Non-colonic features of irritable bowel syndrome.
Open accessAbstract
In 100 patients with irritable bowel syndrome a wide variety of non-gastrointestinal symptoms were significantly more common than in a group of 100 age, sex, and social class matched controls. Nocturia, frequency and urgency of micturition, incomplete bladder emptying, back pain, an unpleasant taste in the mouth, a constant feeling of tiredness and in women dyspareunia were particularly prominent (p less than 0.001). With reference to non-colonic gastrointestinal symptoms nausea, vomiting, dysphagia and early satiety were very common (p less than 0.0001). This symptom diversity was observed irrespective of whether the patient had a psychiatric disorder or not. Patients smoked more than controls (p = 0.02) drank more caffeine containing drinks (p = 0.03) and 26% had taken at least one week off work in the previous 12 months. Thirty three per cent of patients had a family history of irritable bowel syndrome. Cognisance of these diverse symptoms may prevent referral to the wrong medical specialty and inappropriate investigation. They may also be indicative of a much more diffuse disorder of smooth muscle than has previously been appreciated.
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Several studies have reported an increased prevalence of sexual dysfunction among IBS patients, including reduced sexual drive, increased dyspareunia, and more severe IBS symptoms following intercourse.
“Several studies have reported an increased prevalence of sexual dysfunction among IBS patients, including reduced sexual drive,43 increased dyspareunia,39,44 and more severe IBS symptoms following intercourse.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [44]
Other studies have observed an excess somatization tendency in outpatients with IBS.
“Other studies (21–23) have also observed an excess somatization tendency in outpatients with IBS.”
From Psychosocial Distress and Somatic Symptoms in Community Subjects With Irritable Bowel Syndrome: A Psychological Component Is the Rule (2009) · cites this paper as [21]
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Cites
A standardized psychiatric interview for use in community surveys.
Goldberg, D. P., Cooper, B. K., Eastwood, M. R., Kedward, H. B., & Shepherd, M. (1970) · Journal of Epidemiology & Community Health · doi:10.1136/jech.24.1.18 · Cited by 807 · see citing works
Functional bowel disorders in apparently healthy people
Thompson, W., & Heaton, K. W. (1980) · Gastroenterology · doi:10.1016/0016-5085(80)90142-0 · Cited by 665 · see citing works
Chaudhary, N. A., & Truelove, S. C. (1962) · QJM · doi:10.1093/oxfordjournals.qjmed.a066971 · Cited by 498 · see citing works
Learned illness behavior in patients with irritable bowel syndrome and peptic ulcer
Whitehead, W. E., Winget, C. N., Fedoravicius, A. S., Wooley, S. C., & Blackwell, B. (1982) · Digestive Diseases and Sciences · doi:10.1007/bf01296915 · Cited by 302 · see citing works
PROGNOSIS IN THE IRRITABLE BOWEL SYNDROME: A 5-YEAR PROSPECTIVE STUDY
Harvey, R. F., Mauad, E. C., & Brown, A. M. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90304-7 · Cited by 212 · see citing works
SITE OF PAIN FROM THE IRRITABLE BOWEL
Swarbrick, E. T., Bat, L., Hegarty, J. E., Williams, C. B., & Dawson, A. M. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91885-1 · Cited by 175 · see citing works
Lumsden, K., Chaudhary, N. A., & Truelove, S. C. (1963) · Clinical Radiology · doi:10.1016/s0009-9260(63)80010-0 · Cited by 163 · see citing works
Abbona, C., GATO, E., & Raffetto, A. (2014) · Springer eBooks · doi:10.1007/978-94-007-0753-5_102136 · Cited by 147 · see citing works
PROGNOSIS IN THE IRRITABLE-BOWEL SYNDROME
Waller, S., & Misiewicz, J. J. (1969) · The Lancet · doi:10.1016/s0140-6736(69)90475-9 · Cited by 135 · see citing works
Psychological characteristics of patients with the irritable bowel syndrome
Palmer, R. L., Crisp, A. H., Stonehill, E., Waller, S. L., & Misiewicz, J. J. (1974) · Postgraduate Medical Journal · doi:10.1136/pgmj.50.585.416 · Cited by 130 · see citing works
Thompson, W. (1984) · Gut · doi:10.1136/gut.25.3.305 · Cited by 110 · see citing works
Oesophageal motility in the irritable bowel syndrome.
Whorwell, P. J., Clouter, C., & Smith, C. S. (1981) · BMJ · doi:10.1136/bmj.282.6270.1101 · Cited by 103 · see citing works
Self-citationKirsner, J. B., & Palmer, W. L. (1958) · Gastroenterology · doi:10.1016/s0016-5085(58)80012-8 · Cited by 97 · see citing works
ABNORMAL SMALL-BOWEL MOTILITY DEMONSTRATED BY RADIOTELEMETRY IN A PATIENT WITH IRRITABLE COLON
Thompson, D. G., Laidlow, J. M., & Wingate, D. L. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92811-3 · Cited by 91 · see citing works
Fielding, J. F. (1977) · Clinics in Gastroenterology · doi:10.1016/s0300-5089(21)00178-4 · Cited by 71 · see citing works
The irritable bowel syndrome. Part I: clinical spectrum.
Fielding, J. F. (1977) · PubMed · Cited by 64 · see citing works
A year in out-patients with the irritable bowel syndrome
Fielding, J. F. (1977) · Irish Journal of Medical Science (1971 -) · doi:10.1007/bf03030953 · Cited by 61 · see citing works
Globus and headache: common symptoms of the irritable bowel syndrome.
Watson, W. C., Sullivan, S. N., Corke, M., & Rush, D. (1978) · PubMed Central · Cited by 56 · see citing works
Paton, A., & Saunders, J. B. (1981) · BMJ · doi:10.1136/bmj.283.6301.1248 · Cited by 41 · see citing works
Irritable bowel—Still more questions than answers
Alpers, D. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90085-8 · Cited by 22 · see citing works
Murney, R. G., & Winship, D. H. (1982) · Clinics in Gastroenterology · doi:10.1016/s0300-5089(21)00545-9 · Cited by 14 · see citing works
Part II: Manometric and Cineradiographic Studies
Ritchie, J. (1977) · Clinics in Gastroenterology · doi:10.1016/s0300-5089(21)00179-6 · Cited by 14 · see citing works
The irritable bowel syndrome. Part II: manometric and cineradiographic studies.
Ritchie, J. (1977) · PubMed · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Rubin L, Wald A, Schuster MM. Unrecognised com- mon features of irritable bowel syndrome. Gastroenter- ology 1979, 76: 1230.
- Goldberg DP, Cooper B, Eastwood MR, Kenward HB, Sheperd M. A standardised psychiatric interview for use in community services. Br J Prevent Soc Med 1970, 24: 18-23.
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Wessely, S., Nimnuan, C., & Sharpe, M. (1999) · The Lancet · doi:10.1016/s0140-6736(98)08320-2 · Cited by 1,211 · see citing works
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · see citing works
Guidelines on the irritable bowel syndrome: mechanisms and practical management
Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N., et al. (2007) · Gut · doi:10.1136/gut.2007.119446 · Cited by 818 · see citing works
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Lee, O. Y., Mayer, E. A., Schmulson, M., Chang, L., & Naliboff, B. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03961.x · Cited by 228 · see citing works
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Self-citation
- Authors
- Whorwell, P. J., McCallum, M., Creed, F. H., & Roberts, C. T.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1986-01
- Volume
- 27
- Issue
- 1
- Pages
- 37-40
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1433171
- OpenAlex
- W2112286648
- Cited by
- 473
- References
- 23
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 14 · 2019: 11 · 2018: 5 · 2017: 15 · 2016: 13 · 2015: 7 · 2014: 16 · 2013: 16 · 2012: 18
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- irritable bowel syndrome, nocturia, urinary urgency, dyspareunia, fatigue, nausea and vomiting, dysphagia, early satiety, smoking, caffeine consumption, absenteeism, family history (medicine), psychiatric comorbidity
- MeSH terms
- Adolescent, Adult, Mental Disorders, Colonic Diseases, Functional, Female, Gastrointestinal Diseases, Genital Diseases, Female, Humans, Male, Middle Aged, Smoking, Urination Disorders
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