Retinal nerve fiber layer abnormalities in Alzheimer's disease
Open accessAbstract
Retinal nerve fiber layer (RNFL) photographs from 26 patients with Alzheimer's disease and 23 normal, age-matched, control subjects were reviewed for quality and abnormalities by two observers. A higher proportion of Alzheimer's patients showed RNFL abnormalities when compared to control subjects. There was some disagreement between the two observers regarding quality and frequency of abnormalities, reflecting suboptimal quality of the photographs obtained in patients with advanced Alzheimer's disease. Although these findings add to the clinical and histopathological evidence that ganglion cell degeneration occurs in Alzheimer's disease, the difficulty in obtaining and evaluating retinal nerve fiber layer photographs, especially in advanced cases, may limit the clinical usefulness of retinal nerve fiber layer analysis in such patients.
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Patients with AD often develop visual anomalies correlated with abnormalities in the eye.
“However, in the last few decades it has been demonstrated that patients with AD often develop visual anomalies, which are correlated with abnormalities in the eye.”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Hedges et al., 1996
AD is associated with reduction in number of optic nerve head axons and decrease in thickness of peripapillary and macular RNFL.
“Among them, there is a reduction in the number of optic nerve head axons and a decrease in the thickness of the peripapillary and macular retinal nerve fiber layer (RNFL) (Tsai et al., 1991; Hedges et al., 1996; Danesh-Meyer et al., 2006; Iseri et al., 2006; Paquet et al., 2007; Garcia-Martin et al., 2014; Salobrar-Garcia et al., 2015; Salobrar-García et al., 2016c) (Table 1).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Hedges et al., 1996
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The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.
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- Authors
- Hedges, T. R., Galves, R. P., Speigelman, D., Barbas, N. R., Peli, E., & Yardley, C. J.
- Affiliations
- Tufts University (US)
- Harvard University (US)
- Corresponding author
- Hedges, Thomas R.
- ORCID
- Hedges, Thomas R.
- Venue
- Acta Ophthalmologica Scandinavica
- Publisher
- Wiley
- Published
- 1996-06
- Volume
- 74
- Issue
- 3
- Pages
- 271-275
- ISSN
- 1395-3907 (ISSN-L)
- 1600-0420
- OpenAlex
- W2139551917
- Cited by
- 92
- References
- 22
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 1
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Acta Ophthalmologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- Alzheimer's disease, retinal nerve fiber layer, ganglion cell degeneration, retinal imaging, interobserver agreement, advanced Alzheimer's disease, retinal biomarkers
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Fundus Oculi, Humans, Middle Aged, Nerve Fibers, Optic Nerve, Photography, Retina, Observer Variation
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