Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

Molecular characterization of mitochondrial apoptosis-inducing factor

Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060

The Bcl2 family: regulators of the cellular life-or-death switch

Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032

Self-eating and self-killing: crosstalk between autophagy and apoptosis

Maiuri, M. C., Zalckvar, E., Kimchi, A., & Kroemer, G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2239 · Cited by 3,638

Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536

Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

Hartl, F. U., & Hayer-Hartl, M. K. (2002) · Science · doi:10.1126/science.1068408 · Cited by 3,335

Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration

Linsley, J. W., Shah, K. D., Castello, N. A., Chan, M. Y., Haddad, D., Doric, Z., Wang, S., Leks, W., Mancini, J., Oza, V. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25549-9 · Cited by 37

Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future

Levin, L. A., Patrick, C., Choudry, N. B., Sharif, N. A., & Goldberg, J. L. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.964197 · Cited by 37

New 1,2,3-Triazole-genipin Analogues and Their Anti-Alzheimer’s Activity

Silalai, P., Jaipea, S., Tocharus, J., Athipornchai, A., Suksamrarn, A., & Saeeng, R. (2022) · ACS Omega · doi:10.1021/acsomega.2c01593 · Cited by 37

Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death

Galimov, E. R., Pryor, R. E., Poole, S. E., Benedetto, A., Pincus, Z., & Gems, D. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.050 · Cited by 36

Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy

Bosoi, C. R., & Rose, C. F. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9573-9 · Cited by 35

Molecular biomarkers of neurodegeneration

Höglund, K., & Salter, H. (2013) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2013.850033 · Cited by 33

Partial loss of parvalbumin-containing hippocampal interneurons in dementia with Lewy bodies

Bernstein, H., Johnson, M. K., Perry, R. H., LeBeau, F. E. N., Dobrowolny, H., Bogerts, B., & Perry, E. K. (2010) · Neuropathology · doi:10.1111/j.1440-1789.2010.01117.x · Cited by 33

Silymarin promotes longevity and alleviates Parkinson’s associated pathologies in Caenorhabditis elegans

Srivastava, S., Sammi, S. R., Laxman, T. S., Pant, A., Nagar, A., Trivedi, S., Bhatta, R. S., Tandon, S., & Pandey, R. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.01.029 · Cited by 32

Cell death assays for neurodegenerative disease drug discovery

Linsley, J. W., Reisine, T., & Finkbeiner, S. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1623784 · Cited by 32

Increased BrdU incorporation reflecting DNA repair, neuronal de-differentiation or possible neurogenesis in the adult cochlear nucleus following bilateral cochlear lesions in the rat

Zheng, Y., Begum, S., Zhang, C., Fleming, K., Masumura, C., Zhang, M., Smith, P. F., & Darlington, C. L. (2010) · Experimental Brain Research · doi:10.1007/s00221-010-2491-0 · Cited by 31

Progressive Degeneration of Dopaminergic Neurons through TRP Channel-Induced Cell Death

Nagarajan, A., Ning, Y., Reisner, K., Buraei, Z., Larsen, J. P., Hobert, O., & Doitsidou, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4540-13.2014 · Cited by 30

Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress

Lehman, B. J., López-Díaz, F. J., Santisakultarm, T. P., Fang, L., Shokhirev, M. N., Diffenderfer, K. E., Manor, U., & Emerson, B. M. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009277 · Cited by 30

Induction of Autophagic Cell Death in the Rat Brain Caused by Iron

Chen, G., Jing, C., Liu, P., Ruan, D., & Wang, L. (2012) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318271c031 · Cited by 30

Natural Products as the Potential to Improve Alzheimer’s and Parkinson’s Disease

Kim, S. W., Lee, J. H., Kim, B., Yang, G., & Kim, J. U. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108827 · Cited by 30

Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency

Shirao, K., Okada, S., Tajima, G., Tsumura, M., Hara, K., Yasunaga, S., Ohtsubo, M., Hata, I., Sakura, N., Shigematsu, Y., et al. (2010) · Human Genetics · doi:10.1007/s00439-010-0822-7 · Cited by 29

Genetic pathway‐based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes

Sloan, C., Shen, L., West, J. D., Wishart, H. A., Flashman, L. A., Rabin, L. A., Santulli, R. B., Guerin, S. J., Rhodes, C. H., Tsongalis, G. J., et al. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31078 · Cited by 28

Amyloid fibrillogenesis of lysozyme is suppressed by a food additive brilliant blue FCF

Chen, Y.-H., Tseng, C., How, S.-C., Lo, C.-H., Chou, W., & Wang, S. S. ‐. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.02.064 · Cited by 29

PACAP and VIP Modulate LPS-Induced Microglial Activation and Trigger Distinct Phenotypic Changes in Murine BV2 Microglial Cells

Karunia, J., Niaz, A., Mandwie, M., Broome, S. T., Keay, K. A., Waschek, J. A., Al‐Badri, G., & Castorina, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010947 · Cited by 29

Second Sphere Interactions in Amyloidogenic Diseases

Roy, M., Nath, A. K., Pal, I., & Dey, S. G. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00941 · Cited by 29

Friend or foe: role of pathological tau in neuronal death

Wu, M., Chen, Z., Jiang, M. H., Bao, B., Li, D., Yin, X., Wang, X., Liu, D., & Zhu, L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02024-z · Cited by 28

Synergistic Toxicity of the Neurometabolites Quinolinic Acid and Homocysteine in Cortical Neurons and Astrocytes: Implications in Alzheimer’s Disease

Pierozan, P., Biasibetti, H., Schmitz, F., Ferreira, F. S., Netto, C. A., & Wyse, Â. T. D. S. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9834-6 · Cited by 28

Mesenchymal Stem Cells (MSCs) Coculture Protects [Ca2+]i Orchestrated Oxidant Mediated Damage in Differentiated Neurons In Vitro

Alhazzani, A. A., Rajagopalan, P., Albarqi, Z., Devaraj, A., Mohamed, M. H., Al‐Hakami, A. M., & Chandramoorthy, H. C. K. (2018) · Cells · doi:10.3390/cells7120250 · Cited by 27

Berberine Protects C17.2 Neural Stem Cells From Oxidative Damage Followed by Inducing Neuronal Differentiation

Shou, J., Cheung, C.-K., Gao, J., Shi, W.-W., & Shaw, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00395 · Cited by 27

Targeted imaging of activated caspase-3 in the central nervous system by a dual functional nano-device

Liu, Y., Hu, Y., Guo, Y., Ma, H., Li, J., & Jiang, C. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.09.001 · Cited by 28

A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry

Zhang, J., Weinrich, J. A. P., Russ, J. B., Comer, J. D., Bommareddy, P. K., DICASOLI, R. J., Wright, C. V. E., Li, Y., van Roessel, P., & Kaltschmidt, J. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.079 · Cited by 26

CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1

Chen, Z., Zhang, W., Deng, M., Zhou, Y., & Li, Y. (2020) · Aging · doi:10.18632/aging.104035 · Cited by 26

Neuroprotective potential of biochanin-A and review of the molecular mechanisms involved

Singh, L., Kaur, N., & Bhatti, R. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08397-2 · Cited by 26

Oxytocin as neuro-hormone and neuro-regulator exert neuroprotective properties: A mechanistic graphical review

Kamrani-Sharif, R., Hayes, A. W., Gholami, M., Salehirad, M., Khani, M. A., Motaghinejad, M., & Emanuele, E. (2023) · Neuropeptides · doi:10.1016/j.npep.2023.102352 · Cited by 27

Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation

Ghosh, D. K., Roy, A., & Ranjan, A. (2018) · Biochemistry · doi:10.1021/acs.biochem.7b00776 · Cited by 24

Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer’s Disease

Castañeda, A., Ferraz, R., Vieira, M., Cardoso, I., Vasconcelos, V. M., & Martins, R. F. (2021) · Marine Drugs · doi:10.3390/md19060343 · Cited by 25

Neuroprotective effects of some seaweeds against Zn – induced neuronal damage in HT-22 cells via modulation of redox imbalance, inhibition of apoptosis and acetylcholinesterase activity

Olasehinde, T. A., Olaniran, A. O., & Okoh, A. I. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00469-2 · Cited by 27

Traditional Chinese medicine-based neurorestorative therapy for Alzheimer’s and Parkinson’s disease

Zhang, Z., Zhang, S., Lui, C. N. P., Zhu, P., Zhang, Z., Lin, K., Dai, Y., & Yung, K. K. L. (2019) · Journal of Neurorestoratology · doi:10.26599/jnr.2019.9040026 · Cited by 24

Polyozellin, a key constituent of the edible mushroom Polyozellus multiplex, attenuates glutamate-induced mouse hippocampal neuronal HT22 cell death

Yang, E. J., & Song, K. (2015) · Food & Function · doi:10.1039/c5fo00636h · Cited by 24

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Jin, L. J., Nie, L., Deng, Y., Khana, G. J., & He, N. (2025) · Cell Proliferation · doi:10.1111/cpr.13804 · Cited by 24

Interaction and inhibitory influence of the azo dye carmoisine on lysozyme amyloid fibrillogenesis

Basu, A., & Kumar, G. S. (2017) · Molecular BioSystems · doi:10.1039/c7mb00207f · Cited by 23

Vitamin K2 Modulates Organelle Damage and Tauopathy Induced by Streptozotocin and Menadione in SH-SY5Y Cells

Shandilya, S., Kesari, K. K., & Ruokolainen, J. (2021) · Antioxidants · doi:10.3390/antiox10060983 · Cited by 23

In situ detection of gliosis and apoptosis in the brains of young rats exposed in utero to a Wi-Fi signal

Aït-Aïssa, S., Billaudel, B. J. L., de Gannes, F. P., Hurtier, A., Haro, E., Taxile, M., Ruffié, G., Athané, A., Veyret, B., & Lagroye, I. (2010) · Comptes Rendus Physique · doi:10.1016/j.crhy.2010.10.005 · Cited by 23

The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2

Hu, X., Wu, J., Shi, L., Wang, F., He, K., Tan, P., Hu, Y., Yang, Y., Wang, D., Ma, T., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.02.026 · Cited by 23

Role of natural bioactive compounds in the management of neurodegenerative disorders

Mursal, M., Kumar, A. B., Hasan, S. M., Hussain, S., Singh, K., Kushwaha, S. P., Arif, M., Singh, R., Singh, D., Mohammad, A., et al. (2023) · Intelligent Pharmacy · doi:10.1016/j.ipha.2023.09.006 · Cited by 22

Distribution of apoptosis-related proteins in sporadic Creutzfeldt–Jakob disease

Kovács, G. G., & Budka, H. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.089 · Cited by 22

Perspectives on the therapeutic modulation of an alternative cell death, programmed necrosis (Review)

Cho, Y. S. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1716 · Cited by 22

20S proteasome and glyoxalase 1 activities decrease in erythrocytes derived from Alzheimer’s disease patients

Jian, C., Lv, H., Wei, G., Guo, C.-S., Deng, Y.-F., Jiang, Y., & Gao, C. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.264473 · Cited by 22

N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells

Cheng, B., Anand, P., Kuang, A., Akhtar, F., & Scofield, V. L. (2016) · Parkinson s Disease · doi:10.1155/2016/6564212 · Cited by 20

On entropy and information in gene interaction networks

Wallace, Z. S., Rosenthal, S. B., Fisch, K. M., Ideker, T., & Sasik, R. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty691 · Cited by 19

An alginate-based encapsulation system for delivery of therapeutic cells to the CNS

Eleftheriadou, D., Evans, R. E., Atkinson, E. A., Abdalla, A., Gavins, F. K. H., Boyd, A. S., Williams, G. R., Knowles, J. C., Roberton, V. H., & Phillips, J. B. (2022) · RSC Advances · doi:10.1039/d1ra08563h · Cited by 23

Nano-mediated Strategies for Metal Ion–Induced Neurodegenerative Disorders: Focus on Alzheimer’s and Parkinson’s Diseases

Harini, K., Girigoswami, K., Anand, A. V., Pallavi, P., Gowtham, P., Elboughdiri, N. A., & Girigoswami, A. (2022) · Current Pharmacology Reports · doi:10.1007/s40495-022-00307-7 · Cited by 20

Intrahippocampal Pathways Involved in Learning/Memory Mechanisms are Affected by Intracerebral Infusions of Amyloid-β25-35 Peptide and Hydrated Fullerene C60 in Rats

Gordon, R. Y., Podolski, I. Y., Makarova, E. G., Деев, А. Д., Mugantseva, E., Khutsyan, S. S., Sengpiel, F., Murashev, A. N., & Vorobyov, V. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161182 · Cited by 20

Beneficial effect of β-elemene alone and in combination with hyperbaric oxygen in traumatic brain injury by inflammatory pathway

Meng, X.-E., Li, N., Zhang, Y., Fan, D.-F., Chen, Y., Li, H., Guo, D., & Pan, S. (2018) · Translational Neuroscience · doi:10.1515/tnsci-2018-0007 · Cited by 20

Annona atemoya leaf extract ameliorates cognitive impairment in amyloid-β injected Alzheimer’s disease-like mouse model

Lim, H.-S., Kim, Y. J., Sohn, E., Yoon, J., Kim, B., & Jeong, S. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219886269 · Cited by 20

Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, Aβ42andAppl) inDrosophila melanogaster

Panchal, K., & Tiwari, A. K. (2020) · Biology Open · doi:10.1242/bio.049569 · Cited by 21

Long term therapeutic effects of icariin‐loaded PLGA microspheres in an experimental model of optic nerve ischemia via modulation of CEBP ‐β/ G‐CSF /noncanonical NF‐ κ B axis

Desai, T. D., Wen, Y., Daddam, J. R., Cheng, F., Chen, C., Pan, C., Lin, K., & Tsai, R. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10289 · Cited by 19

Neurodegenerative effect of DAPK1 after cerebral hypoxia-ischemia is associated with its post-transcriptional and signal transduction regulations: A systematic review and meta-analysis

Khan, Z. A., Sumsuzzman, D. M., Choi, J., & Hong, Y. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101593 · Cited by 19

Drug reprofiling history and potential therapies against Parkinson’s disease

Latif, K., Ullah, A., Shkodina, A. D., Boiko, D. I., Rafique, Z., Alghamdi, B. S. A., Alfaleh, M. A., & Ashraf, G. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1028356 · Cited by 20

The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer’s disease

Torres, M., Marcilla-Etxenike, A., Fiol-deRoque, M. A., Escribá, P. V., & Busquets, X. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1099-z · Cited by 19

Undifferentiated and Differentiated PC12 Cells Protected by Huprines Against Injury Induced by Hydrogen Peroxide

Pera, M., Camps, P., Muñoz‐Torrero, D., Pérez, B., Badı́a, A., & Guillen, M. V. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074344 · Cited by 19

The Neurotrophic and Neuroprotective Potential of Macrofungi

Badalyan, S. М., & Rapior, S. (2021) · Springer eBooks · doi:10.1007/978-981-33-4141-8_2 · Cited by 19

Scalable mapping of myelin and neuron density in the human brain with micrometer resolution

Chang, S., Varadarajan, D., Yang, J., Chen, A., Kura, S., Magnain, C. V., Augustinack, J. C., Fischl, B. R., Greve, D. N., Boas, D. A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-021-04093-y · Cited by 18

The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration

Fodder, K., de Silva, R., Warner, T. T., & Bettencourt, C. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01607-9 · Cited by 22

Evaluating the Performance of wav2vec Embedding for Parkinson's Disease Detection

Klempíř, O., Příhoda, D., & Krupička, R. (2023) · Measurement Science Review · doi:10.2478/msr-2023-0033 · Cited by 19

Alzheimer’s disease via enhanced calcium signaling caused by the decrease of endoplasmic reticulum–mitochondrial distance

Qi, H., & Shuai, J. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.01.022 · Cited by 18

Contribution of Pro-inflammatory Cytokine Signaling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson’s Disease via GABAergic Pathway

Zhuang, X., Chen, Y., Zhuang, X., Chen, T., Xing, T., Wang, W., & Yang, X. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00104 · Cited by 18

Insights Into the Role of Mortalin in Alzheimer’s Disease, Parkinson’s Disease, and HIV-1-Associated Neurocognitive Disorders

Priyanka, & Seth, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.903031 · Cited by 17

System level modeling and analysis of TNF-α mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets

Banaras, S., Paracha, R. Z., Nisar, M., Arif, A., Ahmad, J., Saeed, M. T., Mustansar, Z., Shuja, M. N., & Paracha, R. N. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.872421 · Cited by 17

Neuroprotectant Effects of Hibiscetin in 3-Nitropropionic Acid-Induced Huntington’s Disease via Subsiding Oxidative Stress and Modulating Monoamine Neurotransmitters in Rats Brain

Mahdi, W. A., AlGhamdi, S. A., Alghamdi, A. M., Imam, S. S., Alshehri, S., Almaniea, M. A., Hajjar, B. M., Al-Abbasi, F. A., Sayyed, N., & Kazmi, I. A. (2023) · Molecules · doi:10.3390/molecules28031402 · Cited by 17

Endoplasmic Reticulum Stress Induces the Early Appearance of Pro-apoptotic and Anti-apoptotic Proteins in Neurons of Five Familial Alzheimer's Disease Mice

Shen, H., Pan, X., Zhang, J., Zeng, Y., Zhou, M., Yang, L., Ye, B., Dai, X., Zhu, Y., & Chen, X. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.194643 · Cited by 17

Necroptosis Contributes to LPS-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis in a Piglet Model

Zhou, B., Xu, Q., Guo, J., Chen, Q., Lv, Q., Xiao, K., Zhu, H., Zhao, J., & Liu, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911218 · Cited by 17

Time-lapse imaging of cell death in cell culture and whole living organisms using turn-on deep-red fluorescent probes

Jarvis, T. S., Roland, F. M., Dubiak, K. M., Huber, P. W., & Smith, B. D. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01495g · Cited by 16

Co-expression of caspase-3 or caspase-8 with galanin in the human stomach section affected by carcinoma

Kozłowska, A., Kozera, P., Majewski, M. K., & Godlewski, J. (2018) · APOPTOSIS · doi:10.1007/s10495-018-1470-y · Cited by 16

Reduction of glutamate-induced excitotoxicity in murine primary neurons involving calpain inhibition

Gold, M., Koczulla, A. R., Mengel, D., Koepke, J., Dodel, R. C., Dontcheva, G., Habib, P., & Bach, J. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.11.016 · Cited by 16

D-Galactose Causes Motor Coordination Impairment, and Histological and Biochemical Changes in the Cerebellum of Rats

Rodrigues, A. F., Biasibetti, H., Zanotto, B. S., Sanches, E. F., Schmitz, F., Nunes, V. T., Pierozan, P., Manfredini, V., Magro, D. D. D., Netto, C. A., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9981-4 · Cited by 16

Computational Analysis Indicates That PARP1 Acts as a Histone Deacetylases Interactor Sharing Common Lysine Residues for Acetylation, Ubiquitination, and SUMOylation in Alzheimer’s and Parkinson’s Disease

Gupta, R. V., & Kumar, P. (2021) · ACS Omega · doi:10.1021/acsomega.0c06168 · Cited by 15

Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability

Ramos-Brossier, M., Romeo-Guitart, D., Lanté, F., Boitez, V., Mailliet, F., Saha, S., Rivagorda, M., Siopi, E., Nemazanyy, I., Leroy, C., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-023-06292-z · Cited by 15

Glyceraldehyde-3-phosphate dehydrogenase is involved in the pathogenesis of Alzheimer's disease

Schmalhausen, E. V., Medvedeva, M. V., & Muronetz, V. I. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.110065 · Cited by 17

Deficiency of aminopeptidase P1 causes behavioral hyperactivity, cognitive deficits, and hippocampal neurodegeneration

Bae, Y. ‐., Yoon, S. H., Han, J. Y., Woo, J., Cho, Y. S., Kwon, S., Bae, Y. C., Kim, D., Kim, E., & Kim, M. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12419 · Cited by 15

Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1

Steinberg, N., Galleguillos, D., Zaidi, A. K., Horkey, M., & Sipione, S. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02963-y · Cited by 14

A comprehensive review on therapeutic potentials of photobiomodulation for neurodegenerative disorders

Ramakrishnan, P., Joshi, A., Fazil, M., & Yadav, P. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122334 · Cited by 13

Application of adverse outcome pathway networks to integrate mechanistic data informing the choice of a point of departure for hydrogen sulfide exposure limits

Goyak, K. O., & Lewis, R. J. (2021) · Critical Reviews in Toxicology · doi:10.1080/10408444.2021.1897085 · Cited by 14

ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities

Sagwal, S. K., & Bekeschus, S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6816214 · Cited by 15

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Han, E. J., Zhang, C., Kim, H., Kim, J.-Y., Park, S. M., Jung, W., Ahn, G., & Cha, S. (2022) · Marine Drugs · doi:10.3390/md20110710 · Cited by 14

A Novel Cell Penetrating Peptide for the Differentiation of Human Neural Stem Cells

Ma, W., Jin, G., Gehret, P. M., Chada, N. C., & Suh, W. H. (2018) · Biomolecules · doi:10.3390/biom8030048 · Cited by 13

Geniposide ameliorated fluoxetine-suppressed neurite outgrowth in Neuro2a neuroblastoma cells

Chen, M., Peng, C.-C., Maner, R. S., Zulkefli, N. D., Huang, S.-M., & Hsieh, C.-L. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.04.003 · Cited by 13

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De, R., Jo, K. W., & Kim, K. (2022) · Biomedicines · doi:10.3390/biomedicines10061265 · Cited by 14

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Tirtawijaya, G., Mohibbullah, M., Meinita, M. D. N., Moon, I. S., & Hong, Y. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1448-8 · Cited by 13

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Drastichová, Z., Rudajev, V., Pallag, G., & Novotný, J. (2021) · Biological Research · doi:10.1186/s40659-021-00327-5 · Cited by 12

Interaction of myelin basic protein and 2′,3′-cyclic nucleotide phosphodiesterase with mitochondria

Baburina, Y. L., Gordeeva, A. E., Moshkov, D. A., Krestinina, O. V., Azarashvili, A. A., Odinokova, I. V., & Azarashvili, T. (2014) · Biochemistry (Moscow) · doi:10.1134/s0006297914060091 · Cited by 12

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Saima, Latha, S., Sharma, R., & Kumar, A. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3662-6_13 · Cited by 13

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Gholinejad, M., Anarkooli, I. J., Taromchi, A. H., & Abdanipour, A. (2018) · Biomedical Reports · doi:10.3892/br.2018.1083 · Cited by 13

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Pokkunuri, I. D., Lokhandwala, M. F., & Banday, A. A. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00049.2020 · Cited by 12

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Erickson, J. D., & Bazan, N. G. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.107 · Cited by 12

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Panda, S. P., Kesharwani, A., Singh, B., Marisetti, A. L., Chaitanya, M., Dahiya, S., Ponnusankar, S., Kumar, S., Singh, M., Shakya, P. K., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102572 · Cited by 12

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Bashir, B., Vishwas, S., Gupta, G., Paudel, K. R., Dureja, H., Kumar, P., Cho, H., Sugandhi, V. V., Kumbhar, P., Disouza, J., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102693 · Cited by 11

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Mesias, A., Borges, S., Pintado, M., & Baptista-Silva, S. (2025) · Neuropeptides · doi:10.1016/j.npep.2025.102515 · Cited by 11

Detection of Cell Death and Phagocytosis in the Drosophila Ovary

Meehan, T. L., Yalonetskaya, A., Joudi, T. F., & McCall, K. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2851-4_14 · Cited by 11

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Mao, D.-D., Yang, W., Li, Y., Lin, J., Gao, S., Wang, Y., & Hu, H. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/9267653 · Cited by 11

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Zhang, X., Fan, L., Fan, L., Jin, X., Liu, H., Lei, H., Song, X., Zhang, Z., Zhang, F., & Song, J. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115064 · Cited by 10

Neuroprotective Properties of Coriander-Derived Compounds on Neuronal Cell Damage under Oxidative Stress-Induced SH-SY5Y Neuroblastoma and in Silico ADMET Analysis

Jongwachirachai, P., Ruankham, W., Apiraksattayakul, S., Intharakham, S., Prachayasittikul, V., Suwanjang, W., Prachayasittikul, V., Prachayasittikul, S., & Phopin, K. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04239-0 · Cited by 10

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Nagpal, D., Nema, S., Nagpal, S., Pandey, M. M., Kaushik, D. K., & Kathuria, H. (2025) · Antioxidants · doi:10.3390/antiox14091078 · Cited by 13

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Kaluski-Kopatch, S., Stein, D., García-Venzor, A., Campos, A. M. F., Planque, M., Goldstein, B., Allende-Becerra, E. D., Smirnov, D., Zaretsky, A., Eremenko, E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67021-y · Cited by 12

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Hu, S., Cui, W., Mak, S., Choi, C., Yuanjia, H., Li, G., Tsim, K. W. K., Pang, Y., & Han, Y. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12401 · Cited by 10

Neuronal cell death in neurodegenerative diseases: Recurring themes around protein handling: Apoptosis Review Series

Gorman, A. M. (2008) · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) · doi:10.13025/15409

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Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 640

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El-Nikhely, N. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32852-7.00002-4

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