy, N. M. (2020) · DigitalCommons (California Polytechnic State University)
The Psychology of Irritable Bowel Syndrome
Ballou, S., & Keefer, L. (2013) · Wiley eBooks · doi:10.1002/9781394260454.ch21
Prevalencia de síndrome de intestino irritable en familiares de primer grado de pacientes con enfermedad inflamatoria intestinal. Evaluación del impacto sobre la calidad de vida
Peris, M. A. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

The genetics of irritable bowel syndrome.
Saito, Y., Petersen, G., Locke, G., & Talley, N. J. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00184-9 · Cited by 42 · see citing works
Self-citation
Genetic epidemiology of irritable bowel syndrome
Makker, J. S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i40.11353 · Cited by 57 · see citing works
Genetic determination of irritable bowel syndrome.
Hoţoleanu, C., Popp, R., Trifa, A., Nedelcu, L., & Dumitrascu, D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6636 · Cited by 53 · see citing works
Genes and irritable bowel syndrome: Is there a link?
Saito, Y. A. (2008) · Current Gastroenterology Reports · doi:10.1007/s11894-008-0069-9 · Cited by 12 · see citing works
Self-citation
Genome-Wide Association Study Identifies Two Novel Genomic Regions in Irritable Bowel Syndrome
Holliday, E. G., Attia, J., Hancock, S. J., Koloski, N. A., McEvoy, M., Peel, R., D’Amato, M., Agréus, L., Nyhlin, H., Andréasson, A., et al. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.56 · Cited by 34 · see citing works
Self-citation

Authors: Saito, Y. A., & Talley, N. J.
Affiliations: Mayo Clinic (US)
ORCID: Saito, Yuri A.
Talley, Nicholas J.
Venue: The American Journal of Gastroenterology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-08
Volume: 103
Issue: 8
Pages: 2100-2104
ISSN: 0002-9270 (ISSN-L)
1572-0241
DOI: 10.1111/j.1572-0241.2008.02048.x
PMC: PMC3935287
OpenAlex: W2075209865
Cited by: 69
References: 30
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 4 · 2015: 2 · 2014: 2 · 2013: 8 · 2012: 5
FWCI: 10.83
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: The American Journal of Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-66271, K23DK066271)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Health Professions › Pharmacy › Infant Health and Development
Keywords: irritable bowel syndrome, genetic susceptibility, candidate gene association, twin and family studies, gene-environment interaction, phenotype definition, environmental risk factors
MeSH terms: Humans, Membrane Proteins, Irritable Bowel Syndrome, Intracellular Signaling Peptides and Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genetics of Irritable Bowel Syndrome

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks