The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Mechanisms of Toxoplasma gondii persistence and latency
Open accessAbstract
Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic disease, particularly in immunocompromised individuals. Central to its transmission and pathogenesis is the ability of the proliferative stage (tachyzoite) to convert into latent tissue cysts (bradyzoites). Encystment allows Toxoplasma to persist in the host and affords the parasite a unique opportunity to spread to new hosts without proceeding through its sexual stage, which is restricted to felids. Bradyzoite tissue cysts can cause reactivated toxoplasmosis if host immunity becomes impaired. A greater understanding of the molecular mechanisms orchestrating bradyzoite development is needed to better manage the disease. Here, we will review key studies that have contributed to our knowledge about this persistent form of the parasite and how to study it, with a focus on how cellular stress can signal for the reprogramming of gene expression needed during bradyzoite development.
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Cites
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Cited by
CNS Infection and Immune Privilege
Forrester, J. V., McMenamin, P. G., & Dando, S. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0070-8 · Cited by 313
Promising drug targets and compounds with anti-Toxoplasma gondii activity
Silva, M. D., Teixeira, C., Gomes, P., & Borges, M. (2021) · Microorganisms · doi:10.3390/microorganisms9091960 · Cited by 44
Metadata
- Authors
- Sullivan, W. J., & Jeffers, V.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-05
- Volume
- 36
- Issue
- 3
- Pages
- 717-733
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W1996510078
- Cited by
- 259
- References
- 87
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
