Cited by 710Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Evolution of the neuropathology of Alzheimer's disease

Braak, H., Braak, E.·1996·Acta Neurologica Scandinavica

DOI 10.1111/j.1600-0404.1996.tb05866.x

Open this paper in CoChat — free account

Abstract

Our knowledge of the etiology and pathogenesis of Alzheimer's disease is limited. The most conspicuous changes seen in the brain are deposits of insoluble proteins in both extracellular and intraneuronal locations. The extracellular deposits consist primarily of a specific A4 amyloid protein. The significance of these deposits remains to be determined, as they are often found in the cerebral cortex of non-demented elderly persons. More telling is the gradual accumulation of insoluble fibrous material within some neurons that consists mainly of abnormally phosphorylated tau protein. Six stages of increasingly severe cortical destruction can be distinguished. Stages I and II are characterized by neurofibrillary changes that are largely confined to the transentorhinal region, whereas stages III and IV are marked by severe involvement of both the entorhinal and transentorhinal regions. Isocortical destruction occurs during stages V and VI. This progression in cortical pathology correlates with the gradual worsening of clinical symptoms.

Integrity signals

Registry

Crossref · 10.1111/j.1600-0404.1996.tb05866.x

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Self-citation
Distributed hierarchical processing in the primate cerebral cortex
Felleman, D. J., & Van Essen, D. C. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.1 · Cited by 7,783
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.
Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676
Preface: Cerebral Cortex Has Come of Age
Goldman, P. S., & RAKIC, P. T. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.1-a · Cited by 3,537
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499
Staging of alzheimer's disease-related neurofibrillary changes
Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357
Self-citation
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268
Functional Assessment Staging (FAST)
Gauthier, S. G. (2001) · CRC Press eBooks · doi:10.3109/9780203213896-33 · Cited by 1,023

Show all 53 references

Research works printed but not linked: 2

Kemper, 1978, Senile dementia: a biomedical approach, 105
Braak, 1993, Alzheimer's disease: advances in clinical and basic research. Third International Conference on Alzheimer's Disease and Related Disorders, 131

Sorted by citations

Items 201–300 of 710

Identifying severely atrophic cortical subregions in Alzheimer's disease
Halliday, G. M. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00227-0 · Cited by 72
Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease
Okamoto, M., Gray, J. D., Larson, C. S., Kazim, S. F., Soya, H., McEwen, B. S., & Pereira, A. C. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0201-z · Cited by 70
Dementia: Alzheimer pathology and vascular factors: From mutually exclusive to interaction
van Norden, A. G. W., van Dijk, E. J., de Laat, K. F., Scheltens, P., Olde-Rikkert, M. G. M., & de Leeuw, F. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.07.003 · Cited by 75
Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease
Xu, W., Fitzgerald, S. M., Nixon, R. A., Levy, E., & Wilson, D. A. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.12.008 · Cited by 69
Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: Sensitivity, Specificity and Potential for Clinical Use
d’Abramo, C., D'adamio, L., & Giliberto, L. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030116 · Cited by 71
Getting lost in Alzheimer’s disease: A break in the mental frame syncing
Serino, S., & Riva, G. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2012.12.031 · Cited by 74
Chronic traumatic encephalopathy: clinical‐biomarker correlations and current concepts in pathogenesis
Gandy, S., Ikonomović, M. D., Mitsis, E. M., Elder, G. A., Ahlers, S. T., Barth, J. T., Stone, J. R., & DeKosky, S. T. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-37 · Cited by 68
A Scoping Review of Cognitive Training in Neurodegenerative Diseases via Computerized and Virtual Reality Tools: What We Know So Far
Lasaponara, S., Marson, F., Doricchi, F., & Cavallo, M. (2021) · Brain Sciences · doi:10.3390/brainsci11050528 · Cited by 72
Extracellular protein deposition correlates with glial activation and oxidative stress in Creutzfeldt-Jakob and Alzheimer’s disease
Van Everbroeck, B., Dobbeleir, I., De Waele, M., De Leenheir, E., Lübke, U., Martin, J.-J., & Cras, P. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0879-2 · Cited by 66
Functional Connectivity between the Resting-State Olfactory Network and the Hippocampus in Alzheimer’s Disease
Lu, J., Testa, N., Jordan, R., Elyan, R., Kanekar, S. G., Wang, J., Eslinger, P. J., Yang, Q. X., Zhang, B., & Karunanayaka, P. (2019) · Brain Sciences · doi:10.3390/brainsci9120338 · Cited by 66
Hyperphosphorylated Tau is Elevated in Alzheimer's Disease with Psychosis
Murray, P. S., Kirkwood, C. M., Gray, M. C., Fish, K. N., Ikonomović, M. D., Hamilton, R. L., Kofler, J., Klunk, W. E., López, O. L., & Sweet, R. A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131166 · Cited by 67
Altered Functional Connectivity of Fusiform Gyrus in Subjects with Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study
Cai, S., Chong, T., Zhang, Y., Li, J., von Deneen, K. M., Ren, J., Dong, M., & Huang, L. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00471 · Cited by 68
Neuropsychology of Alzheimer's Disease
Peña‐Casanova, J., Sánchez‐Benavides, G., de Sola, S., Manero-Borràs, R. M., & Casals-Coll, M. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.08.015 · Cited by 65
Hippocampal subregions differentially associate with standardized memory tests
Brickman, A. M., Stern, Y., & Small, S. A. (2010) · Hippocampus · doi:10.1002/hipo.20840 · Cited by 69
Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS
Mueller, S. G., Schuff, N. W., & Weiner, M. W. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1062 · Cited by 66
A Sparse Structure Learning Algorithm for Gaussian Bayesian Network Identification from High-Dimensional Data
Huang, S., Li, J., Ye, J., Fleisher, A., Chen, K., Wu, T., & Reiman, E. M. (2012) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.2012.129 · Cited by 63
Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease
Mousavi, M. T., Hellström‐Lindahl, E., Guan, Z.-Z., Shan, K.-R., Ravid, R., & Nordberg, A. K. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00460-3 · Cited by 61
Progressive Reduction of Synaptophysin Message in Single Neurons in Alzheimer Disease
Callahan, L. M., Vaules, W. A., & Coleman, P. D. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.5.384 · Cited by 61
Elevated MARK2-Dependent Phosphorylation of Tau in Alzheimer's Disease
Gu, G. J., Wu, D., Lund, H., Sunnemark, D., Kvist, A. J., Milner, R. D. B., Eckersley, S., Nilsson, L. N. G., Agerman, K., Landegren, U. D., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121357 · Cited by 58
Secondary prevention of Alzheimer’s dementia: neuroimaging contributions
ten Kate, M., Ingala, S., Schwarz, A. J., Fox, N. C., Chételat, G., van Berckel, B. N. M., Ewers, M., Foley, C., Gispert, J. D., Hill, D., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0438-z · Cited by 65
Cerebral Cortical Arteriolar Angiopathy, Vascular Beta-Amyloid, Smooth Muscle Actin, Braak Stage, and APOE Genotype
Stopa, E. G., Butala, P., Salloway, S., Johanson, C. E., González, L., Tavares, R., Hovanesian, V., Hulette, C. M., Vitek, M. P., & Cohen, R. A. (2008) · Stroke · doi:10.1161/strokeaha.107.493429 · Cited by 60
Cognitive reserve and the risk for Alzheimer's disease: a longitudinal study
Serra, L., Musicco, M., Cercignani, M., Torso, M., Spanò, B., Mastropasqua, C., Giulietti, G., Marra, C., Bruno, G., Koch, G., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.10.010 · Cited by 60
Reduction of NR1 and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease
Amada, N., Aihara, K., Ravid, R., & Horie, M. (2005) · Neuroreport · doi:10.1097/01.wnr.0000185015.44563.5d · Cited by 59
Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease
Lesuis, S. L., Maurin, H., Borghgraef, P., Lucassen, P. J., LEUVEN, F. V., & Krugers, H. J. (2016) · Oncotarget · doi:10.18632/oncotarget.9776 · Cited by 62
Icariin Attenuates M1 Activation of Microglia and Aβ Plaque Accumulation in the Hippocampus and Prefrontal Cortex by Up-Regulating PPARγ in Restraint/Isolation-Stressed APP/PS1 Mice
Wang, Y., Zhu, T., Wang, M., Zhang, F., Zhang, G., Zhao, J., Zhang, Y., Wu, E., & Li, X. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00291 · Cited by 58
Amyloid-β, Tau, and Dementia
Takashima, A. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1090 · Cited by 57
Investigation of the effective connectivity of resting state networks in Alzheimer's disease: a functional MRI study combining independent components analysis and multivariate Granger causality analysis
Liu, Z., Zhang, Y., Bai, L., Yan, H. J., Dai, R., Zhong, C., Wang, H., Wei, W., Xue, T., Feng, Y., et al. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2803 · Cited by 58
Expression of the Fe65 adapter protein in adult and developing mouse brain
Kesavapany, S., Banner, S. J., Lau, K., Shaw, C. E., Miller, C. C. J., Cooper, J. D., & McLoughlin, D. M. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00422-0 · Cited by 57
Proteomic Atlas of the Human Brain in Alzheimer’s Disease
McKetney, J., Runde, R. M., Hebert, A. S., Salamat, S. M., Roy, S., & Coon, J. J. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00004 · Cited by 54
Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Bueichekú, E., Diez, I. P., Kim, C. M., Becker, J. A., Koops, E. A., Kwong, K. K., Papp, K. V., Salat, D. H., Bennett, D. A., Rentz, D. M., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00626-y · Cited by 70
Hippocampal atrophy is related to impaired memory, but not frontal functions in non-demented Parkinsonʼs disease patients
Riekkinen, P. J., Kejonen, K., Laakso, M. P., Soininen, H. S., Partanen, K. P. L., & Riekkinen, M. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00048 · Cited by 56
Variations in cortical thickness with dementia severity in Alzheimer's disease
Im, K., Lee, J. M., Seo, S. W., Yoon, U., Kim, S. T., Kim, Y., Kim, S. I., & Na, D. L. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.03.032 · Cited by 57
Contribution of neural networks to Alzheimer disease's progression
Savioz, A., Leuba, G., Vallet, P. G., & Walzer, C. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.06.006 · Cited by 59
M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?
Scarpa, M., Hesse, S., & Bradley, S. J. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2019.12.003 · Cited by 55
Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology.
Kurumatani, T., Fastbom, J., Bonkale, W., Bogdanovic, N., Winblad, B., Ohm, T., & Cowburn, R. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00347-3 · Cited by 60
Rates of brain atrophy over time in autopsy-proven frontotemporal dementia and Alzheimer disease
Whitwell, J. L., Jack, C. R., Pankratz, V. S., Parisi, J. E., Knopman, D. S., Boeve, B. F., Petersen, R. C., Dickson, D. W., & Josephs, K. A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.001 · Cited by 55
Hypocretin and brain β-amyloid peptide interactions in cognitive disorders and narcolepsy
Dauvilliers, Y. A., Lehmann, S., Jaussent, I., & Gabelle, A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00119 · Cited by 56
Modulating disease-relevant tau oligomeric strains by small molecules
Cascio, F. L., García, S., Montalbano, M., Puangmalai, N., McAllen, S., Pace, A., Piccionello, A. P., & Kayed, R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014630 · Cited by 53
Inclusion of Neuropsychological Scores in Atrophy Models Improves Diagnostic Classification of Alzheimer’s Disease and Mild Cognitive Impairment
Goryawala, M., Zhou, Q., Barker, W., Loewenstein, D., Duara, R., & Adjouadi, M. (2015) · Computational Intelligence and Neuroscience · doi:10.1155/2015/865265 · Cited by 53
Clinical significance of fluid biomarkers in Alzheimer’s Disease
Lewczuk, P., Łukaszewicz‐Zając, M., Mroczko, P., & Kornhuber, J. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00107-0 · Cited by 56
A method for assessing tissue respiration in anatomically defined brain regions
Underwood, E., Redell, J. B., Zhao, J., Moore, A. N., & Dash, P. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-69867-2 · Cited by 51
Networks involved in olfaction and their dynamics using independent component analysis and unified structural equation modeling
Karunanayaka, P., Eslinger, P. J., Wang, J., Weitekamp, C. W., Molitoris, S., Gates, K. M., Molenaar, P. C. M., & Yang, Q. X. (2013) · Human Brain Mapping · doi:10.1002/hbm.22312 · Cited by 54
Entorhinal cortical defects in Tg2576 mice are present as early as 2–4 months of age
Duffy, Á., Morales‐Corraliza, J., Bermudez‐Hernandez, K., Schaner, M. J., Magagna‐Poveda, A., Mathews, P. M., & Scharfman, H. E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.001 · Cited by 52
Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid
Selnes, P., Blennow, K., Zetterberg, H., Grambaitė, R., Rosengren, L., Johnsen, L., Stenset, V. T. V., & Fladby, T. (2010) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-7-10 · Cited by 52
Attenuation of Choroidal Thickness in Patients With Alzheimer Disease
Trebbastoni, A., Marcelli, M., Mallone, F., D’Antonio, F., Imbriano, L., Campanelli, A., de Lena, C., & Gharbiya, M. (2016) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000176 · Cited by 52
Identification of Early-Stage Alzheimer's Disease Using Sulcal Morphology and Other Common Neuroimaging Indices
Cai, K., Xu, H., Guan, H., Zhu, W., Jiang, J., Cui, Y. J., Zhang, J., Liu, T., & Wen, W. X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170875 · Cited by 51
Cognitive map in patients with mild Alzheimer's disease: A computer-generated arena study
Jheng, S.-S., & Pai, M. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.029 · Cited by 59
Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model
Rossano, S. M., Johnson, A. S., Smith, A. P., Ziaggi, G., Roetman, A. E., Guzman, D., Okafor, A., Klein, J., Tomljanovic, Z., Stern, Y., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13699 · Cited by 54
Whole brain atrophy rate predicts progression from MCI to Alzheimer’s disease
Spulber, G., Niskanen, E. I., MacDonald, S. W. S., Smilovici, O., Chen, K., Reiman, E. M., Jauhiainen, A. M., Hallikainen, M., Tervo, S., Wahlund, L., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.08.018 · Cited by 51
Rating of Different Olfactory Judgements in Alzheimer's Disease
Royet, J. (2001) · Chemical Senses · doi:10.1093/chemse/26.4.409 · Cited by 51
Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium
Seripa, D., Solfrizzi, V., Imbimbo, B. P., Daniele, A., Santamato, A., Lozupone, M., Zuliani, G., Greco, A., Logroscino, G., & Panza, F. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1140039 · Cited by 50
Targeting Post-translational Modifications on Tau as a Therapeutic Strategy for Alzheimer's Disease
Marcus, J., & Schachter, J. B. (2011) · Journal of Neurogenetics · doi:10.3109/01677063.2011.626471 · Cited by 51
Clinicopathological phenotype of codon 129 valine homozygote sporadic Creutzfeldt–Jakob disease
Kovács, G. G., Head, M. W., Bunn, T. J. R., László, L., Will, R. G., & Ironside, J. W. (2000) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2000.00279.x · Cited by 50
Education Attenuates the Effect of Medial Temporal Lobe Atrophy on Cognitive Function in Alzheimer's Disease: The MIRAGE Study
Perneczky, R., Wagenpfeil, S., Lunetta, K. L., Cupples, L. A., Green, R. C., DeCarli, C. S., Farrer, L. A., & Kurz, A. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1117 · Cited by 49
Lexical retrieval in discourse: An early indicator of Alzheimer's dementia
Pekkala, S., Wiener, D., Himali, J., Beiser, A., Obler, L., Liu, Y.-L., Mckee, A., Auerbach, S., Seshadri, S., Wolf, P., et al. (2013) · Clinical Linguistics & Phonetics · doi:10.3109/02699206.2013.815278 · Cited by 48
Is there a neuropathology difference between mild cognitive impairment and dementia?
Haroutunian, V. H., Hoffman, L. B., & Been, M. S. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/vharoutunian · Cited by 52
PET amyloid imaging as a tool for early diagnosis and identifying patients at risk for progression to Alzheimer's disease
Pontecorvo, M. J., & Mintun, M. A. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt70 · Cited by 49
Predicting neurocognitive function with hippocampal volumes and DTI metrics in patients with Alzheimer's dementia and mild cognitive impairment
Shim, G., Choi, K., Kim, D., Suh, S., Lee, S., Jeong, H., & Jeong, B. (2017) · Brain and Behavior · doi:10.1002/brb3.766 · Cited by 46
Olfactory impairment increases as a function of age in persons with Down syndrome
Nijjar, R. K., & Murphy, C. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00263-9 · Cited by 48
Acceleration of cortical thinning in familial Alzheimer's disease
Knight, W. D., Kim, L. G., Douiri, A., Frost, C. D., Rossor, M. N., & Fox, N. C. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.11.013 · Cited by 48
Odor Identification and Self-reported Olfactory Functioning in Patients with Subtypes of Mild Cognitive Impairment
Lehrner, J. P., Pußwald, G., Gleiß, A., Auff, E., & Dal‐Bianco, P. (2009) · The Clinical Neuropsychologist · doi:10.1080/13854040802585030 · Cited by 48
Disentangling the pathology of schizophrenia and paraphrenia
Casanova, M. F., Stevens, J. R., Brown, R., Royston, C., & Bruton, C. J. (2002) · Acta Neuropathologica · doi:10.1007/s00401-001-0468-6 · Cited by 47
Gray Matter Network Disruptions and Regional Amyloid Beta in Cognitively Normal Adults
ten Kate, M., Visser, P. J., Bakardjian, H., Barkhof, F., Sikkes, S. A. M., van der Flier, W. M., Scheltens, P., Hampel, H., Habert, M.-O., Dubois, B., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00067 · Cited by 41
Selective tau tyrosine nitration in non-AD tauopathies
Reyes, J. F., Geula, C., Vana, L., & Binder, L. I. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0898-8 · Cited by 46
Phenomenological Model of Diffuse Global and Regional Atrophy Using Finite-Element Methods
Cámara, Ó., Schweiger, M. J., Scahill, R. I., Crum, W. R., Sneller, B., Schnabel, J. A., Ridgway, G. R., Cash, D. M., Hill, D., & Fox, N. C. (2006) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2006.880588 · Cited by 46
Common childhood and adolescent infections and multiple sclerosis
Granieri, E., & Casetta, I. (1997) · Neurology · doi:10.1212/wnl.49.2_suppl_2.s42 · Cited by 46
Resting State Cortical Electroencephalographic Rhythms and White Matter Vascular Lesions in Subjects with Alzheimer's Disease: An Italian Multicenter Study
Babiloni, C., Lizio, R., Carducci, F., Vecchio, F., Redolfi, A., Marino, S., Tedeschi, G., Montella, P., Guizzaro, A., Esposito, F., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101710 · Cited by 45
Apolipoprotein E genotypes in primary progressive aphasia
Mesulam, M. M., Johnson, N., Grujic, Z., & Weıntraub, S. (1997) · Neurology · doi:10.1212/wnl.49.1.51 · Cited by 45
Yes/No Versus Forced-Choice Recognition Memory in Mild Cognitive Impairment and Alzheimer's Disease: Patterns of Impairment and Associations with Dementia Severity
Clark, L. R., Stricker, N. H., Libon, D. J., Delano‐Wood, L., Salmon, D. P., Delis, D. C., & Bondi, M. W. (2012) · The Clinical Neuropsychologist · doi:10.1080/13854046.2012.728626 · Cited by 44
Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer’s Disease
Martinez, J. L., Zammit, M. D., West, N. R., Christian, B. T., & Bhattacharyya, A. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.703876 · Cited by 47
A quantitative autoradiographic study of [3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits
Bonkale, W. L., Cowburn, R. F., Ohm, T. G., Bogdanović, N., & Fastbom, J. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01307-9 · Cited by 43
APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation
Marino, C., Perez‐Corredor, P., O'Hare, M., Heuer, A., Chmielewska, N., Gordon, H., Chandrahas, A. S., Gonzalez‐Buendia, L., Delgado‐Tirado, S., Doan, T. H., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13436 · Cited by 45
Mild Cognitive Impairment: Same Identity for Different Entities
Serra, L., Giulietti, G., Cercignani, M., Spanò, B., Torso, M., Castelli, D., Perri, R., Fadda, L., Marra, C., Caltagirone, C., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121663 · Cited by 42
Tau and Caspase 3 as Targets for Neuroprotection
Idan-Feldman, A., Ostritsky, R., & Gozes, I. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/493670 · Cited by 42
Interneurons in the human olfactory system in Alzheimer's disease
Saiz‐Sánchez, D., Flores‐Cuadrado, A., Úbeda‐Bañón, I., de la Rosa‐Prieto, C., & Martı́nez-Marcos, A. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.11.009 · Cited by 44
A method for inferring regional origins of neurodegeneration
Torok, J., Maia, P. D., Powell, F., Pandya, S., & Raj, A. (2017) · Brain · doi:10.1093/brain/awx371 · Cited by 42
Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use
Burggren, A. C., Siddarth, P., Mahmood, Z., London, E. D., Harrison, T. M., Merrill, D. A., Small, G. W., & Bookheimer, S. Y. (2018) · Cannabis and Cannabinoid Research · doi:10.1089/can.2018.0035 · Cited by 43
Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy
Nehls, M. (2016) · Journal of Molecular Psychiatry · doi:10.1186/s40303-016-0018-8 · Cited by 41
Serial position effects are sensitive predictors of conversion from MCI to Alzheimer's disease dementia
Egli, S. C., Beck, I. R., Berres, M., Foldi, N. S., Monsch, A. U., & Sollberger, M. A. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.09.012 · Cited by 41
Early Brain Loss in Circuits Affected by Alzheimer’s Disease is Predicted by Fornix Microstructure but may be Independent of Gray Matter
Fletcher, E. M., Carmichael, O. T., Pasternak, O., Maier-Hein, K. H., & DeCarli, C. S. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00106 · Cited by 42
Biomarkers of agitation and aggression in Alzheimer's disease: A systematic review
Ruthirakuhan, M. T., Lanctôt, K. L., Scipio, M. D., Ahmed, M. A., & Herrmann, N. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.04.013 · Cited by 43
Tau Overexpression Inhibits Cell Apoptosis with the Mechanisms Involving Multiple Viability-Related Factors
Wang, H.-H., Li, H.-L., Liu, R., Zhang, Y., Liao, K., Wang, Q., Wang, J., & Liu, S.-J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091279 · Cited by 41
Cognitive changes in the preclinical phase of familial Alzheimer's disease
Arango‐Lasprilla, J. C., Cuetos, F., Valencia, C., Uribe, C., & Lopera, F. J. (2007) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390601174151 · Cited by 41
Inverse correlation between Alzheimer’s disease and cancer: implication for a strong impact of regenerative propensity on neurodegeneration?
Li, J., Liu, C., Hu, X., Cai, Y., Ma, C., Luo, X., & Yan, X. (2014) · BMC Neurology · doi:10.1186/s12883-014-0211-2 · Cited by 41
A promoter polymorphism in the monoamine oxidase A gene is associated with the pineal MAOA activity in Alzheimer's disease patients
Wu, Y., Fischer, D. F., & Swaab, D. F. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.053 · Cited by 40
The Role of Quantitative Structural Imaging in the Early Diagnosis of Alzheimer's DiseaseQ4
Głodzik-Sobańska, L., Rusinek, H., Mosconi, L., Li, Y., Zhan, J., Santi, S. D., Convit, A. J., Rich, K. E., Bryś, M., & de Leon, M. J. (2005) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2005.09.004 · Cited by 40
Amnestic MCI future clinical status prediction using baseline MRI features
Duchesne, S., Bocti, C., Sousa, K. D., Frisoni, G. B., Chertkow, H. M., & Collins, D. L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.09.003 · Cited by 39
Putative Survival Advantages in Young Apolipoprotein ɛ4 Carriers are Associated with Increased Neural Stress
Smith, C. J., Ashford, J. W., & Perfetti, T. A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181089 · Cited by 40
Disruptions of the olfactory and default mode networks in Alzheimer's disease
Lu, J., Yang, Q. X., Zhang, H., Eslinger, P. J., Zhang, X., Wu, S., Zhang, B., Zhu, B., & Karunanayaka, P. (2019) · Brain and Behavior · doi:10.1002/brb3.1296 · Cited by 40
Olfaction et pathologies neurologiques : revue de la littérature
Demarquay, G., Ryvlin, P., & Royet, J. (2007) · Revue Neurologique · doi:10.1016/s0035-3787(07)90387-2 · Cited by 39
Therapeutic Potential of Astrocyte Transplantation
Hastings, N., Kuan, W., Osborne, A., & Kotter, M. (2022) · Cell Transplantation · doi:10.1177/09636897221105499 · Cited by 39
Memory markers in the continuum of the Alzheimer’s clinical syndrome
Parra, M. A., Calia, C., Pattan, V., & Sala, S. D. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01082-9 · Cited by 39
Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease
Kayed, R. (2010) · Human Vaccines · doi:10.4161/hv.6.11.12689 · Cited by 38
Glucocorticoid receptors signaling impairment potentiates amyloid‐β oligomers‐induced pathology in an acute model of Alzheimer’s disease
Canet, G., Pineau, F., Zussy, C., Hernandez, C., Hunt, H., Chevallier, N., Perrier, V., Torrent, J., Belanoff, J. K., Meijer, O. C., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900723rrr · Cited by 37
Patterns of tau pathology identified with 18 F‐MK‐6240 PET imaging
Kreisl, W. C., Lao, P. J., Johnson, A. S., Tomljanovic, Z., Klein, J., Polly, K., Maas, B., Laing, K. K., Chesebro, A. G., Igwe, K. C., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12384 · Cited by 42
Clonidine impairs sustained attention and memory in Alzheimer's disease
Riekkinen, M., Laakso, M. P., Jäkälä, P., & Riekkinen, P. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00070-6 · Cited by 39
Role of PrPC Expression in Tau Protein Levels and Phosphorylation in Alzheimer’s Disease Evolution
Vergara, C., Ordóñez‐Gutiérrez, L., Wandosell, F. G., Ferrer, I., del Rı́o, J. A., & Gavı́n, R. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8793-7 · Cited by 38
GSK-3β and memory formation
Takashima, A. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00047 · Cited by 39
The role of neuroimaging in dementia
DeCarli, C. S. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70068-9 · Cited by 39
The role of neurogenesis during development and in the adult brain
Jin, X. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13251 · Cited by 43

Authors: Braak, H., & Braak, E.
Affiliations: Goethe University Frankfurt (DE)
Corresponding author: Braak, H.
ORCID: Braak, H.
Venue: Acta Neurologica Scandinavica
Publisher: Wiley
Published: 1996-04
Volume: 94
Issue: S165
Pages: 3-12
ISSN: 0001-6314 (ISSN-L)
DOI: 10.1111/j.1600-0404.1996.tb05866.x
OpenAlex: W1971744915
Cited by: 710
References: 53
Citations by year: 2026: 13 · 2025: 24 · 2024: 27 · 2023: 22 · 2022: 29 · 2021: 22 · 2020: 29 · 2019: 27 · 2018: 29 · 2017: 25 · 2016: 31 · 2015: 36 · 2014: 36 · 2013: 31 · 2012: 36
FWCI: 2.02
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 7092 d)
Locations: Acta Neurologica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, neuropathology, amyloid plaques, tau protein, neurofibrillary tangles, entorhinal cortex, cortical atrophy, disease stage, etiopathogenesis
MeSH terms: Alzheimer Disease, Hippocampus, Humans, Neurofibrillary Tangles, Entorhinal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evolution of the neuropathology of Alzheimer's disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks