Vision function abnormalities in Alzheimer disease
Abstract
Alzheimer disease (AD) is a progressive, age-related debilitating condition that is a growing public health problem in the developed world. Visual system abnormalities in AD were recognized in the early 1970s, but were initially considered to be of strictly cortical origin. Studies in the past 20 years reveal that all parts of the visual system may be affected, including the optic nerve and the retina. Some aspects of this involvement are still not well understood and are the subjects of intensive research. We summarize and focus on findings that may be of more practical interest to the ophthalmologist.
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Loss of visual recognition is a characteristic pathology associated with AD.
“the loss of visual recognition is a characteristic pathology associated with AD”
From AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease (2018) · cites this paper as [50]
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AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease
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- Authors
- Tzekov, R., & Mullan, M.
- Affiliations
- University of South Florida (US)
- Roskamp Institute (US)
- Corresponding author
- Tzekov, Radouil
- Venue
- Survey of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 59
- Issue
- 4
- Pages
- 414-433
- ISSN
- 0039-6257 (ISSN-L)
- OpenAlex
- W2021464110
- Cited by
- 94
- References
- 335
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 14 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 13 · 2015: 11 · 2014: 4
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Survey of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- Alzheimer's disease, visual system, optic nerve, retina, retinal involvement, cerebral visual impairment, ophthalmology
- MeSH terms
- Alzheimer Disease, Humans, Vision Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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