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Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
Open accessAbstract
Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell death and the initiating factors difficult to determine. In vitro and in vivo models have proved invaluable in this regard, yielding insight into cell death pathways. This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, Alzheimer's, Parkinson's and Huntington's diseases. Crosstalk between these death mechanisms is also discussed. The link between cell death and protein mishandling, including misfolded proteins, impairment of protein degradation, protein aggregation is described and finally, some pro‐survival strategies are discussed.
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“AD is a neurodegenerative disorder marked by neuronal loss, especially in the hippocampus and cerebral cortex (49, 50).”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [50]
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Metadata
- Authors
- Gorman, A. M.
- Affiliations
- Ollscoil na Gaillimhe – University of Galway (IE)
- Corresponding author
- Gorman, Adrienne M.
- ORCID
- Gorman, Adrienne M.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2008-07-10
- Volume
- 12
- Issue
- 6a
- Pages
- 2263-2280
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC4514105
- OpenAlex
- W1965453486
- Cited by
- 362
- References
- 222
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 35 · 2023: 34 · 2022: 38 · 2021: 36 · 2020: 11 · 2019: 26 · 2018: 28 · 2017: 26 · 2016: 11 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 10
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Research Repository UCD (University College Dublin) (cc-by)
- Funders
- National University of Ireland
- University of Galway
- Irish Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuronal cell death, neurodegenerative diseases, apoptosis, necrosis, excitotoxicity, autophagic cell death, protein misfolding, protein aggregation, protein degradation, ischemia, Alzheimer's disease, Parkinson's disease, Huntington's disease, neuroprotection
- MeSH terms
- Alzheimer Disease, Autophagy, Brain Ischemia, Endoplasmic Reticulum, Humans, Huntington Disease, Models, Neurological, Necrosis, Nerve Tissue Proteins, Neurons, Parkinson Disease, Stress, Physiological, Receptors, N-Methyl-D-Aspartate, Cell Death, Apoptosis, Neurodegenerative Diseases, Ubiquitin, Proteasome Endopeptidase Complex
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