Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?: Table 1
Open accessAbstract
Background and aims: Inflammation may play a role in the pathogenesis of irritable bowel syndrome in some individuals, such as in those who develop symptoms following a dysenteric illness. Persisting inflammation, resulting from an imbalance of cytokines regulating the inflammatory response, is one possible mechanism. As the elaboration of cytokines is under genetic control, this study was designed to establish whether there might be a genetic predisposition to an altered pattern of anti-inflammatory cytokine production in patients with irritable bowel syndrome. Subjects: A total of 230 unselected patients with irritable bowel syndrome and 450 healthy, ethnically matched controls were studied. Methods: DNA was extracted from peripheral blood leucocytes of subjects. Allele and genotype frequencies were determined for the anti-inflammatory cytokine interleukin 10 at the site (−1082) concerned with production in lymphocytes. Transforming growth factor β 1 (codons 10 and 25) genotypes were also examined in a smaller group of subjects. Results: Patients with irritable bowel syndrome had significantly reduced frequencies of the high producer genotype for interleukin 10 than controls (21% v 32%; p=0.003). There was no apparent relationship with any particular bowel habit subtype. Genotypes for transforming growth factor β 1 were not altered. Conclusions: These preliminary results suggest that at least some patients with irritable bowel syndrome may be genetically predisposed to produce lower amounts of the anti-inflammatory cytokine interleukin 10. This lends some support to the hypothesis that there may be an inflammatory or genetic component in some cases of this condition and that further studies in specific irritable bowel syndrome subgroups are justified.
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Inflammation is present in IBS, as indicated by studies on mast cells and cytokines.
“Studies on mast cells and cytokines point out that inflammation is present in IBS. 2, 13-20”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [18]
IBS patients may have a genetic predisposition to a proinflammatory state.
“Moreover, IBS patients appear to be genetically predisposed towards a proinflammatory state. 17, 18”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [18]
IBS is associated with polymorphisms in genes involved in immune and inflammatory responses.
“Evidence supporting this hypothesis includes increased concentrations of inflammatory/immune cells in intestinal tissue from IBS patients, altered levels of pro- and anti-inflammatory cytokines in the GI tract and peripheral blood of patients with IBS (Table 1) (11, 13, 24, 36, 46, 50, 51, 62, 73, 75, 89, 90, 94, 98, 102, 118, 121–124, 168, 174, 185, 187), and IBS-associated polymorphisms in genes”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [70]
Gene polymorphisms in TNF-α, IL-2, IL-4, IL-6, and IL-10 have been associated with IBS or PI-IBS.
“Gene polymorphisms (188) in TNF-α (15, 179), IL-2 (16), IL-4 (16), IL-6 (15), and IL-10 (16, 70) have been associated with IBS or PI-IBS (Table 2).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [70]
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- Authors
- Gonsalkorale, W. M., Perrey, C., Pravica, V, Whorwell, P. J., & Hutchinson, I. V.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Gonsalkorale, W M
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2003-01
- Volume
- 52
- Issue
- 1
- Pages
- 91-93
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1773523
- OpenAlex
- W2130067522
- Cited by
- 273
- References
- 26
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 8 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 9 · 2014: 14 · 2013: 25 · 2012: 16
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Directorate for Biological Sciences
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, IL-10, TGF-β1, genetic susceptibility, anti-inflammatory cytokines, inflammation, cytokine imbalance
- MeSH terms
- Alleles, Gene Frequency, Humans, Inflammatory Bowel Diseases, Case-Control Studies, Transforming Growth Factor beta, Interleukin-10, Genetic Predisposition to Disease
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