The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool
Abstract
The dramatic spread of antibiotic resistance is a crisis in the treatment of infectious diseases that affect humans. Several studies suggest that wastewater treatment plants (WWTP) are reservoirs for diverse mobile antibiotic resistance elements. This review summarizes findings derived from genomic analysis of IncP-1 resistance plasmids isolated from WWTP bacteria. Plasmids that belong to the IncP-1 group are self-transmissible, and transfer to and replicate in a wide range of hosts. Their backbone functions are described with respect to their impact on vegetative replication, stable maintenance and inheritance, mobility and plasmid control. Accessory genetic modules, mainly representing mobile genetic elements, are integrated in-between functional plasmid backbone modules. These elements carry determinants conferring resistance to nearly all clinically relevant antimicrobial drug classes, to heavy metals, and quaternary ammonium compounds used as disinfectants. All plasmids analysed here contain integrons that potentially facilitate integration, exchange and dissemination of resistance gene cassettes. Comparative genomics of accessory modules located on plasmids from WWTP and corresponding modules previously identified in other bacterial genomes revealed that animal, human and plant pathogens and other bacteria isolated from different habitats share a common pool of resistance determinants.
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Citations
Cites
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Roberts, M. C. (1996) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1996.tb00251.x · Cited by 689
Trimethoprim and sulfonamide resistance.
Huovinen, P., Sundström, L., Swedberg, G., & Sköld, O. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.2.279 · Cited by 523
Cited by
Buffet-Bataillon, S., Tattevin, P., Bonnaure-Mallet, M., & Jolivet-Gougeon, A. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2012.01.011 · Cited by 601
Distribution of antibiotic resistance genes in the environment
Zhuang, M., Achmon, Y., Cao, Y., Liang, X., Chen, L., Wang, H., Siame, B. A., & Leung, K. Y. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117402 · Cited by 422
Hegstad, K., Langsrud, S., Lunestad, B. T., Scheie, A. A., Sunde, M., & Yazdankhah, S. P. (2010) · Microbial Drug Resistance · doi:10.1089/mdr.2009.0120 · Cited by 396
Persistence and reversal of plasmid-mediated antibiotic resistance
Lopatkin, A. J., Meredith, H. R., Srimani, J. K., Pfeiffer, C., Durrett, R., & You, L. (2017) · Nature Communications · doi:10.1038/s41467-017-01532-1 · Cited by 359
Mutuku, C., Gazdag, Z., & Melegh, S. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-022-03334-0 · Cited by 280
Metadata
- Authors
- Schlüter, A., Szczepanowski, R., Pühler, A., & Top, E. M.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-07
- Volume
- 31
- Issue
- 4
- Pages
- 449-477
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W1966393989
- Cited by
- 399
- References
- 3
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schlüter, A., Szczepanowski, R., Pühler, A., & Top, E. M. (2007). Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool. FEMS Microbiology Reviews. https://doi.org/10.1111/j.1574-6976.2007.00074.x
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