The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems
Abstract
Multidrug efflux pumps have emerged as relevant elements in the intrinsic and acquired antibiotic resistance of bacterial pathogens. In contrast with other antibiotic resistance genes that have been obtained by virulent bacteria through horizontal gene transfer, genes coding for multidrug efflux pumps are present in the chromosomes of all living organisms. In addition, these genes are highly conserved (all members of the same species contain the same efflux pumps) and their expression is tightly regulated. Together, these characteristics suggest that the main function of these systems is not resisting the antibiotics used in therapy and that they should have other roles relevant to the behavior of bacteria in their natural ecosystems. Among the potential roles, it has been demonstrated that efflux pumps are important for processes of detoxification of intracellular metabolites, bacterial virulence in both animal and plant hosts, cell homeostasis and intercellular signal trafficking.
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Cites
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Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
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Thematic Review Series: Skin Lipids. Antimicrobial lipids at the skin surface
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Cited by
Call of the wild: antibiotic resistance genes in natural environments
Allen, H. K., Donato, J., Wang, H. H., Cloud-Hansen, K. A., Davies, J., & Handelsman, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2312 · Cited by 2,361
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Moradali, M. F., Ghods, S., & Rehm, B. H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00039 · Cited by 1,537
Seiler, C., & Berendonk, T. U. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00399 · Cited by 1,018
Functional diversity within the simple gut microbiota of the honey bee
Engel, P., Martinson, V. G., & Moran, N. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202970109 · Cited by 874
Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations
Sun, J., Deng, Z., & Yan, A. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.05.090 · Cited by 746
Metadata
- Authors
- Martinez, J. L., Sánchez, M. B., Martínez-Solano, L., Hernandez, A., Garmendia, L., Fajardo, A., & Alvarez-Ortega, C.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03
- Volume
- 33
- Issue
- 2
- Pages
- 430-449
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W1924338650
- Cited by
- 491
- References
- 6
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Martinez, J. L., Sánchez, M. B., Martínez-Solano, L., Hernandez, A., Garmendia, L., Fajardo, A., & Alvarez-Ortega, C. (2009). Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems. FEMS Microbiology Reviews. https://doi.org/10.1111/j.1574-6976.2008.00157.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
